Sodium Channel inhibitor 1_1198117-23-5_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening

Safety Data SheetRevision Date:Oct.-03-2018Print Date:Oct.-03-2018

1. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :TCS 1102

Catalog No. :HY-10900

CAS No. :916141-36-11.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USA

Tel:609-228-6898

Fax:609-228-5909

E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-6898

2. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.

Product Name:A-803467

CAS No.: 944261-79-4

Product Data Sheet

Cat. No.:HY-11079

MWt:357.79

Formula:C19H16ClNO4

Purity :

>98%

Solubility:

Mechanisms:

Biological Activity: Pathways:Membrane Transporter/Ion Channel; Target:Sodium Channel

DMSO: >10 mg/mL

gy

A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.

IC50 value: 8 nM

Target: Nav1.8 sodium channel

A 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and

inflammatory pain models.

References:

[1]. McGaraughty, et al. A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-

N-(3,5-dimethoxyphenyl)furan-2-carboxamide)], attenuates spinal neuronal activity in neuropathic rats. Journal of Pharmacology and Experimental Therapeutics (2008), 324(3), 1204-1211.

Product Name:BIX02189

CAS No.: 1265916-41-3Product Data Sheet

Cat. No.:HY-12056

MWt:440.54

Formula:C27H28N4O2

Purity :

>98%

Solubility:

Mechanisms:

Biological Activity: Pathways:MAPK ; Target:MEK

DMSO

gyBIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM.

References:[1]. Tatake RJ et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5.[2]. Kondo M, Inamura H, Matsumura K, Matsuoka M.Cadmium activates extracellular signal-regulated kinase 5 in HK-2 human renal proximal tubular cells.Biochem Biophys Res Commun. 2012gppy May 11;421(3):490-3. Epub 2012 Apr 10.[3]. Li P, Ma YC, Sheng XY, Dong HT, Han H, Wang J, Xia YY.Cyclic fluid shear stress promotesosteoblastic cells proliferation through ERK5 signaling pathway.Mol Cell Biochem. 2012 May;364(1- 2):321-7.[4]. Gilley R, Lochhead PA, Balmanno K, Oxley D, Clark J, Cook SJ.CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.Cell Signal. 2012 Jan;24(1):170-80. Epub 2011 Sep 8.[5]. Obara Y, Nemoto W, Kohno S, Murata T, Kaneda N, Nakahata N.Basic fibroblast growth factorpromotes...

Inhibitors, Agonists, Screening

Safety Data SheetRevision Date:Mar.-30-2017Print Date:Mar.-30-2017

1. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :BML-277

Catalog No. :HY-13946

CAS No. :516480-79-81.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USA

Tel:609-228-6898

Fax:609-228-5909

E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-6898

2. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.