1,3-Dihydro-α-methyl-1-methylene-3-oxo-2H-isoindole-2-acetic_acid_DataSheet_MedChemExpress

地法替尼结构式
地法替尼（Difertini）是一种口服的小分子靶向药物，属于酪氨酸激酶抑制剂的一种。

它的主要作用是抑制表皮生长因子受体（EGFR）和人类表皮生长因子受体2（HER2）的信号通路，从而抑制肿瘤细胞的生长和增殖。

地法替尼的结构式中包含了一个苯环和一个吡啶环，通过一个亚甲基（-CH2-）相连。

在苯环上有一个硝基（-NO2）和一个甲氧基（-OCH3）取代基，而吡啶环上则有一个氯原子（-Cl）和一个甲酰胺基（-CONH2）取代基。

这种结构式赋予了地法替尼特定的化学性质和药理学活性。

其中，苯环和吡啶环是该药物分子的核心结构，它们通过共轭体系相互作用，对药物的溶解度、亲脂性和生物利用度等产生影响。

硝基和甲氧基等取代基的存在可能会影响药物的药代动力学特性和生物活性。

地法替尼作为一种靶向药物，通过与EGFR 和HER2 受体的特定区域结合，阻断了它们的酪氨酸激酶活性，从而抑制了肿瘤细胞的增殖和转移。

这种作用机制使得地法替尼在治疗某些癌症类型方面具有潜在的应用价值。

需要注意的是，结构式只是描述药物分子的化学结构的一种方式，对于药物的药理学特性、临床应用和安全性等方面的了解还需要进一步的研究和临床试验。

在使用任何药物之前，都应该遵循医生的建议，并按照医嘱使用药物。

齐多夫定结构式一、齐多夫定基本信息齐多夫定（Zidovudine，AZT）是一种核苷类逆转录酶抑制剂，用于治疗艾滋病和某些癌症。

它是由美国制药公司开发，于1987年获美国食品药品监督管理局批准上市。

齐多夫定的化学名称为3'-叠氮-3'-脱氧胸腺嘧啶核苷，是一种白色结晶粉末，易溶于水。

二、化学结构式化学结构式为：化学式: C10H13N5O4分子量: 267.24结构式: 1-(3-叠氮-2,3-二脱氧-β-D-呋喃核糖基)-5-甲基嘧啶-2,4(1H,3H)-二酮三、合成路线齐多夫定的合成路线主要有两条：一条是以胸腺嘧啶为原料，经过还原、溴代、消除、氧化等步骤得到；另一条是以2',3'-二脱氧胸腺嘧啶核苷为原料，经过还原、溴代、消除、氧化等步骤得到。

