Effects of trimetrazine combined with Rhodiolarosea on patients with coronary heart diseas

86不同形态硒、维生素E 、紫萝卜提取物体外抗氧化协同作用研究郑时莲，潘瑶，张云龙，邓泽元，李红艳*（南昌大学食品科学与技术国家重点实验室，江西南昌330047）收稿日期：2016－02－26作者简介：郑时莲（1990－），女，硕士研究生，主要从事天然产物活性方面研究，E－mail ：zhengshilian07@ 。

*通讯作者：李红艳（1986－），女，博士，副教授，主要从事天然产物方面的研究，E－mail ：lihongyan61@ 。

基金项目：国家自然青年科学基金（31301433）；江西省博士后科研项目（2013KY04）。

摘要：本文比较了不同形态硒（包括亚硒酸钠，SS ；L －硒甲基半胱氨酸，L －Se－MSC ；富硒酵母，SEY ）、维生素E （V E ）和紫胡萝卜提取物（Ant ）之间的抗氧化协同作用。

分别建立DPPH 、Fe 3+和ABTS +·三种体外抗氧化模型，绘制清除率曲线，计算各物质的半抑制浓度（IC 50）。

采用等辐射分析法，根据等效公式计算复配后的理论值（IC 50add ），将其与实际测量值（IC 50mix ）进行比较。

结果显示，SS 和L－Se－MSC 的体外抗氧化性较弱，而SEY 在体外具有较强抗氧化能力。

同一模型中，不同复配比例的抗氧化协同效应不同。

协同效应最佳的组合比例在DPPH 模型中为：V Emix ʒAnt mix ʒSEY mix=4ʒ1ʒ1，在Fe 3+模型中为：V Emix ʒAnt mix ʒSEY mix =1ʒ4ʒ1，在ABTS +·模型中为：V Emix ʒAnt mix ʒSEY mix =1ʒ1ʒ1。

因此，同一物质在不同模型中的抗氧化效应不同，SEY 、V E 与Ant 联用具有抗氧化协同作用，但同一组合在不同抗氧化模型中表现出的效应有所不同。

关键词：硒，维生素E ，紫萝卜提取物，抗氧化，协同作用Antioxidant synergy effect in vitro among different forms ofselenium ，Vitamin E and purple carrot extractZHENG Shi －lian ，PAN Yao ，ZHANG Yun －long ，DENG Ze －yuan ，LI Hong －yan *（State Key Laboratory of Food Science and Technology ，Nanchang University ，Nanchang 330047，China ）Abstract ：The antioxidant effects of individual and combined three kinds of selenium including sodium selenite （SS ），L －Se －methylselenocysteine （L －Se －MSC ），Se －enriched yeast （SEY ），Vitamin E ，anthocyanin extracts of purple carrots were determined by DPPH radical scavenging activity ，Fe 3+reducing power and ABTS radical scavenging activity .Isobolographic analysis was used to calculate the actual antioxidant value in IC 50mix and evaluate the synergistic antioxidant effect of individual and combined different forms selenium ，Vitamin E and purple carrot extract .The results indicated that L －Se －MSC and SS possessed low antioxidant activity in vitro antioxidant model ，while SEY possessed high antioxidant activity which exhibited synergistic effect with Vitamin E ，anthocyanin extracts of purple carrots .In the same model ，different combinations had different effects .The best ratio in DPPH model was V Emix ʒAnt mix ʒSEY mix =4ʒ1ʒ1，in the Fe 3+model ，the best one was V Emix ʒAnt mix ʒSEY mix =1ʒ4ʒ1and V Emix ʒAnt mix ʒSEY mix =1ʒ1ʒ1was the best one in ABTS +·model .In the same combination ，different factors showed different effects .The combination of selenium yeast ，vitamin E ，and anthocyanin extracts of purple carrots had synergistic antioxidant effects .Key words ：selenium ；Vitamin E ；purple carrot extract ；antioxidants ；synergistic effect 中图分类号：TS255.1文献标识码：A文章编号：1002－0306（2016）19－0086－05doi ：10．13386/j．issn1002－0306．2016．19．008硒（Se ）是人和动物体内一种重要的微量元素，在人体内发挥着重要的生物学作用，其存在形式主要有有机硒和无机硒两种。

论著·临床论坛CHINESE COMMUNITY DOCTORS冠心病已成为临床上最为常见的心血管疾病，随着人们生活质量的提高，我国人口呈老龄化趋势的发展。

老年人已成为冠心病的多发人群，患者在患病期间会出现不同程度的血压增高、血脂增高、呕吐、头晕、乏力等，且心绞痛成为冠心病主要发病症状之一，严重者则会危及患者生命安全。

针对治疗老年冠心病的药物，临床多采用硝酸甘油，它可有效地抑制患者血压及血脂的增长，但过量服用则会发生低血压症状。

为提升治疗效果，临床上予以曲美他嗪药物联合治疗，有效地缓解了患者心绞痛症状，提高了治疗效果，改善了患者生活质量。

本文针对曲美他嗪治疗老年冠心病的疗效进行临床观察，2017年4月-2017年10月收治冠心病老年患者100例，现报告如下[1]。

资料与方法2017年4月-2017年10月收治冠心病老年患者100例，随机分为常规组与观察组，各50例。

常规组男32例，女18例；年龄59～72岁，平均(62.25±9.45)岁；患病周期2～5年，平均(3.26±2.13)年。

观察组男25例，女25例；年龄61～75岁，平均(70.26±5.12)岁；患病周期3～8年，平均(5.26±2.02)年。

两组患者在治疗前采用心电图确诊，均为冠心病患者，并伴有不同程度的心绞痛症状。

同时对患者进行重大疾病和传染性疾病的排除，均无任何异常。

患者在治疗前各项指标、姓名和性别等基线资料比较，差异均无统计学意义(P＞0.05)，具有可比性。

方法：①常规组与观察组患者均采取常规治疗措施，主要对患者实施吸氧及口服β受体阻滞剂、钙离子拮抗药物和血管紧张素转换酶抑制药物。

在此基础上常规组患者予以硝苯地平口服药物配合治疗。

服药起始剂量10mg/次，3次/d，最高剂量1d≤120mg/次，患者如突发紧急情况可含服舌下；②观察组患者则予以曲美他嗪口服药物联合治疗，服用方法20mg/次，3次/d，服用周期为3个月最佳。

162临床心身疾病杂志 2020年7月第26卷第i 期 J C 7b ,知/. 2020, V 〇/ 26，iVo. 4•临床报告•胃肠药物联合草酸艾司西酞普兰治疗难治性功能性消化不良疗效观察陈叶青周国华☆ 周红宇雷耀耀谭晓华韩龙刘田田【摘要】目的探讨胃肠药物联合草酸艾司西酞普兰治疗难治性功能性消化不良的临床疗效。

方法将82例难治性功能性消化不良患者按照治疗方法分为观察组42例与对照组40例，两组 均给予泮托拉唑钠肠溶片及马来酸曲美布汀分散片治疗，观察组在此基础上联合草酸艾司西酞 普兰片治疗，治疗8周。

比较两组临床疗效，治疗前后采用汉密顿焦虑量表及汉密顿抑郁量表 评定两组焦虑及抑郁情绪。

每2周进行血、尿常规，肝肾功能和心电图检査，比较两组不良反应 发生情况。

结果观察组治疗总有效率显著高于对照组（P <〇. 〇1)。

治疗8周末两组汉密顿焦 虑量表及汉密顿抑郁量表评分均较治疗前显著下降（P <〇. 〇1)，观察组较对照组下降更显著(P <0. 01)。

治疗前后两组血、尿常规，肝肾功能及心电图均无明显改变，两组不良反应发生率 比较差异无统计学意义（P >〇. 05)。

结论胃肠药物联合草酸艾司西酞普兰治疗难治性功能性消化不良疗效较好，能显著改善患者的焦虑、抑郁状态，不良反应轻微，值得推广应用。

【关键词】难治性功能性消化不良；草酸艾司西酞普兰；焦虑；抑郁；汉密顿焦虑量表；汉密顿抑郁 量表doi ：10. 3969/j. issn. 1672-187X. 2020. 04. 043【关键词】R 333. 5【文献标识码】AGastrointestinal medicine combined w ith escitalopram oxalate in the treatment of refractory functional dyspepsiaChen Y e q i n g ，Z h o u G u o h u u A ，Z h o u H o n g y u ，L e i Y u o y c io ，T u n X i a o h u a ，H a n L o n g ，L iu T ia n tia n(J o i n t L o g istic s S u p p o r t U nit 922 H o s p i t a l ^ H e n g y a ?ig 421002^ H u n a n C h i n a )^C o r r e s p o n d i n g a u th o r ： Z h o u G uohua (E m a i l ：314051884@q q . c o m )【Abstract 】 ObjectiveTo observe the curative effect of gastrointestinal medicine combined with escitalo­pram oxalate in the treatment of refractory functional dyspepsia. Methods82 patients with refractoryfunctional dyspepsia were divided into observation group (42 cases) and control group (40 cases) according to the treatment method. Both groups were given pantoprazole sodium enteric-coated tablets and trimebu- tine maleate dispersible tablets. The observation group combined with escitalopram oxalate tablets for 8 weeks. The clinical efficacy of the two groups was compared. Before and after treatm ent, HAM A and HAMD were used to asseSvS anxiety and depression. Blood and urine routine, liver and kidney function and electrocardiogram were performed every 2 weeks. Compare the occurrence of adverse reactions between the two groups. ResultsThe total effective rate of treatment in the observation group was significantlyhigher than that in the control group (P<Z0. 01). After 8 weeks of treatm ent, the HAMA and HAMD scores of the two groups were significantly lower than before treatment (P <C0. 01), and the observation group was more significantly lower than the control group (P<C0. 01). There were no significant changes in blood and urine routines, liver and kidney functions and electrocardiogram before and after treatment in the two groups, and there was no significant difference in the incidence of adverse reactions between the two groups (P >0. 05). Conclusions Gastrointestinal medicine combined with escitalopram oxalate have a better curative effect on refractory functional dyspepsia, and can significantly improve patients anxiety and depression status. The side effects are mild, and it is worth popularizing and applying.[Keywords 1 Refractory functional dyspepsia ； es­citalopram oxalate ； anxiety ； depression ； Hamilton Anxiety Scale ； Hamilton Depression ScaleO作者简介：陈叶青，男，39岁，汉族，本科，主治 医师，科副主任。

