Meclizine dihydrochloride_1104-22-9_DataSheet_MedChemExpress

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Product Name:Meclizine dihydrochloride

CAS No.: 1104-22-9

Cat. No.:HY-B0349Product Data Sheet

MWt:463.87

Formula:C25H29Cl3N2

Purity :>98%

Solubility:

DMSO 1 mg/mL; Water <1 mg/mL

Mechanisms:

Biological Activity: Pathways:GPCR/G protein; Target:Histamine Receptor

Pathways:Immunology/Inflammation; Target:Histamine Receptor

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness

Target: Histamine H1 Receptor

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness,

possesses anticholinergic, central nervous system depressant, and local anesthetic effects [1].

Meclizine is an agonist ligand for mouse CAR (constitutive androstane receptor), and an inverse

agonist for human CAR. Meclizine increases mCAR transactivation in a dose-dependent manner,

stimulates binding of steroid receptor coactivator 1 to the murine receptor in vitro. In contrast,

meclizine suppresses hCAR transactivation and inhibits the phenobarbital-induced expression of the

CARtargetgenescytochromep450monooxygenase(CYP)2B10CYP3A11andCYP1A2in

References:

[1]. King, C.T., S.A. Weaver, and S.A. Narrod, Antihistamines and Teratogenicity in the Rat. J

Pharmacol Exp Ther, 1965. 147: p. 391-8.

[2]HuangWetalMeclizineisanagonistligandformouseconstitutiveandrostanereceptorCAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in

primary hepatocytes derived from mice expressing hCAR, but not mCAR [2].

...

[2]. Huang, W., et al., Meclizine is an agonist ligand for mouse constitutive androstane receptor

(CAR) and an inverse agonist for human CAR. Mol Endocrinol, 2004. 18(10): p. 2402-8.

Caution: Not fully tested. For research purposes only

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