Roche-Tiberal

L ife wr i t e s t he q u e st ion sW e p ursu e t he a n sw e rsL ife wr i t e s t he q u e st ion s. R o c he W e I nno v a t e H e a l t h ca r e1W h a t w ill help me?Ca n I h a v e hope?H o w ba d ca n i t ge t?H o w m a n y su mme rs h a v e I go t lef t?S ho u ld Ifigh t?H o w m u c h longe r?W ho ca n t ell me if I’m doing t he r igh t t hing?I s t he r e a s ol ut ion?W hen i t c ome s t o di s e a s e t he r e a r e a s m a n y q u e st ion s a s people. W e ca n’t p r o v ide a n a n sw e r t o t hem a ll–b ut w e ca n help w i t h o ur e x pe rt i s e.I nno v a t ion i s o ur a n sw e r t o medi ca l c h a llenge s.O ur d a il y w o r k i s s a v ing p a t ien ts’li v e s a nd helping million s of people a r o u nd t he w o r ld.W e c on t in u-o us l y in v e st in medi ca l r e s e a r c h a nd de v elopmen t t o p r o v ide ne w d ru g sa nd di a gno st i c p r od u c ts fo r c ondi-t ion s su c h a s ca n c e r,AIDS,hep a t i t i s, A l z heime r’s di s e a s e,r he u m a t oida rt h r i t i s a nd di ab e t e s.F o r mo r e t h a n 110y e a rs R o c he h a s pl a y ed a pio-nee r ing r ole in he a l t h ca r e.T od a y ,a s w o r ld le a de r in in-v i tr o di a gno st i c s ,w e su ppl y a w ide r a nge of di a g-no st i c in stru men ts a nd t e sts fo r r a pid a nd r eli ab le di s e a s e de t e c t ion a nd moni t o r ing b y do c t o rs ,l ab o r a -t o r ie s o r p a t ien ts t hem s el v e s .I n t he t he r a pe ut i c field ,R o c he h a s b r o u gh t m a n y highl y effe c t i v e d ru g s on t o t he m a r ke t in t he l a st fe w y e a rs .O ur d a il y w o r k fo c us e s on di s e a s e a r e a s w he r e medi ca l need s a r e g r e a t .T he s e in c l u de ca n c e rs ,v i r a l infe c t ion s ,me t a -b oli c a nd c en tr a l ne rv o us syst em di s o r de rs a nd infla mm a t o ry di s e a s e s .R o c he i s t he w o r ld’s le a ding su pplie r of p r e s c r ip t ion d ru g s fo r ca n c e r tr e a t men t .R o c he in v e sts he a v il y in t he r e s e a r c h a nd de v elop-men t of ne w d ru g s a nd di a gno st i c p r od u c ts a nd c omplemen ts i ts o w n w o r ld w ide r e s e a r c h ac t i v i t ie s w i t h a w e a l t h of c oope r a t ion a g r eemen ts w i t h u ni-v e rs i t ie s ,r e s e a r c h in st i tut e s a nd b io t e c h c omp a nie s .T hi s ne tw o r k a nd o ur m a jo r i ty st a ke s inG enen t e c h in t he USA a nd C h u g a i in Ja p a n p r o v ide us w i t h b r o a d acc e ss t o inno v a t ion.A s t he w o r ld’s l a r ge st b io t e c h c omp a n y ,w e e x ploi t t he l a t e st di s c o v e r ie s a nd t e c hnologie s t o de v elop o ur p r od u c ts .T oge t he r w i t h o ur p a rt ne rs w e tur n t he m u l t ipli c i ty of ide a s in t o medi ca l s ol ut ion s .T he r a pid p r og r e ss in r e s e a r c h gi v e s us impo rt a n t in s igh ts in t o t he mole c u l a r me c h a ni s m s of di s e a s e.W e a l s o kno w t h a t tw o people ca n r e ac t diffe r en t l y t o t he s a me medi ca t ion a nd t h a t t hi s i s ba s ed on v a r i a t ion s in o ur gene s .P e rs on a li s ed medi c ine t a ke s t he s e ne w di s c o v e r ie s in t o acc o u n t in t he de v elop-men t of d ru g s a nd di a gno st i c t e sts .R o c he pl a ys a pionee r ing r ole in t hi s a r e a a nd i s a l r e a d y m a r ke t ing t he first pe rs on a li s ed medi c in a l p r od u c ts t h a t a r e t a ilo r ed t o t he need s of s pe c ific p a t ien t g r o u p s .F o c us on u n s ol v ed medi ca l p r o b lem sP e rs on a li s ed medi c ine –a n in t e r pl a y of di a gno s i s a nd tr e a t men tW e di s c o v e r ,de v elop a nd deli v e r inno v a t i v e di a gno st i c a