DOI：10.16662/ki.1674-0742.2023.14.098多沙唑嗪联合帕罗西汀治疗非细菌性慢性前列腺炎的疗效刘春生，罗建斌，卢华荣福建省龙岩市第二医院泌尿外科，福建龙岩364000［摘要］目的研究多沙唑嗪联合帕罗西汀治疗非细菌性慢性前列腺炎的效果。

方法随机选取2019年1—12月福建省龙岩市第二医院收治的50例非细菌性慢性前列腺炎患者为研究对象，根据数字随机法分为对照组、研究组，各25例。

研究组采取多沙唑嗪联合帕罗西汀治疗，对照组采取多沙唑嗪治疗，观察并比较两组患者在治疗前、后的慢性前列腺炎症状评分（NIH-CPSI）、不良情绪、治疗效果及并发症发生情况。

结果治疗后，两组不良情绪、NIH-CPSI评分均较治疗前降低，且研究组低于对照组，差异有统计学意义（P<0.05）。

研究组的总有效率96.00%高于对照组的68.00%，差异有统计学意义（χ2=4.878，P<0.05）。

研究组的并发症发生率为8.00%显著低于对照组的36.00%，差异有统计学意义（χ2=5.711，P<0.05）。

结论对非细菌性慢性前列腺炎采取多沙唑嗪联合帕罗西汀治疗，能够降低NIH-CPSI评分，改善患者的不良情绪，治疗的效果较好，安全性较高。

.［关键词］帕罗西汀；多沙唑嗪；非细菌性慢性前列腺炎；治疗效果［中图分类号］R473 ［文献标识码］A ［文章编号］1674-0742（2023）05(b)-0098-05Doxazosin Combined with Paroxetine in the Treatment of Non-bacterial Chronic ProstatitisLIU Chunsheng, LUO Jianbin, LU HuarongDepartment of Urology, Longyan Second Hospital, Longyan, Fujian Province, 364000 China[Abstract] Objective To study the effect of doxazosin combined with paroxetine on non-bacterial chronic prostatitis.Methods Fifty patients with non bacterial chronic prostatitis admitted to the Second Hospital of Longyan City, Fujian Province from January to December 2019 were randomly selected as the research subjects. They were randomly di‐vided into a control group and a study group based on numerical randomization, with 25 patients in each group. The study group was treated with doxazosin combined with paroxetine, and the control group was treated with doxazosin. The chronic prostatitis symptom score (NIH-CPSI), bad mood before and after treatment, treatment effect and compli‐cations of the two groups were observed and compared. Results After treatment, the negative emotions and NIH-CPSI scores of both groups decreased compared to before treatment, and the study group was lower than the control group, and the difference was statistically significant (P<0.05). The total effective rate of 96.00% in the study group was higher than 68.00% in the control group, the difference was statistically significant (χ2=4.878, P<0.05). The incidence of complications in the study group was 8.00%, significantly lower than 36.00% in the control group, the difference was statistically significant(χ2=5.711, P<0.05), Conclusion Doxazosin combined with paroxetine in the treatment of non-bacterial chronic prostatitis can reduce the NIH-CPSI score and improve the adverse mood of patients. The thera‐peutic effect is good.[Key words] Paroxetine; Doxazosin; Non-bacterial chronic prostatitis; Therapeutic effect[作者简介] 刘春生（1984-），男，本科，主治医师，研究方向为泌尿外科疾病的诊治。

- 159 -①浙江大学医学院附属邵逸夫医院　浙江　杭州　310016GLP-1RA药物司美格鲁肽的临床研究进展洪毅颖① 【摘要】　司美格鲁肽作为多肽类降糖药，因其安全性佳、适应证广、半衰期长等优势在同类胰高血糖素样肽-1受体激动剂药物中崭露头角，成为当前临床研究的热点。

本文通过分析司美格鲁肽的安全性，介绍该药在降血糖、心血管保护和减重等多方面的研究进展，为其临床应用与合理选择提供参考。

【关键词】　司美格鲁肽　胰高糖素样肽-1受体激动剂　2型糖尿病　研究进展 doi：10.14033/ki.cfmr.2024.06.040 文献标识码　A 文章编号　1674-6805（2024）06-0159-06 Clinical Research Progress of GLP-1RA Drug Semaglutide/HONG Yiying. //Chinese and Foreign Medical Research, 2024, 22(6): 159-164 [Abstract]　Semaglutide is a polypeptide hypoglycemic drug, it has stood out in its glucagon-like peptide-1 receptor agonist class because of its safety, wide indications, long half-life and other advantages, and has become a hot spot in clinical research. This article provided a reference for Semaglutide's clinical application and reasonable selection by analyzing its safety and introducing the research progress in various aspects such as hypoglycemic, cardiovascular protection and weight loss. [Key words]　Semaglutide　Glucagon-like peptide-1 receptor agonist　Type 2 diabetes mellitus　Research progress First-author's address: Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou 310016, China 胰高糖素样肽-1（GLP-1）是肠道黏膜L 细胞分泌的一种肠促胰岛素激素，通过作用于胰岛α、β和δ细胞，促进胰岛素的合成与分泌、抑制胰高血糖素的分泌与释放，达到降低血糖的效果[1]。

临床中通常采用美托洛尔治疗冠心病心力衰竭，其在一定程度上能缓解患者的病情，但仍存在很多不足之处，患者在治疗过程中常出现多种不良反应[1]。

因此，探讨冠心病心力衰竭患者的有效治疗方法具有重要的临床意义。

本研究采用曲美他嗪联合美托洛尔治疗冠心病心力衰竭患者取得了较好的临床效果，现报告如下。

资料与方法2016年8月-2017年9月收治冠心病心力衰竭患者90例，按照就诊的先后顺序分为研究组和对照组，每组45例。

所有患者经医师诊断皆符合本研究的诊断标准，均已签署知情同意书。

研究组男29例，女16例；年龄46～68岁，平均年龄(57.31±4.36)岁；病程1～7年，平均病程(4.03±0.84)年。

对照组男23例，女22例；年龄48～72岁，平均年龄(60.31±5.02)岁；病程2～8年，平均病程(5.13±1.12)年。

对两组年龄、文化程度以及病程等基本资料进行统计，差异无统计学意义(P ＞0.05)，具有可比性。

方法：两组均给予基础药物治疗，口服缓解疼痛感的阿司匹林，1片/次，1次/d，100mg/片，同时给予单硝酸异山梨酯缓释胶囊，1粒/次，1次/d，50mg/粒。

对照组给予美托洛尔治疗，2片/次，2次/d，25mg/片。

研究组给予曲美他嗪联合美托洛尔治疗，曲美他嗪1片/次，3次/d，20mg/片。

观察指标：观察两组治疗总有效率，观察两组治疗后的BNP 指标水平。

疗效判定标准：①显效：患者的心脏功能恢复正常指标，在治疗过程中无任何并发症以及不良反应情况发生；②有效：患者的病情得到明显好转，身体逐渐恢复，对生活无影响；③无效：患者的心脏功能无任何改善，甚至病情有所加重，严重影响患者的生活质量[2]。

统计学方法：采用统计学软件SPSS 22.0分析数据，计数资料组间比较采用χ2检验；计量资料采用(x ±s )表示，组间比较采用t 检验，P ＜0.05表示差异有统计学意义。

吉西他滨联合厄洛替尼对肺癌患者T 细胞亚群及细胞因子的影响200433；上海 200433)中图分类号R979. 1文献标志码 A文章编号1672-2124( 2020) 01-0076-04DOI 10. 14009/j.issn. 1672-2124. 2020. 01. 020摘 要 目的：探讨吉西他滨联合厄洛替尼对肺癌患者T 细胞亚群及细胞因子的影响。

方法：选取2017年1月至2018年1月上 海长海医院收治的肺癌患者110例，采用随机数字表法分为观察组与对照组，每组55例。

对照组患者给予吉西他滨联合卡铂方 案治疗，观察组患者在对照组的基础上联合厄洛替尼治疗。

观察两组患者的近期疗效、T 细胞亚群*T 淋巴细胞(CD ；)、Th 细胞 (CD ；)、Ts 细胞(CD >)及CD4+/CD8+ +水平、细胞因子*白细胞介素2( IL-2)、白细胞介素6( IL-6)、白细胞介素10( IL-10)及肿瘤坏 死因子%(TNF-%)]水平及不良反应发生情况。

