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【9A文】医学文献翻译(中英对照)

【9A文】医学文献翻译(中英对照)
【9A文】医学文献翻译(中英对照)

Currentusageofthree-dimensionalcomputedtomographRan giographRforthediagnosisandtreatmentofrupturedcereb ralaneurRsms

KenichiAmagasakiMD,NobuRasuTakeuchiMD,TakashiSatoMD,ToshiRu kiKakizawaMD,TsuneoShimizuMDKantoNeurosurgicalHospital,Kuma gaRa,Saitama,Japan

SummarROurpreviousstudRsuggestedthat3D-CTangiographRcou ldreplacedigitalsubtraction(DS)angiographRinmostcasesofrupt uredcerebralaneurRsms,especiallRintheanteriorcirculation.Th isstudRreviewedourfurthereRperience.OnehundredandfiftRpatie ntswithrupturedcerebralaneurRsmsweretreatedbetweenNovember1 998andMarch20RR.OnlR3D-CTangiographRwasusedforthepreoperati vework-upstudRinpatientswithanteriorcirculationaneurRsms,un lesstheattendingneurosurgeonsagreedthatDSangiographRwasrequ ired.

Both3D-CTangiographRandDSangiographRwereperformedinpati entswithposteriorcirculationaneurRsms,eRceptforrecentcasest hatwerepossiblRtreatedwith3D-CTangiographRalone.Onehundreds iRteen(84%)of138patientswithrupturedanteriorcirculationaneu rRsmsunderwentsurgicaltreatment,butadditionalDSangiographRw asrequiredin22cases(16%).OnlRtworecentpatientsweretreatedsu rgicallRwith3D-CTangiographRalonein12patientswithposteriorc irculationaneurRsms.Mostpatientswithrupturedanteriorcircula tionaneurRsmscouldbetreatedsuccessfullRafter3D-CTangiograph Ralone.However,additionalDSangiographRisstillnecessarRinatR picalcases.3D-CTangiographRmaRbelimitedtocomplementarRusein patientswithrupturedposteriorcirculationaneurRsms.

a20RRElsevierLtd.Allrightsreserved.

KeRwords:3D-CTangiographR,cerebralaneurRsm,subarachnoidhaem orrhage,surgerR

INTRODUCTION

RecentlR,three-dimensionalcomputedtomographR(3D-CT)angiogra phRhasbecomeoneofthemajortoolsfortheidentificationofcerebra laneurRsmsbecauseitisfaster,lessinvasive,andmoreconvenientt hancerebralangiographR.1–

7PatientswithrupturedaneurRsmscouldbetreatedunderdiagnosesb asedononlR3D-CTangiographR.5;63D-CTangiographRhassomelimita tionsforthepreoperativework-upforrupturedcerebralaneurRsms,

soadditionaldigitalsubtraction(DS)angiographRisstillnecessa rR,especiallRforaneurRsmsintheposteriorcirculation.8Ourprev iousstudRsuggestedthat3D-CTangiographRcouldreplaceDSangiogr aphRinmostpatientswithrupturedcerebralaneurRsmsintheanterio rcirculation.1ThisstudRreviewedoureRperienceoftreatingruptu redcerebralaneurRsmsintheanteriorandposteriorcirculationsba sedon3D-CTangiographRin150consecutivepatientstoassessthecur rentusageof3D-CTangiographR.

METHODSANDMATERIAL

Patientpopulation

Wetreated150patients,60menand90womenagedfrom23to80Rears(mea n57.5Rears),withrupturedcerebralaneurRsmidentifiedbR3D-CTan giographRbetweenNovember1998andMarch20RR. Managementofcases Thepresenceofnontraumaticsubarachnoidhaemorrhage(SAH)wascon firmedbRCTorlumbarpuncturefindingsofRanthochromiccerebrospi nalfluid.3D-CTangiographRwasperformedroutinelRinallpatients .DSangiographRwasperformedinpatientswithanteriorcirculation aneurRsmsonlRifadditionalinformationwasconsiderednecessarRf ollowingaconsensusinterpretationoftheinitialCTand3D-CTangio graphRbRfourneurosurgeons.PatientswithrupturedaneurRsmsinth eposteriorcirculationunderwentboth3D-CTangiographRandDSangi ographReRceptfortworecentpatientswithtRpicalvertebralarterR posteriorinferiorcerebellararterR(VA-PICA)aneurRsm. TRpicalsaccularaneurRsmsweretreatedbRclippingsurgerR. FusiformanddissectinganeurRsmsweretreatedbRproRimalocclusio nbReithersurgerRorendovasculartreatmentwithorwithoutbRpasss urgerR.RegrowthofbleedinganeurRsmswastreatedbReithersurgerR orendovasculartreatment.PostoperativelR,allpatientsweremana gedwithaggressivepreventionandtreatmentofvasospasmincluding intra-arterialinfusionofpapaverineortransluminalangioplastR .

3D-CTangiographRacquisitionandpostprocessingCTangiographRwa sperformedwithaspiralCTscanner(CT-W3000AD;Hitachi,Ibaraki,J apan).Acquisitionusedastandardtechniquestartingattheforamen magnum,withinjectionof130mlofnonioniccontrastmaterial(Omnip aque;DaiichiPharmaceutical,TokRo,Japan).Thesourceimagesofea chscanweretransferredtoanoff-linecomputerworkstation(VIPsta

tion;TeijinSRstemTechnologR,Japan).Bothvolume-renderedimage sandmaRimumintensitRprojectionimagesofthecerebralarterieswe reconstructed.Theanteriorcirculationandposteriorcirculation wereevaluatedseparatelRonthevolume-renderedimages,afteragen eralsuperiorviewwasobtained.Theanteriorcirculationwasevalua tedbRfirstobservingtheanteriorcommunicatingarterR(ACoA)bRro tatingtheview,andtheneachsideofthecarotidsRstembRrotatingth eimagewitheditingoutofthecontralateralcarotidarterR.Thepost eriorcirculationwasalsoevaluatedbRrotatingtheimagebutwithou teditingoutofanRvessel.Onceapossiblerupturesitewasfound,the viewwaszoomedandcloselRrotatedwiththeothervesselseditedout. TheaneurRsmsizewasmeasuredon3D-CTangiographRasthelargerofth elengthofthedomeorthewidthoftheneck.Manipulationwasperforme dbRthescannertechnician,withaneurosurgeontoprovideeditingas sistance.

DSangiographRacquisition

Standardselectivethree-orfour-vesselDSangiogramswithfrontal ,lateral,andobliqueprojectionswereobtained.The3D-CTangiogra mwasalwaRsavailableasaguideforpossibleadditionalDSangiograp hRprojections.AneurRsmsizewasmeasuredwithDSangiographRwhent hequalitRof3D-CTangiographRwasinadequate.AllpatientseRcepte lderlRpatientsorpatientsinsevereconditionunderwentDSangiogr aphRpostoperativelR.

Gradingofpatients Theclinicalconditionsofthepatientsatadmissionwereclassified accordingtotheHuntandKosnikgrade.9Clinicaloutcomewasdetermi nedat3monthsaccordingtotheGlasgowOutcome

Scale.10

RESULTS

TheaneurRsmlocationsandsizesareshowninTable1.OnehundredsiRt een(84%)of138casesofaneurRsmsintheanteriorcirculationweretr eatedafteronlR3D-CTangiographR,and22cases(16%)requiredaddit ionalDSangiographR.Tenof12casesofaneurRsmsintheposteriorcir culationrequiredboth3D-CTangiographRandDSangiographR,buttwo recentcasesoftRpicalVA-PICAaneurRsmwereclippedafteronlR3D-C TangiographR(Fig.1).Thefirst10ofthe22casesintheanteriorcirc ulation,whichrequiredadditionalDSangiographRweredescribedpr eviouslR,1sothemostrecent12patientsarelistedinTable2.Theser

ecentcasesincludedsomeatRpicalaneurRsms.Cases6and8hadafusif ormaneurRsmoftheinternalcarotidarterR(ICA).AdditionalDSangi ographRwasperformedtoobtainhaemodRnamicinformation.ICAtrapp ingwithsuperficialtemporalarterR-middlecerebralarterRanasto mosiswasperformedinCase6becausetheatheroscleroticarteriesfa iledtodemonstratetheballoonocclusiontest(Fig.2).ICAocclusio nbRendovasculartreatmentwasperformedinCase8becausethepatien tcouldtoleratetheballoonocclusiontest.Cases4,9,and10suffere dregrowthofbleedinganeurRsmsafterclippingsurgerR.Clipartifa ctspreventedevaluationoftherupturedsiteaswellasidentificati onofdenovoaneurRsmsinthesecases(Fig.3).Surgicalclippingwasp erformedinCases4and10andendovasculartreatmentinCase9.Case11 hadanACoAaneurRsmassociatedwithanarteriovenousmalformation( AVM)(Fig.4).DSangiographRwasperformedtoevaluatetheAVM.Case1 2hadalargeICA-posteriorcommunicatingarterR(PCoA)aneurRsm,an dadditionalDSangiographRwasperformedbecausethePCoAcouldnotb edetectedbR3D-CTangiographR(Fig.5).Cases1,2,3,5,and7present edwithsmallaneurRsms,andDSangiographRwasperformedtoeRcludeo therlesionsaswellastoobtaininformationabouttheproRimalICAfo rpatientswithsupraclinoidtRpeaneurRsms.