nd t he r a pe ut i c p r od u c ts a nd s e rv i c e s t h a t tr a n s fo r mp a t ien ts ’li v e s a nd b r ing r e a l b enefits –f r om e a r l y de t e c t ion a nd p r e v en t ion of di s e a s e s t o di a gno s i s ,tr e a t men t a nd tr e a t men t moni t o r ing.B r o a d acc e ss t o inno v a t ionR o c hein a n uts hellUS $in v e st men t ho urs of w o r k e x pe r imen ts r e s e a r c he rs d ru gCa n c e r i s no t a s ingle ,st a t i c di s e a s e.I t i s a c omple x c ondi t ion of w hi c h o v e r 250ty pe s h a v e b een iden t ified s o f a r .I ts de v elopmen t in v ol v e s a m u l t i tu de of c h a nge s in t he a ffe c t ed c ell s ,a nd t hi s m a ke s i t diffic u l t t o figh t .W o r ld le a de r in inno v a t i v e ca n c e r d ru g sR o c he c urr en t l y h a s a n u m b e r of inno v a t i v e ca n c e r d ru g s on t he m a r ke t .T he y gi v e p a t ien ts t he mo st impo rt a n t t hing in life :t ime t o li v e.F i v e of t he s e d ru g s –H e r c ep t in ,A v a st in ,MabT he r a /R i tux a n ,X elod a a nd Ta r c e v a –offe r c le a r surv i v a l b enefits in diffe r en t ty pe s of ca n c e r a nd e ac h h a s i ts o w n u niq u e me c h a ni s m of ac t ion t h a t h a l ts tu mo ur g r o wt h.I n a ddi t ion t o t he s e p r od u c ts ,w e su ppl y a v a r ie ty of t he r a pie s t h a t help t o e a s e t he po ss i b le s ide effe c ts a ss o c i a t ed w i t h ca n c e r tr e a t men t .Ca n c e r r em a in s t he s e c ond le a ding ca us e of de a t h in t he ind ustr i a li s ed w o r ld a nd i ts in c iden c e i s g r o w ing.B ut if de t e c t ed e a r l y eno u gh ,m a n y fo r m s of t he di s e a s e ca n b e effe c t i v el y tr e a t ed.1,000,000,0007,000,87465874231P r e c i s e di a gno s i s –t he ke y t o su cc e ss f u l tr e a t men tP r e c i s e di a gno s i s i s t he ke y t o su cc e ss f u l tr e a t men t .B iom a r ke rs ,i.e.c omponen ts of o ur b od y c ell s t h a t ca n b e us ed a s indi ca t o rs fo r t he di s e a s e ,w ill en ab le do c t o rs t o de t e r mine w hi c h ca n c e r ty pe a p a t ien t h a s m u c h mo r e q u i c kl y a nd s pe c ifica ll y .W e a r e a l s o w o r king t o iden t if y tu mo ur m a r ke rs t h a t w ill de t e c t tu mo ur c ell s long b efo r e t he first sy mp t om s b e c ome a pp a r en t .T hi s info r m a t ion w ill help ph ys i c i a n s t o ini-t i a t e t a r ge t ed a nd effe c t i v e tr e a t men t w i t ho ut del a y ,t he r e b y enh a n c ing p a t ien t w ell-b eing a nd de c r e a s ing t he c o st t o t he he a l t h ca r e syst em.R o c he s e a r c he s fo r po t en t i a l c ur e sO ur u nde rst a nding of t he mole c u l a r me c h a ni s m s of tu mo ur de v elopmen t a nd ho w tu mo urs s p r e a d h a s c on t in u a ll y imp r o v ed.T hi s help s o ur s c ien t i sts t o t a r -ge t t he p r o c e ss e s t h a t le a d t o ca n c e r .T hi s i s a n a r e a w he r e b ioph a r m ac e ut i ca l s ,a nd e s pe c i a ll y highl y s pe c ific a n t i b odie s ,pl a y a n impo rt a n t r ole.O ur go a l i s t o us e mode r n t e c hnologie s t o m a ke t he s e b io-ph a r m ac e ut i ca l s e v en mo r e effe c t i v e in t he f utur e.F ig ur e s a r e a pp r o x im a t e.V i r a l di s e a s e s a r e a n in s idio us a nd s e r io us he a l t h h a z a r d.V i rus e s a r e of t en no t de t e c t ed e a r l y eno u gh ,w hi c h a llo ws t hem t o s p r e a d u n c on tr olled.T hei r infini t e a d a p t ab ili ty a l s o m a ke s t hem h a r d t o t a r ge t a nd tr a p.N e w me c h a ni s m s of ac t ion help t ho s e li v ing w i t h HIV /AIDSHIV /AIDS r em a in s in c ur ab le.B ut de a t h s f r om AIDS h a v e de c lined