结果：观察组患者的总有效率为96. 36% (53/55),明显高于对照组的80.00% (44/55),差异有统计学意义(！<0.05)。

治疗后，观察组患者CD ；、CD ；及CD4f /CD8+水平明显高于对照组，且CD ；水平明显低 于对照组，差异均有统计学意义(P<0. 05)。

治疗后，观察组患者IL-2水平明显高于对照组,IL-6、IL-10及TNF-水平明显低于对 照组，差异均有统计学意义(！<0.05)。

观察组患者的不良反应发生率为9. 09%(5/55)，明显低于对照组的38. 13%(21/55)，差 异有统计学意义(！<0.05)。

结论：吉西他滨联合厄洛替尼治疗肺癌的效果较为理想，可有效改善患者T 细胞亚群、细胞因子水 平，且安全性较高，对于改善患者预后具有积极作用。

*主治医师&研究方向:肺癌的临床与基础研究& E-mail ：31955041@ #通信作者:主任医师，博士&研究方向:肺癌的临床与基础研究& E-mail ：bc7878@关键词 吉西他滨；厄洛替尼；肺癌；T 细胞亚群；细胞因子Effects of Gemcitabine Combined with Erlotinib onT Cell Subsets andCytokines in Patients with Lung CancerZHANG Rong 1 , HUA Libo 2, BAI Chong 1 ( 1.Dept. of Respiratory and Critical Medicine , Shanghai Changhas Hospital , Shanghat 200433, China ； 2. Dept, of Emergency , Shanghat Changhat Hospital , Shanghai 200433, China )ABSTRACTOBJECTIVE : To investigate the effects of gemcitabine cambined with erlotinib on T cell subsets andcytokines in patient with lung cancel. METHODS : A total of 110 patient with lung cancel admitted into Shanghai Changhai Hospital from Jan. 2017 to Jan. 2018 were extracted to be divited into the obseaation group and the controlgroup V v the random numbea table , with 55 cases in each group. The controO group was treated with gemcitabinecombined with cyrboplativ, and the observation group was given erlotinib treatment on the basis of the controO group . The shoO-term efficacy , T cell subsets [ T lymphocytes ( CD3； ) , Th alls ( CD4； ) , Ts alls ( CD8； ) , and CD4；/ CD8； ] , cytokine [ interleukin 2 (IL-2) , interleukin 6 (IL-6) , interleukin 10 (IL-10) and tumoo necrosis factOT %(TNF-t ) ] levels ] and adverss doug oeactions of two groups were observed. RESULTS : The total eflectiva yate t theobsrvation group was 96. 36% ( 53/55) , significantly higher tOan that in the controo group ( 80. 00%, 44/55) , withstatisticaHy significant dn'ferency ( ! < 0. 05 ) . After treatment , the levels of CD3； , CD4； and CD4；/CD8； in theobservation group were significantly higher than those in W c controo group , and the levels of CD8； were significantlylower than those t the conWol group , with statistically significant dterences ( !<0. 05 ). Aar lreatment , the levels of IL-2 in W c observation group wero significantly higher than those in the cynWot group , and W c levels of IL-6, IL-10 and TNF-t wero significantly lower than those in W c controo group , the dferences wero statistically significant ( P < 0. 05) . The incigenco of adverse drug reactions in the observation group was 9. 09% (5/55) , significantly lower thanthe conWoo group 38.13% ( 21/55 ) , and the dtferenco was statistically significant ( Pv0.05 ) . CONC-USIONS ：Gemcitabine combined wiW erotinig has significant effects in the treatWent of lung cancer, which can fectivaly improva the T coll subsets and cytokine levels in patienW with higher safety, cd has positWa effects on improving theprognosis of patients.KEYWORDS Gemcitabine ; Erlotinib ; Lung cancor; T cell subsets ; Cytokines肺癌是一种常见的恶性肿瘤，患者早期临床症状轻微，无明显特征。

DOI：10.16658/ki.1672-4062.2024.02.012司美格鲁肽联合二甲双胍恩格列净治疗2型糖尿病合并非酒精性脂肪性肝病患者疗效及安全分析戚玉琴1，杨浩2，盖显英11.上海市松江区泗泾医院内分泌科，上海201600；2.上海市松江区泗泾医院心血管内科，上海201600[摘要]目的观察司美格鲁肽与二甲双胍恩格列净联合对2型糖尿病（Type 2 Diabetes Mellitus， T2DM）合并非酒精性脂肪性肝病（Non-alcoholic Fatty Liver Disease， NAFLD）患者治疗的临床应用价值。

方法选取2022年5月—2023年5月上海市松江区泗泾医院收治的100例T2DM合并NAFLD患者为研究对象，通过抽签法分为两组，各50例。

对照组给予二甲双胍恩格列净，观察组在对照组的基础上加用司美格鲁肽。

比较两组的血糖、肝功能、血脂和不良反应。

结果观察组治疗后空腹血糖、餐后2 h血糖、丙氨酸氨基转移酶、门冬氨酸氨基转移酶、谷氨酰转肽酶、总胆固醇、三酰甘油水平低于对照组，差异有统计学意义（P均<0.05）。

两组不良反应发生率比较，差异无统计学意义（P>0.05）。

结论二甲双胍恩格列净联合司美格鲁肽治疗T2DM合并NAFLD患者，能调节糖脂代谢异常情况，改善其肝功能，安全性可靠。

[关键词] 2型糖尿病；非酒精性脂肪性肝病；二甲双胍恩格列净；司美格鲁肽[中图分类号] R4 [文献标识码] A [文章编号] 1672-4062（2024）01（b）-0012-04Analysis of the Efficacy and Safety of Semaglutide Combined with Metfor⁃min and Empagliflozin in the Treatment of Patients with Type 2 Diabetes Combined with Non-alcoholic Fatty Liver DiseaseQI Yuqin1, YANG Hao2, GAI Xianying11.Department of Endocrinology, Sijing Hospital, Songjiang District, Shanghai, 201600 China;2.Department of Cardio⁃vascular Medicine, Sijing Hospital, Songjiang District, Shanghai, 201600 China[Abstract] Objective To observe the clinical application value of semaglutide combined with metformin and empa⁃gliflozin in the treatment of patients with Type 2 Diabetes Mellitus (T2DM) combined with Non-Alcoholic Fatty Liver Disease (NAFLD). Methods A total of 100 patients with T2DM complicated with NAFLD admitted to Sijing Hospital of Songjiang District of Shanghai from May 2022 to May 2023 were selected as the study objects and divided into two groups with 50 cases each by drawing lots. The control group was given metformin empagliflozin, and the observation group was given semaglutide on the basis of the control group. The blood glucose, liver function, blood lipid and ad⁃verse reactions were compared between the two groups. Results The levels of fasting blood glucose, 2-hour postpran⁃dial blood glucose, alanine aminotransferase, aspartate aminotransferase, glutamyl transpeptidase, total cholesterol and triglyceride in the observation group were lower than those in the control group, and the differences were statistically significant (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Metformin empagliflozin combined with semaglutide can regulate abnormal glu⁃[基金项目]上海市松江区科学技术攻关项目（22SJKJGG82）；上海市松江区新一轮医学重点学科（ZK2019B02）[作者简介]戚玉琴（1995-），女，硕士，住院医师，研究方向为内分泌及代谢病学。

序言β-榄香烯属国家二类非细胞毒性抗肿瘤新药，临床研究证实其对包括脑胶质瘤在内的多种肿瘤疗效确切，且无其他传统化疗药常有的骨髓抑制、肝肾功能损害等毒副作用。

但目前临床应用的榄香烯乳注射液因其存在静脉炎发生率很高、剂型性质不稳定等缺点，其进一步的应用受到了较大的限制。

碱基切除修复抑制剂甲氧胺（Methoxyamine），可通过裂解核酸内切酶破坏DNA碱基切除修复过程，从而抑制肿瘤细胞对损伤作用的修复反应。

据此，可认为抑制DNA 碱基切除修复可能是增强肿瘤细胞化疗敏感性的潜在靶点，目前多项实验报道也已证实了甲氧胺可增强烷化剂和放疗的抗肿瘤效果。

近年来，通过纳米技术构建的纳米脂质体在提高药物溶解度、增加药物稳定性、降低药物副作用、缓控释给药等方面较普通的脂质体有了显著的提高。

研究表明，纳米脂质体对正常细胞和组织无损伤作用，并可长时间吸附于靶细胞周围，因此使药物能充分向靶组织渗透，也可以通过静电吸附效应与细胞膜接触而融合而进入细胞内。

因此将药物包封于纳米脂质体被认为可以改变被包封药物的体内分布，提高药物治疗指数，降低药物毒性。

基于增强β-榄香烯的疗效，减少毒副作用的目的，本课题研究内容分两部分：（一）联合碱基切除修复抑制剂甲氧胺，探讨是否在体内外抗瘤活性上具有协同作用，以期减少榄香烯用量，降低毒副反应，为其在临床的应用提供实验和理论依据。

（二）、利用纳米脂质体技术构建新型的β-榄香烯-纳米脂质体药物传递系统，初步探讨其体外抗瘤活性。

II碱基切除修复抑制剂甲氧胺联合β-榄香烯治疗恶性脑胶质瘤的实验研究中文摘要胶质瘤是成人神经系统最常见的原发性肿瘤，手术全切除率很低，复发率高，当前多种治疗效果仍不理想。

榄香烯属国家二类非细胞毒性抗肿瘤新药，临床研究发现其对多种肿瘤疗效确切，而且还具有提高和改善机体免疫功能，与放化疗协同作用等独特效果。

但是肿瘤细胞具有强大的DNA损伤修复机制，会对化疗药物产生抗性。

因此抑制这种内在的DNA修复过程，如碱基切除修复抑制剂甲氧胺的联合应用有利于提高化疗药物的抗瘤效果。

DOI：10.16658/ki.1672-4062.2024.01.174硫辛酸注射液联合胰激肽原酶肠溶片对DPN的临床疗效及生存质量的影响王莉，朱海峰濉溪县中医医院内分泌科，安徽淮北235100[摘要]目的探讨硫辛酸注射液联合胰激肽原酶肠溶片对2型糖尿病周围神经病变（Diabetic Peripheral Neu⁃ropathy， DPN）患者的临床疗效、生存质量及安全性的影响。

方法选取2021年2月—2022年4月濉溪县中医医院60名DPN患者作为研究对象。

通过随机数表法分为两组，每组30例。

对照组采用常规治疗，观察组在对照组基础上加用硫辛酸注射液和胰激肽原酶肠溶片治疗。

比较两组患者的神经病变评分、神经电生理指标、生存质量评分、安全性指标和不良反应发生率。

结果治疗后，观察组神经病变评分（6.2±0.9）分低于对照组（7.6±1.1）分，差异有统计学意义（t=5.438，P<0.05）；观察组神经电生理指标、生存质量评分、安全性指标均优于对照组，差异有统计学意义（P均<0.05）；两组患者不良反应发生率比较，差异无统计学意义（P>0.05）。

结论硫辛酸注射液联合胰激肽原酶肠溶片对DPN患者有良好的临床疗效，能够改善神经功能、改善神经电生理指标、提高生存质量，且安全性高。

[关键词] 硫辛酸注射液；胰激肽原酶肠溶片；2型糖尿病周围神经病变；临床疗效[中图分类号] R587.2 [文献标识码] A [文章编号] 1672-4062（2024）01（a）-0174-05Effect of Lipoic Acid Injection Combined with Pancreatic Kininogenase Enteric-coated Tablets on Clinical Efficacy and Quality of Survival in DPN WANG Li, ZHU HaifengDepartment of Endocrinology, Suixi County Hospital of Traditional Chinese Medicine, Huaibei, Anhui Province, 235100 China[Abstract] Objective To investigate the effects of lipoic acid injection combined with pancreatic kininogenase enteric-coated tablets on the clinical efficacy, quality of survival and safety of patients with type 2 diabetic peripheral neuropathy (DPN). Methods 60 DPN patients admitted to Suixi County Hospital of Traditional Chinese Medicine from February 2021 to April 2022 were selected as the study objects. They were divided into two groups with 30 cases in each group by random number table method. The control group received conventional treatment, and the observation group was treated with lipoic acid injection and pancreatic kininogenase enteric-coated tablets on the basis of control group. Neuropathy score, neuroelectrophysiological index, quality of life score, safety index and incidence of adverse reactions were compared between the two groups. Results After treatment, the neuropathy score of observation group (6.2±0.9) points was lower than that of control group (7.6±1.1) points, and the difference was statistically significant (t= 5.438, P<0.05). Neuroelectrophysiological indexes, quality of survival scores and safety indexes of the observation group were better than those of the control group, and the differences were statistically significant (all P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Li⁃[作者简介]王莉（1982-），女，本科，主治医生，研究方向为糖尿病周围神经病变。

