第41卷第1期 光电工程V ol.41, No.1 2014年1月Opto-Electronic Engineering Jan, 2014 文章编号：1003-501X(2014)01-0065-08
Clifford代数空间上的三维多模医学图像配准华亮1,2，黄宇1，丁立军1,2，冯浩1，顾菊平2
( 1. 浙江工业大学信息工程学院，杭州 310023；
2. 南通大学电气工程学院，浙江南通 226019 )
摘要：3D/3D医学图像的配准在临床上具有重要的临床意义与医学价值，尤其在脑外科手术导航与病灶点定位上，病人的不同模态影像数据需要3D配准，便于更加全面、精确的分析目标组织的医学特性。本文在研究经典配准方法的基础上，将经典配准方法内嵌于Clifford代数计算空间，在Clifford代数空间上构建配准过程计算的几何要素与配准操作的平移算子、几何旋转算子，浮动图像进行对应的算子运算，实现头颅部3D多模医学图像配准。
配准方法应用于国际上两个著名3D医学数据库，实验结果表明：本文方法不仅继承经典配准算法的优点，而且配准精度高，几何意义直观，计算时间短。
关键词：Clifford代数；多模医学图像；三维配准；旋转算子
中图分类号：TN911.73 文献标志码：A doi：10.3969/j.issn.1003-501X.2014.01.012
Multimodality 3D Medical Image Registration in Clifford Algebra Space HUA Liang1，2，HUANG Yu1，DING Lijun1，2，FENG Hao1，GU Juping2
( 1. College of Information Engineering, Zhejiang University of Technology, Hangzhou 310023, China;
2. School of Electrical Engineering, Nantong University, Nantong 226019, Zhejiang Province, China )
Abstract: 3D/3D medical image registration has important clinical significances and medical value, especially to the operation navigation and lesion location in brain surgery, the different modal 3D image data of patients need to be registered so that the medical characteristics of target tissue can be analyzed more completely and accurately. On the basis that classical registration methods are researched, the classical registration methods are embedded in Clifford algebra space, and the Geometric elements during registration calculating and the translation operator Geometric rotation operator during registration operation are built in Clifford algebra space. Then the floating image is operated with corresponding operator to achieve multimodality 3D medical image registration in head and skull. This registration method is applied to two famous 3D medical data base in the world. The experimental result indicates that this method not only inherits the advantage of classical registration methods, but also has high registration precision and intuitive geometric meaning, reducing the computing time.
Key words: Clifford algebra; multimodality medical image; 3D registration; rotation operator
0 引 言
随着生物影像技术的不断发展，医学图像的配准技术在临床上越来越显示出它的应用价值与临床意义，经近几十年的发展，医学图像配准技术有了长足的发展[1-2]，并且由起初的2D/2D平面图像的配准逐渐延
收稿日期：2013-08-15；收到修改稿日期：2013-10-14
基金项目：国家自然科学基金(61273024)；江苏省自然科学基金青年基金(KB2012227)；浙江省重中之重学科信息处理与自动化技术开放基金项目(20120816)；宁波市自然科学基金(2012A610050)资助
作者简介：华亮(1979-)，男(汉族)，江苏南通人。副教授，博士研究生，主要研究工作是医学图形图像处理，模式识别等。
通信作者：丁立军(1979-)，男(汉族)，浙江绍兴人。博士研究生，主要研究工作是医学图形图像处理，模式识别。E-mail:dljun2009@https://www.doczj.com/doc/d712250630.html,。
https://www.doczj.com/doc/d712250630.html,