d r a m a t i ca ll y in r e c en t y e a rs .T hi s i s d u e in no s m a ll p a rt t o mode r n mole c u l a r di a gno st i c s w ho s e ca p ac i ty fo r r a pid ,r eli ab le a nd r o ut ine de t e c -t ion a nd moni t o r ing of t he v i rus a nd v i rus r e s i st a n c e en ab le s p a t ien ts ’tr e a t men t t o b e a dj ust ed acc o r d-ingl y .W e a r e p r o u d t o h a v e de v eloped tw o en t i r el y ne w c l a ss e s of effe c t i v e d ru g s t h a t r ep r e s en t m a jo r b r e a k t h r o u gh s fo r HIV tr e a t men t a nd p a t ien ts .R o c he r e s pond s t o glo ba l c h a llenge sT he w o r ld’s poo r e st c o u n tr ie s h a v e acc e ss t o o ur v i r olog y p r od u c ts .B y a dop t ing a c om b in a t ion oft ie r ed p r i c ing ,a fle x i b le p a t en t poli c y a nd t e c hnolog y tr a n s fe r ini t i a t i v e s ,w e’r e m a king i t e a s ie r fo r t hem t o a dd r e ss t hei r he a l t h ca r e c h a llenge s .W e’r e w o r king in p a rt ne rs hip w i t h t he W o r ld H e a l t h O r g a ni z a t ion (WHO ),c ommi tt ed go v e r nmen ts ,non-go v e r nmen t a l o r g a ni s a t ion s a nd o t he r st a keholde rs t o de v elop s o-l ut ion s t h a t b enefit t he le a st de v eloped c o u n tr ie s .F l u i s a r e a l c h a llenge t o o ur imm u ne syst em E v e ry y e a r flu v i rus e s a tt ac k t he imm u ne syst em s of 100million people in E ur ope ,Ja p a n a nd t he USA a lone ,a nd u p t o 500,000people die e ac h y e a r w o r ld-w ide.B y c h a nging t hei r p r ofile s ligh t l y e v e ry y e a r ,t he y m a ke i t diffic u l t fo r o ur imm u ne syst em t o figh t t hem off.I n a join t p r oje c t ,R o c he a ndG ile a d de v el-oped Ta miflu ,a d ru g t h a t a tt ac k s t he flu v i rus a nd i s no w us ed t h r o u gho ut t he w o r ld fo r t he tr e a t men t a nd p r e v en t ion of influ en z a .Ea r l y de t e c t ion of hep a t i t i s in c r e a s e s t he likelihood of c ur eH ep a t i t i s i s a v i r a l infe c t ion t h a t ca n go u nde t e c t ed in t he b od y fo r y e a rs .L ef t u n tr e a t ed ,i t ca n le a d t o c i rr ho s i s ,li v e r f a il ur e a nd ca n c e r .D e t e c t ion a nd tr e a t men t a r e e ss en t i a l in t he e a r l y st a ge s w hen t he likelihood of c ur e i s r el a t i v el y high.T e sts t h a t di a g-no s e a nd moni t o r t he v i rus in t he b lood a nd tr e a t men t w i t h o ur b io t e c h d ru g P eg a sys h a v e helped m a n y of t he people w ho h a v e b een infe c t ed.U nfo rtu n a t el y ,no t a ll p a t ien ts r e s pond eq u a ll y w ell t o t hi s tr e a t men t .T h a t ’s w h y w e’r e w o r king in t en s i v el y on ne w str a t e-gie s t o p r o v ide effe c t i v e tr e a t men t t o mo r e p a t ien ts .F l u ,hep a t i t i s a nd HIV /AIDS a r e s ome of t he mo st w ide s p r e a d v i r a l infe c t ion s .O n c e u pon a t ime ,onl y t empe r a tur e s w e r e t a ken t o gi v e a n indi ca t ion of illne ss .T od a y ’s mole c u l a r medi c ine offe rs ne w di a gno st i c t e c hniq u e s a nd tr e a t men ts t o r elie v e su ffe r ing ,limi t ne w infe c t ion s a nd r ed u c e mo rt a li ty .T he r e v ol ut ionin o ur di a gno st i c in stru men tsR eg u l a t ion of o ur b od y ’s b lood su g a r le v el i s a v i t a l y e t deli ca t e ba l a n c e ,w hi c h ca n e a s il y b e di sru p t ed.T he r e su l t i s di ab e t e s .T he WHO e st im a t e s t h a t mo r e t h a n 180million people w o r ld w ide su ffe r f r om di ab e t e s .T y pe 2di ab e t e s –t he c ommone st fo r m of t he di s e a s e –i s no w r e c ogni s ed glo ba ll y a s a g r o w ing epidemi c .D i ab e t e s p r e v en t ion in A f r i caT he n u