Sildenafil_139755-83-2_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening

Safety Data SheetRevision Date:May-24-2017Print Date:May-24-2017

1. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Vardenafil (hydrochloride)

Catalog No. :HY-B0442A

CAS No. :224785-91-51.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USA

Tel:609-228-6898

Fax:609-228-5909

E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-6898

2. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.

Product Name:Lu AE58054 Hydrochloride

CAS No.: 467458-02-2

Cat. No.:HY-14338AProduct Data Sheet

MWt:434.83

Formula:C20H20ClF5N2O

Purity :>98%

Solubility:DMSO 11 mg/mL; Water <1 mg/mL

Mechanisms:

Biological Activity:

LuAE58054hydrochlorideisanin-vitropotencyandselectivityin-vivobindingaffinityandeffectof Pathways:GPCR/G protein; Target:5-HT Receptor

Pathways:Neuronal Signaling; Target:5-HT Receptor

Lu AE58054 hydrochloride is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM.

IC50 Value: 0.83 nm[1]

Target: 5-HT(6)R

in vitro: Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of

0.83 nm. In a 5-HT(6) GTPgammaS efficacy assay Lu AE58054 showed no agonist activity, but

demonstrated potent inhibition of 5-HT-mediated activation. Besides medium affinity to adrenergic

Product Name:E-7050

CAS No.: 928037-13-2

Cat. No.:HY-13068Product Data Sheet

MWt:633.69

Formula:C33H37F2N7O4

Purity :>98%

Solubility:

DMSOy

Mechanisms:

Biological Activity:

E7050(Golvatinib)isadualcMetandVEGFR2inhibitorwithIC50of14nMand16nM Pathways:Protein Tyrosine Kinase/RTK; Target:c-Met/HGFR

Pathways:Protein Tyrosine Kinase/RTK; Target:VEGFR

E7050(Golvatinib) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM.

IC50 value: 14/16 nM (c-Met/VEGFR2) [1]

Target: c-Met/VEGFR2

in vitro: In vitro studies indicate that E7050 potently inhibits phosphorylation of both c-Met and

VEGFR-2. E7050 also potently represses the growth of both c-met amplified tumor cells and

endothelial cells stimulated with either HGF or VEGF [1]. E7050 circumvents resistance to all of the

reversible, irreversible, and mutant-selective EGFR-TKIs induced by exogenous and/or endogenous

PdtDtSh

t

Product Name:Silodosin

CAS No.: 160970-54-7

Cat. No.:HY-10122Product Data Sheet

MWt:495.53

Formula:C25H32F3N3O4

Purity :>98%

Solubility:DMSO 100 mg/mL; Water <1

Mechanisms:

Biological Activity:

Silodosin (Rapaflo; KMD-3213) is an α1-adrenoceptor antagonist with high uroselectivity; In Pathways:GPCR/G protein; Target:Adrenergic Receptor

mg/mL

()ggy treatment of dysuria.

IC50 Value:

Target: Adrenergic Receptor

in vitro: Silodosin potently inhibited 2-[2-(4-hydroxy-3-[125I]iodophenyl)ethylaminomethyl]-alpha-

tetralone binding to the cloned human alpha 1a-AR, with a Ki value of 0.036 nM, but had 583- and

56-fold lower potency at the alpha 1b- and alpha 1d-ARs, respectively. Silodosin inhibited

norepinephrine-induced increases in intracellular Ca2+ concentrations in alpha 1a-AR-expressing

Chinese hamster ovary cells with an IC50 of 0.32 nM but had a much weaker inhibitory effect on thelh1bdlh1dAR