具体合成过程较为复杂，涉及多步化学反应。

四、药理作用齐多夫定通过抑制逆转录酶活性，从而阻断病毒DNA的合成。

具体来说，它能够与逆转录酶结合，抑制酶的活性，从而阻止病毒DNA链的延长。

此外，齐多夫定还能掺入病毒DNA，阻止病毒DNA的复制。

五、药物代谢齐多夫定口服后易吸收，血药浓度达峰时间为0.5-1.5小时。

主要分布在细胞外液，易透过胎盘屏障。

在体内代谢为5'-单磷酸酯和3'-叠氮-5'-腺苷酸。

主要通过肾脏排泄，约40%-50%以原形排出，其余为代谢产物。

消除半衰期为1.1-1.9小时。

六、临床应用齐多夫定主要用于治疗艾滋病和某些癌症，如急性淋巴细胞性白血病等。

在艾滋病的治疗中，齐多夫定常与其他抗逆转录病毒药物联合使用，以抑制HIV 病毒的复制。

在某些癌症治疗中，齐多夫定可作为辅助治疗手段，与其他化疗药物联合使用。

七、不良反应齐多夫定的不良反应主要包括骨髓抑制、胃肠道反应、过敏反应等。

骨髓抑制表现为贫血、白细胞减少和血小板减少等。

胃肠道反应包括恶心、呕吐、腹泻等。

过敏反应表现为皮疹、荨麻疹等。

List of 179 substances banned for use in hair dye products(Updated: February 2010)Ref. No.Annex IIto CDChemical Name / INCI - Name CAS No.289 Leadacetate 301-04-2 363 o-Phenylenediamine 95-54-5 364 2,4-Diaminotoluene 95-80-7 376 1-Methoxy-2,4-diaminobenzen 615-05-4 377 1-Methoxy-2,5-diaminobenzene 5307-02-8 380 Basic Violet 3 548-62-9383 2-Amino-4-nitrophenol 99-57-0 384 2-Amino-5-nitrophenol 121-88-0 386 CI42640 1694-09-3 387 Acid Yellow 36 587-98-4388 Basic Violet 1 8004-87-3398 CI 45170, CI 45170:1 81-88-9; 509-34-2 406 4-Ethoxy-2,4-diaminobenzene 5862-77-1 407 1-beta-Hydroxyethyl-2,4-diaminobenzene 14572-93-1 408 Catechol 120-80-9 409 Pyrogallicacid 87-66-1 412 4-Amino-2-nitrophenol 119-34-6 413 1-Methyl-2,6-diaminobenzen 823-40-5 700 Disperse Blue 1 2475-45-81055 Disperse Yellow 3 2832-40-81188 Basic Green 4 569-64-21204 m-Phenylenediamine 108-45-2 1212 6-Methoxy-2,3-pyridinediamineHCl 94166-62-8 1213 2,3-Naphthalenediol 92-44-4 1214 2,4-Diaminodiphenylamine 136-17-4 1215 2,6-Bis(2-hydroxyethoxy)-3,5-pyridinediamineHCl 117907-42-3 1216 2-Methoxymethyl-p-aminophenol HCl 29785-47-5 (HCl) 1217 4,5-Diamino-1-methylpyrazole HCl; sulfate 21616-59-1 HCl 1218 4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate 163183-00-4 1219 4-Chloro-2-aminophenol 95-85-2 1220 4-Hydroxyindole 2380-94-1 1221 4-Methoxytoluene-2,5-diamineHCl 56496-88-9 1222 5-Amino-4-fluoro-2-methylphenolsulfate 163183-01-5 1223 N,N-Diethylm-aminophenol 91-68-9 1224 N,N-Dimethyl-2,6-pyridinediamineHCl -1225 N-cyclopentyl-m-aminophenol 104903-49-3 1226 N-Methoxyethyl-p-phenylenediamineHCl 72584-59-9 1227 2,4-Diamino-5-methylphenetolHCl 113715-25-6 1228 1,7-Naphthalenediol 575-38-2 1229 3,4-Diaminobenzoicacid 619-05-61230 2-Aminomethyl-p-aminophenolHCL 135043-65-1; 79352-72-01231 SolventRed1 1229-55-61232 Acid Orange 24 1320-07-61233 Acid Red 73 5413-75-21234 PEG-3,2′,2′-di-p-Phenylenediamine 144644-13-3 1235 6-Nitro-o-Toluidine 570-24-11236 HC Yellow No 11 73388-54-21237 HC Orange No 3 81612-54-6 1238 HC Green No 1 52136-25-11239 HC Red No 8 and its salts 97404-14-3; 13556-29-11240 Tetrahydro-6-nitroquinoxaline and its salts 158006-54-3; 41959-35-71241 Disperse Red 15, except as impurity in Disperse Violet 1 116-85-81242 4-amino-3-fluorophenol 399-95-1 1244 1-Methyl-2,4,5-trihydroxybenzene and its salts 1124-09-0 1245 2,6-Dihydroxy-4-methylpyridine and its salts 4664-16-8 1246 5-Hydroxy-1,4-benzodioxane and its salts 10288-36-5 1247 3,4-Methylenedioxyphenol and its salts 533-31-31248 3,4-Methylenedioxyaniline and its salts 14268-66-7 1249 Hydroxypyridinone and its salts 822-89-91250 3-Nitro-4-aminophenoxyethanol and its salts 50982-74-6 1251 2-methoxy-4-nitrophenol (4-Nitroguaiacol) and its salts 3251-56-7 1252 C.I. Acid Black 131 and its salts 12219-01-1 1253 1,3,5-Trihydroxybenzene (Phloroglucinol) and its salts 108-73-61254 1,2,4-Benzenetriacetate and its salts 613-03-61255 Ethanol, 2,2'-iminobis-, reaction products with epichlorohydrinand 2-nitro-1,4-benzenediamine (HC Blue No. 5) and its salts68478-64-8;158571-58-51256 N-Methyl-1,4-diaminoanthraquinone, reaction products withepichlorohydrin and monoethanolamine (HC Blue No. 4) andits salts158571-57-41257 4-Aminobenzenesulfonic acid and its salts 121-57-31258 3,3'-(Sulfonylbis(2-nitro-4,1-phenylene)imino)bis(6-(phenylamino)) benzenesulfonic acid and its salts1259 3(or5)-((4-(Benzylmethylamino)phenyl)azo)-1,2-(or1,4)-dimethyl-1H-1,2,4-triazolium and its salts1260 2,2'-((3-Chloro-4-((2,6-dichloro-4-nitrophenyl)azo)phenyl)imino)bisethanol (Disperse Brown 1)and its salts23355-64-81261 Benzothiazolium, 2-[[4-[ethyl(2-hydroxyethyl)amino]phenyl]azo]-6-methoxy-3-methyl- and its salts1262 2-[(4-Chloro-2-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxobutanamide (Pigment Yellow 73) and its salts13515-40-71263 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[3-oxo-N-phenylbutanamide] (Pigment Yellow 12) and its salts6358-85-61264 2,2'-(1,2-Ethenediyl)bis[5-((4-ethoxyphenyl)azo]benzenesulfonic acid) and its salts1265 2,3-Dihydro-2,2-dimethyl-6-[(4-(phenylazo)-1-naphthalenyl)azo]-1H-pyrimidine (Solvent Black 3) and itssalts4197-25-51266 3(or5)-[[4-[(7-amino-1-hydroxy-3-sulphonato-2-naphthyl)azo]-1-naphthyl]azo]salicylic acid and its salts1267 2-Naphthalenesulfonic acid, 7-(benzoylamino)-4-hydroxy-3-[[4-[(4-sulfophenyl)azo]phenyl]azo]- and its salts1268 (µ-((7,7'-Iminobis(4-hydroxy-3-((2-hydroxy-5-(N-methylsulphamoyl)phenyl)azo)naphthalene-2-sulphonato))(6-)))dicuprate(2-) and its salts1269 3-[(4-(Acetylamino)phenyl)azo]-4-hydroxy-7-[[[[5-hydroxy-6-(phenylazo)-7-sulfo-2-naphthalenyl]amino]carbonyl]amino]-2-naphthalenesulfonic acid and its salts1270 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis(4-hydroxy-3-[[2-sulfo-4-[(4-sulfophenyl)azo]phenyl]azo]-, and itssalts25188-41-41271 Ethanaminium, N-(4-[bis[4-(diethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene)-N-ethyl- and its salts1272 3H-Indolium, 2-[[(4-methoxyphenyl)methylhydrazono]methyl]-1,3,3-trimethyl- and its salts1273 3H-Indolium, 2-(2-((2,4-dimethoxyphenyl)amino)ethenyl)-1,3,3-trimethyl- and its salts1274 Nigrosine spirit soluble (Solvent Black 5) 11099-03-9 1275 Phenoxazin-5-ium, 3,7-bis(diethylamino)-, and its salts 47367-75-9 1276 Benzo[a]phenoxazin-7-ium, 9-(dimethylamino)-, and its salts1277 6-Amino-2-(2,4-dimethylphenyl)-1H-benz[de]isoquinoline-1,3(2H)-dione (Solvent Yellow 44) and its salts2478-20-81278 1-Amino-4-[[4-[(dimethylamino)methyl]phenyl]amino]anthraquinone and itssalts12217-43-51279 Laccaic Acid (CI Natural Red 25 ) and its salts 60687-93-61280 Benzenesulfonic acid, 5-[(2,4-dinitrophenyl)amino]-2-(phenylamino)-, and its salts15347-52-11281 4-[(4-Nitrophenyl)azo]aniline (Disperse Orange 3) and its salts 730-40-5 1282 4-Nitro-m-phenylenediamine and its salts 5131-58-81283 1-Amino-4-(methylamino)-9,10-anthracenedione (DisperseViolet 4)and its salts1220-94-61284 N-Methyl-3-nitro-p-phenylenediamine and its salts 2973-21-91285 N1-(2-Hydroxyethyl)-4-nitro-o-phenylenediamine (HC YellowNo. 5)and its salts56932-44-61286 N1-(Tris(hydroxymethyl))methyl-4-nitro-1,2-phenylenediamine(HC Yellow No. 3)and its salts56932-45-71287 2-Nitro-N-hydroxyethyl-p-anisidine and its salts 57524-53-51288 N,N'-Dimethyl-N-Hydroxyethyl-3-nitro-p-phenylenediamine andits salts10228-03-21289 3-(N-Methyl-N-(4-methylamino-3-nitrophenyl)amino)propane-1,2-diol and its salts93633-79-51290 4-Ethylamino-3-nitrobenzoic acid (N-Ethyl-3-Nitro PABA)andits salts2788-74-11291 (8-[(4-Amino-2-nitrophenyl)azo]-7-hydroxy-2-naphthyl)trimethylammonium and its salts, except Basic Red 118(CAS 71134-97-9) as impurity in Basic Brown 171292 5-((4-(Dimethylamino)phenyl)azo)-1,4-dimethyl-1H-1,2,4-triazolium and its salts1293 m-Phenylenediamine, 4-(phenylazo)-, and its salts 495-54-5 1294 1,3-Benzenediamine, 4-methyl-6-(phenylazo)- and its salts1295 2,7-Naphthalenedisulfonic acid, 5-(acetylamino)-4-hydroxy-3-((2-methylphenyl)azo)- and its salts1296 4,4'-[(4-Methyl-1,3-phenylene)bis(azo)]bis[6-methyl-1,3-benzenediamine] (Basic Brown 4)and its salts4482-25-11297 Benzenaminium, 3-[[4-[[diamino(phenylazo)phenyl]azo]-2-methylphenyl]azo]-N,N,N-trimethyl- and its salts1298 Benzenaminium, 3-[[4-[[diamino(phenylazo)phenyl]azo]-1-naphthalenyl]azo]-N,N,N-trimethyl- and its salts1299 Ethanaminium, N-[4-[(4-(diethylamino)phenyl)phenylmethylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl- and its salts1300 9,10-Anthracenedione, 1-[(2-hydroxyethyl)amino]-4-(methylamino)- and its derivatives and salts86722-66-91301 1,4-Diamino-2-methoxy-9,10-anthracenedione (Disperse Red11)and its salts2872-48-21302 1,4-Dihydroxy-5,8-bis[(2-hydroxyethyl)amino]anthraquinone(Disperse Blue 7)and its salts3179-90-61303 1-[(3-Aminopropyl)amino]-4-(methylamino)anthraquinone and its salts1304 N-[6-[(2-Chloro-4-hydroxyphenyl)imino]-4-methoxy-3-oxo-1,4-cyclohexadien-1-yl]acetamide (HC Yellow No. 8)and its salts66612-11-11305 [6-[[3-Chloro-4-(methylamino)phenyl]imino]-4-methyl-3-oxocyclohexa-1,4-dien-1-yl]urea (HC Red No. 9)and its salts56330-88-21306 Phenothiazin-5-ium, 3,7-bis(dimethylamino)- and its salts1307 4,6-Bis(2-Hydroxyethoxy)-m-Phenylenediamine and its salts1308 5-Amino-2,6-Dimethoxy-3-Hydroxypyridine and its salts 104333-03-1 1309 4,4'-Diaminodiphenylamine and its salts 537-65-5 1310 4-Diethylamino-o-toluidine and its salts 148-71-0 1311 N,N-Diethyl-p-phenylenediamine and its salts 93-05-0 1312 N,N-Dimethyl-p-phenylenediamine and its salts 99-98-9 1313 Toluene-3,4-Diamine and its salts 496-72-0 1314 2,4-Diamino-5-methylphenoxyethanol and its salts 141614-05-3 1315 6-Amino-o-cresol and its salts 17672-22-9 1316 Hydroxyethylaminomethyl-p-aminophenol and its salts 110952-46-0 1317 2-Amino-3-nitrophenol and its salts 603-85-01318 2-Chloro-5-nitro-N-hydroxyethyl-p-phenylenediamine and itssalts50610-28-11319 2-Nitro-p-phenylenediamine and its salts 5307-14-2 1320 Hydroxyethyl-2,6-dinitro-p-anisidine and its salts 122252-11-3 1321 6-Nitro-2,5-pyridinediamine and its salts 69825-83-8 1322 Phenazinium, 3,7-diamino-2,8-dimethyl-5-phenyl- and its salts1323 3-Hydroxy-4-[(2-hydroxynaphthyl)azo]-7-nitronaphthalene-1-sulphonic acid and its salts16279-54-21324 3-[(2-nitro-4-(trifluoromethyl)phenyl)amino]propane-1,2-diol(HC Yellow No. 6) and its salts104333-00-81325 2-[(4-chloro-2-nitrophenyl)amino]ethanol (HC Yellow No. 12)and its salts59320-13-71326 3-[[4-[(2-Hydroxyethyl)Methylamino]-2-Nitrophenyl]Amino]-1,2-Propanediol and its salts173994-75-71327 3-[[4-[Ethyl(2-Hydroxyethyl)Amino]-2-Nitrophenyl]Amino]-1,2-Propanediol and its salts114087-41-11328 Ethanaminium, N-[4-[[4-(diethylamino)phenyl][4-(ethylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl- and its salts1329 4-[(4-Aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-o-toluidine (CAS 3248-93-9; EINECS 221-832-2) and its hydrochloride salt (Basic Violet 14; CI 42510) (CAS 632-99-5; EINECS 211-189-6)1330 4-(2,4-Dihydroxyphenylazo)benzenesulphonic acid (CAS 2050-34-2; EINECS 218-087-0) and its sodium salt (Acid Orange 6; CI 14270) (CAS 547-57-9; EINECS 208-924-8)1331 3-Hydroxy-4-(phenylazo)-2-naphthoic acid (CAS 27757-79-5; EINECS 248-638-0) and its calcium salt (Pigment Red 64:1; CI 15800) (CAS 6371-76-2; EINECS 228-899-7)1332 2-(6-Hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid; Fluorescein (CAS 2321-07-5; EINECS 219-031-8) and its disodium salt (Acid yellow 73 sodium salt; CI 45350) (CAS 518-47-8; EINECS 208-253-0)1333 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one; 4',5'-Dibromofluorescein; (Solvent Red 72) (CAS 596-03-2; EINECS 209-876-0) and its disodium salt (CI 45370) (CAS 4372-02-5; EINECS 224-468-2)1334 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)-benzoic acid; Fluorescein, 2',4',5',7'-tetrabromo-; (Solvent Red 43) (CAS 15086-94-9; EINECS 239-138-3), its disodium salt (Acid Red 87; CI 45380) (CAS 17372-87-1; EINECS 241-409-6) and its aluminium salt (Pigment Red 90:1 Aluminium lake) (CAS 15876-39-8; EINECS 240-005-7)1335 Xanthylium, 9-(2-carboxyphenyl)-3-(2-methylphenyl)amino)-6-((2-methyl-4-sulfophenyl)amino)-, inner salt (CAS 10213-95-3); and its sodium salt (Acid Violet 9; CI 45190) (CAS 6252-76-2; EINECS 228-377-9)1336 3',6'-Dihydroxy-4',5'-diiodospiro(isobenzofuran-1(3H),9'-[9H]xanthene)-3-one; (Solvent Red 73) (CAS 38577-97-8; EINECS 254-010-7) and its sodium salt (Acid Red 95; CI 45425) (CAS 33239-19-9; EINECS 251-419-2)1337 2',4',5',7'-Tetraiodofluorescein (CAS 15905-32-5; EINECS 240-046-0), its disodium salt (Acid Red 51; CI 45430) (CAS 16423-68-0; EINECS 240-474-8) and its aluminium salt (Pigment Red 172 Aluminium lake)(CAS 12227-78-0; EINECS 235-440-4)1338 1-Hydroxy-2,4-diaminobenzene (2,4-Diaminophenol) (CAS 95-86-3; EINECS 202-459-4 ) and its dihydrochloride salt (2,4-Diaminophenol HCl) (CAS 137-09-7; EINECS 205-279-4)1339 1,4-Dihydroxybenzene (Hydroquinone) (CAS 123-31-9; EINECS 204-617-8)1340 [4-[[4-anilino-1-naphthyl][4-(dimethylamino)phenyl]methylene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride (Basic Blue 26; CI 44045) (CAS 2580-56-5; EINECS 219-943-6)1341 Disodium 3-[(2,4-dimethyl-5-sulphonatophenyl)azo]-4-hydroxynaphthalene-1-sulphonate (Ponceau SX; CI 14700) (CAS 4548-53-2; EINECS 224-909-9)1342 Trisodium tris[5,6-dihydro-5-(hydroxyimino)-6-oxonaphthalene-2-sulphonato(2-)-N5,O6]ferrate(3-) (Acid Green 1; CI 10020) (CAS 19381-50-1; EINECS 243-010-2)1343 4-(Phenylazo)resorcinol (Solvent Orange 1; CI 11920) (CAS 2051-85-6; EINECS 218-131-9) and its salts1344 4-[(4-Ethoxyphenyl)azo]naphthol (Solvent Red 3; CI 12010) (CAS 6535-42-8; EINECS 229-439-8) and its salts1345 1-[(2-Chloro-4-nitrophenyl)azo]-2-naphthol (Pigment Red 4; CI 12085) (CAS 2814-77-9; EINECS 220-562-2) and its salts1346 3-Hydroxy-N-(o-tolyl)-4-[(2,4,5-trichlorophenyl)azo]naphthalene-2-carboxamide (Pigment Red 112; CI 12370) (CAS 6535-46-2; EINECS 229-440-3) and its salts1347 N-(5-Chloro-2,4-dimethoxyphenyl)-4-[[5-[(diethylamino)sulphonyl]-2-methoxyphenyl]azo]-3-hydroxynaphthalene-2-carboxamide (Pigment Red 5; CI 12490) (CAS 6410-41-9; EINECS 229-107-2) and its salts1348 Disodium 4-[(5-chloro-4-methyl-2-sulphonatophenyl)azo]-3-hydroxy-2-naphthoate (Pigment Red 48; CI 15865) (CAS 3564-21-4; EINECS 222-642-2)1349 Calcium 3-hydroxy-4-[(1-sulphonato-2-naphthyl)azo]-2-naphthoate (Pigment Red 63:1; CI 15880) (CAS 6417-83-0; EINECS 229-142-3)1350 Trisodium 3-hydroxy-4-(4'-sulphonatonaphthylazo)naphthalene-2,7-disulphonate (Acid Red 27; CI 16185) (CAS 915-67-3; EINECS 213-022-2)1351 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)-3-oxobutyramide] (Pigment Yellow 13; CI 21100) (CAS 5102-83-0; EINECS 225-822-9)1352 2,2'-[Cyclohexylidenebis[(2-methyl-4,1-phenylene)azo]]bis[4-cyclohexylphenol] (Solvent Yellow 29; CI 21230) (CAS 6706-82-7; EINECS 229-754-0)1353 1-((4-Phenylazo)phenylazo)-2-naphthol (Solvent Red 23; CI 26100) (CAS 85-86-9; EINECS 201-638-4)1354 Tetrasodium 6-amino-4-hydroxy-3-[[7-sulphonato-4-[(4-sulphonatophenyl)azo]-1-naphthyl]azo]naphthalene-2,7-disulphonate (Food Black 2; CI 27755) (CAS 2118-39-0; EINECS 218-326-9)1355 Ethanaminium, N-(4-((4-(diethylamino)phenyl)(2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-ethyl-, hydroxide, inner salt, sodium salt (Acid Blue 1; CI 42045) (CAS 129-17-9; EINECS 204-934-1)1356 Ethanaminium, N-(4-((4-(diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-ethyl-, hydroxide, inner salt, calcium salt (2:1) (Acid Blue 3; CI 42051) (CAS 3536-49-0; EINECS 222-573-8)1357 Benzenemethanaminium, N-ethyl-N-(4-((4-(ethyl((3-sulfophenyl)methyl)amino)phenyl)(4-hydroxy-2-sulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-3-sulfo-, hydroxide, inner salt, disodium salt (Fast Green FCF; CI 42053) (CAS 2353-45-9; EINECS 219-091-5)1358 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline (Solvent Yellow 33; CI 47000) (CAS 8003-22-3; EINECS 232-318-2)1359 Nigrosine (CI 50420) (CAS 8005-03-6)1360 8,18-Dichloro-5,15-diethyl-5,15-dihydrodiindolo[3,2-b:3',2'-m]triphenodioxazine (Pigment Violet 23; CI 51319) (CAS 6358-30-1; EINECS 228-767-9)1361 1,2-Dihydroxyanthraquinone (Pigment Red 83; CI 58000) (CAS 72-48-0; EINECS 200-782-5)1362 Trisodium 8-hydroxypyrene-1,3,6-trisulphonate (Solvent Green 7; CI 59040) (CAS 6358-69-6; EINECS 228-783-6)1363 1-Hydroxy-4-(p-toluidino)anthraquinone (Solvent Violet 13; CI 60725) (CAS 81-48-1; EINECS 201-353-5),1364 1,4-bis(p-Tolylamino)anthraquinone (Solvent Green 3; CI 61565) (CAS 128-80-3; EINECS 204-909-5)1365 6-Chloro-2-(6-chloro-4-methyl-3-oxobenzo[b]thien-2(3H)-ylidene)-4-methylbenzo[b]thiophene-3(2H)-one (VAT Red 1; CI 73360) (CAS 2379-74-0; EINECS 219-163-6)1366 5,12-Dihydroquino[2,3-b]acridine-7,14-dione (Pigment Violet 19; CI 73900) (CAS 1047-16-1; EINECS 213-879-2)1367 (29H,31H-Phthalocyaninato(2-)-N29,N30,N31,N32)copper (Pigment Blue 15; CI 74160) (CAS 147-14-8; EINECS 205-685-1)1368 Disodium [29H,31H-phthalocyaninedisulphonato(4-)-N29,N30,N31,N32]cuprate(2-) (Direct Blue 86; CI 74180) (CAS 1330-38-7; EINECS 215-537-8)1369 Polychloro copper phthalocyanine (Pigment Green 7; CI 74260) (CAS 1328-53-6; EINECS 215-524-7)。