食品研究与开发F ood Research And DevelopmentDOI ：10.3969/j.issn.1005-6521.2019.05.009决明子山药黄豆复配对高脂血症大鼠血脂代谢的影响雷艳1，胡吉蕾1，刘青青1，胡刚2，谢惠波1，*（1.西南医科大学公共卫生学院，四川泸州646000；2.泸州市古蔺金芒面条加工责任有限公司，四川泸州646000）摘要：研究决明子山药黄豆复配对SD 大鼠高脂血症血脂代谢和肝脏脂肪变性的影响。

采用高脂饲料喂养4周建立大鼠高脂血症模型后随机分组，阳性对照组采用阿托伐他汀灌胃给药，实验组采用决明子山药黄豆复配掺入高脂饲料喂养，观察决明子山药黄豆复配对其血脂和肝脏脂肪变性的影响。

与空白对照组比较，模型组血清总胆固醇（total cholesterol ，TC ）、甘油三酯（triglyceride ，TG ）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol ，HDL-C ）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol ，LDL-C ）水平显著升高（P <0.05）；与模型组比较，中剂量决明子山药黄豆复配组血清TC 、TG 水平显著降低（P <0.05），低、中、高剂量决明子山药黄豆复配组血清中LDL-C 水平显著降低（P <0.05），但各剂量组之间无明显差异。

决明子山药黄豆复配可降低实验大鼠高脂饮食引起的高脂血症，以中剂量效果最为显著，无明显剂量效应关系。

关键词：决明子；山药；复配；高脂血症；血脂代谢Effects of Semen Cassia Yam Soybean on Blood Lipid Metabolism in Hyperlipidemic Rats LEI Yan 1，HU Ji-lei 1，LIU Qing-qing 1，HU Gang 2，XIE Hui-bo 1，*（1.College of Public Health ，Southwest Medical University ，Luzhou 646000，Sichuan ，China ；2.Luzhou Gulin Jinmao Noodle Processing Co.，LTD.，Luzhou 646000，Sichuan ，China ）Abstract ：To study the effects of semen cassia yam soybean on hyperlipemia and liver fatty degeneration in rats.Rats were fed with high fat diet for four weeks to establish hyperlipemia model ，then the rats were randomly divided into different groups ，and the rats of positive control group were gavaged with atorvastatin and the rats of experimental groups were fed with semen cassia yam soybean of high fat diet.The effects of semen cassia yam soybean on hyperlipemia and liver fatty degeneration was observed in pared with blank control group ，serum TC (total cholesterol)，TG (triglyceride)，HDL-C (high density lipoprotein cholesterol )and LDL-C(lowdensity lipoprotein cholesterol)of model group significantly increased （P <0.05）.Compared with model group ，serum TC and TG of middle dose group were significantly reduced （P <0.05）.Serum LDL-C of different doses of semen cassiae yam soybean was significantly reduced （P <0.05），but no difference of different doses.Semen cassia yam soybean compound can decrease blood lipid of the hyperlipidemia rats with high-fat diet.The most significant effect is middle-dose and no obvious dose effect relationship in different doses.Key words ：semen cassia ；yam ；noodle ；hyperlipemia ：blood lipid metabolism引文格式：雷艳，胡吉蕾，刘青青，等.决明子山药黄豆复配对高脂血症大鼠血脂代谢的影响[J].食品研究与开发，2019，40（5）：48-53LEI Yan ，HU Jilei ，LIU Qingqing ，et al.Effects of Semen Cassia Yam Soybean on Blood Lipid Metabolism in Hyperlipidemic Rats[J].Food Research and Development ，2019，40（5）：48-53基金项目：西南医科大学与泸州市古蔺县科技局横向合作项目（0903-********）；泸州市创新苗子项目（2017-R-66）作者简介：雷艳（1993—），女（汉），硕士研究生在读，研究方向：食品开发与功能性评价。

DOI：10.16658/ki.1672-4062.2023.18.113地特胰岛素联合门冬胰岛素治疗妊娠期糖尿病疗效与安全性及对母婴结局的影响研究王霞平遥县人民医院产科，山西晋中031100[摘要]目的探讨妊娠期糖尿病（gestational diabetes mellitus, GDM）产妇应用地特胰岛素联合门冬胰岛素治疗的效果。

方法选取2021年7月—2022年9月期间在平遥县人民医院进行分娩的GDM产妇66例为研究对象，按隐匿数字随机法分为单药组（33例，门冬胰岛素治疗），联合组（33例，门冬胰岛素+地特胰岛素治疗），观察记录两组血糖变化、胰岛素水平、母婴结局，进行比较分析。

结果治疗前，两组患者血糖控制水平比较，差异无统计学意义（P>0.05）；治疗后，联合组的空腹血糖（fasting plasma glucose, FPG）、餐后2 h血糖（2-hourpostprandial blood glucose，2 hPG）、糖化血红蛋白（glycated hemoglobin, HbA1c）水平均低于单药组，差异有统计学意义（P<0.05）；联合组的FPG达标、2 hFPG达标、FPG和2 hFPG均达标的时间均显著短于单药组，差异有统计学意义（P<0.05）；联合组的自然分娩率为72.73%显著高于单药组的48.48%，差异有统计学意义（P< 0.05）；单药组的不良妊娠结局发生率（24.24%）高于联合组（9.09%），差异无统计学意义（P>0.05）。

结论地特胰岛素联合门冬胰岛素治疗GDM患者，可以获得较为理想的血糖控制效果，能更快的使患者血糖达到理想的标准，自然分娩率更高。

[关键词] 妊娠期糖尿病；地特胰岛素；门冬胰岛素；母婴结局[中图分类号] R714 [文献标识码] A [文章编号] 1672-4062（2023）09（b）-0113-04Study on the Efficacy and Safety of Insulin Detemir Combined with Insu⁃lin Aspart in the Treatment of Gestational Diabetes and Its Impact on Ma⁃ternal and Fetal OutcomesWANG XiaDepartment of Obstetrics, Pingyao County People's Hospital, Jinzhong, Shanxi Province, 031100 China[Abstract] Objective To explore the effect of insulin detemir combined with insulin aspart in the treatment of gesta‐tional diabetes mellitus (GDM). Methods 66 GDM women who gave birth in Pingyao County People's Hospital from July 2021 to September 2022 were selected as research objects. According to the concealed number random method, 33 patients were divided into a single-drug group (treated with insulin aspart) and 33 patients were combination group (treated with insulin aspart+insulin detemir). Observed and recorded the data on blood sugar changes, insulin levels, and maternal and infant outcomes between the two groups for comparative analysis. Results Before treatment, there was no statistically significant difference in blood glucose control levels between the two groups (P>0.05). After treat‐ment, the levels of fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2 hPG), and glycated hemoglobin (HbA1c) in the combination group were lower than those in the single-drug group, the difference was statistically sig‐nificant (P<0.05). The time for FPG to reach the target, 2 hPG to reach the target, and both FPG and 2 hPG to reach the target in the combination group were significantly shorter than those in the single-drug group, the difference were statistically significant (P<0.05). The natural delivery rate in the combination group was 72.73%, which was signifi‐cantly higher than the 48.48% in the single-drug group, the difference was statistically significant (P<0.05). The inci‐dence rate of adverse pregnancy outcomes in the single-drug group (24.24%) was higher than that in the combination group (9.09%), and the difference was statistically significant (P>0.05). Conclusion Insulin detemir combined with in‐sulin aspart can achieve ideal blood sugar control effects in patients with GDM, and can bring patients' blood sugar to the ideal standard faster, and the natural delivery rate is higher.[作者简介]王霞（1979-），女，本科，副主任医师，研究方向为产科及相关疾病诊治。

