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AT7867 dihydrochloride_1431697-86-7_DataSheet_MedChemExpress

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Product Name:AT7867 dihydrochloride

CAS No.: 1431697-86-7

Cat. No.:HY-12059AProduct Data Sheet

MWt:410.77

Formula:C20H22Cl3N3

Purity :>98%

Solubility:

DMSOy

Mechanisms:

Biological Activity:

AT7867HclisapotentATPcompetitiveinhibitorofAkt1/2/3andp70S6K/PKAwithIC50of32

Pathways:PI3K/Akt/mTOR; Target:Akt

AT7867 Hcl is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.

IC50 value: 32 nM/17 nM/47 nM(Akt1/2/3) [1]

Target: Akt

in vitro: AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50 of 20 nM

and 85 nM, respectively. AT7867 shows ATP-competitive activity to Akt2 with Ki of 18 nM. AT7867

exhibits antiproliferation in cell lines with PTEN or PIK3CA mutations and shows great potent to

MES-SA, MDA-MB-468, MCF-7, HCT116 and HT29 with IC50 of 0.94 μM, 2.26 μM, 1.86 μM, 1.76 μ

M and 3.04 M, respectively. AT7867 also suppresses the cell growth of U87MG, PC-3 and DU145

References:

[1]. Grimshaw KM, et al. AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that

induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol Cancer Ther, 2010, 9(5), 1100-1110.μ,pyppg,

cells with IC50 of 8.22 μM, 10.37 μM and 11.86 μM, respectively. AT7867 suppresses Akt activity by

inhibiting phosphorylation of GSK-3β in human tumor cells with IC50...

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

www.medchemexpress.com

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Cytarabine hydrochloride_69-74-9_DataSheet_MedChemExpress

Cytarabine hydrochloride_69-74-9_DataSheet_MedChemExpress

Product Name:Cytarabine hydrochlorideCAS No.: 69-74-9Cat. No.:HY-13605AProduct Data Sheet

MWt:279.68Formula:C9H14ClN3O5Purity :>98%

Solubility:

Mechanisms:

Biological Activity:Ctbi(AC)ititblitdDNAthiihibit Pathways:Cell Cycle/DNA Damage; Target:DNA/RNA Synthesis

DMSO

Cytarabine (AraC) is an antimetabolic agent and DNA synthesis inhibitor. Target: DNA/RNA SynthesisCytarabine (AraC) is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidinekinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNAsynthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a highergrowth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenousleukemia (AML) cells with IC50 of 16 nM [1]. Cytarabine apparently induces apoptosis of ratsympathetic neurons at 10 μM, of which 100 μM shows the highest toxicity and kills over 80% of theneuronsby84hours,involvingthereleaseofmitochondrialcytochrome-candtheactivationof

GSK2256294A_DataSheet_MedChemExpress

GSK2256294A_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening Libraries

Data Sheet

References:

[1]. Podolin PL, et al. In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. Prostaglandins Other Lipid Mediat. 2013 Jul–Aug;

104–105:25–31.Product Name:GSK2256294A

Cat. No.:HY-19644

CAS No.:1142090-23-0

Molecular Formula:C

21H

24F

3N

7O

Molecular Weight:447.46

Target:Others

Pathway:Others

Solubility:

DMSO: ≥ 47 mg/mL

Caution: Product has not been fully validated for medical applications. For research use only.

Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

ALK inhibitor 2_761438-38-4_DataSheet_MedChemExpress

ALK inhibitor 2_761438-38-4_DataSheet_MedChemExpress

Product Name:ALK inhibitor 2

CAS No.: 761438-38-4Product Data Sheet

Cat. No.:HY-15358

MWt:518.03

Formula:C23H28ClN7O3S

Purity :

>98%

Solubility:

Mechanisms:

Biological Activity: Pathways:Protein Tyrosine Kinase/RTK; Target:ALK

DMSO

gyALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase.

References:[1]. A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase (ALK).

Caution: Not fully tested. For research purposes only

Medchemexpress

18Wilkinson Way, Princeton, NJ 08540,USAEmail: info@ Web:

ICA_COA_26857_MedChemExpress

ICA_COA_26857_MedChemExpress

Inhibitors, Agonists, Screening Certificate of Analysis

PHYSICAL AND CHEMICAL PROPERTIES Molecular Formula:C13H10N4SMolecular Weight:254.31Storage:Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 monthChemical Structure:

ANALYTICAL DATA Appearance:Light brown to brown (Solid)1 H NMR Spectrum:Consistent with structureLCMS:Consistent with structurePurity (LCMS):99.63%Conclusion:The product has been tested and complies with the given specifications.Product Name:ICACat. No.:HY-22044CAS No.:3374-88-7Batch No.:26857Chemical Name:2–Pyridinamine, N–[4–(2–pyridinyl)–2–thiazolyl]–

Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA