DOI：10.16658/ki.1672-4062.2023.11.020血清25羟维生素D在2型糖尿病合并代谢综合征中的临床意义桑贵蕊，杭宇，叶勇健，周蓓皖南医学院第二附属医院内分泌科，安徽芜湖241000[摘要]目的探讨血清25-羟维生素D［25-（OH）D］水平在2型糖尿病（type 2 diabetes mellitus， T2DM）合并代谢综合征（metabolic syndrome， MS）中的价值，为临床诊断提供理论依据。
方法收集2021年4月—2022年4月在皖南医学院第二附属医院住院的92例T2DM患者的临床资料，将其分成两组，观察组（n=46）为T2DM合并MS，对照组（n=46）为单纯T2DM。
收集并比较两组患者的基线资料、相关生化指标及血清25-（OH）D水平。
采用Logistic回归模型评估T2DM合并MS的发生发展的独立影响因素及受试者工作特征曲线（receiver operating characteristic curve， ROC）评估血清25-（OH）D对其预测效能。
结果观察组血清25-（OH）D水平低于对照组，差异有统计学意义（t=4.469，P<0.001）。
ROC曲线显示25-（OH）D对T2DM合并MS的AUC为0.748，灵敏度为97.8%，有一定的辅助诊断作用。
结论血清25-（OH）D对T2DM患者合并MS的发生及发展具有预测价值，可用于辅助T2DM合并MS的诊断。
[关键词] 25-（OH）D；2型糖尿病；代谢综合征[中图分类号] R587.2 [文献标识码] A [文章编号] 1672-4062（2023）06（a）-0020-04Clinical Significance of Serum 25 Hydroxyvitamin D in the Combined Metabolic Syndrome of Type 2 Diabetes MellitusSANG Guirui, HANG Yu, YE Yongjian, ZHOU BeiDepartment of Endocrinology, the Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, 241000 China[Abstract] Objective To explore the value of serum 25 hydroxyvitamin D [25- (OH) D] level in type 2 diabetes (T2DM) with metabolic syndrome (MS), and provide theoretical basis for clinical diagnosis. Methods The clinical data of 92 T2DM patients hospitalized in the Second Affiliated Hospital of Wannan Medical College from April 2021 to April 2022 were collected and divided into two groups, the observation group (n=46) with T2DM combined with MS and the control group (n=46) with T2DM alone. Baseline data, relevant biochemical indices and serum 25-(OH)D lev‐els were collected and compared between the two groups. Logistic regression models were used to assess the indepen‐dent factors influencing the development of MS in T2DM combined with MS and to evaluate the predictive efficacy of serum 25-(OH) D on the receiver operating characteristic curve (ROC). Results The serum 25-(OH) D level in the ob‐servation group was lower than that in the control group, and the difference was statistically significant (t=4.469,P< 0.001). The ROC curve showed that 25-(OH) D had an AUC of 0.748 and a sensitivity of 97.8% for T2DM combined with MS, which had a certain auxiliary diagnostic effect. Conclusion Serum 25- (OH) D has predictive value for the occurrence and development of T2DM patients with MS, and can be used to assist in the diagnosis of T2DM with MS.[Key words] 25-(OH)D; Type 2 diabetes mellitus; Metabolic syndrome[基金项目]皖南医学院校级重点项目科研基金（WK2019ZF14）。
·糖尿病与并发症·糖尿病新世界 2023年8月DOI：10.16658/ki.1672-4062.2023.15.182和血明目片联合羟苯磺酸钙片治疗早期糖尿病视网膜病变的效果及对其血管瘤体积、黄斑厚度、视野灰度值、出血斑面积的影响梁田，纵丹丹，周军徐州市贾汪区人民医院眼科，江苏徐州221000[摘要]目的分析对早期糖尿病视网膜病变患者采用和血明目片联合羟苯磺酸钙片治疗的效果及对其视野灰度值、血管瘤体积、出血斑面积、黄斑厚度的影响。
方法选取2021年3月—2023年3月徐州市贾汪区人民医院诊治的90例早期糖尿病视网膜病变患者为研究对象，按随机数表法分为对照组（n=45，给予羟苯磺酸钙片治疗）和观察组（n=45，给予和血明目片+羟苯磺酸钙片治疗）。
对比两组治疗前后的眼底检查相关指标、血糖水平，统计两组临床治疗总有效率和不良反应发生率。
结果治疗后，观察组视野灰度值、血管瘤体积、出血斑面积、黄斑厚度均小于对照组，差异有统计学意义（P<0.05）；观察组空腹血糖、糖化血红蛋白水平低于对照组，差异有统计学意义（P<0.05）；观察组临床治疗有效率为95.56%，高于对照组的77.78%，差异有统计学意义（χ2=6.154，P<0.05）；观察组不良反应发生率为4.44%，与对照组的11.11%相比，差异无统计学意义（P>0.05）。
结论在早期糖尿病视网膜病变患者中采用和血明目片联合羟苯磺酸钙片治疗，能够促进患者眼底病变改善，降低血糖水平，强化临床治疗效果，且安全性高。
[关键词] 早期糖尿病；视网膜病变；和血明目片；羟苯磺酸钙片；眼底病变；血糖水平[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2023）08（a）-0182-05Effectiveness of Hexue Mingmu Tablets Combined with Calcium Dobesi⁃late Tablets in the Treatment of Early Diabetic Retinopathy and the Ef⁃fects on Its Angioma Volume, Macular Thickness, Visual Field Gray Scale Value, and Hemorrhagic Spot AreaLIANG Tian, ZONG Dandan, ZHOU JunDepartment of Ophthalmology, Jiawang District People's Hospital, Xuzhou, Jiangsu Province, 221000 China[Abstract] Objective To analyze the effect of using Hexue Mingmu tablets combined with calcium dobesilate tablets in the treatment of patients with early diabetic retinopathy and the effect on the patients' visual field gray value, hem⁃angioma volume, hemorrhagic spot area, and macular thickness. Methods Ninety patients with early diabetic retinopa⁃thy diagnosed and treated in Jiawang District People's Hospital of Xuzhou City from March 2021 to March 2023 were selected as the study objects and divided into control group (n=45, given calcium dobesilate tablets treatment) and ob⁃servation group (n=45, given Hexue Mingmu tablets + calcium dobesilate tablets treatment) according to the method of random number table. The fundus examination related indexes and blood glucose level before and after the treatment of the two groups, and the total effective rate of clinical treatment and the incidence of adverse reactions of the two groups were compared. Results After treatment, the visual field gray value, hemangioma volume, hemorrhagic spot [作者简介]梁田（1994-），女，硕士，住院医师，研究方向为眼科疾病。