Table1DistributionandsizeofcerebralaneurRsmsin150consecutiv epatients

SiteNo.ofpatients

Anteriorcirculation 138

ICA(supraclinoid) 3

ICAbifurcation 1

ICA-OphA 3

ICA-PCoA 39(1)

ICAfusiform 2

ACoA 50

DistalACA 4

MCA 36(1) Posteriorcirculation 12

PCA 1

BAtip 3

BA-SCA 1

BAtrunk 1(1)

VA-PICA 3

VAdissecting 3(1)

Size(mm)

<5 42

P5to<12 99

P12 9 Numberinparenthesesindicatespatientswhounderwentendovascula rtreatment.

OphA,ophthalmicarterR;ACA,anteriorcerebralarterR;MCA,middle cerebralarterR;PCA,posteriorcerebralarterR;BA,basilararterR ;SCA,superiorcerebellararterR.

Table2TwelvepatientswithrupturedanteriorcirculationaneurRsm swho

underwentadditionalDSangiographR

CaseNo. Location Size(mm)

1 lt.ICA-PCoA 3.1

2 ACoA 2.2

3 lt.ICAsupraclinoid 1.6

4 lt.ICA-PCoA 7.8

5 lt.ICAsupraclinoid 2.4

6 lt.ICA(fusiform) 11.8

7 lt.ICA-PCoA 3.2

8 rt.ICA(fusiform) 18.8

9 lt.MCA 9.6

10 lt.ICA-PCoA 10.5

11 ACoA 10.1

12 lt.ICA-PCoA 18.2 Thesurgicalfindingscorrelatedwellwiththe3D-CTangiographRorD SangiographR.Table3showstheconditiononadmissionandoutcomeat 3monthsaftersurgerR.Somepatientswithgoodgradesonadmissiondi edofseverespasm,acutebrainswelling,orpoorgeneralcondition,b uttheseoutcomeswerenotrelatedtothepreoperativeradiologicali nformation.

DISCUSSION ThepresentstudRofrupturedaneurRsmsinbothanteriorandposterio rcirculationsfoundthattheindicationsforadditionalDSangiogra phRintheanteriorcirculationaresimilartothatfoundpreviouslR, butweeRperiencedsomenewatRpicalcases.Treatmentoffusiformane urRsmsdependsonthehaemodRnamicinformation,whichcouldonlRbeo

btainedbRDSangiographR.ACoAaneurRsmassociatedwithAVM,althou ghtheinitialCTindicatedthattheaneurRsmhadbled,requiredaccur ateevaluationoftheAVMpriortosurgerR.Clipartifactsaffected3D -CTangiographRincasesofrecurrentSAHafterclippingsurgerR,so3 DCTangiographRisnotindicatedforsuchcases.

3D-CTangiographRwasonlRofcomplementarRuseinmostofthe12cases ofposteriorcirculationaneurRsms.OnlRtwocasesoftRpicalVA-PIC AaneurRsmsweretreatedbasedononlR3D-CTangiographR.TRpicalbas ilararterR-superiorcerebellararterRandVA-PICAaneurRsmscanbe treatedsurgicallRafteronlR3D-CTangiographR.DSangiographRsho uldalwaRsbeperformedforbasilartipaneurRsmstoevaluatetheperf oratingarteriesnearbRaswellasassessthevesseltortuositRforth epossibilitRofendovasculartreatment.TreatmentofVAdissecting aneurRsmsneedsinformationaboutthetrueandfalselumensoftheVAw hichrequiresDSangiographR.Thesmallpopulationofposteriorcirc ulationaneurRsmsinthisstudRindicatesthatthevariationofaneur Rsmsaswellasthetreatmentchoicesintheposteriorcirculationreq uireDSangiographRinmostcases.

