SK2..

sk261液晶电源驱动电路原理SK261 液晶电源驱动电路就像是一个神奇的小魔法师，默默在背后为咱们的液晶屏幕提供着稳定而强大的能量支持。

想象一下，这个电路就像是一个能量运输大队。

电源输入进来，就像是一批批货物到达了仓库。

而这个电路呢，它得把这些“货物”，也就是电能，有条有理地分配出去，保证每一个需要能量的地方都能得到充足的供应。

它里面有各种各样的小元件，就像是一个个勤劳的小工人。

比如说那些电容，它们就像一个个小水库，能储存电能，在需要的时候迅速释放出来，让电流变得平稳流畅，不会一会儿大一会儿小，把咱们的液晶屏幕给“吓着”。

还有那些电阻，它们就像是道路上的收费站，控制着电流的大小，不让电流像脱缰的野马一样乱跑。

再来说说那些晶体管，它们可是电路里的“指挥官”。

它们能根据不同的情况，开关电流的通道，决定电能往哪儿走，走多少。

这个驱动电路工作起来可认真啦！它时刻关注着液晶屏幕的需求。

当屏幕需要更多的亮度，它就赶紧加大能量的供应；当屏幕不需要那么亮的时候，它又能聪明地减少能量输出，节省能源，就像咱们过日子要精打细算一样。

而且哦，这个电路还得应对各种各样的外部干扰。

比如说，电网电压突然波动了，它得迅速调整，保证输出给液晶屏幕的电压电流依然稳定。

这就像是在暴风雨中稳稳掌舵的船长，不管风浪多大，都能让船平稳前行。

它还得考虑到散热的问题呢。

毕竟工作的时候会产生一些热量，如果不把这些热量散发出去，电路可能就会“发脾气”，甚至罢工。

所以，在设计的时候就得给它安排好散热的通道，让它能舒舒服服地工作。

你看，这个小小的 SK261 液晶电源驱动电路，虽然我们平时看不见它，但它却在默默地为我们的液晶屏幕服务，让我们能清晰地看到精彩的画面。

是不是很厉害呀？SK261 液晶电源驱动电路虽然复杂，但它就像是一个默默守护的英雄，用它的智慧和力量，为我们带来了清晰明亮的液晶显示世界。

下次当你看着液晶屏幕的时候，可别忘了背后有这个小家伙在辛勤工作哦！。

Super Kids2 知识点汇总Unit 1 Feelings1 单词：happy sad sleepy angry sick hot cold scared高兴伤心瞌睡生气生病热冷害怕复习单词：hungry饥饿的thirsty口渴的2 关键句型：Hi, Beth. How are you ?I’m OK. And you ? I’m great ,thanks.你好吗？我很好，你呢？我也非常好，谢谢！What’s that? I don’t know.那是什么？我不知道.Are you scared? Yes, I am. 你害怕吗？是的，我害怕。

3 补充：How are you? 的另外几种回答:Just so so.一般般Not so bad.不是太坏Not so good.不是太好让孩子能根据自己的实际情况表达。