阿齐沙坦片阿齐沙坦（又称阿齐沙坦酯，英语：Azilsartan）（INN）是治疗高血压症的血管紧张素II受体拮抗剂药物，多用于治疗高血压症，也是血管紧张素II受体拮抗剂（沙坦类）药物。

作为前体药物的阿齐沙坦酯（azilsartan medoxomil、INN、代码 TAK-491），2010年4月28日，日本武田制药公司（Takeda）所研发的该药物完成了三期临床试验，2011年获得美国FDA批准，该药物为一种血管紧张素II受体拮抗剂，可单独使用或与其它降血压药物一起使用，被视作坎地沙坦酯的下一代产品。

中文名: 阿齐沙坦英文名：Azilsartan商品名： Edarbi (Azilsartan medoxomil) 依达比化学英文名(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl2-ethoxy-1-([2'-(5-oxo-4,5-dihy dro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl)-1H-benzimidazole-7-car boxylateCAS号863031-21-4分子式化学式 C30H24N4O8分子量 568.5临床实验: 阿齐沙坦酯对于降低血压有着较为显著的疗效，一项1291位病人参与、长达六星期的实验比较40毫克、80毫克的阿齐沙坦酯和40毫克的奥美沙坦酯（Benicar®、由第一制药三共株式会社研发）或320毫克的缬沙坦的效果，结果40毫克的阿齐沙坦酯可降低13.4mmHg的血压、80毫克的阿齐沙坦酯则是14.5mmHg、40毫克的Benicar是12mmHg、320公克的缬沙坦则是10.2mmHg。

另有一项为期六周的实验，将20毫克、40毫克、80毫克的阿齐沙坦酯和40毫克的奥美沙坦酯进行了比较，共有1272位病人参与。

结果显示，20毫克的阿齐沙坦酯能降血压10.8mmHg、40毫克的阿齐沙坦酯则是12.1mmHg、80毫克的阿齐沙坦酯是13.2mmHg、40毫克的奥美沙坦酯则为11.2mmHg。