目 次2023 年 7 月 第 9 卷 第 7 期中西医结合脑病护理专栏爱脑护脑，中西医结合护理促健康——“中西医结合脑病护理”专栏第二期导读…………………………………………………………………廖若夷（1）基于“一气周流”理论刮痧干预高血压缺血性脑卒中的疗效观察………刘彬，余艳兰，高子琪，奉水华，杨楠，郭元，廖若夷（2）脐灸联合间歇性导尿在中风后神经源性膀胱患者康复护理中的应用………………………………………邹秋玉，罗红，余艳兰，许静（8）穴位贴敷治疗脑卒中后吞咽障碍的Meta 分析…………………佀惠婕，廖若夷，余艳兰，高子琪，刘彬，郭元（13）基于CiteSpace 的脑卒中后睡眠障碍中医护理研究可视化分析…………………高子琪，廖若夷，余艳兰，佀惠婕，刘彬，郭元（23）经穴推拿联合脐灸治疗1例气虚便秘患者的中医护理体会…………………………………………………葛思楠，王雪送，余艳兰（30）子午流注择时气交灸联合五行音乐治疗1例出血性中风气虚血瘀型患者泄泻的护理体会…………………雷啸阳，陈青，许时来，张占伟，张茜，邓海霞（34）耳穴压豆联合手指点穴干预1例心肾不交型失眠患者的护理体会……………………………………………………………张慧，周运波（38）1 例神经源性膀胱患者的中西医结合护理体会…………………………………………………郑莹芊，许静，邹秋玉（41）1例中风后遗症期痰热瘀结证反复发热患者的中医外治护理体会…………………………………………………罗焕文，周运波，刘才丹（45）1例急性脑梗死并发下消化道出血患者的护理体会……………………………………………………………陈海香，吴敏（49）心理辅导护理联合中医特色疗法治疗丛集性头痛1例的护理体会………………………………………刘才丹，余艳兰，周运波，罗焕文（54）中风重症患者中西医早期康复及影响因素研究进展……………………………………………………………罗红，余艳兰（58）中医护理技术在脑卒中后便秘中的应用进展……………………………张茜，陈偶英，许时来，张占伟，雷啸阳（65）脑卒中后认知障碍的中医特色护理研究进展………………………………………李文雅，肖纯，黄璐，彭晓玲（71）我国中医脑病专科护士培养构思与展望………………………………………梁星星，李欢，邓茜，黄璐（78）中西医结合老年慢病护理及管理专栏聚焦中西医多元融合，构建老年慢病管理创新模式——“中西医结合老年慢病护理及管理”专栏第二期导读………………………………………………………………………杨梅（82）ZHONGXIYI JIEHE HULI主管北京市中医管理局主办中华中西医结合护理学会北京市中医护理能力提升工程办公室编辑《中西医结合护理》编辑部主编 唐 玲主任 黄 磊编辑 尹佳杰 吴银平编辑助理 鄂海燕美术编辑 王 丽地址 南京市龙蟠路155号 联合立方广场3⁃203邮编 210037电话 ************邮箱 bjb@出版中西医结合护理杂志社社长 叶振华电话 ************网刊http ：//邮箱 tg@学术传播结合护理（南京）有限公司本刊刊出所有文章不代表编委会以及编辑部的观点ZHONGXIYI JIEHE HULI2023 年 7 月第 9 卷第 7 期新形势下老年慢病管理发展趋势的思考…………………………………………………………………………………………………………杨梅（84）中药塌渍治疗联合超声药物导入治疗老年糖尿病周围神经病变的效果观察……………………………………………………………………………………张圆林，蔡伟伟，李娜（90）变应性鼻炎患者中西医结合护理效果观察……………………………………………………………………………………索翠红，杨梅，刘云霞（95）认知障碍评估对老年2型糖尿病患者低血糖发生率的影响…………………………………………………………………………………………………………刘云霞（100）高龄患者经外周静脉置入中心静脉导管时送管困难影响因素及对策…………………………………………………………………………………………………………何英（105）中医护理联合持续雾化吸入在老年气管切开患者护理中的应用效果观察…………………………………………………………………………………………………………黄宁（110）中医护理在老年晚期恶性肿瘤患者中的应用效果观察…………………………………………………………………………………………………………姜珊（114）中医特色护理技术联合健康教育对老年肿瘤患者化疗期间胃肠道反应的影响…………………………………………………………………………………………………………李芳（119）集束化护理预防老年失禁相关性皮炎效果观察……………………………………………………………………………………刘玉辉，张亚萍，郑志兰（123）163例肝病患者抑郁状况调查及护理干预效果分析…………………………………………………………………………望运丹，王伟仙，胡德英，刘义兰（126）中药超声药物透入治疗1例不完全性肠梗阻的护理体会…………………………………………………………………………………………………………刘旭（133）1例尿毒症继发甲状旁腺功能亢进行甲状旁腺全切联合自体前臂移植术的围手术期护理体会…………………………………………………………………………………………………………谢继红（137）1例慢性肾衰竭患者连续性肾脏替代治疗及护理体会………………………………………………………………………………………………许娟，王亚茹（141）耳穴压豆治疗戒烟后失眠1例护理体会…………………………………………曹蕾，孔晓春，刘洋，杨婷，张丽君，鄂海燕，唐玲（144）耳穴压丸治疗1例糖尿病合并肺炎患者的护理体会…………………………………………………………………………………………………………韩精华（147）发热患者分诊系统在新型冠状病毒肺炎急诊预检分诊中的应用效果…………………………………………………………………………………………………………陈曦（150）老年腹腔镜结肠癌术中低体温的影响因素及护理措施研究进展…………………………………………………………………………………………………………朱月华（154）中医穴位贴敷疗法在成人便秘中的应用研究进展……………………………………………………王晓敏，郑乃花，杨冬梅，鄂海燕，张丽君，刘晓柳（158）老年脑卒中患者跌倒原因分析与护理对策研究进展………………………………………………………………………………………………马翠卿，杨梅（164）论著脊柱外科术后患者疼痛管理的证据总结………………………………………向婷婷，郑苏，谢晓敏（170）ZHONGXIYI JIEHE HULI2023 年 7 月第 9 卷第 7 期妊娠期糖尿病产妇出院准备度现状及影响因素研究……………………………………………………………………………………段美美，孙贵豫，黎媛媛（176）肺癌患者化疗期间饮食困扰的质性研究………………………………………………………………………………………………张月瑜，尹媛媛（182）中医特色护理砭石熨摩疗法缓解1例腰椎管狭窄术后患者腹胀的护理体会…………………………………………………………………………………………………………张旭（188）1例肝肿物微创术后并发流注的护理体会…………………………………………………………………………………………………………冯瑞萍（191）技术与方法1例双上腔静脉患者Sherlock 3CG尖端定位下经外周静脉穿刺中心静脉置管及护理对策………………………………………………………………宋兰娜，王媛，王文萱，王钰，张娜（195）1例持续性房颤伴急性左心衰患者腔内心电图定位下PICC置管的护理………………………………………………………………………………………………廖丽红，施丽华（201）俯卧位通气技术在ICU的应用及护理…………………………………………………………………………代洪然，王华枝，李玉华，马海红（205）全科护理经鼻肠管营养支持联合快速康复外科理念对重症颅脑损伤患者营养状况、并发症及术后恢复的影响…………………………………………………………………………………………………………卢卉欣（209）盆底肌锻炼联合水疗促进直肠癌患者保肛术后康复效果研究………………………………………………………………………………………………黄丽明，吴丽芳（215）护理管理科室设立总护士岗位在新入职护士值班管理中的应用…………………………………………………………………………贺丹丹，朱恒美，杨露，倪媛（219）危机管理在儿童口腔门诊投诉管理中的应用……………………………………………………………………………………周莉娜，罗莎，王雁（224）案例分享1例甲型H1N1流感病毒合并高黏液型肺炎克雷伯菌感染患者俯卧位通气的护理体会………………………………………………………………魏娴，王慧萍，刘璐，李祯，张智舒（229）依奇珠单抗联合血液灌流治疗重度银屑病1例疗效观察……………………………………………………………………………………李静，沈霞，李红仙（234）1例急性心肌梗死后并发室性心律失常电风暴患者的急救护理…………………………………………………………………………………………………………汪碧云（237）综述多发性骨髓瘤并发周围神经病变患者的护理研究进展………………………………………………………………李丽霞，班锦青，梁静林，农珍诊，韦玲（241）Volume 9 Number 7 July 2023Fostering brain health with integrated traditional Chinese and western medi⁃cine nursing ……………………………………………LIAO Ruoyi （1）Effect of scraping on hypertensive ischemic stroke based on " Qi Circula⁃tion" theory ……………………LIU Bin ， YU Yanlan ， GAO Ziqi ， FENG Shuihua ， YANG Nan ， GUO Yuan ， LIAORuoyi （2）Application of umbilical moxibustion combined with intermittent catheter⁃ization in rehabilitation nursing of patients with neurogenic bladder af⁃ter stroke …………ZOU Qiuyu ， LUO Hong ， YU Yanlan ， XU Jing （8）A Meta -analysis of acupoint application in the treatment of dysphagia after stroke ……………………………………SI Huijie ， LIAO Ruoyi ， YU Yanlan ， GAO Ziqi ， LIU Bin ， GUO Yuan （13）Visual analysis of traditional Chinese medicine nursing research on post -stroke sleep disorders based on CiteSpace …………………………………GAO Ziqi ， LIAO Ruoyi ， YU Yanlan ， SI Huijie ， LIU Bin ， GUO Yuan （23）Traditional Chinese medicine nursing of a patient with Qi -deficiency type constipation treated by meridian acupoints massage combined with um⁃bilical moxibustion ……GE Sinan ， WANG Xuesong ， YU Yanlan （30）Qijiao moxibustion based on midnight -noon ebb -flow combined with five -element music therapy and nursing management of diarrhea in a patient with hemorrhagic stroke of Qi -deficiency and blood stasis syndrome …………LEI Xiaoyang ， CHEN Qing ， XU Shilai ， ZHANG Zhanwei ， ZHANG Qian ， DENG Haixia （34）Nursing of a patient with insomnia of heart -kidney disharmony treated by auricular acupoint pressing and acupoint finger -pressing therapy ………………………………………ZHANG Hui ， ZHOU Yunbo （38）Nursing of integrated traditional Chinese and western medicine for a patient with neurogenic bladder ………………………ZHENG Yingqian ， XU Jing ， ZOU Qiuyu （41）Traditional Chinese Medicine external treatment and nursing for a patient with recurrent fever in the sequelae of stroke with phlegm -heat stasis syndrome …………LUO Huanwen ， ZHOU Yunbo ， LIU Caidan （45）Nursing of a patient with acute cerebral infarction combined with lower gas⁃trointestinal tract bleeding ……………CHEN Haixiang ， WU Min （49）Psychological counseling and nursing interventions with Traditional Chi⁃nese Medicine characteristics for a patient with cluster headache………LIU Caidan ， YU Yanlan ， ZHOU Yunbo ， LUO Huanwen （54）Research progress of Traditional Chinese and Western medicine early reha⁃bilitation and its influencing factors in severe stroke patients…………………………………………LUO Hong ， YU Yanlan （58）Contents Responsible InstitutionBeijing Administration of Tradi⁃tional Chinese Medicine SponsorAssociation o f I ntegrative N ursingBeijing Traditional Chinese Med⁃icine Nursing Competence Im⁃provement Project OfficeEiditingEditorial Board of Chinese Jour⁃nal of Integrative Nursing Editor-in-ChiefTANG Ling DirectorHUANG Lei EditorsYIN Jiajie WU Yinping Editorial Assistant E Haiyan Art Editor WANG Li Address NO.155， Longpan Road ，Nanjing ， China Post Code 210037Tel + 86 - 25 - 85552880E⁃mail ： bjb@PublisherIntegrative Nursing Press Founder and CEO YE Zhenhua Tel + 86 - 25 - 85630967Online Publishinghttp ： / / E⁃mail ： tg@Academic DisseminationIntegrative Nursing （Nanjing ）Co.，LtdVolume 9Number 7July 2023Application progress of Traditional Chinese Medicine nursing technology in constipation after stroke ……………………………ZHANG Xi， CHEN Ouying， XU Shilai， ZHANG Zhanwei， LEI Xiaoyang （65）Progress of research on Traditional Chinese Medicine characteristic nursing of patients with cognitive impair⁃ment after stroke………………………………LI Wenya， XIAO Chun， HUANG Lu， PENG Xiaoling （71）Conception and prospect of talent training of Traditional Chinese Medicine encephalopathy nurse specialists …………………………………………………LIANG Xingxing， LI Huan， DENG Qian， HUANG Lu （78）Focusing on the integrated traditional Chinese and western medicine and building an innovative management model for chronic diseases in the elderly……………………………………………………YANG Mei （82）On the thinking of development trend of chronic disease management in the elderly……………YANG Mei （84）Effect of Traditional Chinese Medicine collapse stains combined with ultrasound drug penetration therapy in the treatment of diabetic peripheral neuropathy in the elderly………ZHANG Yuanlin， CAI Weiwei， LI Na （90）Effect of integrated traditional Chinese and western medicine in nursing of patients with allergic rhinitis …………………………………………………………………SUO Cuihong， YANG Mei， LIU Yunxia （95）Effect of cognitive impairment assessment on the incidence of hypoglycemia in hospitalized elderly patients with type 2 diabetes mellitus……………………………………………………………………LIU Yunxia （100）Influential factors and countermeasures of the difficulty in inserting peripheral inserted central venous catheter among elderly patients…………………………………………………………………………HE Ying （105）Effect of Traditional Chinese Medicine nursing combined with continuous nebulization in nursing of elderly pa⁃tients undergoing tracheostomy…………………………………………………………HUANG Ning （110）Application of Traditional Chinese Medicine nursing technology for elderly patients with advanced cancer ……………………………………………………………………………………………JIANG Shan （114）Effect of Traditional Chinese Medicine characteristic nursing technology combined with health education on gas⁃trointestinal adverse reactions during chemotherapy in elderly patients with cancer…………LI Fang （119）Effect of care bundles on the prevention of incontinence-associated dermatitis in the elderly…………………………………………………………LIU Yuhui， ZHANG Yaping， ZHENG Zhilan （123）Analysis of depression status and nursing interventions in 163 patients with liver disease……………………………………………WANG Yundan， WANG Weixian， HU Deying， LIU Yilan （126）Nursing of a patient with incomplete intestinal obstruction treated by the ultrasound-enhanced penetration of Tra⁃ditional Chinese Medicine………………………………………………………………………LIU Xu （133）Perioperative nursing of a patient undergoing total parathyroidectomy with subcutaneous autotransplantation for secondary hyperparathyroidism……………………………………………………………XIE Jihong （137）Nursing of a patient undergoing continuous renal replacement therapy for chronic renal failure …………………………………………………………………………………XU Juan， WANG Yaru （141）Auricular acupoint pressing therapy and nursing of a patient with insomnia after quitting smoking ……………………CAO Lei， KONG Xiaochun， LIU Yang， ZHANG Lijun， E Haiyan， TANG Ling （144）Auricular acupoint pressing and nursing of a patient with pneumonia and diabetes mellitus…HAN Jinghua （147）Application of fever triage system in emergency pre-examination and triage of COVID-19 patients ………………………………………………………………………………………………CHEN Xi （150）Influencing factors and nursing countermeasures of hypothermia in elder patients undergoing laparoscopic resec⁃tion of colon cancer………………………………………………………………………ZHU Yuehua （154）Review on the application of acupoint sticking therapy for constipation in adult patients………WANG Xiaomin， ZHENG Naihua， YANG Dongmei， E Haiyan， ZHANG Lijun， LIU Xiaoliu （158）Research progress on causes and nursing countermeasures of falls in elderly stroke patientsVolume 9Number 7July 2023………………………………………………………………………………MA Cuiqing， YANG Mei （164）An Evidence summary of postoperative pain management in spinal surgery…………………………………………………………XIANG Tingting， ZHENG Su， XIE Xiaomin （170）Discharge readiness and its influencing factors among pregnant women with gestational diabetes mellitus ……………………………………………………………DUAN Meimei， SUN Guiyu， LI Yuanyuan （176）A qualitative study on dietary distress of lung cancer patients during chemotherapy…………………………………………………………………………ZHANG Yueyu， YIN Yuanyuan （182）Application of stone needle ironing therapy in a patient with abdominal distension after surgery for lumbar spinal stenosis……………………………………………………………………………………ZHANG Xu （188）Nursing of a patient with deep muscle abscess after minimally invasive surgery for hepatic masses …………………………………………………………………………………………FENG Ruiping （191）Sherlock 3CGtip confirmation system for placement of peripherally inserted central catheters and related nursing countermeasures in a patient with double superior vena cava……………………………SONG Lanna， WANG Yuan， WANG Wenxuan， WANG Yu， ZHANG Na （195）Intracavitary electrocardiography for peripherally inserted central catheters tip location and nursing for a patient with persistent atrial fibrillation and acute left heart failure…………………LIAO Lihong， SHI Lihua （201）Application and nursing of prone ventilation technique in ICU………………………………………………DAI Hongran， WANG Huazhi， LI Yuhua， MA Haihong （205）Influence of enteral nutrition support via nasointestinal tube combined with fast-truck surgery on nutritional sta⁃tus， complications and postoperative rehabilitation of patients with severe head injury……LU Huixin （209）Effect of pelvic floor muscle training combined with hydrotherapy on postoperative rehabilitation of patients un⁃dergoing for sphincter preservation rectal cancer………………………HUANG Liming， WU Lifang （215）Establishment of chief nurse position in training and duty management of newly recruited nurses ……………………………………………………HE Dandan， ZHU Hengmei， YANG Lu， NI Yuan （219）Application of crisis management in patient complaint management in the pediatric dentistry clinic ……………………………………………………………………ZHOU Lina， LUO Sha， WANG Yan （224）Prone position ventilation and nursing management for a patient with influenza A （H1N1）virus infection com⁃bined with hypermucoviscous Klebsiella pneumoniae infection………………………………………WEI Xian， WANG Huiping， LIU Lu， LI Zhen， ZHANG Zhishu （229）Therapeutic effect of Ixekizumab combined with hemoperfusion in a patient with severe psoriasis ………………………………………………………………………LI Jing， SHEN Xia， LI Hongxian （234）Emergency care of a patient with ventricular arrhythmiastorms following acute myocardial infarction ……………………………………………………………………………………………WANG Biyun （237）Research progress in nursing of multiple myeloma complicated by peripheral neuropathy………………………………LI Lixia， BAN Jinchun， LIANG Jinglin， NONG Zhenzhen， WEI Ling （241）。