4 音标：A a / / alligatorB b /b/ birdC c /k/ catD d /d/ dogE e /e/ elephantF f/ f/ fishG g /g/ gorillaH h /h/ hamsterI i /i/ iguanaJ j /j/ jacketK k /k/ kangaroo L l /l / lion5 Do it:Knock the door.敲门Open the door.开门Say,“Hello.”说“您好”Say, “Come in.”说“请进” Go inside. 进入Close the door. 关门Unit 1 StoryThe super kids are at Peter and Ton’s house. Toni is in bed. She’s sick. Her mother is angry. The dog ate the newspaper. The dog is sad. There’s Peter and his friend Beth. Peter is happy. Beth is hot. Donny and Chip are on the sofa. They see something strange in the yard. What is it? Look at Mojo the mouse. He’s sleepy. Joey and Lisa are in the bedroom. Joey has a toy alligator. Lisa is looking at a bird. She’s cold. Peter, Beth, Donny and Chip are look ing out the door. What do they see? It’s a spaceship. Donny is scared.Unit 2 Our house1 单词kitchen 厨房living room 客厅dining room 餐厅hall 走廊bedroom 卧室bathroom 卫生间closet 衣柜yard 院子2 关键句型：Hi. I’m Beth. What’s your name? My name’s Pluto. 你好我是Beth.,你叫什么名字?我是Pluto.How old are you? I’m 10. 你几岁了?我10岁了Where’s Joey? He’s in the bathroom.. Joey在哪？他在卫生间3 音标：M m monkey N n notebook O o octopus P p parrot Q q questionR r rabbit S s snake T t turtle U u umbrella Vv violinW w witch X x fox Y y yo-yo Z z zebra4 DO it:Hang up your coat. 挂衣服Make the bed.整理床Wash the dishes. 洗盘子Wipe the table.擦桌子Vacuum the carpet.（用吸尘器）打扫地毯Rake the leaves.扫树叶Unit 2 StoryLook. Beth and Donny are in the yard. Beth is talking to Pluto. Donny is talking to Jupiter. Pluto and Jupiter are aliens. They have a blue spaceship. Point to the living room. Who’s in the living room? Mojo the mouse. Hello, Mojo, Lisa is in t he hall. Lisa’s father is in the bedroom. Point to the closet. Joey’s in the bathroom. He’s brushing his teeth. Who’s in the dining room? Peter and his mother. Looking at the kitchen. What color is the kitchen? It’s green.Unit 3 Weather1 单词sunny 晴朗的cloudy 阴天的windy 有风的rainy下雨的snowy下雪的foggy 有雾的warm暖和的cool凉快的2 关键句型This is my friend, Lisa. 这是我的朋友Lisa.Nice to meet you. 很高兴见到你。