白胡椒成分(+-)-1-(ACETOXY)-2-(1-BROMOETHYL)-3-METHOXYANTHRAQUINONE(1S*,4R*,5S*,8R*,9S*,10S*)-N-PHENYL-8-METHYL-9-METHOXY-9-(PHENYLTHIO)-10-CHLO RO-11-OXATRICYCLO[6.2.1.0(2,7)]UNDEC-2(7)-ENE-4,5-DICARBOXIMIDE(1SR,5RS,9SR,13RS,18RS)-18-ALLYLHEXACYCLO[16.3.0.0(15).0(5,9).0(9,13).0(13,17 ]HENICOS-16-ENE(2,3-DIMETHOXYPHENYL)TRIMETHYLSILANE(2,5-DIMETHOXYPHENYL)TRIMETHYLSILANE(2R(*),3AR(*),7AR(*))-HEXAHYDRO-2-((BENZOYLOXY)METHYL)-4(2H)-BENZOFURANONE (2S,4AS,5S,8AS)-2-(T-BUTYL)-PERHYDRO-5-METHYL-2H,4H-[1,3]BENZODIOXIN-4-ONE (3S,5R)-3-(HYDROXYMETHYL)-1,4,4,5-TETRAMETHYLCYCLOPENTENE(4R,8S)-P-MENTH-1-ENE-8,9-DIOL(4RS,5SR,6RS)-6-HYDROXY-4,5-(ISOPROPYLIDENEDIOXY)CYCLOHEX-2-EN-1-ONE(E)-1,4-DIMETHYL-1,3-HEPTADIEN-5-IN-1-YL-TRIFLATE(E)-2,6,6,10-TETRAMETHYL-8,10-UNDECADIEN-3,7-DIONE(E)-2-ETHOXY-3-PHENYLSULFONYL-5,6,7,8-TETRAHYDROAZOCINE(E)-3-HYDROXY-2,2,4,4-TETRAMETHYL-3-(3'-METHYL-1',3'-BUTADIENYL)CYCLOHEXANONE (E)-DI-T-BUTYL [2-((E)-2-BUTENYLOXY)-2-BUTENYL]-PHOSPHONATE(E,E)-6-(DIMETHYLAMINO)-3-METHYL-3,5-HEXADIEN-2-ONE(S)-(+)-5-SEC-BUTYL-2-PYRIMIDINOL(Z)-2-(1-(METHOXYCARBONYL)ETHYLIDENE)-.GAMMA.-BUTYROLACTONE(Z)-3,3-DIETHOXY-1-(2-FURYL)-1-PROPENE(Z)-8-Hydroxy-4,7-dimethyl-oct-6-enoic acid lactone.ALPHA.-SANTALAN-12-ONE[2-(2,4-CYCLOHEXADIENYL)ETHYL]AMMONIUM CHLORIDE[METHYL 3-(4-METHOXYCYCLOHEXA-1,3-DIENYL)PROPANOATE]1-(1(Z)-1-METHYLTHIO-1,3-BUTADIEN-1-YL)-6,6-DIMETHYL-2-METHYLENECYCLOHEXANE 1,1,1,3,5,5,5-Heptamethyltrisiloxane1,1-DICHLORO-4-[(TRIMETHYLSILYL)OXY]-4-PHENYLBUT-1-ENE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)1,2-BENZENEDICARBOXYLIC ACID, DIBUTYL ESTER (CAS)1,2-BENZENEDICARBOXYLIC ACID, DICYCLOHEXYL ESTER (CAS)1,2-BENZENEDICARBOXYLIC ACID, DIISOOCTYL ESTER (CAS)1,2-Dihydro-2,4-diphenyl-quinazoline1,2-DIHYDROXY-4-(1-PROPYL)BENZENE1,3-Benzenediol, 2-methyl-1,4-BENZENEDICARBOXYLIC ACID, METHYL ESTER (CAS)1,4-Benzenediol, 2-methyl-1,5-Cyclohexadiene-1-carboxylic acid, 3,4-dihydroxy-, methyl ester, trans-1-AMINO-1-ORTHO-CHLOROPHENYL-2-(2-QUINOXALINYL)ETHENE1-BUTOXY-1-(TRIMETHYLSILOXY)ETHYLENE1-Cyclohexenyl-cyclohexanol1-DECYLAMINOMETHYL-1,2,3,4-TETRA-HYDROISOQUINOLINE1-Hexyl-2-nitrocyclohexane1-PHENYL-4-METHYL-1,3-PENTANEDIOL BISTRIMETHYLSILYL ETHER1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENE2(1H)-Pyridinone, 1,4,6-trimethyl-2-(2,3-EPOXYPROPYL)-TETRAHYDROFURANE2-(2-HYDROXY-2-PHENYLACETAMIDO)-2-METHYLPROPIONIC ACID2-(2-METHOXYCARBONYLETHYL)-3-(2-THIENYL)-4- AND-5-METHOXYCARBONYLISOXAZOLIDINE2-(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID METHYL ESTER2-(4-NITROPHENYL)-3-(2-NITROPHENYL)-3-OXO-1-PROPANAL2-(BENZYLCARBONYL)AMINO-BENZOTHIAZOLE2,3:5,6-DIEPOXY-2,3,4,5,6-PENTAMETHYL-4-VINYLCYCLOHEXANONE2,4-HEPTADIENAL2-ACETYLTETRAHYDROFURAN2-Cyclopentene-1-thione, 3,4-dimethyl-2-HYDROXY-2-PHENYL-1,3-PROPANEDIOL DICARBAMATE2-Isopropyl-2-phenyl-1,3-dithiane2-METHOXY[1]BENZOTHIENO[2,3-C]QUINOLIN-6(5H)-ONE2-METHOXYMETHOXYMETHYL-2-METHYLCYCLOHEXANONE3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACID3,4-DIHYDROXY-L-PHENYLALANINE3,4-DIMETHOXYBENZENE-1,2-DIOL3,7,11-(3-METHYL-TRIDEUTERIO)-TRIMETHYL-(4,4-DIDEUTERIO)DODECA-1,6,10-TRIEN-3 -OL3-BROMO-4-HYDROXY-PENTADECA-6(Z),9(Z)-DIENE3-BUTENOIC ACID, 2,2-DIETHYL-3-METHYL- (CAS)4-(TRIMETHYLSILYL)DIBENZOFURAN4-IODO-4,5-ETHANOSPIRO(2.3)HEXANE4-Tolyl trifluoromethanesulfonate5-AMINO-2-METHYL-2-PHENYL-2,3-DIHYDRO[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE 5-AMINO-2-PHENYL-2-METHYL-2H-[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE5-AMINO-3,4-DIHYDRO-4-(1-METHOXYETHYL)-3-METHYL-2H-PYRROL-2-ONE5-ETHENYL-5-(1-METHYLBUTYL)BARBITURIC ACID6,10,13-TRIMETHYL-17-ACETYL-17-ACETOXY-3-OXO-ESTRA-4,6-DIENE6-ISOPROPYLTRICYCLO[4.1.0.0(2,7)]HEPT-4-EN-3-ONE7-(2-BROMO-2-PROPENYL)-5-METHOXY-2-METHYLBENZOFURAN7-(TRIMETHYLSILYLMETHOXY)BICYCLO[4.1.0]HEPTANE9-DEUTERIO-2,2,8,8,10(S)-PENTAMETHYL-TRANS-1-DECALONEá-(4-Hydroxy-3-methoxyphenyl)propionic acidARABITOL-1,2,3,4,5-PENTAACETATEArsenous acid, tris(trimethylsilyl) esterARSENOUS ACID, TRIS(TRIMETHYLSILYL) ESTER (CAS)Benzaldehyde, 2-hydroxy-Benzaldehyde, 2-hydroxy-, oximeBENZALDEHYDE, 4-HYDROXY- (CAS)Benzeneethanol, 3-hydroxy-BENZENEETHANOL, 3-HYDROXY- (CAS)Benzeneethanol, 4-hydroxy-Benzenemethanol, 3-hydroxy-Benzoic acid, 4-hydroxy-3,5-dimethoxy-BENZOIC ACID, 4-HYDROXY-3,5-DIMETHOXY- (CAS)BIS(2-ETHYLHEXYL) PHTHALATEBUTANOIC ACID, 3-OXO-, PHENYLMETHYL ESTER (CAS)BUTYL (2,2-DIFLUOROBUTYL) ETHERCyclohexene, 1,5,5-trimethyl-6-(2-propenylidene)-Cyclopentasiloxane, decamethyl-Cyclotetrasiloxane, octamethyl-Cyclotrisiloxane, hexamethyl-CYCLOTRISILOXANE, HEXAMETHYL- (CAS)DI-DEUTERIO-3,4,9-TRIMETHYL-DECA-4,6,8-TRIENE-2-OLDIHYDRO-5-HYDROXY-5-[(8-PENTYL-2-OXOCANYL)ACETYL]-2(3H)-FURANONEERYTHRO-1-HYDROXY-1-PHENYL-2,4,4-TRIMETHYL-3-PENTANONEETHYL1-[1-(TRIMETHYLSILYLOXY)-1,2-DIPHENYLETHYLOXY]-7-AZABICYCLO[4.1.0]HEPTAN-7-CA RBOXYLATEEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENEHEXADECANOIC ACID, TRIMETHYLSILYL ESTER (CAS)HOTRIENOLISOLYRATOLMETHOXYMETHYL-2 METHYL-1 [ETHYLOXYCARBONYLMETHYLENE]-3 CYCLOPENTENE-1 METHYL(2E,4E)-4-(2,3,5,6-TETRAHYDRO-3-OXOIMIDAZO[2,1-B]THIAZOL-2-YLIDENE)BUT-2-EN-1 -OATEMETHYL (2S,3R)-2,3-DIHYDROXY-3-(4-METHOXYPHENYL)PROPANOATEMETHYL (3R,5Z)-3-(TRIISOPROPYLSILYLOXY)DEC-5-ENOATEMETHYL 2-PHENYL-2,3-DIHYDROXY-3-BENZYLBUTANOATEMETHYL 2-TRIDEUTERIOMETHYL-3,4-DI-O-METHYL-.BETA.,L-ARABOPYRANOSIDEMETHYL(+-)-M-METHOXYMANDELATEN-(3-HYDROXYPHENYLETHYL)-TRIFLUOROACETYLAMIDEN-METHYL-N,N-DI[2-(4-PYRIDYL)ETHYL]-(2-PYRIDYL)ETHYLAMINENoradrenaline tetraTMSO-NITROPIVALOPHENONEPhenol, 2,2'-[(hydroxyimino)bis(4,5-dihydro-5,3-isoxazolediyl)]bis- PHENOL, 4,4'-(1-METHYLETHYLIDENE)BIS- (CAS)Pyrrolidine, 1-(m-methoxycinnamoyl)-PYRROLIDINE, 1-(M-METHOXYCINNAMOYL)- (CAS)REL-(1R,4R)-4-ACETYL-6-MORPHOLINOTETRACYCLO[6.4.0.0(2,4).0(3,7)]DODECA-8,10,1 2-TRIENE-6-CARBONITRILESELINEN-11-EN-4-OLSILANE,[[4-[1,2-BIS[(TRIMETHYLSILYL)OXY]ETHYL]-1,2-PHENYLENE]BIS(OXY)]BIS[TRIMETHYL-(CAS)Silane, trimethyl(1-methylethoxy)-SPIRO[2,5]OCT-6-ENE-4-ACETALDEHYDESYM-TETRAMETHYLDIMETHOXYDISILOXANETERT BUTYL1,6,8-TRI-TERT-BUTYL-3,4-(TETRACHLOROBENZO)-2,5-DIOXABICYCLO[4.2.0]OCTA-3,7-D IENE-7-CARBOXYLATETRANS-1-(PHENYLTHIO)-6-OXO-4-OXAHEPT-1-ENETRIMETHYLSILYL DERIVATIVE OF 4-NITROSOPHENOLUROTERPENOLWAITZIACUMINONEZ-ISOMER, 2-(2-HYDROXYETHYLIDENE)-3-METHOXYNORBORNANEArsenous acid, tris(trimethylsilyl) ester3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACIDCyclotrisiloxane, hexamethyl-3-(1'-ETHOXYETHOXY)-1-BUTANOLPropane, 1-(1-ethoxyethoxy)-1,3-BIS(TRIMETHYLSILYL)-4,4-DICARBOMETHOXY-1,8-NONADIENE2-METHOXY[1]BENZOTHIENO[2,3-C]QUINOLIN-6(5H)-ONECyclotetrasiloxane, octamethyl-3-Butoxy-1,1,1,5,5,5-hexamethyl-3-(trimethylsiloxy)trisiloxane DIHEXYLSULFIDENIZATIDINE1,2-Dihydro-2,4-diphenyl-quinazolineNitric acid, ethyl esterTRANS-3-CHLOROALLYL 2,3-EPOXYPROPYL ETHERD,L-1,4-PHENYLENE-BIS{[(T-BUTYLTHIO)THIOXOMETHYLTHIO]ACETIC ACID} HOTRIENOLButanedioic acidCyclopentanol, 2-methyl-, cis-[(TERT-BUTYL)DIMETHYLSILYL]CYCLOPROPYLMETHANOLCIS-2-(7-OCTYNYL)CYCLOHEXANOL2-(ALLYLTHIO)-1-NITROBUTANESalicyl AlcoholBENZENEMETHANOL, 2-HYDROXY- (CAS)BUTANOIC ACID, 3-METHYL-, 2-METHYLPROPYL ESTER (CAS)Butanoic acid, 3-oxo-, 1-methylpropyl ester(Z)-7-(TETRAHYDROPYRANYLOXY)-3-[(TRIMETHYLSILY)-METHYL]-2-METHYL-3-HEPTEN-2-O LN-[3-(2-CARBOXYPHENOXY)PROPYL]-3,4-DIHYDROXYPHENYLACETAMIDEMETHYL22-(TRIMETHYLSILOXY)DOCOSAN-4(Z),7(Z),10(Z),13(Z),16(Z),19(Z)-HEXAENOATE(1R,2R,4R)-p-Menthane-1,2,8-triol3-BROMO-4-HYDROXY-PENTADECA-6(Z),9(Z)-DIENE2-Cyclopentene-1-thione, 3,4-dimethyl-2,4-HEPTADIENAL2-(2,3-EPOXYPROPYL)-TETRAHYDROFURANE2-ACETYLTETRAHYDROFURANBenzenemethanol, 3-hydroxy-1,4-Benzenediol, 2-methyl-1,3-Benzenediol, 2-methyl-4-(PHENYLTHIOXOMETHYL)MORPHOLINE(2S,3R,4S,5R,6R,7R)-2,3-EPOXY-1-IODO-5,6-ISOPROPYLIDENE-DIOXY-7-(4-METHOXYBEN ZYLOXY)-2,4,6-TRIMETHYLNONANENIZATIDINE(E)-DI-T-BUTYL [2-((E)-2-BUTENYLOXY)-2-BUTENYL]-PHOSPHONATE1,3-Benzodioxole-5-methanol5,5'-BIS(2,2-DIMETHYL-(5H)-1,3-PYRONE)ETHER2H-Pyran-2-one, tetrahydro-6-(2-pentenyl)-3-(2-pyridinylsulfinyl)-(1.ALPHA.,2.BETA.,4.ALPHA.)-1-[4-(1,1-DIMETHYLETHYL)-2-(2-PROPENYL)CYCLOPENTY L]ETHANONE1-[[(P-TOLYLSULFONYL)OXY]METHYL]TRICYCLO[5.4.0.0(2,6)]-8-UNDECANONE3-METHOXY-1-TOSYL-1-CYCLOHEXANEBenzeneethanol, 4-hydroxy-Benzeneethanol, 3-hydroxy-BENZENEETHANOL, 3-HYDROXY- (CAS)UROTERPENOL(4R,8S)-P-MENTH-1-ENE-8,9-DIOL6-(3-Methyl-3-cyclohexenyl)-2-methyl-2,6-heptadienol1-METHYL-2-METHYLENE-TRANS-4-DEUTERODECALIN3-O-BENZYL-4,5-O-CARBONYL-D-FRUCTOSE1,2-Dihydro-2,4-diphenyl-quinazolineCHLORO-9-FORMYLACRIDINE1-BENZYL-6,7-DIMETHOXY-3-ISOCROMANONE2-Cyclohexen-1-one, 3-(3-hydroxy-1-butenyl)-2,4,4,5-tetramethyl-2,6-DIMETHOXYBENZALDEHYDE(2,3-DIMETHOXYPHENYL)TRIMETHYLSILANE(2,5-DIMETHOXYPHENYL)TRIMETHYLSILANEBENZOIC ACID, 3-HYDROXY- (CAS)Ethanone, 1-(4-hydroxyphenyl)-2-phenyl-Isobutyl p-hydroxybenzoateHomovanillyl alcohol4-HYDROXY-3-METHOXYBENZYL METHYL ETHER2-(2-HYDROXYETHYL)-3-METHOXY-TRICYCLO(2.2.21.0*2,6)HEPTANE4-TERT-BUTYL-CHLOROBENZENEBenzoic acid, 4-hydroxy-3-methoxy-4'-CHLORO-2'-METHYL-ACETOPHENONE6-ISOPROPYLTRICYCLO[4.1.0.0(2,7)]HEPT-4-EN-3-ONE1-TOSYLCYCLOHEXA-1,3-DIENEBICYCLO[3.1.1]HEPT-2-ENE-2-CARBOXALDEHYDE, 6,6-DIMETHYL- (CAS)BIS (2-CHLOROISOPROPYL) ETHER(2R,6R)-6-METHYL-2-PHENYL-1,3-DIOXANE-4-ONE3,5-O-BENZYLIDENE-1-DEOXY-D-THREO-2-PENTULOSE1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENEEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENEERYTHRO-1-HYDROXY-1-PHENYL-2,4,4-TRIMETHYL-3-PENTANONE1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENETRIMETHYLSILYL DERIVATIVE OF 4-NITROSOPHENOLEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENEBenzene, 1-(1,1-dimethylethoxy)-2-methyl-L-TYROSINE (CAS)2-Cyclohexen-1-one, 4-(3-hydroxy-1-butenyl)-3,5,5-trimethyl-3-BUTENOIC ACID, 2,2-DIETHYL-3-METHYL- (CAS)3,4-DIMETHOXYBENZENE-1,2-DIOLREL-(1R,4R)-4-ACETYL-6-MORPHOLINOTETRACYCLO[6.4.0.0(2,4).0(3,7)]DODECA-8,10,1 2-TRIENE-6-CARBONITRILE2-(3',4'-DIHYDROXYPHENYL)-3-HYDROXY-6-(2''-HYDROXYETHYL)-2,3-DIHYDRO-1,4-BENZ ODIOXIN2,4-Pentadiyn-1-one, 1-phenyl-5-ETHENYL-5-(1-METHYLBUTYL)BARBITURIC ACID1-PHENYL-1,1-DIMETHOXY-2,2-DIFLUOROPENTANE1,3-Benzenediol, 4-propyl-1-METHYL-2-CYANO-2-DEUTERIO-3-ETHYL-3-PIPERIDEINE4-(5'-T-BUTYLCYCLOHEX-1'-ENYL)BUT-1-ENE5-EXO-METHYL-5-ENDO-NITROBICYCLO-[2.2.1]HEPTAN-2-ONE8,8-DIDERITERIOCAMPHENE1-(2-METHYLPHENYL)-3-CYANO-2(1H)-PYRIDINETHONE5-ACETYL-2-DIMETHYLAMINO-4-T-BUTYLTHIAZOLE1-TRIMETHYLSILYL-1-(2-NAPHTHYL)ETHYLENEá-(4-Hydroxy-3-methoxyphenyl)propionic acid2-(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID METHYL ESTERMETHYL(+-)-P-METHOXYMANDELATE2-HYDROXY-2-PHENYL-1,3-PROPANEDIOL DICARBAMATEtert-Butyl-benzyl-dimethylaminomethyl-phosphine1-Cyclohexenyl-cyclohexanol(1RS,2SR)-[2,2-DIMETHYL-6-(PHENYLSELENYL)METHYLCYCLOHEXANE-1-CARBOXYLIC ACID (2S,4AS,5S,8AS)-2-(T-BUTYL)-PERHYDRO-5-METHYL-2H,4H-[1,3]BENZODIOXIN-4-ONE (4RS,5SR,6RS)-6-HYDROXY-4,5-(ISOPROPYLIDENEDIOXY)CYCLOHEX-2-EN-1-ONE(2A.ALPHA.,5A.BETA.,8A.ALPHA.,8B.ALPHA.)