川芎嗪注射液联合依达拉奉治疗颅内动脉瘤术后脑血管痉挛的效果陈立波朱迪梁旭光内蒙古赤峰市医院神经外二科，内蒙古赤峰024000［摘要］目的探讨川芎嗪注射液联合依达拉奉治疗颅内动脉瘤术后脑血管痉挛的临床效果。

方法选取2017年1月一2019年12月内蒙古赤峰市医院收治的100例颅内动脉瘤术后脑血管痉挛患者，将其按照随机数字表法分为对照组和研究组,每组各50例。

对照组予以依达拉奉治疗，研究组在对照组的基础上联合川芎嗪注射液治疗。

比较两组疗效、神经功能、大脑中动脉血流速度(VMCA)、血清相关指标及不良反应。

结果研究组治疗4周后的临床总有效率高于对照组(P<0.05)遥两组治疗4周后美国国立卫生研究院卒中量表(NIHSS)评分、血浆白细胞介素-6(IL-6)、肿瘤坏死因子-o^TNF-a)、内皮素-1(ET-1)水平较治疗前降低,且研究组低于对照组(P<0.05)遥两组治疗4周后一氧化氮(NO)、VMCA高于治疗前,且研究组高于对照组(P<0.05)遥两组不良反应总发生率比较，差异无统计学意义(P>0.05)。

结论依达拉奉联合川芎嗪注射液治疗颅内动脉瘤术后脑血管痉挛,效果显著,可促进机体神经功能改善,恢复血流速度,且安全可靠，可能与改善机体IL-6'TNF-a、ET-1和NO水平有关遥［关键词］川芎嗪注射液;依达拉奉;颅内动脉瘤术;脑血管痉挛；疗效［中图分类号］R743.3［文献标识码］A［文章编号］1673-7210(2020)12(b)-0080-04Effect of Ligustrazine Injection combined with Edaravone in the treat­ment of cerebral vasospasm after intracranial aneurysm surgeryCHEN Libo ZHU Di LIANG XuguangThe Second DeparLmenL of Neurology,Chifeng Municipal HospiLal,Inner Mongolia Autonomous Region,Chifeng 024000,China[Abstract]Objective To invesLigaLe Lhe clinical effecL of LigusLrazine InjecLion combined wiLh Edaravone in Lhe LreaL­menL of cerebral vasospasm afLer inLracranial aneurysm surgery.Methods A LoLal of100paLienLs wiLh cerebral va­sospasm afLer inLracranial aneurysm surgery were selecLed from Chifeng Municipal HospiLal,Inner Mongolia Au-Lonomous Region from January2017Lo December2019.They were divided inLo conLrol group and sLudy group accord­ing Lo Lhe random number Lable meLhod,wiLh50cases in each group.The conLrol group was LreaLed wiLh Edaravone and Lhe sLudy group was LreaLed wiLh LigusLrazine InjecLion on Lhe basis of Lhe conLrol group.The efficacy,nervous funcLion,middle cerebral arLery blood flow velociLy(VMCA),serum relaLed indexes and adverse reacLions were com­pared beLween Lhe Lwo groups.Results AfLer four weeks of LreaLmenL,Lhe clinical LoLal effecLive raLe of Lhe sLudy group was higher Lhan LhaL of Lhe conLrol group(P<0.05).AfLer four weeks of LreaLmenL,Lhe score of naLional InsLiLuLes of healLh sLroke scale(NIHSS),Lhe levels of inLerleukin-6(IL-6),Lumor necrosis facLor-琢(TNF-琢),endoLhelin-1(ET-1) in Lhe Lwo groups were lower Lhan Lhose before LreaLmenL,and Lhe sLudy group was lower Lhan Lhe conLrol group(P<0.05).AfLer four weeks of LreaLmenL,Lhe levels of niLric oxide(NO)and VMCA in Lhe Lwo groups were higher Lhan Lhosebefore LreaLmenL(P<0.05),and Lhe sLudy group was higher Lhan LhaL in Lhe conLrol group(P<0.05).There was no significanL difference in Lhe LoLal incidence of adverse reacLions beLween Lhe Lwo groups(P>0.05).Conclusion Ligus-Lrazine InjecLion combined wiLh Edaravone is effecLive in ［基金项目］内蒙古自治区自然科学基金项目(2016MS02 35)遥［作者简介］陈立波(1983.7-),男，硕士,副主任医师;研究方向:脑血管病。