SK2500/SK3000/DX4000/DX5000 Unbroken SuperioritySK2500CAUTIONRISK OF ELECTRIC SHOCKDO NOT OPENIMPORTANT SAFETY SYMBOLSThe symbol is used to indicate that some hazardous live terminals are involved within this apparatus, even under the normal operating conditions, which maybe sufficient to constitute the risk of electric shock or death.The symbol is used in the service documentation to indicate that specific com-ponent shall be replaced only by component specified in that documentation for safety reasons.Protective grounding terminal Alternating current/voltage Hazardous live terminalON: Denotes the apparatus is turned on OFF: Denotes the apparatus is turned off.WARNING: Describes precautions that should be observed to prevent the danger ofiInjury or death to the operator.CAUTION: Describes precautions that should be observed to prevent danger of the apparatus.¡ã1. IMPORTANT SAFETY INSTRUCTIONSRead these instructions.Keep these instructions.Heed all warning.Follow all instructions.Water & MoistureThe apparatus should be protected from moisture and rain, can not used near water, for example: near bathtub, kitchen sink or a swimming pool, etc.HeatThe apparatus should be located away from the heat source such as radiators, stoves or other appliances that produce heat.F. TECHNICAL SPECIFICATIONVentilationDo not block ventilation areas. Failure to do so could result in fire. Always install accordance with the manufacturer's instructions.Object and Liquid EntryObjects do not fall into and liquids are not spilled into the inside of the apparatus for safety.Power Cord and PlugProtect the power cord from being walked on or pinched particularly at plugs, convenience receptacles, and the point where they exit from the apparatus.Do not defeat the safety purpose of the polarized or grounding-type plug.Power SupplyThe apparatus should be connected to the power supply only of the type as marked on the apparatus or described in the manual. Failure to do so will result in damage to theproduct and possibly to user.Unplug this apparatus during lightning storms or when unused for long periods of time.FuseT o prevent the risk of fire and damaging the unit, please use only the recommended type of fuse as described in the manual. Before replacing the fuse, make sure the unit is turned off and Type disconnected with AC outlet.Electrical ConnectionImproper electrical wiring may invalidate the product warranty.CleaningClean only with a dry cloth. Do not use any solvents such as benzol or alcohol. MaintenanceDo not accept any servicing other than that described in the manual. Consult with a qualified service personnel only.Only use accessories or parts recommended by the munufacturer.E. BLOCK DIAGRAMB. CONTROLS PART Front panel controlsCH 1CH 2input connection hint BalancedunbalancedHow to connect bridge modeIn this mode, signal input from channel1, and output from channel 1+, channel 2+, or bridged output connector. Volume is adjusted by volume knob of channel 1. To avoid crosstalk, please turn down the volume knob of channel 2 to lowest. Before operating bridge mode, please set mode select switch to the right positionBRIDGE. About details,please take reference to the following figure.A. INTRODUCTIONThank you for purchasing the professional power amplifier.This product is based on many years of R&D experience and the current professional technology to ensure the high performance cost ratio. The high efficiency soft switch makes the product light weight and reliable, compact, easy to operate. Protections includes clip/limit protection, thermal protection, over-load protection. It is equipped with power switch, CH1/2, volume control, clip LED, signal LED, power LED, protection LED. Rear panel: TRS connector, speak-on/binding-post output, parallel/bridge/stereo mode switch, sensitivity switch, etc.Please read the manual carefully before operation.CH 1CH 2input connection hintBalancedunbalancedHow to connect parallel modeIn the mode, signal that input from CH1 or CH2, and output from CH1 and CH2output outlet. Volume is controlled separately by volume knob of each channel.Before operating parallel mode, please set mode select switch to left position (PARALLEL), details please take reference to the following figure.1. Power switch(ON/OFF)Turns on/off power switch. When turned on, power LED lights up.Note: please set the volume control to minimum position to avoid device damage. 5. Clip LED (CLIP)Clip LED for each channel. When input signal reaches or surpasses clip level(distortion 0.5%), the corresponding channel LED lights up. Please adjust the level control to avoid distortion. 4. Protection LED (PROTECT)6. Signal LED (SIG)One LED for each channel. When output signal surpasses 3V (or input track has a input signal), the corresponding LED lights up.2. Power LED (POWER)When the amplifier turned on, blue LED lights up.7. Volume control (CH1/CH2)One control for each channel. Turn the control to adjust the input sensitivity .Adjustable range -~0dB. Turn counterclockwise to end is OFF .This setting can protect loudspeaker.When the power amplifier is in protection the corresponding LED lights up.This LED lights up yellow when power amplifier operates in Bridge Mode.3. Bridge LEDFront/rear panel controls8. AC input socket: Standard 3PIN IEC power connector, which connects to mainpower network through attached power cable. Please make sure the power is rightbefore connecting to voltage.Note: to prevent shock or fire, please make sure amplifier and all relateddevice all connect to ground.9. audio input/output connector: CH 1 and CH 2 electrical balanced COMBO(compliance XLR and 1/4" ), terminal input connector, is used for connecting externalaudio signal. These connectors internally parallelize and can receive balanced andunbalanced audio signal. The amplifier adopts electrical balanced circuit of low noise,wide dynamic processing scope can make it receive signal of any audio level.CH 1CH 2How to connect stereo modeIn stereo mode, channel1 and channel 2 work separately, signal that input from CH1would output from CH1, signal that input from CH2 would output from CH2. Volume iscontrolled by volume knob of each channel. Before connecting stereo mode, pleaseset mode select switch to the middle position--- STEREO. About details, please takereference to the following figure.input connection hintBalanced unbalanced810. grounding Separated switch: GND indicates apparatus ground connect with external shell, LIFT indicates external shell doesn't connect with apparatus ground (mainly used for decreasing noise in system matching )11. sensitivity transfer switch: According to different signals input size, select different sensitivity, make sure power amplifier is not at state of peak clipping.12. mode select switch: The select switch supplies three operating modes: parallel, stereo and bridge. Please select appropriate operating mode accordingto requirements.1) PARALLEL mode:In the mode, there are on solo input, two channels output, that is, signals that input from CH1 or CH2, can output from CH1 and CH2, the volume can be adjusted by volume knobs of each channel.2) STEREO modeIn the mode, CH1 and CH2 operates separately, signal that input from CH1 can output from CH1 outlet; signal that input from CH2 would output from CH2 socket. The volume is adjusted separately by volume knob of each channel.3) BRIDGED modeIn the mode, there is one solo input and one solo output, that is , signal that input from CH1 can output from CH 1+CH 2+ or bridged output socket, the volume is adjusted by CH1 volume knob. T o avoid crosstalk, please turn down CH2 volume knob to lowest. Concrete operation please takes reference to the fourth chapter of the manual.13. audio output connector: Standard speaker socket (speak-on) and binding post output connector, usually used for outputting amplified audio signal to external speaker. To avoid damage your apparatus, please pay attention to impedance matching, don't make it be lower than minimum impedance.14. fan: The fan can adjust speed automatically according to apparatus inside temperature. Wind direction: front panelrear panel.C. INSTALLA TION AND CONNECTION1) cabinet installation: the 19" 2U of PA is fit for standard cabinet installation. To avoid too hot, please keep PA have enough space for cooling. And don't block ventilation of PA.2) audio connection: PA equips with COMBO, 1/4" TRS and terminal input connector, speaker socket (speak-on) and binding post output connector, all these are convenient for different connecting ways.3) power connection: Before connecting PA with power, please check if the voltage is correct. Voltage and fuss should be the same as marked on rear panel. Please use manufacture's power cable, it equips with a standard IEC plug, which meets international safety standard.Wiring configurationD. OPERATION1) please confirm before operating:AC voltage is correctall apparatus are grounded rightlyoperating mode is rightvolume knob is on right position, usually, before turning on P A, two volume knobs should be set to minimum to avoid damaging speaker.2) turn on the power switch of PA.3) adjust PA volume knob to optimal S/N ratio.4) after operating, please turn off power.。

知识经济2007年第1期93“公关”是公共关系的简称，是英语Public Relations的翻译词，通常简写为PR。

公共关系，指的是社会组织与周围社会环境中的其他组织、机构、团体以及公众的社会联系。

危机公关，它是指“当企业遭遇突发事件或事故，其正常的生产经营活动受到影响，原有的良好企业形象受到破坏时，企业从公共关系的角度来应付、处理，使企业以尽可能低的成本渡过危机的公关活动”,具体体现在危机的爆发期、扩散蔓延期、危机消失期。

事件缘起于2006年9月14日，来自新华社的消息称：国家质检总局最新消息显示，广东出入境检验检疫机构从来至日本宝洁株式会社蜜丝佛陀公司制造的SK-II品牌系列化妆品中检出禁用物质铬和钕。

宝洁公司发表声明表示：SK-II产品在进入中国市场前都经过卫生部严格检验和注册，产品的安全和质量有充分的保障，在其生产过程中并未添加违禁成分。

对于本进口批次产品中发现的问题，宝洁公司将权利配合政府部门了解情况，使之得以顺利解决。

消息传开以后，京城几家商场做出反应：停止SK-II有问题产品的销售。

随之消费者也纷纷提出退货的要求。

全国各地多处因退货发生消费者与SK-II工作人员的肢体冲突。

在此冲突前宝洁公司设置了很高的退货门槛，并提出了霸王条款。

后因发生治安事件，2006年9月16日晚退货条件开始放宽，持小票和产品到产品柜台进行协商退货。

2006年9月22日SK-II 通过某跨国公司发表声明，决定暂停在中国的产品销售。

2006年10月23日，国家质检总局与卫生部发布联合声明，就SK-II产品的有关安全问题进行了说明。

基于该声明对于SK-II 产品安全性的澄清，宝洁公司决定将在今后几周内恢复SK-II在中国内地的销售。

II一般来说，由媒体负面报道引起的企业危机是企业危机管理中比较常见的危机类型。

SK-II在这次公关危机中有得也有失，但纵观事件全局，我们不难看出SK-II屡屡触犯危机公关的禁区。

在危机爆发期内，SK-II的反映速度不可谓不快，危机公关通常是要求在24小时之内做出反映，SK-II在数小时之内就发表了声明，这充分体现出危机公关的速度第一的原则。

