药物投递系统.pptx
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【 Diffusion controlled】
Diffusion through membrane or bulk polymer
【 Chemically controlled】
˙ polymer erosion： surface erosion, bulk erosion ( combination of erosion and diffusion )
2.Chemically controlled
˙ pendent chain △ drug is covalently bound to the polymer and is released by
bond scission owing to water or enzymes
3. Solvent-activated controlled
Desired Range
Therapeutic Dose
藥物釋控系統
1.何謂藥物釋控 2.發展釋控的優點 3.藥物釋控的種類
A. Diffusion controlled B. Chemically controlled C. Solvent-activated controlled
Types of Controlled Release Devices
Drug Delivery System 藥物投遞系統
生科系04級 黃玫璇 891672 生科系04級 許哲源 891659 生科系04級 蕭宏展 891631 生科系04級 楊淳竣 891625
藥物投遞系統
(Drug Delivery System)
【必要時將必要限度藥物對必要部位之供應】
2. 市場分析
3. arget)
傳輸 (Transport)
控釋 (Controlled Release)
藥物釋控系統
黃玫璇 891672
藥物釋控系統
1.何謂藥物釋控 2.發展釋控的優點 3.藥物釋控的種類
A. Diffusion controlled B. Chemically controlled C. Solvent-activated controlled
effects 3. improved patient compliance 4. protection from degradation for drugs with short in vivo lifetimes.
Controlled Release vs. Single Dose
Side Effects
2.Chemically controlled
˙ erosion： Surface erosion, Bulk erosion
△ capsule is eroded by the acids in the stomach △ advantage
˙ inject able (micro spheres) ˙ biodegradable (need not be removed surgically) △ disadvantage ˙ difficult to stop once injected
△ the active agent is dissolved or dispersed within a polymeric matrix and is not able to diffuse through that matrix.
△ advantage ˙ complex control
藥物釋控系統
1.何謂藥物釋控 2.發展釋控的優點 3.藥物釋控的種類
A. Diffusion controlled B. Chemically controlled C. Solvent-activated controlled
【藥物釋控】：Drug Controlled Release System
˙ pendent chain
【 Solvent-activated controlled】
˙ osmotic transport of water through semi permeable membrane ˙ water penetration into glassy polymer
1.Diffusion controlled
△advantage ˙ drug diffuses out of matrix at defined rate
△disadvantage ˙ efficiency of diffusion of large molecules ˙ danger of ‘dose dumping’ in barrier systems
將藥物以特殊的化學包覆，讓藥物在某一種狀態(如PH值改變)下 適時(ex:延長)適量釋出。
這種控釋劑型的技術發展，目前廣泛地應用於一般的製藥化學工 業中。
藥物釋控系統
1.何謂藥物釋控 2.發展釋控的優點 3.藥物釋控的種類
A. Diffusion controlled B. Chemically controlled C. Solvent-activated controlled
【 Stomach/Intestine – Liquid】 【 Capsule edge – Gel 】
– Biocompatible polymer
【 Capsule center – Dry 】
– Allows for delayed release
△ release rates are determined by polymer property and partition coefficient of the drug to be released.
Potential Advantages of Controlled Release Systems
1. maintenance of drugs at therapeutically desirable levels 2. the ability to localize drugs to target organs to minimize systemic
Diffusion through membrane or bulk polymer
【 Chemically controlled】
˙ polymer erosion： surface erosion, bulk erosion ( combination of erosion and diffusion )
2.Chemically controlled
˙ pendent chain △ drug is covalently bound to the polymer and is released by
bond scission owing to water or enzymes
3. Solvent-activated controlled
Desired Range
Therapeutic Dose
藥物釋控系統
1.何謂藥物釋控 2.發展釋控的優點 3.藥物釋控的種類
A. Diffusion controlled B. Chemically controlled C. Solvent-activated controlled
Types of Controlled Release Devices
Drug Delivery System 藥物投遞系統
生科系04級 黃玫璇 891672 生科系04級 許哲源 891659 生科系04級 蕭宏展 891631 生科系04級 楊淳竣 891625
藥物投遞系統
(Drug Delivery System)
【必要時將必要限度藥物對必要部位之供應】
2. 市場分析
3. arget)
傳輸 (Transport)
控釋 (Controlled Release)
藥物釋控系統
黃玫璇 891672
藥物釋控系統
1.何謂藥物釋控 2.發展釋控的優點 3.藥物釋控的種類
A. Diffusion controlled B. Chemically controlled C. Solvent-activated controlled
effects 3. improved patient compliance 4. protection from degradation for drugs with short in vivo lifetimes.
Controlled Release vs. Single Dose
Side Effects
2.Chemically controlled
˙ erosion： Surface erosion, Bulk erosion
△ capsule is eroded by the acids in the stomach △ advantage
˙ inject able (micro spheres) ˙ biodegradable (need not be removed surgically) △ disadvantage ˙ difficult to stop once injected
△ the active agent is dissolved or dispersed within a polymeric matrix and is not able to diffuse through that matrix.
△ advantage ˙ complex control
藥物釋控系統
1.何謂藥物釋控 2.發展釋控的優點 3.藥物釋控的種類
A. Diffusion controlled B. Chemically controlled C. Solvent-activated controlled
【藥物釋控】：Drug Controlled Release System
˙ pendent chain
【 Solvent-activated controlled】
˙ osmotic transport of water through semi permeable membrane ˙ water penetration into glassy polymer
1.Diffusion controlled
△advantage ˙ drug diffuses out of matrix at defined rate
△disadvantage ˙ efficiency of diffusion of large molecules ˙ danger of ‘dose dumping’ in barrier systems
將藥物以特殊的化學包覆，讓藥物在某一種狀態(如PH值改變)下 適時(ex:延長)適量釋出。
這種控釋劑型的技術發展，目前廣泛地應用於一般的製藥化學工 業中。
藥物釋控系統
1.何謂藥物釋控 2.發展釋控的優點 3.藥物釋控的種類
A. Diffusion controlled B. Chemically controlled C. Solvent-activated controlled
【 Stomach/Intestine – Liquid】 【 Capsule edge – Gel 】
– Biocompatible polymer
【 Capsule center – Dry 】
– Allows for delayed release
△ release rates are determined by polymer property and partition coefficient of the drug to be released.
Potential Advantages of Controlled Release Systems
1. maintenance of drugs at therapeutically desirable levels 2. the ability to localize drugs to target organs to minimize systemic