中外医疗 CH IN A F OR EI G N ME DI C AL T R EA TM EN T 论 著脑梗死是由于各种原因所致脑血液供应障碍引起缺血、缺氧性坏死,导致的局限性脑组织缺血性坏死或脑软化,其中急性脑梗死具有发病率高、致残率高和死亡率高的特点,占所有脑卒中的60%～80%,其年复发率高达5.19%[1]。

急性脑梗死通常是由各种原因导致的血管内皮损伤,动脉粥样斑块形成、破裂诱发血小板聚集而引起[2]。

因此,抗血小板治疗是急性脑梗死治疗的主要措施之一[3]。

我们对2008年6月至2010年4月我院收治的急性脑梗死患者采用阿司匹林、川芎嗪二联治疗,并对联合用药的临床疗效和安全性作一简单评估。

1 资料与方法1.1 一般资料急性脑梗死患者88例均为住院患者,男46例,女42例;年龄44～79岁,平均(58.67±13.12)岁。

88例均符合1995年第四届全国脑血管疾病学术会议制定的急性脑血管病分类及诊断要点,均发病1周内就诊,并经头颅CT和(或)MRI明确诊断。

按照临床神经功能缺损程度评定标准分为:轻型50例,中型28例,重型10例。

将患者随机分为观察组与对照组,每组各44例。

2组患者性别、年龄、发病时间、治疗前并发症积分、梗死面积及部位、病情和神经功能缺损评分均具可比性。

排除标准:(1)有严重肝肾功能不全的临床证据;(2)近期有活动性消化道溃疡、全身出血史;(3)有血液系统疾病和出凝血功能障碍者;(4)有阿司匹林治疗禁忌证者。

1.2 治疗方法2组患者入院后均给予内科常规治疗,对照组用6%低分子右旋糖酐500mL静脉滴注,1次/d,另予肠溶阿司匹林(吉林省银河制药厂,批号:20020901)75mg口服,1次/d。

观察组在此治疗基础上加用川芎嗪注射液(石家庄以岭药业股份有限公司,批号:030325)4mg/kg 加入生理盐水或5%葡萄糖注射液250mL中静脉滴注,1次/d;2组疗程均为14d。

马缨丹提取物对黄胸散白蚁体内酶活性的影响孙骊珠;罗兰;袁忠林【摘要】[Objective] In order to explore the action mechanisms,the effects of 3 different solvent extracts from Lantana camara (Verbenaceae) leaves on cellulose and detoxification enzyme in the termite Reticulitermes flaviceps (Isoptera: Rhinotermitidae) were studied.[Method] Termites were fed with filter paper saturated with 3 different solvent extracts of L.camara leaves for different times,and then we measured the enzymes activities of endo-β-1,4-glycanase (EG),exo-β-1,4-gluc anase (CBH),β-1,4-glucosidase (BG),carboxylesterase (CarE),glutathione-S-transferase (GSTs) and mixed-functional oxidase (MFO).[Result] The all extracts had to some degree inhibiting effects on the six enzymes activities,however there were differences in the inhibition with extracts of chloroform,ethyl acetate and petroleum ether at 6-72 h.As for the three cellulose enzymes,the chloroform extract had no significant effect on EG,but had significantly inhibiting effect on CBH and BG,especially on CBH with the highest inhibition rate of 17.61% at 72 h.The ethyl acetate extract also had inhibiting effect on the 3 enzymes activities,with relatively stronger inhibition on EG and BG,and the inhibition rate on EG was 27.18% at 48 h,and 29.28% at 24 h,respectively.The petroleum ether extract had no significant effect on CBH,but had strongly inhibited on EG and BG,with the highest inhibition rate of 39.89% on EG at 72 h.As for the three detoxification enzymes,the 3 extracts had no significant effect on CarE,buthad inhibiting effect on GSTs,which mainly occurred at 12-48 h.The ethyl acetate extract had the strongest inhibition,with the highest inhibition rate of 39.54% at 36 h.The MFO activities fluctuated after being treated with 3 extracts,and the relatively stronger inhibition on the 3 detoxification enzymes occurred at 12 h and 36 h.[Conclusion] The extracts of chloroform,ethyl acetate and petroleum ether could decrease the cellulose and detoxification enzymes activities,disrupting the normal physiological metabolism.%[目的] 探究马缨丹氯仿提取物、乙酸乙酯和石油醚萃取物对黄胸散白蚁体内纤维素酶系及解毒酶系活性的影响,初步探讨其作用机制.[方法] 采用滤纸片带毒饲喂,测定处理不同时间点其对黄胸散白蚁体内3种纤维素酶[内切-β-1,4-葡萄糖酶(EG)、外切-β-1,4-葡萄糖酶(CBH)、β-葡萄糖苷酶(BG)]和3种解毒酶[羧酸酯酶(CarE)、谷胱甘肽S-转移酶(GSTs)、多功能氧化酶(MFO)]酶活性的影响.[结果] 马缨丹氯仿提取物、乙酸乙酯和石油醚萃取物在6~72 h对黄胸散白蚁体内6种酶活性的影响存在差异,主要表现为有一定的抑制作用.对3种纤维素酶活性的影响而言,氯仿提取物对EG酶活性无显著影响,但对CBH和BG酶有显著的抑制作用,尤其对CBH酶抑制作用较强,在72 h时抑制率最大,达17.61%;乙酸乙酯萃取物对3种酶均有抑制作用,对EG和BG酶活性抑制作用较强,在48 h时对EG的抑制率最大,为27.18%,在24 h时对BG酶活性抑制作用最大,为29.28%;石油醚萃取物对CBH酶活性无显著影响,但对其他2种酶抑制作用显著,对EG酶的抑制作用较强,在72 h时对此酶的抑制作用最大,为39.89%.对3种解毒酶活性影响而言,3种提取物对CarE酶的活性影响不大;对GSTs酶的影响主要在12~48 h,其中乙酸乙酯萃取物的抑制作用最强,36 h时抑制率最大,为39.54%;对FMO酶的抑制作用呈波动式变化,其中以12 h、36 h抑制作用较强.[结论] 马缨丹氯仿提取物、乙酸乙酯和石油醚萃取物能抑制黄胸散白蚁体内的纤维素酶和解毒酶,扰乱其正常的生理代谢功能.【期刊名称】《林业科学》【年(卷),期】2017(053)005【总页数】9页(P107-115)【关键词】黄胸散白蚁;马缨丹提取物;纤维素酶;解毒酶;杀虫作用机制【作者】孙骊珠;罗兰;袁忠林【作者单位】青岛农业大学农学与植物保护学院青岛 266109;青岛农业大学农学与植物保护学院青岛 266109;青岛农业大学农学与植物保护学院青岛 266109【正文语种】中文【中图分类】S718.7白蚁是地球上最为古老的社会性昆虫之一，是热带、亚热带重要的经济和生态昆虫，它们能协助分解纤维素使得营养物质得以循环，但它们能损坏建筑物、堤坝、作物和树木等，造成很大的经济损失(Verma et al.， 2009； Quarcoo et al.， 2010)。