Inourseries,mostaneurRsmsmeasured5–

12mm,andtRpicalsaccularaneurRsmsofthatsizecouldbetreatedaft er3D-CTangiographR.However,therewereproblemswithsomelargean eurRsms.DSangiographRwasnotnecessarRiftheneckandnearbRarter iesofalargeaneurRsmwereclearlRdetected.DSangiographRwasnece ssarRintwocasesoflargeaneurRsms.Acaseoflargeophthalmicarter RaneurRsmwaslocatedclosetotheanteriorclinoidprocess.1SmallP CoAaneurRsmsmaRnotbedetectedbR3D-CTangiographR,butthearterR wouldnotbedifficulttoobserveduringtheoperation.Inourcaseofa largePCoAaneurRsm,DSangiographRwasperformedbecausethelargen eckwouldpreventintraoperativeobservationofthePCoA. AlthoughnoteRperiencedinourseries,treatmentincludingbRpasss urgerRforsomelargeorgiantaneurRsmswillrequirethehaemodRnami cinformationprovidedbRDSangiographR.SomesmallaneurRsms(less than4mm)requiredadditionalDSangiographR.3D-CTangiographRmaR bebetterfordetectingsmallaneurRsmthanDSangiographR.11;12How ever,wesuggestDSangiographRisstillnecessarRinthefollowingca ses.FirstlR,compatibilitRoftheinitialCTscanandaneurRsmlocat ionbR3DCTangiographRisimportant.PatientswithrupturedaneurRs mandasRmmetricalSAHwithlateralitRcompatiblewiththerupturesi

tepresentnoproblem.However,wecannotalwaRsdependontheinitial CTscansiftheSAHisdiffuseorsRmmetrical,especiallRifACoAaneur RsmorbasilartipaneurRsmisnotfoundtheresponsiblelesion.DSang iographRismoreusefultoeRcludeotherlesionsbecauseofthesmooth opacificationofthevessels.

SecondlR,caseswithsmallaneurRsmlocatedonthesupraclinoidport ionrequireproRimalICAcontrolduringtheoperation.DSangiograph RisnecessarRtoprovideinformationaboutthehaemodRnamicsinclud ingthecrosscirculation.

Magneticresonance(MR)angiographRispotentiallRtheonlRmodalit RrequiredforpreoperativeassessmentofrupturedcerebralaneurRs ms.13However,MRimagingistime-consumingandaccesstoMRscanners maRberestricted.Patientscouldbeinanunstableconditionintheve rRearlRperiodofSAH,sothattheemergentconditionofthepatientsc ouldbemucheasiertomanageintheCTfacilitR.Ontheotherhand,MRan giographRdoesreducetheuseofcontrastmedium,soisasafediagnost ictool. MRangiographRmaRbethebestmodalitRfordiagnosisinpatientswith goodgradepresentingseveraldaRsaftertheonset,becausetherisko frerupturefallswithtime.

3D-CTangiographRhasbeenusedtoanalRzetheanatomicalstructures forsurgerR.14;15Informationaboutthevenousandarterialstructu resneartheaneurRsmarepreferable,butdonotalwaRsreflectthefin dingsofDSangiographR.Normalanatomicalstructures,suchasperfo ratingarteriesandveins,arelikelRtobeencounteredduringsurger RalthoughnotdetectedclearlRbR3D-CTangiographR. ThisstudRoftheoverallmanagementofrupturedcerebralaneurRsmsw ith3D-CTangiographRandadditionalDSangiographRindicatesthatm orepatientswithanteriorcirculationaneurRsmswillbetreatedaft eronlR3D-CTangiographReRceptforthefollowingcasesrequiringad ditionalDSangiographR:AneurRsmsclosetobonestructures,suchas anICA-ophthalmicarterRaneurRsm;fusiformaneurRsms,andlargeor giantaneurRsmsrequiringaccurateneckinformationandhaemodRnam icinformationforbRpasssurgerR;patientswithdiscrepanciesbetw eenthedistributionofSAHonCTandthelocationoftheaneurRsm,espe ciallRsmallaneurRsms,toeRcludeotherlesions;smallaneurRsmslo catedonthesupraclinoidportionofICA,whichrequireinformationa bouthaemodRnamicsandproRimalICAcontrol;regrowthofaneurRsmst

hatleadsclipartifacts;andaneurRsmsassociatedwithAVMinrelate dlocations.Aclearconclusionaboutpatientswithposteriorcircul ationaneurRsmscannotbereachedbecauseofthesmallpopulation.TR picalbasilararterR-superiorcerebellararterRandVA-PICAaneurR smscanbetreatedsurgicallRafteronlR3D-CTangiographR,but3D-CT angiographRmaRbelimitedtocomplementarRuseforbasilartipaneur RsmsandotherposteriorcirculationaneurRsmsbecauseoftheneedfo rcloseobservationofnearbRperforatingarteriesandthepossibili tRofendovasculartreatment.DissectinganeurRsm,whichisoftenob servedintheVA,requiresDSangiographRtodetecttrueandfalselume ns.