-1,2,2A,3,4,5,5A,8,8A,8B-DECAHYDRO-1-OXO-1H-CYCLOPENTA[CD]INDENE-3,3-DI(METHOXYCARBONYL)ACENAPHTHYLENE1,1-DIMETHYL-4-PHENYLSEMICARBAZIDE6-HYDROXY-1,4-DICHLORO-5-DECANONEDIMETHYL [3-(TERT-BUTYLACETOXY)-3-METHYL-2-OXOBUTYL]PHOSPHONATE-(18)O VOMIFOLIOLN-METHYLMETHANESULFONAMIDO-2-CYCLOHEXENE-2-ONEBENZOIC ACID, 4-HYDROXY-3,5-DIMETHOXY- (CAS)3-Hydroxy-4,5-dimethoxybenzoic acidTRANS-1-(PHENYLTHIO)-6-OXO-4-OXAHEPT-1-ENE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)N-METHYL-N,N-DI[2-(4-PYRIDYL)ETHYL]-(2-PYRIDYL)ETHYLAMINEBenzoic acid, 2,4-dihydroxy-3,6-dimethyl-, methyl ester1,6-Dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-a]pyrimidine6,8-Dimethyl-5-oxo-2,3,5,8-tetrahydroimidazo[1,2-a]pyrimidine3-(1-BROMOCYCLOPENTYL)-2-BUTENOLIDE(4ARS,5SR,6RS,7RS)-7-(DIMETHYLAMINO)-1,2,3,4,4A,5,6,7-OCTAHY-DRONAPHTHALENE-5 ,6-DICARBOXYLATE2-TERT-BUTYLADAMANTAN-2-OL(+-)-5.BETA.-HYDROXY-2.BETA.-DIMETHOXYMETHYL-3.BETA.-TERT-BUTYLDIMETHYLSILYLO XYCYCLOPENTYL-1.ALPHA.-ACETIC ACID METHYL ESTERETHYL6-O-ACETYL-2,3,4-TRIDEOXY-4-PIPERIDINO-.ALPHA.-D-ERYTHRO-HEX-2-ENOPYRANOSIDE P-PHENYLPHENACYL [2-DEUTERIO)ISOBUTYRATETRANS-1-(PHENYLTHIO)-6-OXO-4-OXAHEPT-1-ENE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)N-METHYL-N,N-DI[2-(4-PYRIDYL)ETHYL]-(2-PYRIDYL)ETHYLAMINE2-Azafluorenone3-AZAFLUORENONEEthanone, 1-(4-hydroxy-3,5-dimethoxyphenyl)-1,3-BENZENEDICARBOXYLIC ACID (CAS)1,4-BENZENEDICARBOXYLIC ACID (CAS)3,4-MethylenedioxybenzhydrazidePyrrolidine, 1-(m-methoxycinnamoyl)-Phenol, 2,2'-[(hydroxyimino)bis(4,5-dihydro-5,3-isoxazolediyl)]bis-N-HEXYLDI-N-PROPOXYMETHYLSILANE1,3-DIACETOXYPROPA-2-ONE1,1,1,3,5,5,5-Heptamethyltrisiloxane1-(1'-CYCLOHEXENYL)-3-(TRIMETHYLSILYL)-2-BUTEN-1-ONE2-[(TRIMETHYLSILYL)METHYL]-1-[1-HYDROXY-4-(TERT-BUTYLDIMETHYLSILOXY)BUTYL]CYC LOPROPANE1,3-DIACETOXYPROPA-2-ONE1-(1'-CYCLOHEXENYL)-3-(TRIMETHYLSILYL)-2-BUTEN-1-OL3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACID2,5-Pyrrolidinedione, 3-ethylidene-4-methyl-Cyclotrisiloxane, hexamethyl-3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACIDCYCLOTRISILOXANE, HEXAMETHYL- (CAS)3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACID(+-)-1-(ACETOXY)-2-(1-BROMOETHYL)-3-METHOXYANTHRAQUINONE6,10,13-TRIMETHYL-17-ACETYL-17-ACETOXY-3-OXO-ESTRA-4,6-DIENE(1SR,5RS,9SR,13RS,18RS)-18-ALLYLHEXACYCLO[16.3.0.0(15).0(5,9).0(9,13).0(13,17 ]HENICOS-16-ENE2-METHOXY[1]BENZOTHIENO[2,3-C]QUINOLIN-6(5H)-ONECyclotetrasiloxane, octamethyl-1-AMINO-1-ORTHO-CHLOROPHENYL-2-(2-QUINOXALINYL)ETHENE4-[[6-(ETHOXYCARBONYL)-TRANS-5-HEXENYL]OXY]-6-METHYL-2-PYRONE3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACIDArsenous acid, tris(trimethylsilyl) ester(+,-)-2-HYDROXY-1,5-DIMETHYL-6,8-DIOXABICYCLO[3.2.1]OCTANE PermethylspermidineBUTYL 4-OXOOCTANOATEBIS(TRIMETHYLSILYL)[9-(TRIMETHYLSILYL)-9-FLUORENYL]SILANOL1,1,3,3,5,5,7,7,9,9,11,11,13,13-TETRADECAMETHYLHEPTASILOXANENIZATIDINE1-METHYL-1-(METHOXYCARBONYLAMINO-HYDROXY-METHYL)-CYCLOHEXA-3-ENETRANS-4-(T-BUTYL)-1-ETHENYL-1-(DIMETHYLAMINOCARBONYLOXY)CYCLOHEXANETRANS-CISOID-TRANS-TRICYCLO[9.3.0.0(3,7)]TETRADECANE-2,9-DIONE Benzeneethanol, 4-hydroxy-5-CYCLOPROPYL-3,3A,4,5,6,7-HEXAHYDROISOXAZOLO[4,3-C]PYRIDINE Benzaldehyde, 3,4-dimethoxy-1,3-Benzodioxole-5-carboxylic acid1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENEEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENEERYTHRO-1-HYDROXY-1-PHENYL-2,4,4-TRIMETHYL-3-PENTANONETRIMETHYLSILYL DERIVATIVE OF 4-NITROSOPHENOLEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENE[(T-BUTYL)DIMETHYLSILYL] 5-PHENYLVALERIANATE2,2-BIS(3',3'-DIMETHYLBUTOXY)ADAMANTANEO-NITROPIVALOPHENONEBenzeneacetic acid, 3-hydroxy-, ethyl esterSILANE, TRIMETHYL[[5-METHYL-2-(1-METHYLETHENYL)-1-CYCLOHEXEN-1-YL]OXY]-2,6,6-TRIMETHYL-4-(TRIMETHYLSILOXY)-2,4-CYCLOHEXADIEN-1-ONEDIETHYL ESTER OF HYDROXY(4-METHOXY-3-METHYLPHENYL)-PROPANEDIOIC ACID DIETHYL ACETOXY(4-METHOXY-3-METHYLPHENYL)PROPANEDIOATESYN-(4,5)-4-METHYL-5-PHENYL-5-TRIMETHYLSILOXY-1-PENTEN-3-ONE1-TRIMETHYLSILYLOXY-2.BETA.H-6-[(TRIMETHYLSILYLOXY)(PHENYL)METHYL]-3,4,5,6-TE TRAHYDROBENZENEERYTHRO-1-HYDROXY-1-PHENYL-2,4,4-TRIMETHYL-3-PENTANONEEXO-5-(2-METHYL-3-PHENYL-3-TRIMETHYLSILOXY-1-PROPANON-1-YL)BICYCLO[2.2.1]HEPT -2-ENETHREO-2-BROMO-3,4-EPOXYOCTANE2-FORMYL-2',5,5'-TRIMETHYLPYRROLIDINE-N-OXYLERYTHRO-2-BROMO-3,4-EPOXYOCTANE2,4-Pentadiyn-1-one, 1-phenyl-(3S,5R)-3-(HYDROXYMETHYL)-1,4,4,5-TETRAMETHYLCYCLOPENTENE5-ETHENYL-5-(1-METHYLBUTYL)BARBITURIC ACID(9R)-9-HYDROXY-4-MEGASTIGMEN-3-ONE1-(CYANO-ACETOXYMETHYLENE)-2-CYCLOHEXENE3-OXO-7,8-DIHYDRO-.ALPHA.-IONOLà-Ethyl-O-methoxybenzyl alcohol1,1,1,3,5,5,5-HeptamethyltrisiloxaneArsenous acid, tris(trimethylsilyl) esterCYCLOTRISILOXANE, HEXAMETHYL- (CAS)3-(2',4'-DIMETHOXY-6'-PROPYLBENZOYLOXY)-2-HYDROXY-4-METHOXY-6-PROPYLBENOIC ACID2-TRIMETHYLSILYL(ISOPROPOXYDIMETHYLSILYL)BENZENE1,2-BIS{(4S)-4-ISOPROPYL-2-OXAZOLIN-2-YL} ETHANE(+-)-N-(1-METHYL-3,3-DIPHENYLPROPYL)FORMAMIDE(+)-[1R-(1.BETA.,2.BETA.,3.BETA.,7.ALPHA.,10.ALPHA.)]-3-[1'-METHYL-1'-HYDROXY ETHYL]-6-METHYLIDENE-10-METHYLBICYCLO[5.3.0]DECAN-2-OLTricyclo[4.4.0.02,7]dec-3-ene-3-methanol, 1-methyl-8-(1-methylethyl)-.BETA.-CHENOPODIOL(6)MONOACETATE2-METHYL-1-OXASPIRO[5.5]UNDECANE-2-CARBONITRILE(1RS,5SR,8ARS)-1-(3-FURYL)-5,8A-DIMETHYL-1,5,6,7,8,8A-HEXAHYDRO-3H-2-BENZOPYR AN-3-ONE5-(1-CHLOR-1-METHYLETHYL)-3,5-DIMETHYL-2-CYCLOPENTEN-1-ONE1-Propanone, 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-BIS(ETHYLTHIO)(PHENYL)METHANE1-PROPANONE, 3-HYDROXY-1-(4-HYDROXY-3-METHOXYPHENYL)- (CAS) Cyclotrisiloxane, hexamethyl-ETHYL ESTER OF 3-OXO-4-(TRIMETHYLSILYL)CYCLOHEXANEACETIC ACID1,2-Dihydro-2,4-diphenyl-quinazolineTRANS-1-(PHENYLTHIO)-6-OXO-4-OXAHEPT-1-ENE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)N-METHYL-N,N-DI[2-(4-PYRIDYL)ETHYL]-(2-PYRIDYL)ETHYLAMINEMETHYL (2S,3R)-2,3-DIHYDROXY-3-(4-METHOXYPHENYL)PROPANOATE1-(4'-METHOXYPHENYL)-2-METHYLPROPANE-1-OL(E)-4-(2',6',6'-TRIMETHYL-1',2'-EPOXYCYCLOHEXYL)-3-PENTEN-2-ONE3,7,11-(3-METHYL-TRIDEUTERIO)-TRIMETHYL-(4,4-DIDEUTERIO)DODECA-1,6,10-TRIEN-3 -OL1,10-DICYANO-DECANE(+)-1-ISOPROPYL-7-METHOXY-4-METHYLSPIRO(4.5)DEC-6-EN-8-ONE1,2-BENZENEDICARBOXYLIC ACID, BIS(2-METHYLPROPYL) ESTER (CAS)2-METHYL-6-.BETA.-D-RIBOFURANOSYLIMIDAZO[1,2-C]PYRIMIDIN-5(6H)-ONEDibutyl phthalatePALMITOLEIC ACID 1TMSPalmitelaidic acid, trimethylsilyl esterPALMITELAIDIC ACID 1TMS1-DECYLAMINOMETHYL-1,2,3,4-TETRA-HYDROISOQUINOLINEHexadecanoic acid, trimethylsilyl esterMETHYL (3R,5Z)-3-(TRIISOPROPYLSILYLOXY)DEC-5-ENOATE(2S,3R)-3-DIMETHYL-T-BUTYLSILOXY-2,4-DIMETHYLPENTAN-1-OL(E)-3-ALLYL-2-DIMETHYLPHENYLSILYL-1-CYCLONONENE4-(1,3-BENZODIOXOL-5-YLMETHYL)-4,5-DIHYDROFURAN-2(3H)-ONE1-Hexyl-1-nitrocyclohexane1-Hexyl-2-nitrocyclohexaneBROMOCYCLODODECANE1-PHENYL-6-DEUTEROMETHYL-5,7-DIDEUTEROHEPTA-1,6-DIEN-3-ONE(E)-(1,3-DIMETHYL-5-PYRAZOYL) 3-PHENYL-2-PROPENOATEPyrrolidine, 1-cinnamoyl-1-Hexyl-2-nitrocyclohexaneETHYL 2,2-DIFLUORO-4-IODO-12-HYDROXYDODECANOATE9-OCTADECENOIC ACID (Z)-, ETHYL ESTER (CAS)(MESO)-3,4-DIHYDROXYMETHYL-3,4-DIMETHYLHEXANE(1,3-DIISOPROPYLCYCLOPENTADIENYL)DIMETHYL(TRIMETHYLPHOSPHAN)-COBALT(III) .GAMMA.-OCTADECALACTONE5-AMINO-2-PHENYL-2-METHYL-2H-[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE5-AMINO-2-METHYL-2-PHENYL-2,3-DIHYDRO[1,2,4]TRIAZOLO[1,5-A][1,3,5]TRIAZINE PHENOL, 4,4'-(1-METHYLETHYLIDENE)BIS- (CAS)(E)-DIHYDRO-3-CARBOMETHOXYMETHYLENE-4,4,5,5-TETRAMETHYL-2(3H)-FURANONE TRANS-3-ACETOXY-6,6-DIMETHYL BICYCLO(3.1.1)HEPTAN-2-ONE2.ALPHA.-ACETOXY-1.ALPHA.,3,3-TRIMETHYLCYCLOHEXANOLN-HEXYLDI-N-PROPOXYMETHYLSILANEPyrrolidine, 1-(m-methoxycinnamoyl)-PYRROLIDINE, 1-(M-METHOXYCINNAMOYL)- (CAS)BIS(3-METHYLPHTHALIDYL)PEROXIDEETHANONE, 1,1'-(1,4-PHENYLENE)BIS- (CAS)Benzene, 1-(1,1-dimethylethyl)-3-ethyl-1-Hexyl-1-nitrocyclohexane8-METHYL-HEXACOSANOL1-Hexyl-2-nitrocyclohexane1-BROMO-8-METHYLHEXACOSANEMethyl (1s*,2s*,5R*)-1,5-dimethyl-2-ethenyl-cyclohexane-1-carboxylate (E)-3-HYDROXY-2,3-BIS(2,4,6-TRIMETHYLPHENYL)-2-PROPENSAURE-BENZYLESTER(2R,5E)-2,12-EPOXYCARYOPHYLL-5-ENEMETHYL 2,5-BIS(METHOXYCARBONYL)-3-(TOSYLMETHYL)ADIPATE3.ALPHA.,17,19-TRIACETOXYSPONGIA-13(16),14-DIEN-2-ONE1,2-BENZENEDICARBOXYLIC ACID, DIISOOCTYL ESTER (CAS)1,2-BENZENEDICARBOXYLIC ACID, DICYCLOHEXYL ESTER (CAS)BIS(2-ETHYLHEXYL) PHTHALATE4-METHYL-1,2,4-TRIAZOLINE-3,5-DIONE ADDUCT WITH NOPADIENE1-CYCLOPROPYL-4-ETHOXY-3-METHOXYBENZENE1-CYCLOHEPTYL-2,2-HEXAMETHYLENE-1H-PYRROL-3(2H)-ONE1-Hexyl-2-nitrocyclohexaneDIHYDRO-5-HYDROXY-5-[(8-PENTYL-2-OXOCANYL)ACETYL]-2(3H)-FURANONE3,7,11-(3-METHYL-TRIDEUTERIO)-TRIMETHYL-(4,4-DIDEUTERIO)DODECA-1,6,10-TRIEN-3 -OL。