SK2-1.2-12K型开启式管式电阻炉操作规程与注意事项
操作规程：
1、检查整个设备各处是否正常。

2、打开不锈钢法兰，将试件放入石英管内。

3、如需真空操作，先密封法兰，再关闭进气阀，利用真空泵抽真空达到目的后关闭阀门。

4、如需气体保护操作，先密封法兰，再将所需要保护的气体通过进气阀通入石英管内，利用真空泵抽真空达到目的后关闭阀门。

5、如不需2、3步操作，应先密封法兰，打开进气阀、出气阀，连接好进气路和出气路，如需流量计控制流量应将流量计连接在进气路和出气路上。

6、将控制器通电（旋钮开关转到右侧），按照实验要求和控制器说明调整实验各段所需温度、时间，然后按“RUN”键进行升温加热操作。

7、根据实验要求通入所需气体并调节气体流量。

8、实验期间，及时观察温度、流量与指标变化，进行对应调整。

9、实验完毕，按“END”键结束程序运行。

关闭控制器电源。

10、打开不锈钢法兰，取出物料。

注意事项：
1、本仪器无防爆装置，不得放入易燃易爆物样。

2、仪器应放在通风良好区域，周围无易燃易爆物品。

3、仪器外壳必须有效接地，以保证使用安全。

4、取放物料应轻拿轻放避免碰坏炉膛。

5、加热期间禁止接触加热电炉丝，避免触电或烫伤。

6、炉温不得超过设备额定温度，以免损坏加热元件。

7、禁止向炉膛内各种液体（会导致炉膛爆炸或断裂）及溶解金属（易结镏）。

8、经常清除炉膛内的铁屑、氧化物，以保持炉膛内的清洁。

SK22 THRU S210SURFACE MOUNT SCHOTTKY BARRIER RECTIFIER VOLTAGE - 20 to 100 Volts CURRENT - 2.0 AmperesFEATURESl Plastic package has Underwriters Laboratory Flammability Classification 94V-O l For surface mounted applications l Low profile package l Built-in strain relief l Metal to silicon rectifier majority carrier conductionl Low power loss, High efficiency l High current capability, low V F l High surge capacityl For use in low voltage high frequency inverters,f ree wheeling, and polarity protection applications l High temperature soldering guaranteed: 260¢J /10 seconds at terminals MECHANICAL DA TACase: JEDEC DO-214AA molded plasticTerminals: Solder plated, solderable per MIL-STD-750, Method 2026Polarity: Color band denotes cathodeStandard packaging: 12mm tape (EIA-481)Weight: 0.003 ounce, 0.093 gramMAXIMUM RA TINGS AND ELECTRICAL CHARACTERISTICSRatings at 25¢J ambient temperature unless otherwise specified.Resistive or inductive load.SYMBOLS SK22SK23SK24SK25SK26SK28SK29S210UNITS Maximum Recurrent Peak Reverse Voltage V RRM20304050608090100Volts Maximum RMS Voltage V RMS1421283542566471Volts Maximum DC Blocking Voltage V DC20304050608090100Volts Maximum Average Forward Rectified Current at T L (See Figure 1)I (AV) 2.0Amps Peak Forward Surge Current 8.3ms single half sine-wave superimposed on rated load(JEDEC method)I FSM 50.0AmpsMaximum Instantaneous Forward Voltage at 2.0A (Note 1)V F 0.500.700.85Volts Maximum DC Reverse Current T A =25¢J (Note 1)At Rated DC Blocking Voltage T A =100¢JI R 0.520.0mAMaximum Thermal Resistance (Note 2)R £K JLR £K JA1775¢J /W Operating Junction Temperature Range T J -50 to +125¢J Storage Temperature Range T STG -50 to +150¢J NOTES:1. Pulse Test with PW=300£g sec, 2% Duty Cycle.2. Mounted on P.C.Board with 8.0mm 2(.013mm thick) copper pad areas.SMB/DO-214AARATING AND CHARACTERISTIC CURVES SK22 THRU S210LEAD TEMPERATURE, ¢JINSTANTANEOUS FORW ARD VOLTAGE, VOLTSFig. 1-FORWARD CURRENT DERATING CURVEFig. 2-TYPICAL INSTANTANEOUS FORWARDCHARACTERISTICSREVERSE VOLTAGE VOLTSFig. 4-TYPICAL JUNCTION CAPACITANCEPERCENT OF RATED PEAK REVERSE VOLTAGE, %Fig. 3-TYPICAL REVERSE CHARACTERISTICSNUMBER OF CYCLES AT 60HzFig. 5-MAXIMUM NON-REPETITIVE PEAK FORWARD SURGE CURRENT。