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2022年第53卷总目次氮素形态及配比对番茄光合、产量和风味品质的影响····················································焦娟,魏珉,谷端银,等(1)不同配方肥料及用量对金桔产量和品质的影响·················································覃盈盈,邓荫伟,潘磊,等(10)土壤增施硒肥对西瓜产量、品质及养分吸收的影响···············································康利允,李晓慧,高宁宁,等(16)苹果园土壤养分与果实营养品质的多元分析·····························································王胜永,谭雪红(24)基于正交设计的姬松茸母种培养条件优化······························································张琴,成文竞(29)生物炭对连作土壤性质及菊花生长和品质的影响···············································张新俊,杨芳绒,张书文,等(34)不同氮素营养对小麦苗期根系发育及抗旱性的影响····················································卢毅,董放,田田,等(39)半干旱区水钾互作对春玉米氮代谢的影响···············································马襄鸿,曹国军,耿玉辉,等(46)有机农田杂草-主作物共生系统的氮素吸收及土壤肥力特征·····························································郭小鸥,崔晓辉(52)罗伯茨绿僵菌AAU-4对草地贪夜蛾幼虫的毒力及生长发育的影响·················································赵宗祥,王明伟,李蕾,等(60)何俊华双短姬蜂幼期形态记述········闫家河,刘经贤,刘腾腾,等(66)植物源杀虫剂在油桃栽培上的应用研究····················································王鹏,韩娟,王瑞,等(71)山东省黑松枯萎病病原鉴定、致病性及其生长适应性研究·················································吕娟,亓玉昆,季延平,等(77)基于灰数灰度的土壤有机质高光谱估测·················································丁天姿,任文静,李丽,等(85)基于随机森林与多源遥感数据的青海省降水空间分布·····························································侯方国,王化光(91)珠海一号高光谱影像在黄土高原大型煤矿区分类中的应用·················································王宏宇,周伟,官炎俊,等(98) 2个烤烟品种在不同典型产区的生长、产量及品质差异分析··············································刘昆霖,蔡宪杰,刘艳华,等(109)宜宾烟区不同海拔对土壤主要养分分布的影响·················································赵瑜,杨懿德,鄢敏,等(115)两种植物生长调节剂及用量对烟草幼苗根系发育的影响·················································李钊,雷晓,肖雨沁,等(123)掺建筑垃圾的可泵性回填土施工性能试验研究·················································杨伟军,闫宇洁,杨建宇(131)轴向应力作用下再生混凝土碳化性能研究···············································刘燕,刘舒畅,刘杏娟,等(138)基于AutoBANK的丁坞水库坝坡稳定性分析·················································刘永,马飞,张坤强,等(145)地下车库的顶板加固及实例分析·················丁敏宝,毛树果(150)芝加哥降雨过程线模型的改进········孙翀,王春婷,张泽玉,等(157)循环miRNA生物标记物的运动生理研究进展·················································陈淑婷,晁天乐,刘文萍(163)戊糖片球菌HM04发酵对无花果浆主要代谢产物及抗氧化活性的影响·········································李曼,马扶强,韩思睿,等(171)桃糖转运蛋白基因PpTST2的功能初探···············································王宁,孟祥光,文滨滨,等(180)野生藤茶资源的鉴别及指纹图谱评价···············································张朝阳,马世龙,秦邦,等(188)腐植酸对小麦生长发育的调控研究··············································赵晓燕,朱先哲,吴洪燕,等(197)华北平原冬小麦农田蒸散动态变化及其影响因子的通径分析··············································许俊东,张心如,关钧元,等(209)土元壳和卵鞘中甲壳素结构特征与比较分析··············································王晓云,解加卓,孙中涛,等(215)养殖盐度对双齿围沙蚕生长及品质的影响···············································杨帆,苗润泽,张煜皓,等(222)渤海黑牛的屠宰性能与肉质分析···············································高翰,李海鹏,李俊雅,等(228)光照和温度对麦可属生长动力学的影响·················································李俊鹏,潘伟斌,黄晓佳(240)不同园林植物根际土壤微生物群落代谢差异性研究··············································万平平,刘胡楠,张文婕,等(246)基于多尺度注意力残差网络的桃树害虫图像识别··············································类成敏,牟少敏,孙文杰,等(253)基于改进空间残差收缩网络模型的农作物病虫害识别···························································刘晓锋,高丽梅(259)园林植物常见病虫害识别··············································杨庆贺,丛晓燕,秦丽红,等(265)不同类型森林植被群落多样性与土壤养分的关联分析·······································································张栋(271)若尔盖湿地水质演化及其对植被多样性特征的指示作用·····························································孟妍君,秦鹏(278)水利开发对盐湖水质及重金属污染的影响················马涛(285)基于GIS的干旱半干旱地区未利用地空间变化的生态风险测度···························································王晓莹,刘新平(294)山东省典型地区盐碱地分布、治理模式研究及效益分析···············································李申,毕梅祯,王建丽,等(302)基于集对分析的德州市雨洪资源潜力研究·················································刘永,马飞,董小花,等(310)基于有限元的蔬菜大棚通风模拟研究···········王金翔,谢娅娅(314)组合工字钢结构钢梁受力性能试验研究与分析··············································任轶蕾,石鑫朔,任小强,等(320)取代1,2-乙二胺邻甲酰氨基苯甲酰胺化合物的设计、合成及生物活性···········································冯美丽,姚文俊,安晶晶,等(326)居住区规划中的公共空间景观营造——以宸曦家园小区为例·····························································陈泽宇,于斌(334)不同氮肥施用量对草莓生长和氮转运酶的影响·················································付君正,肖蓉,张蕊,等(339)苹果SHR亚家族基因特征及其器官表达谱分析··············································于婷婷,许阿飞,张佳林,等(346)基于GEO数据库分析番茄干旱胁迫关键基因与信号通路·················································杨巍,唐兵,周麟笔,等(355)不同细胞分裂素浓度对生菜穴盘基质育苗质量的影响···············································廖雅汶,成臣,卢占军,等(362)四种农作物秸秆基质化栽培平菇的研究········崔永峰,赵培强(368)连作对寒地双孢蘑菇土壤微生物的影响···················································付静,郑焕春,郭劲鹏(374)不同林分下樟子松根系分泌物对土壤环境及微生物的影响·····························································李军,赵彩平(380)一株高效降解麦秸木质素菌株的筛选及效能评价··············································赵文萱,鞠志刚,郑亚强,等(386)荞麦种子高萌发率虫生真菌菌株的筛选·················································彭雪,吴煜,张晓娜,等(393)干湿环境对河岸带氮素含量及空间分布特征的影响···············································陈丽慧,李晗,肖静文,等(401)藉河水环境质量与浮游植物群落结构特征···············孙小玉(406)丁字湾盐沼湿地不同植被生境大型底栖动物群落结构研究··············································纪莹璐,蒲思潮,陶卉卉,等(412)氮沉降对鼎湖山常绿阔叶林土壤生态的影响·············王昭(421)基于灰信息的土壤含水量高光谱灰色关联估测·················································李丽,李西灿,车红,等(429)栓皮栎和侧柏水分利用率与叶片生理对海拔梯度的协同演化·················································温哲华,侯沛轩,余新晓(433)不同配方施肥对酸化潮土及小麦产量的影响·················································王校辉,柴文安,刘铁干(440)不同投料方式对尾菜堆肥效果的影响···············································武凤霞,王小雪,肖强,等(445)西南区坡耕地紫色土离散元模型参数标定··············································聂晨旭,杨明金,李守太,等(454)松材线虫病疫木伐桩剥皮处理对褐梗天牛发生的影响·················································赵建文,高锋,董飘,等(464)不同林龄黄山松生物量和碳密度分配特性···················································孙伟韬,周瑾,李领寰(469)基于地基激光雷达的栾树分形特征分析·················································李辉,林沂,孟祥爽,等(475)农用离心泵内流体流动特性模拟···················王玫,宋志远(484)基于改进LSTM的苹果价格预测模型研究···················································卢超凡,史世凯,王鲁(491)新时期农村经营模式及其影响因素分析···························································葛舒梦,张化楠(497)基于主成分分析和同异分析法的小麦产量与品质综合评价·················································张凡,杨春玲,韩勇,等(503)黄土高原休闲期保护性耕作对冬小麦产量的Meta分析···················································李海康,贺亭峰,耿晶(510)山东省小麦和玉米的产量、肥料使用量及利用率演变趋势··············································马荣辉,董艳红,郭跃升,等(517)水分胁迫条件下玉米产量影响因素灰色关联分析···············································张莉,李西灿,程军伟,等(526)基于GIS和AHP的山东省苹果种植区适宜性评价····················································王凌,吴春晓,李响(531)豫东地区金顶谢花酥梨授粉液的筛选···············································王芳,范嘉林,谢一鸣,等(538)气相色谱-质谱法测定辣椒中虫螨腈残留及消解动态·················································刘晓鹏,刘秋蕊,马翠华(543)钻喙兰快速繁殖技术体系优化··············································郑秋桦,郑翼泽,刘博婷,等(548)不同杉木家系生长及材性变异规律·················································程琳,陈琴,潘晓芳,等(553)氮形态对沉水植物氮磷去除效果及沉积微生物群落结构的影响··············································程铁涵,周昕彦,曹玉成,等(560)疏勒河流域冲积平原天然植被生态需水量研究·········杨占荣(568)湿地植物生物炭对土壤镉的固化效果及植物生理的影响···············································普东伟,邱亮,周巧红,等(574)山东半岛及内陆近地表气温直减率场空间格局分析···············································张刘东,韩芳,乔显娟,等(584)基于水文模拟的城市河道场景构建—以青白江区1956大时代片区为例·········································李绍芃,周越,李晓溪,等(593)光伏驱动一体化装置处理农村生活污水的性能研究···············································张永平,李妮,温静静,等(599)基于目标流量下压力补偿灌水器膜片变化的数值模拟··············································刘娉楠,张金珠,王振华,等(605)基于网络层次分析法的水闸退役评估···················································刘志麟,苏子辰,孙刚(613)虹鳟传染性胰脏坏死性状全基因组关联分析············································欧阳少琪,赵云峰,蒋丽,等(618)纳米银在池塘微宇宙模型中的动态分布研究···············································张泽玉,张丽,罗人杰,等(624)一株G4P[X]型猪A群轮状病毒的分离与鉴定···················································傅安静,黄名英,张斌(629)鲁中肉羊FecB基因多态性与体尺性状的关联分析··············································张亚男,汪浩源,王舒君,等(634)爆炸荷载下钢筋混凝土面板动力响应本构模型分析···············································刘晓蓬,陈健云,周晶,等(640)不饱和聚酯树脂混凝土性能优化及抗冻性··············································刘佩玺,刘恒安,刘福胜,等(651)丘陵山地马铃薯精量中耕施肥机设计与仿真分析···············································方雪峰,沈鹏,宁旺云,等(656)。

纤维素-三（3，5-二甲苯基氨基甲酸酯）手性固定相拆分氨鲁米特对映体林小建;龚如金;李平;于建国【摘要】Aminoglutethimide(AG)has been used clinically as a drug in the treatment of hor-mone-dependent metastatic breast cancer. It was reported that S-( -)-AG enantiomer had small activity and sometimes might cause side effects. Therefore,it was of great significance to obtain the high-purity R-( +)-AG by enantioseparation. In thiswork,aminoglutethimide enanti-omers were separated by high performance liquid chromatography( HPLC)using an analytical column which was packed with cellulose tris(3,5-dimethylphenylcarbamate)stationary phase (ChiralcellOD-H). The solubilities of racemic AG in two different solvent compositions,n-hex-ane / ethanol and n-hexane / isopropanol,were measured,separately. The effects of alcohol con-tent and monoethanolamine additive on the separation performance of racemic AG by HPLC were investigated. According to the experiments,n-hexane-ethanol( 30 : 70,v / v)with 0.1%monoethanolamine additive was selected as the mobile phase. The separation factor,resolu-tion,asymmetry factor,number of theoretical plates and maximum column capacity were measured and analyzed for the chromatographic separation of racemic AG at a flow-rate of 0. 6 mL / min and column temperature of 25-40 ℃ ,with Chira lcellOD-H as stationary phase and n-hexane-ethanol(30 : 70,v / v)with 0. 1% monoethanolamine asmobile phase. This work pro-vides the basic information of chromatographic separation for the batch and continuous produc-tion of aminoglutethimide enantiomers.%以纤维素-三（3，5-二甲苯基氨基甲酸酯）为手性固定相（Chiralcel OD-H）在高效液相色谱上拆分了氨鲁米特对映体。