盐酸吡格列酮合成工艺路线
吡格列酮是一种口服降糖药物，其化学名称为(2S)-1-{2-[(6S)-2,4-dioxo-3,4-dihydro-1(2H)-pyridinyl]ethyl}-3-[3,5-dihydroxy-4-(1,2,3-trihydroxypropyl)oxolan-2-yl]pyrrolidine-2-carboxamide。

下面是盐酸吡格列酮的合成工艺路线：
1. 吡格列酮的合成是以吡嗪-2,4-二酮为原料。

首先将吡嗪-2,4-二酮进行锂盐化处理，得到相应的锂盐。

2. 将锂盐与1,2-环己二醇反应，生成环己二醇盐酸盐。

然后与二溴甲烷在碱性条件下反应，发生取代反应生成2,2'-二甲基环己三烯-1,5-二酮。

3. 将2,2'-二甲基环己三烯-1,5-二酮与氨反应，发生加成反应合成(2S)-1-{2-[(6S)-2,4-dioxo-3,4-dihydro-1(2H)-pyridinyl]ethyl}-3-[3,5-dihydroxy-4-(1,2,3-trihydroxypropyl)oxolan-2-
yl]pyrrolidine-2-carboxamide。

4. 最后，将合成得到的吡格列酮中间体与盐酸反应生成盐酸吡格列酮。

这个反应可以通过向反应体系中加入盐酸或通过滴定来完成。

值得注意的是，合成吡格列酮及其中间体的反应条件和操作方法需根据具体的实验室条件和酌情调整。

合成吡格列酮需要严格控制反应温度、反应时间和反应物的添加顺序，以及使用适当的溶剂和催化剂。

此外，由于吡格列酮是一种药物，其合成工艺路线也需要符合相关法规和标准。

hoat化学名称
HOAT是1-羟基-7-氧代-6-氮代-3,4-二氢喹啉-2,5-二酮的缩写，是一种常用的化学试剂。

它可以用于氨基酸和肽的合成反应中，作为偶联剂加速反应速率。

HOAT的化学名称是7-oxo-1,3-dihydro-1,4-benzodiazepine-2-carboxylic acid，分子式为
C10H6N2O4。

HOAT与其他偶联剂的区别
HOAT与其他常用的偶联剂如EDC、HATU、DIC等相比，具有以下优点：
1. HOAT的偶联效率高。

它可以减少非特异性的副反应，并且可以在中性或微酸性条件下进行反应，避免了碱性条件下可能会引起的脱质子反应。

2. HOAT的反应速率快。

由于HOAT分子中含有两个活性部位，它可以促进氨基酸和肽的偶联反应。

3. HOAT的副反应少。

它可以减少有毒的副产物生成，从而提高合成产率。

4. HOAT的使用方便。

HOAT可以直接加到反应混合物中，不需要进行预处理。

HOAT在氨基酸和肽合成中的应用
HOAT常用于肽的合成反应中，具体的反应条件为：在中性或微酸性条件下，加入HOAT、氨基酸或肽、活性酯或酰氯，反应时间一般在几小时到一天之间。

HOAT可以促进氨基酸和肽的偶联反应，避
免了碱性条件下可能会引起的脱质子反应。

同时，HOAT还可以减少非特异性的副反应，提高合成产率。

地西泮的合成进展2013.10.191.地西泮简介地西泮（diazepam）又名地西畔、戴阿剂盘、安定、苯甲二氮卓，化学式C16H13ClN2O，1-甲基-5-苯基-7-氯-1,3-二氢-2H-1,4 苯并二氮杂䓬-2-酮（7-chloro-1,3 dihydro-1 methyl-5-phenyl-2H-1,4-benzodiazepin-2-zone），相对分子质量为284.74，熔点为130℃——134℃，是苯二氮䓬类药物其中之一，可由对氯苯胺和苯甲酰氯等合成。

地西泮为白色或类白色的结晶性粉末；无臭，味微苦。

易溶于丙酮、三氯甲烷，在乙醇中溶解，在水中几乎不溶。

水解开环发生在1、2位或4、5位，两过程平行进行，最终水解成2-甲氨基-5氯-二苯甲酮，这一水解过程是苯二氮类药物共有的反应。

4、5位开环为可逆性水解。

在体温和酸性条件下，4、5位间开环水解，当pH提高到中性时重新环合，口服本品后，在胃酸作用下，4、5位间开环，当开环化合物进入碱性的肠道又闭环成原药。

因此4、5位间开环，不影响药物的生物利用度。

地西泮结构式癫痫（羊癫疯）是大脑神经元突发性异常放电，导致短暂的大脑功能障碍的一种慢性疾病。

是一种疾病和综合征，以脑部神经元反复突然过度放电所致的间歇性的中枢神经系统功能失调为特征。

世界上每年会出现150万癫痫新病人，我国每年也有近30万人患此病。

地西泮是治疗癫痫病的药物之一，也是治疗持续癫痫病的首选药物，地西泮可对抗化学药物如戊四氮所引起的惊厥，并可抑制癫痫病灶异常放电的扩散。

此外，临床上，地西泮常用为治疗焦虑症的药物;用于镇静催眠；抗惊厥癫痫；对中枢性肌肉松弛有较强的肌肉松弛作用。

苯二氮卓类为中枢神经系统抑制药，可引起中枢神经系统不同部位的抑制，随着用量的加大，临床表现可自轻度的镇静到催眠甚至昏迷。

本类药的作用部位与机制尚未完全阐明，认为可以加强或易化γ-氨基丁酸（GABA）的抑制性神经递质的作用，GABA在苯二氮卓受体相互作用下，主要在中枢神经各个部位，起突触前和突触后的抑制作用。

盐酸左氧氟沙星片的反应-回复盐酸左氧氟沙星片（Levofloxacin Hydrochloride Tablets）是一种广谱抗生素，常用于治疗呼吸道、泌尿道、皮肤软组织等感染症状。

在本文中，我们将详细探讨盐酸左氧氟沙星片的化学反应。

1. 盐酸左氧氟沙星片的基本结构和性质盐酸左氧氟沙星片的化学名为(3S,5S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl) -7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hydrochloride，其分子式为C18H20FN3O4·HCl。

这种药物是一类第四代氟喹诺酮类抗生素，具有广谱抗菌活性。

2. 盐酸左氧氟沙星片的合成方法盐酸左氧氟沙星片的合成方法主要有两步：羟基取代反应和氨基化反应。

首先，通过对环丙基取代左氧氟沙星的苯酚氢氧化，得到叔醇。

然后，在碱性条件下，利用氯丙酮胺与叔醇反应，生成含有酮基的取代产物。

最后，通过在碳酸氢钠的缓冲液中加热，使产物脱去酮基，生成盐酸左氧氟沙星片。

3. 盐酸左氧氟沙星片的水解反应盐酸左氧氟沙星片在水中会发生水解反应。

水解是指一种化合物与水分子反应，生成两个或多个新的化合物的化学反应。

通过水解，盐酸左氧氟沙星片可分解成左氧氟沙星和盐酸，其中左氧氟沙星是其活性成分。

4. 盐酸左氧氟沙星片的酶促反应盐酸左氧氟沙星片可以通过与酶发生反应，从而影响酶的功能。

酶促反应是指酶与底物结合，催化底物发生化学变化的反应。

盐酸左氧氟沙星片可以与细菌DNA双链酶结合，抑制其解旋功能，从而阻碍细菌DNA的复制和修复，导致细菌死亡。

5. 盐酸左氧氟沙星片的氧化反应盐酸左氧氟沙星片可以发生氧化反应，其中一个主要反应是与过氧化氢反应。

过氧化氢是一种强氧化剂，在存在过氧化氢的条件下，盐酸左氧氟沙星片可以被氧化成更活跃的代谢物，从而增强其抗菌活性。

SJL01 MultiVu - C_MSDCHEM_1_DATA_SJL1、 CAS Number:64-17-5 基本信息中文名: 乙醇;酒精;无水乙醇英文名: Etanol分子结构:分子式: C 2H 6O分子量: 46.07 2、 CAS Number:562-74-3 基本信息中文名: 4-萜烯醇;4-甲基-1-(1-甲基乙基)-3-环己烯-1-醇英文名: Terpinen-4-ol分子结构:分子式: C 10H 18O分子量: 154.253、 CAS Number:16728-99-7 基本信息英文名: Naphthalene,1,2,3,4,4a,7-hexahydro-1,6-dimethyl-4-(1-methylethyl)- 分子结构:分子式: C 15H 24分子量: 204.351064、 CAS Number:17066-67-0 基本信息英文名: Naphthalene,decahydro-4a-methyl-1-methylene-7-(1-methylethenyl)-,(4aR,7R,8aS)-分子结构:分子式: C 15H 24分子量: 204.35115、 CAS Number:473-13-2 基本信息英文名: Naphthalene,1,2,3,4,4a,5,6,8a-octahydro-4a,8-dimethyl-2-(1-methylethenyl)-, (2R,4aR,8aR)-分子结构:分子式:C 15H 24分子量: 204.35116、 CAS Number:25360-09-2 基本信息中文名: 叔十六硫醇英文名: tert-Hexadecanethiol分子结构:分子式: C16H34S分子量: 258.5067、CAS Number:19780-11-1 基本信息中文名: 十二烯基丁二酸酐英文名: 2,5-Furandione,3-(2-dodecen-1-yl)dihydro- 分子结构:分子式: C16H26O3分子量: 266.37588、Name: (-)-SpathulenolFormula: C15H24OMW: 220 CAS#: 77171-55-29、CAS Number:661-19-8 基本信息中文名: 山嵛醇;1-二十二醇英文名: 1-Docosanol分子结构:分子式: C22H46O分子量: 326.6010、CAS Number:25360-09-2 基本信息中文名: 叔十六硫醇英文名: tert-Hexadecanethiol分子结构:分子式: C16H34S分子量: 258.50611、Name: 2,5-Furandione, 3-dodecyl Formula: C16H26O3MW: 266 CAS#: 59426-46-912、CAS Number:6750-34-1 基本信息英文名: 1-Dodecanol,3,7,11-trimethyl- 分子结构:分子式: C15H32O分子量: 22813、CAS Number:56847-02-0 基本信息英文名: Methyl 8,11,14-docosatrienoate 分子结构:分子式: C23H40O214、CAS Number:16714-85-5 基本信息英文名: (E)-10-Heptadecen-8-ynoic acid methyl ester 分子结构:分子式: C18H30O2分子量: 278.429615、CAS Number:2490-48-4 基本信息英文名: 1-Hexadecanol,2-methyl-分子结构:分子式: C17H36O分子量: 256.467116、Name: Urea, 1-(2-methylphenyl)-3-propyl Formula: C11H16N2OMW: 192 CAS#: 13143-12-917、Name: Dihydrocoumarin, 5,7,8-trimethyl Formula: C12H14O2MW: 190 CAS#: 40614-33-3。