TOSHIBA Field Effect Transistor Silicon N Channel MOS Type (L 2−π−MOSV)2SK2615DC −DC Converter, Relay Drive and Motor Drive Applicationsz Low drain −source ON resistance : R DS (ON) = 0.23 Ω (typ.) z High forward transfer admittance : |Y fs | = 2.0 S (typ.)z Low leakage current : I DSS = 100 μA (max) (V DS = 60 V) z Enhancement mode : V th = 0.8~2.0 V (V DS = 10 V, I D = 1 mA)Absolute Maximum Ratings (Ta = 25°C)Characteristics Symbol Rating UnitDrain −source voltageV DSS 60 VDrain −gate voltage (R GS = 20 k Ω) V DGR 60 V Gate −source voltage V GSS ±20 V DC (Note 1) I D 2Drain currentPulse (Note 1)I DP 6ADrain power dissipation P D 0.5 WDrain power dissipation (Note 2)P D 1.5 W Channel temperature T ch 150 °C Storage temperature rangeT stg−55~150 °CNote 1: Ensure that the channel temperature does not exceed 150°C. Note 2: Mounted on a ceramic substrate (25.4 mm × 25.4 mm × 0.8 mm)Note 3: Using continuously under heavy loads (e.g. the application of high temperature/current/voltage and the significant changein temperature, etc.) may cause this product to decrease in the reliability significantly even if the operating conditions (i.e. operating temperature/current/voltage, etc.) are within the absolute maximum ratings. Please design the appropriate reliability upon reviewing the Toshiba Semiconductor Reliability Handbook (“Handling Precautions”/Derating Concept and Methods) and individual reliability data (i.e. reliability test report and estimated failure rate, etc).Thermal CharacteristicsCharacteristics Symbol Max UnitThermal resistance, channel toambientR th (ch −a)250°C / WThis transistor is an electrostatic-sensitive device. Please handle with caution.MarkingUnit: mmJEDEC ― JEITA―TOSHIBA 2-5K1B Weight: 0.05 g (typ.)lead (Pb)-free finish.Electrical Characteristics (Ta = 25°C)Characteristics SymbolTest ConditionMin Typ. Max Unit Gate leakage current I GSS V GS = ±16 V, V DS = 0 V — — ±10μA Drain cut −off currentI DSS V DS = 60 V, V GS = 0 V — — 100μA Drain −source breakdown voltage V (BR) DSS I D = 10 mA, V GS = 0 V 60 — — V Gate threshold voltage V th V DS = 10 V, I D = 1 mA 0.8 — 2.0 V VGS = 4 V, ID = 1 A — 0.33 0.44Drain −source ON resistance R DS (ON)VGS = 10 V, ID = 1 A— 0.23 0.30Ω Forward transfer admittance |Y fs | V DS = 10 V, I D = 1 A1.02.0—SInput capacitanceC iss — 150 —Reverse transfer capacitance C rss — 25 — Output capacitanceC ossV DS = 10 V, V GS = 0 V, f = 1 MHz — 70 —pF Rise timet r — 25 —Turn −on timet on — 30 —Fall timet f — 50 — Switching timeTurn −off timet off — 150 — nsTotal gate charge (gate −source plus gate −drain) Q g— 6.0 — Gate −source charge Q gs — 4.6 — Gate −drain (“miller”) ChargeQ gdV DD ≈ 48 V, V GS = 10 V, I D = 2 A— 1.4 —nCSource −Drain Ratings and Characteristics (Ta = 25°C)Characteristics SymbolTest ConditionMin Typ. Max UnitContinuous drain reverse current(Note 1)I DR —— — 2 A Pulse drain reverse current(Note 1) I DRP —— — 6 A Forward voltage (diode) V DSF I DR = 2 A, V GS = 0 V ——−1.5VReverse recovery time t rr — 100 — ns Reverse recovery chargeQ rrI DR = 2 A, V GS = 0 VdI DR / dt = 50 A / μs— 40 — nCRESTRICTIONS ON PRODUCT USE20070701-EN •The information contained herein is subject to change without notice.•TOSHIBA is continually working to improve the quality and reliability of its products. Nevertheless, semiconductor devices in general can malfunction or fail due to their inherent electrical sensitivity and vulnerability to physical stress. It is the responsibility of the buyer, when utilizing TOSHIBA products, to comply with the standards of safety in making a safe design for the entire system, and to avoid situations in which a malfunction or failure of such TOSHIBA products could cause loss of human life, bodily injury or damage to property.In developing your designs, please ensure that TOSHIBA products are used within specified operating ranges as set forth in the most recent TOSHIBA products specifications. Also, please keep in mind the precautions and conditions set forth in the “Handling Guide for Semiconductor Devices,” or “TOSHIBA Semiconductor Reliability Handbook” etc.• The TOSHIBA products listed in this document are intended for usage in general electronics applications (computer, personal equipment, office equipment, measuring equipment, industrial robotics, domestic appliances, etc.).These TOSHIBA products are neither intended nor warranted for usage in equipment that requires extraordinarily high quality and/or reliability or a malfunction or failure of which may cause loss of human life or bodily injury (“Unintended Usage”). Unintended Usage include atomic energy control instruments, airplane or spaceship instruments, transportation instruments, traffic signal instruments, combustion control instruments, medical instruments, all types of safety devices, etc.. Unintended Usage of TOSHIBA products listed in his document shall be made at the customer’s own risk.•The products described in this document shall not be used or embedded to any downstream products of which manufacture, use and/or sale are prohibited under any applicable laws and regulations.• The information contained herein is presented only as a guide for the applications of our products. No responsibility is assumed by TOSHIBA for any infringements of patents or other rights of the third parties which may result from its use. No license is granted by implication or otherwise under any patents or other rights of TOSHIBA or the third parties.• Please contact your sales representative for product-by-product details in this document regarding RoHS compatibility. Please use these products in this document in compliance with all applicable laws and regulations that regulate the inclusion or use of controlled substances. Toshiba assumes no liability for damage or losses occurring as a result of noncompliance with applicable laws and regulations.。