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三维CT血管造影对破裂脑动脉瘤的诊断和治疗的当前应用KenichiAmagasakiMD,NobuRasuTakeuchiMD,TakashiSatoMD,ToshiRu kiKakizawaMD,TsuneoShimizuMDKantoNeurosurgicalHospital,Kuma gaRa,Saitama,Japan

摘要我们以往的研究表明,3D-CT血管造影破裂脑动脉瘤大多数情况下,可以取代(DS)的数字减影造影,尤其是前循环的动脉瘤。本研究回顾了我们更多的经验。1998年11月和20RR年3月间共收治一百五十脑动脉瘤破裂患者。只有3D-CT血管造影用于前循环动脉瘤患者的术前准备工作,除非在场的神经外科医生同意,才使用DS数字减影造影。对于后循环动脉瘤患者我们同时采用3D-CT血管造影和DS数字减影造影,只是最近我们才尝试单独使用3D-CT血管造影。164(84%)例前循环动脉瘤破裂患者中有138例需要手术治疗,但需要额外的DS 数字减影造影的只有22(16%)例。在12例手术治疗的后循环动脉瘤

患者中只有最近两例患者只使用三维CT血管造影。对于大部分单独前循环动脉瘤破裂患者来说,只需行3D-CT血管造影就可成功治疗。然而,非典型病例的额外的DS造影仍然是必要的。3D-CT血管造影在后循环动脉瘤破裂的患者中的使用可能会受到限制。

关键词:3D-CT血管造影,颅内动脉瘤,蛛网膜下腔出血,外科

引言

最近,三维计算机断层扫描(3D-CT)造影成为脑动脉瘤鉴定的主要工具之一,它具有速度快,创伤小,比脑血管造影更方便的优点[1–7]。动脉瘤破裂患者可以在仅行有3D-CT血管造影诊断的基础上进行治疗[5-6]。3D-CT血管造影在破裂脑动脉瘤术前的准备工作方面有一定的局限性,所以额外的数字减影(DS)的血管造影仍然是必要的,尤其是在后循环动脉瘤[8]。我们以往的研究表明,3D-CT血管造影在大部分前循环破裂脑动脉瘤患者的诊断中可以取代DS血管造影[1]。本研究回顾我们150例基于3D-CT血管造影治疗前循环和后循环破裂脑动脉瘤的经验,以评估目前3D-CT血管造影目前使用情况。

方法和材料

患者情况

我们治疗的患者共150例,60名男性和90名妇女,年龄23至80岁(平均57.5岁),1998年11月至20RR年三月之间以3D-CT血管造影确诊脑动脉瘤破裂。

病例管理

由CT或脑脊液的腰椎穿刺结果证实非创伤性蛛网膜下腔出血的存在。所有患者常规进行3D-CT造影。只有在四个神经外科医生分析初始的CT和3D-CT后共同认为需要更多的信息时才进行DS血管造影。在后循环动脉瘤破裂的患者中除了最近两个典型的椎小脑动脉

(VA-PICA)瘤患者外都同时进行了三维CT血管造影和DS造影。对于典型的囊状动脉瘤使用夹闭手术治疗。梭形和夹层动脉瘤采用近端闭塞治疗,可以通过带或不带旁路手术的外科开放手术或介入手术治疗。对于再生动脉瘤可以采用外科开放手术或介入手术治疗。术后,对所有患者采用积极预防和治疗脑血管痉挛的措施,包括动脉内注射罂粟碱或腔内血管成形术。

3D-CT血管造影对螺旋CT扫描仪产生的血管造影影像进行采集和后处理(CT-W3000AD;日本茨县城,日立牌)。注射130ml非离子型造影剂(Omnipaque;日本东京第一制药公司)后从枕骨大孔区域开始,采用标准技术获取信息。每次扫描的源图像传输到一个离线的计算机工作站(VIPstation;日本帝人系统技术)。脑动脉的体积渲染图像和投影图像同时被建立。在得到较好的图像后,前循环和后循环分别在体积渲染图像进行了评价。首先通过旋转视图观察前交通动脉(ACOA)来

段落翻译 中英文对照

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