常见药物中间体常见药物中间体Entecavir恩替卡韦中间体：第1步：3-Cyclopenten-1-ol,2-[(phenylmethoxy)methyl]-,(1R-trans) CAS No:188399-48-6第2步：(1S,2R,3S,5R)-2-(benzyloxymethyl)-6-oxabicyclo[3.1.0]hexan-3-ol CAS No:117641-39-1 第3步：6-Oxabicyclo[3.1.0]hexane,3-(phenylmethoxy)-2-[(phenylmethoxy)methyl]-, (1S,2R,3S,5R) CAS No 110567-22-1 第4步：(1S,2S,3S,5S)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2- (benzyloxymethyl)cyclopentanolcas:142217-77-4第5步：(2R,3S,5S)-3-(benzyloxy)-5-(6-(benzyloxy)-2- ((4-methoxyphenyl)diphenylmethylamino)- 9H-purin-9-yl)-2-(benzyloxymethyl)cyclopentanol CAS No：142217-78-5 第6步：(2R,3S,5S)-3-(benzyloxy)-5-(6-(benzyloxy)-2-((4-methoxyphenyl) diphenylmethylamino)-9H-purin-9-yl)-2-(benzyloxymethyl)cyclopentanone CAS No 142217-79-6 第7步：6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl) -9H-purin-2-amine CAS No 142217-80-9第8步：6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2- methylenecyclopentyl)-9H-purin-2-amine CAS No 204845-95-4钆双胺一水物122795-43-1阿折地平中间体阿折地平中间体 CAS：18621-17-5阿折地平中间体 CAS：116574-14-2阿折地平中间体 CAS：170749-59-4阿折地平中间体 CAS：39562-25-9Anagrelide阿那格雷中间体N-(6-硝基-2.3-二氯苄基)甘氨酸乙酯盐酸盐N-(2.3-dichloro-6-nitrobenzyl)glycine HCl 含量：98%以上 99% N-(6-氨基-2.3-二氯苄基)甘氨酸乙酯Ethyl N-(6-amino-2.3-dichlorobenzyl)glycine 70406-92-7Prasugrel普拉格雷侧链(中间体)150322-73-9 含量：98%以上Adapalene 阿达帕林中间体：2-(1-Adamantyl)-4-bromophenol2-(1-金刚烷基)-4-溴苯酚2-(1-Adamantyl)-4-bromoanisole2-(1-金刚烷基)-4-溴苯甲醚Methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate6-[3-(1-金刚烷基)-4-甲氧基苯基]-2-萘甲酸甲酯1-(5-Bromo-2-Methoxyphenyl)-adamantane CAS NO.104224-63-7 1-（5-溴-2-甲氧基苯基）金刚烷Methyl 6-bromo-2-naphthoate6-溴－2－萘甲酸甲酯Adefovir Dipivoxil 阿徳福韦酯中间体：9-[2-(Diethylphosphonomethoxy)ethyl]adenine9-[2-(二乙基膦酸基甲氧基)乙基]腺嘌呤9-(2-Phosphonylmethoxyethyl]adenine(Adefovir)9-[2-(膦酸基甲氧基)乙基]腺嘌呤（阿德福韦）Amorolfine HCl 盐酸阿莫罗芬中间体：3-[1,1-Dimethylphenyl-4-]-2-methyl-propionic acid3-[1,1-二甲基苯基-4-]-2-甲基-丙酸Anagrelide 阿那格雷中间体：Ethyl N-(2,3-dichloro-6-amino benzyl)glycineN－(2,3－二氯－6－氨基－苄基)甘氨酸乙酯Aripiprazole阿立哌唑中间体：1-(2,3-Dichloro-phenyl)-piperazine hydrobromide1-(2,3-二氯苯基)-哌嗪氢溴酸盐7-(4-Bromo-butoxy)-3,4-dihydro-2(1H)-quinolinone7-(4-溴丁氧基)-3,4-二氢-2(1H)-喹啉酮Brompheniramine Maleate马来酸溴苯那敏中间体：α-(p-Bromophenyl)-α-(β-dimethylaminoethyl)-2-pyridylacetonitrile maleateα-对溴苯基-α-（β-二甲基氨基乙基）-2-吡啶乙腈马来酸盐Candesartan Cilexetil 坎地沙坦酯中间体：Cyclohexyl 1-chloroethylcarbonate环己基1-氯乙基碳酸酯2-Ethoxy-1-[[2’-(1H-tetrezol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylic acid (Candesartan) 1-[[2'-(1-H-四氮唑-5-基)联苯-4-基]甲基]-2-乙氧基-苯并咪唑-7-羧酸（坎地沙坦）Cefepime头孢吡肟中间体：(6R, 7R)-7-Amino-3-[(1-methyl-1-pyrrolidino)methyl]ceph-3-em-4-carboxylate hydriodic acid 7-氨基-3-[(1-甲基-1-吡咯烷基)甲基]头孢-3-烯基-4-羧基氢碘酸盐（头孢吡肟母核）Cefutibuten 头孢布烯中间体：(E/Z) (4-2-Methyl-buten) 4-(2-benzyloxycarbonyolaminothiazol-4-yl)-4-carboxy-3-butyrate (Cefutibuten side chain)(顺/反)4－(2－苄氧羰基氨基噻唑－4－基)－4－羧基－3－丁烯酸(4－2－甲基－2－丁烯)酯（头孢布烯侧链）Dofetilide 多非利特中间体：2-[4-Nitrophenoxy]ethyl chloride4-(2-氯乙氧基)硝基苯N-Methyl-4-nitrophenethylamine hydrochloride CAS: 166943-39-14-硝基-β-苯乙胺盐酸盐N-Methyl-N-[2-(4-nitrophenoxy)ethyl]-4-nitrophenylamineN-甲基-N-[2-(4-硝基苯氧基)乙基]-4-硝基苯乙胺Escitalopram Oxalate草酸依地普仑中间体：(-)-4-[4-(Dimethylamino)-1-(4’-fluorophenyl)-1-hydroxy-1-butyl]-3-(hydroxymethyl)benzonitrile, Tosyltartaric acid salt (-)-4-[4-二甲氨基-1-(4-氟苯基)-1-羟基-1-丁基]-3-羟甲基苯乙腈，苯甲酰基酒石酸盐Finasteride非那雄胺中间体：3-Oxo-4-androstene- 17β-carboxylic acid3-氧代-4-雄甾烯-17β-羧酸Fluoxetine 氟西汀中间体：N-Methyl-3-phenyl-3-hydroxypropylamineN-甲基-3-苯基-3-羟基丙胺Lafutidine 拉呋替丁/拉夫替丁中间体：2-Bromo-4-(1-piepridinomethyl)pyridine2-溴-4-(1-哌啶基甲基)吡啶p-nitrophenyl 2-[(furanylmethyl)sulfinyl]acetic acid （For Lafutidine）a-（2-呋喃甲基亚磺酰基）乙酸-（4-硝基苯酚）酯CAS号为123855-55-0N-{4-[4-(1-Piperidinomethyl)pyridyl-2-oxy]-cis-2-buten}phthalimide maleate CAS No.146447-26-9N-{4-[4-(1-哌啶甲基)吡啶-2-氧]-顺-2-丁烯基}邻苯二甲酰胺,马来酸盐2-(Furfurylsulfinyl)acetic acid p-nitrophenyl ester2-呋喃甲基亚磺酰基乙酸-p-硝基苯Levetiracetam 左乙拉西坦中间体：L-2-Amino butanamideL－2－氨基丁酰胺Levosimendan左西孟旦中间体：6-(4-Aminophenyl)-4, 5-dihydro-5-methyl-3(2H)-pyridazinone CAS:36725-28-7 6-(4-氨基苯基)-5-甲基-4,5- 二氢-3(2H)-哒嗪酮2,7-dichloro-9H-Fluorene CAS: [7012-16-0](-)-6-(4-Aminophenyl)-4, 5-dihydro-5-methyl-3(2H)-pyridazinone(-)-6-(4-氨基苯基)-5-甲基-4,5- 二氢-3(2H)-哒嗪酮Liranaftate利拉萘酯中间体：2-Methoxy-6-methylaminopyridine2-甲氧基-6-甲氨基吡啶5,6,7,8-Tetrahydro-2-naphthol5,6,7,8-四氢-2-萘酚Nevirapine奈韦拉平中间体：2-Chloro-3-amino-4-methylpyridine2－氯－3－氨基－4－甲基吡啶Nifekalant 尼非卡兰中间体：6-Chloro-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione1, 3-二甲基-6-氯尿嘧啶N-(2-Hydroxyethyl)-N-[3-(4-nitrophenyl)propyl]amineN-(2-羟乙基)-3-(4-硝基苯基)丙胺Pramipexole普拉克索中间体：4-[(N-Benzoyl)amino]-cyclohexanone4-[(N-苯甲酰基)-氨基]-环己酮(S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole (S)-2-氨基-6-丙胺基-4,5,6,7-四氢苯并噻唑Prulifloxacin 普卢利沙星中间体：Ethyl 6,7-difluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate6,7－二氟－1－甲基－4－氧代－4H－[1,3]硫氮杂环丁烷[3,2-a]喹啉－3－甲酸乙酯Ethyl6-fluoro-7-(1-piperazinyl)-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate6－氟－7－(1－哌啶基)－1－甲基－4－氧代－4H－[1,3]硫氮杂环丁烷[3,2-a]喹啉－3－甲酸乙酯6-Fluoro-7-(1-piperazinyl)-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid 6－氟－7－(1－哌啶基)－1－甲基－4－氧代－4H－[1,3]硫氮杂环丁烷[3,2-a]喹啉－3－甲酸Racecadotril消旋卡多曲中间体：3-Acetylthio-2-benzylpropanoic acid2-苄基-3-硫代乙酰基丙酸Glycine benzyl ester p-tosylate甘氨酸苄酯对甲苯磺酸盐Risperidone利培酮中间体：6-Fluoro-3-(tetrahydropyridine-4-yl)benzo[b]isoxazol6-氟-3-(4-哌啶基)-1,2-苯并异噁唑3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidine-4-one3-(2-氯乙基)-6,7,8,9-四氢-2-甲基-4H吡啶并[1,2-α]嘧啶-4-酮Rosiglitazone 罗格列酮中间体：5-{4-{2-[Methyl－(2－pyridyl)amino]ethoxy}benzal}-2,4-thiazole-dione5-{4-{2-[甲基-(2-吡啶基)氨基]乙氧基}苄叉}-2,4-噻唑二酮2,4-Thiazolidinedione2,4-噻唑二酮Roxatidine Acetate HCl盐酸罗沙替丁醋酸酯中间体：3-(1-Piperidinylmethyl)phenol3－(1－哌啶基甲基)苯酚N-{3-[3-(1-Piperidinylmethyl)phenoxy]propyl}amineN-{3-[3-(1-哌啶基甲基)苯氧基]}丙胺Telmisartan 替米沙坦中间体：N-Methyl-O-phenylenediamine dihydrochlorideN-甲基邻苯二胺盐酸盐2-N-Propyl-4-methyl-6-carboxybenzimidazole2-丙基-4-甲基-6-羧基苯并咪唑tert-Buthyl 4’-methylbiphenyl-2-carboxylate4'-甲基联苯-2-甲酸叔丁酯tert-Buthyl 4’-(bromomethyl)biphenyl-2-carboxylate4'-溴甲基联苯-2-甲酸叔丁酯Trospium Chloride曲司氯铵中间体：α-Hydroxy-α-phenylbenzeneacetic acidα-羟基-α-苯基苯乙酸Voriconazole伏立康唑中间体：6-(1-Bromo-ethyl)-4-chloro-5-fluoropyrimidine6-(1-溴乙烷)-4-氯-5-氟嘧啶1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanone 1-(2,4-二氟苯基)-2-(1H-1,2,4-三唑)-1-基)乙酮(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)- 1-(1H-1,2,4-triazol- 1-yl)-2- butanolhydrochloride(2R,3S/2S,3R)-3-(4-氯-5-氟嘧啶-6-基)-2-(2,4-二氟苯基)-1-(1H-1,2,4-三唑-1-基)丁-2-醇盐酸盐(2R,3S/2S,3R)-3-(5-Fluoro-4-pyrimidinyl)-2-(2,4-difluorophenyl)- 1-(1H-1,2,4-triazol- 1-yl)-2- butanol(2R,3S/2S,3R)－3－(5－氟嘧啶－4－基)－2－(2,4－二氟苯基)－1－(1H－1,2,4－三唑－1－基)丁－2－醇Ziprasidone齐拉西酮中间体：3-(1-Piperazinyl)-1,2-benzisothiazole hydrochloride3-(1-哌嗪基)-1,2-苯并异噻唑盐酸盐Zolmitriptan佐米曲坦/佐米曲普坦中间体：(S)-4-(4-Nitrobenzyl)-1,3-oxazolidin-2-one(S)-4-(4-硝基苄基)-1.3-噁唑-2-酮Memantine美金刚中间体：1-bromo-3,5-dimethyl adamantane1-溴-3,5-二甲基金刚烷甲磺酸伊马替尼及中间体甲磺酸伊马替尼220127-57-1Imatinib base 152459-95-54-[(4-methyl-1-piperaziny)methyl]benzoic acid 106261-49-8 4-[(4-methyl-1-piperaziny)methyl]benzoic acid dihydrochloride 106261-48-7N-(5-amino-2-methylphenl)-4-(3-pyridyl)-2-pyrimidine-amine 152460-10-1舒尼替尼及中间体舒尼替尼 341031-54-7Sunitinib base 557795-19-45-Fluoro-1,3-dihydro-indol-2-one 56341-41-42-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate 86770-31-24-(ethoxycarbonyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid 5442-91-1ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-51-1ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-59-95-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 253870-02-95-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid 356068-93-4拉帕替尼及中间体拉帕替尼 388082-78-8Lapatinib base 231277-92-22-Amino-5-iodo-benzoic acid 5326-47-66-Iodoquinazolinone 16064-08-74-Chloro-6-iodo-quinazoline 98556-31-12-Chloro-1-(3-fluoro-benzyloxy)-4-nitro-benzene 443882-99-33-Chloro-4-(3-fluoro-benzyloxy)-phenylamine 202197-26-0 N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodoquinazolin-4-amine 231278-20-95-[4-({3-chloro-4-[(3-fluorobenzyl)oxy] phenyl}amino)quinazolin-6-yl]-2-furaldehyde 231278-84-5尼罗替尼及中间体尼罗替尼 641571-10-04-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 641569-94-04-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester3-[(Aminoiminomethyl)amino]-4-methyl-benzoic acid ethylester mononitrate 641569-96-2 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline 641571-11-1达沙替尼及中间体达沙替尼 863127-77-92-Amino-N-(2-chloro-6-methylphenyl)thiazole -5-carboxamide 302964-24-52-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 302964-08-5吉非替尼及中间体吉非替尼 184475-35-2methyl 2-amino-4,5-dimethoxybenzoate 26759-46-66,7-dimethoxyquinazolin-4(3H)-one 13794-72-46-hydroxy-7-methoxyquinazolin-4(3H)-one 179688-52-93,4-dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-04-chloro-7-methoxyquinazolin-6-yl acetate 179688-54-1 (HCl)230955-75-64-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate 184475-70-5 (HCl)788136-89-04-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 184475-71-64-(3-chloropropyl)morpholine 7357-67-7埃罗替尼及中间体埃罗替尼/厄罗替尼 183319-69-9Erlotinib base 183321-74-6ethyl 3,4-dihydroxybenzoate 3943-89-3ethyl 3,4-bis(2-methoxyethoxy)benzoate 183322-16-9ethyl4,5-bis(2-methoxyethoxy)-2-nitrobenzoate 179688-26-7ethyl4,5-bis(2-methoxyethoxy)-2-aminobenzoate 179688-27-86,7-bis-(2-Methoxyethoxy)-quinazolin-4(3h)-one 179688-29-04-Chloro-6,7-(2-methoxyethoxy)-quinazoline 183322-18-1 卡那替尼 289499-45-2凡德他尼 443913-73-3索拉非尼索拉非尼 475207-59-14-CHLORO-(2-(METHYLAMINO)-CARBONYL)-PYRIDINE 220000-87-34-(4-aminophenoxy)-N-methylpicolinamide 284462-37-9免疫抑制剂FTY720 475207-59-1抗糖尿病药西他列汀 486460-32-6维达列汀 274901-16-5盐酸度洛西汀及中间体盐酸度洛西汀 136434-34-9(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine 132335-46-7(HCl) 阿利吉仑及中间体阿利吉仑 173334-58-2Aliskiren base 173334-57-1(2S,4S,5S)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4,5-dihydroxy-2-isopropylpentanamide (R)-3,6-diethoxy-2,5-dihydro-2-isopropylpyrazine 110117-71-02-(3-methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene) 172900-69 -52-(aminomethyl)-2-methylpropanamide 324763-51-1(R)-3-(3-methylbutanoyl)-4-benzyloxazolidin-2-one 145589-03-31-(((S)-2-(bromomethyl)-3-methylbutoxy)methyl)benzene 172901-00-7卡巴拉汀及中间体酒石酸卡巴拉汀129101-54-8卡巴拉汀碱123441-03-2N-Ethyl-N-Methyl carbamoyl chloride 42252-34-63-[1-(Dimethylamino)ethyl]phenol 105601-04-5(s)-3-(1-(dimethylamino)ethyl)phenol 139306-10-8罗库溴铵及中间体罗库溴铵 119302-91-95α-androsta-2-en-17-one 963-75-72-(4-morpholinyl)-16-(1-pyrrolidinyl)-5-androstane-3,17-diol 119302-20-4艾拉莫德及中间体艾拉莫德 123663-49-03-硝基-4-苯甲氧基茴香醚 82780-78-73-氨基-4-苯甲氧基茴香醚 82780-77-63-甲基磺酰胺基-4-苯氧基茴香醚 88381-56-7α-氨基-2-甲氧基-4-甲磺酰胺基-5-苯氧苯乙酮盐酸盐149436-41-9氨来占诺及其中间体6-异丙基-4-氧代-4H-1-苯并吡喃-3-甲醛(取代苯并吡喃—3—甲醛) CAS NO: 49619-58-16-异丙基-4-氧代-4H-1-苯并吡喃-3-甲腈(取代苯并吡喃—3—甲腈) CAS NO: 50743-32-3氨来占诺乙酯瑞舒伐他汀钙及其中间体4－（4-氟苯基）－6－异丙基－2－（N－甲基－N—甲磺酰氨基）嘧啶－5－甲酸甲酯CAS : 289042-11-1 4-(4-氟苯基)－6－异丙基－2－（N－甲基－N—甲磺酰氨基）嘧啶－5－甲醇CAS: 147118-36-3 母核醇4-（4-氟苯基）－6－异丙基－2－（N－甲基－N—甲磺酰氨基）嘧啶－5－甲醛 CAS : 147118-37-4(5S)-瑞舒伐他汀缩合物乙酯瑞舒伐他汀乙酯(3R)-瑞舒伐他汀缩合物甲酯瑞舒伐他汀甲酯3-叔丁基二甲硅氧基戊二酸酐CAS: 91424-40-7(3R)-叔丁基二甲硅氧基戊二酸单甲酯CAS: 109744-49-21-乙氧羰基-5-甲基-(3R)-叔丁基二甲硅氧基戊二酸酯CAS: 158275-79-7(3R)-叔丁基二甲硅氧基-5-氧代-6-三苯基膦烯己酸甲酯[（4R-6S）-6-[（乙酰氧基）甲氧]-2，2-二甲基-1，3-二氧杂-4-基]乙酸叔丁酯侧链匹伐他汀钙及其中间体2-环丙基－4－(4－氟苯基)喹啉－3－甲醇 CAS: 121660-11-52-环丙基－4－(4－氟苯基)喹啉－3－甲醛 CAS: 121660-37-5(E)-3-[2-环丙基－4－(4－氟苯基)－3－喹啉-2-丙烯腈(E)-3-[2-环丙基－4－(4－氟苯基)－3－喹啉-2-丙烯醛CAS: 148901-68-2(E)-(5S)-7-[2--环丙基－4－(4－氟苯基)－3－喹啉] -5-羟基-3-氧代-庚-6-烯酸乙酯厄多司坦及其中间体DL- N-氯乙酰高半胱氨酸硫内酯盐酸艾司洛尔雷诺嗪及其中间体N-(2,6-二甲苯基) -2-氯乙酰胺CAS: 1311-01-7N-(2,6-二甲基苯基)-1-（1-哌嗪）乙酰胺CAS: 5294-61-1雷诺嗪醚化物盐酸雷诺嗪CAS: 95635-56-6盐酸倍他洛尔及其中间体1-[4-(2-羟乙基)苯氧基] -2, 3-环氧丙烷1-{(4-[2-(环丙基甲氧基)-乙基]-苯氧基}-2, 3-环氧丙烷倍他洛尔碱左旋倍他洛尔托美汀托美汀钠Amtolmetin Guacil呱氨托美丁:87344-06-7及其中间体顺苯磺酸阿曲库铵及其中间体四氢罂粟碱盐酸盐1, 5-戊二醇二丙烯酸酯脱甲基阿曲库铵草酸盐(R)- (-)-四氢罂粟碱盐酸盐(1R, 1’R)- 脱甲基阿曲库铵草酸盐苯磺阿曲库铵左亚叶酸钙/左旋亚叶酸钙3-甲基噻吩CAS: 616-44-4鲁米诺及其钠盐 "CAS: 521-31-3地西他滨Decitabine及其中间体替莫普利的中间体: CAS: 110221-26-6(2S,6R)-6-amino-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepine (Intermediate of temocapril) (2S，6R)-6-氨基-2-2-(噻吩基）-1,4-硫氮杂卓-5-酮。