网络出版时间：２０２３－０７－２５１０：４３：３６　网络出版地址：ｈｔｔｐｓ：／／ｌｉｎｋ．ｃｎｋｉ．ｎｅｔ／ｕｒｌｉｄ／３４．１０８６．Ｒ．２０２３０７２４．１３４２．０２４◇内分泌药理学◇达格列净调节糖尿病大鼠心肌ＳＫ２蛋白表达吴　敏１，２，赵江雁１，２，雷　敏２，陈清杰２，郭西英２（湖北科技学院１．医学部药学院２．糖尿病心脑血管病变湖北省重点实验室，湖北咸宁　４３７１００）收稿日期：２０２３－０３－１０，修回日期：２０２３－０６－２０基金项目：国家自然科学基金资助项目（Ｎｏ８２２７０８９２）；湖北科技学院糖尿病专项基金（Ｎｏ２０２０ＴＮＢ１２）作者简介：吴　敏（１９９７－），女，硕士，研究方向：糖尿病心脑血管病变，Ｅ ｍａｉｌ：１３４５５００４５５＠ｑｑ．ｃｏｍ；陈清杰（１９８３－），男，博士，副教授，研究方向：糖尿病心脑血管药理学，通信作者，Ｅ ｍａｉｌ：ｃｈｅｎｑｉｎｇｊｉｅ８８５８＠１６３．ｃｏｍ；郭西英（１９８９－），女，博士，讲师，研究方向：糖尿病心脑血管病变，通信作者，Ｅ ｍａｉｌ：ｇｘｙａｎｇｅｌａ＠１６３．ｃｏｍｄｏｉ：１０．１２３６０／ＣＰＢ２０２２０９０７７文献标志码：Ａ文章编号：１００１－１９７８（２０２３）０８－１４７８－０７中国图书分类号：Ｒ ３３２；Ｒ３２２ １１；Ｒ３４９ １；Ｒ５８７ ２；Ｒ９７７ １５；Ｒ９７７ ６摘要：目的　探讨达格列净（ｄａｐａｇｌｉｆｌｏｚｉｎ，Ｄａｐａ）对糖尿病大鼠心肌小电导钙激活钾通道２（ｓｍａｌｌｃｏｎｄｕｃｔａｎｃｅｃａｌｃｉｕｍ ａｃ ｔｉｖａｔｅｄｐｏｔａｓｓｉｕｍｃｈａｎｎｅｌ２，ＳＫ２通道）蛋白的影响以及可能作用机制。

方法　体内：高糖高脂饮食联合腹腔注射小剂量链脲佐菌素（３５ｍｇ·ｋｇ－１）构建２型糖尿病模型，并给予达格列净（１ｍｇ·ｋｇ－１·ｄ－１）治疗干预；体外：Ｄａｐａ（５μｍｏｌ·Ｌ－１）处理原代心肌细胞并暴露于高糖（３０ｍｍｏｌ·Ｌ－１）；心脏超声检测各组大鼠的心功能情况；ＤＣＦＨ ＤＡ荧光探针检测活性氧（ｒｅａｃｔｉｖｅｏｘｉｄｅｓｐｅｃｉｓ，ＲＯＳ）的水平；Ｗｅｓｔｅｒｎｂｌｏｔ检测ＳＫ２、ＮＯＸ４、ｐ３８ＭＡＰＫ、ｐ ｐ３８ＭＡＰＫ的蛋白表达水平。