甲基三甲氧基硅烷分子式
甲基三甲氧基硅烷是一种有机硅化合物，其分子式可以表示为C4H12O3Si。

这个分子式由四个碳原子、十二个氢原子、三个氧原子和一个硅原子组成，这些原子通过共价键相互连接，形成了一种稳定的化合物。

甲基三甲氧基硅烷的分子式中，甲基（-CH3）是一个由一个碳原子和三个氢原子组成的基团，它通过与硅原子相连，成为了硅烷分子中的一部分。

而甲氧基（-OCH3）则是一个由一个氧原子、一个碳原子和三个氢原子组成的基团，它在分子中占据了三个位置，与硅原子通过氧原子相连。

甲基三甲氧基硅烷作为一种有机硅化合物，在化学工业中有着广泛的应用。

它可以作为硅橡胶、硅油、硅树脂等高分子化合物的原料，用于制造各种硅基材料。

此外，甲基三甲氧基硅烷还可以用于表面涂层、防水剂、防粘剂等领域，提高材料的耐水性、耐候性和抗粘性。

在实际应用中，甲基三甲氧基硅烷的分子式不仅是了解其化学结构和性质的基础，也是进行化学反应和合成的重要参考。

通过对分子式的分析和理解，化学工作者可以设计出更加合理和有效的合成路线，实现甲基三甲氧基硅烷的高效制备和应用。

总之，甲基三甲氧基硅烷的分子式C4H12O3Si是描述其化学结构和组成的重要符号，它不仅是化学研究的基础，也是工业生产和应用的重要依据。

通过对分子式的深入了解和探索，我们可以更好地认识和应用这种有机硅化合物，为化学工业的发展做出更大的贡献。

3-甲氧基-3-甲基乙酸丁酯全文共四篇示例，供读者参考第一篇示例：3-甲氧基-3-甲基乙酸丁酯是一种有机化合物，化学式为C9H18O3，它是一种酯化合物，常被用作溶剂或是在制药和农药生产中的中间体。

它的结构中含有一个甲氧基基团和一个甲基基团，使得它具有一定的活性和特殊的化学反应性。

本文将着重介绍3-甲氧基-3-甲基乙酸丁酯的性质、用途和合成方法等方面的内容。

我们来谈一下3-甲氧基-3-甲基乙酸丁酯的性质。

这种化合物是一种无色到浅黄色液体，具有特殊的香味。

它的密度约为0.962 g/cm3，熔点为-40℃，沸点为238℃。

3-甲氧基-3-甲基乙酸丁酯在常温常压下稳定，但遇到高温或光照时容易发生分解反应。

它是一种可燃性液体，遇火易燃，应避免与氧化剂接触。

我们来探讨一下3-甲氧基-3-甲基乙酸丁酯的用途。

这种化合物在工业生产中有着广泛的应用。

它常被用作有机溶剂，可以用来溶解油脂、树脂和橡胶等物质。

3-甲氧基-3-甲基乙酸丁酯也是一种重要的中间体，可用于合成各种有机物，例如染料、香料、医药和农药等产品的制备。

它在医药领域中的应用也十分广泛，可以用来制备一些抗生素和抗生素前药。

在农业方面，它可以用作农药的原料或中间体，用于控制害虫和病原体的生长。

我们来谈一下3-甲氧基-3-甲基乙酸丁酯的合成方法。

一般来说，它可以通过酸酐与醇反应或是醇与酸反应来合成。

其中一种较为常用的方法是将3-甲氧基-3-甲基乙酸与丁醇在酸性条件下加热反应，生成3-甲氧基-3-甲基乙酸丁酯。

这种方法简单易行，产率较高，因此被广泛应用于工业生产中。

3-甲氧基-3-甲基乙酸丁酯是一种重要的有机化合物，具有广泛的用途和应用前景。

它的性质稳定，化学反应活性强，是许多化工领域不可或缺的中间体之一。

通过不断的研究和开发，相信它在未来会有更广泛的应用和发展空间。

第二篇示例：3-甲氧基-3-甲基乙酸丁酯（Methyl3-methoxy-3-oxopropionate）是一种常用的有机化合物，化学式为C7H12O4，分子量为160.17 g/mol。

三氟甲氧基定位基三氟甲氧基是一种有机化合物中的化学基团，化学式为CF3O-，由一个碳原子与三个氟原子和一个氧原子组成。

该化学基团常常用作有机合成中的定位基，可以引入到目标分子中的特定位置上，从而改变其物理化学性质或增加其活性。

下面将从三氟甲氧基的合成方法、反应性质以及在有机合成中的应用等方面进行介绍，以简体中文写出。

三氟甲氧基的合成方法有多种，其中一种常见的方法是利用三氟甲醇和碱反应得到。

三氟甲醇是从铁三氟甲烷铁、三氟甲烷和碱的反应中获得的，简称TFM法。

铁三氟甲烷铁是一种常见的三氟甲基化试剂，可与异氰酸酯或叔丁基氰酸酯反应得到三氟甲基叔丁氧基化合物，再通过水解反应脱除叔丁氧基基团，得到三氟甲氧基化合物。

三氟甲氧基具有一定的反应性质，可以参与多种有机反应。

例如，三氟甲氧基可被氢化钠处理成甲醇，可以被碱处理生成碱式盐，还可以与酸反应生成对应的酯。

此外，三氟甲氧基还可以与叔醇反应生成叔醚，与硅烷反应生成三氟甲基硅烷等。

在有机合成中，三氟甲氧基常用作定位基，用于引入三氟甲氧基化合物中的特定位置上。

这是因为三氟甲氧基具有较强的电子吸引性，可以在化学反应中起到增强反应活性或改变反应产物选择性的作用。

例如，三氟甲氧基可以通过亲电取代反应引入到芳香化合物的芳香环上，从而改变其电子密度和亲核取代反应的速率。

此外，三氟甲氧基还可以作为活泼的氧化还原试剂，在一些氧化还原反应中发挥关键作用。

三氟甲氧基在药物合成、材料合成等领域中得到了广泛应用。

例如，在药物合成中，三氟甲氧基可以用于引入活性基团、改变药物分子的溶解性、增强活性或改善药物代谢性质等。

在材料合成中，三氟甲氧基可以作为改性试剂，改变材料的表面性质、增强其稳定性或改善材料界面等。

总而言之，三氟甲氧基是一种重要的有机化合物中的定位基团，具有较强的反应活性和应用潜力。

通过合适的合成方法和反应条件，可以将三氟甲氧基引入到目标分子中的特定位置上，从而实现取代或改变其物理化学性质。