m b e r of people w i t h ty pe 2di ab e t e s a ppe a rs t o b e in c r e a s ing s ignifica n t l y in rur a l S o ut h A f r i ca .T he P helophep a tr a in ,a S o ut h A f r i ca n c omm u ni ty he a l t h c lini c on r a il s w hi c h R o c he h a s s pon s o r ed s in c e i ts in c ep t ion ,help s people t o p r e v en t t he on s e t of di ab e t e s a nd t o r e c ogni s e i ts sy mp t om s .T he tr a in b r ing s p r im a ry he a l t h ca r e s e rv i c e s ,gene r a l medi ca l ca r e a nd he a l t h ed u ca t ion p r og r a mme s t o rur a l a r e a s .R o c he’s c ommi t men t t o P helophep a e x empli-fie s o ur philo s oph y of c oll ab o r a t i v e a nd sust a in ab le c o r po r a t e don a t ion s .W e b elie v e in su ppo rt ing no v el ,p r ac t i ca l s ol ut ion s t h a t a r e t a ilo r ed t o lo ca l c ondi-t ion s a nd need s a nd t h a t ca n b e implemen t ed in c onj u n c t ion w i t h c ommi tt ed lo ca l p a rt ne rs .I ndependen c e fo r people w i t h di ab e t e sD i ab e t e s i s n’t a di s e a s e y o u ca n ne c e ss a r il y feel –t o de t e c t i t a nd keep i t u nde r c on tr ol ,t he r e’s no su b st i tut e fo r r eg u l a r l y c he c king y o ur b lood su g a r le v el s .T e st ing t a ke s j ust a s ingle d r op of b lood a nd a fe w min ut e s .W e offe r a w ide r a nge of p r od u c ts t h a t m a ke i t e a sy fo r people w i t h di ab e t e s t o c he c k t hei r b lood su g a r le v el s c on s i st en t l y in d a y -t o-d a y s i tu a t ion s .R o c he –t he le a de r in di ab e t e s ca r eF o r o v e r 30y e a rs o ur Acc u -C hek b lood gl u c o s e me t e rs h a v e en sur ed p r e c i s e a nd r a pid b lood su g a r me a sur emen t b o t h a t home a nd on t he mo v e.N o t onl y t h a t ,t he y h a v e b e c ome in c r e a s ingl y e a sy t o ope r a t e.S t a t e-of-t he-a rt me a sur emen t ,inf us ion a nd d a t a p r o c e ss ing syst em s help do c t o rs a nd p a t ien ts t o implemen t c omp r ehen s i v e di ab e t e s m a n a gemen t a nd hen c e op t imi s e tr e a t men t .R eg u l a r b lood su g a r moni t o r ing gi v e s people w i t h di ab e t e s a m a jo r a d v a n-t a ge ,en ab ling t hem t o lo w e r t he r i s k of po t en t i a ll y life-t h r e a t ening c ompli ca t ion s .N e w r e s e a r c h str a t egie s fo c us on me t ab oli s m R e s e a r c hing ne w d ru g s a g a in st di ab e t e s me a n s t a king a p a t ien t ’s me t ab oli s m in t o acc o u n t .R e c og-ni s ing t h a t o b e s i ty ,lipid me t ab oli s m di s o r de rs a nd high b lood p r e ssur e a r e c lo s el y a ss o c i a t ed w i t h di ab e t e s ,R o c he i s t e st ing v a r io us c ompo u nd s t h a t ac t a t ke y me t ab oli c in t e r f ac e s .A t t he s a me t ime w e’r e us ing a ne w c omp r ehen s i v e a pp r o ac h ca lled syst em s b iolog y t o r e s e a r c h t he c en tr a l r ole pl a y ed b y t he b od y ’s in su lin-p r od u c ing c ell s .D i ab e t e s i s a c omple x c h r oni c di s e a s e.B ut i t ca n b e c on tr olled t h r o u gh a c om b in a t ion of t he r igh t life sty le ,good he a l t h m a n a gemen t a nd ne w tr e a t men t str a t egie s .T he c o r e c omponen t in c on tr olling di ab e t e s i s ca r ef u l b lood su g a r moni t o r ing.T hi s d r opca n s a v e li v e sR he u m a t oid a rt h r i t i s i s one of t he mo st c ommon a ut oimm u ne di s e a s e s ,a ffe c t ing mo r e t h a n 21million people w o r ld w ide.I n 30–40%of ca s e s c on v en t ion a l d ru g s a r e ineffe c t i v e o r poo r l y t ole r a t ed.N o w ,b ioph a r m ac e ut i ca l s a r e p a v ing t he w a y fo r a ne w tr e a t men t t h a t ca n impede p r og r e ss ion of t he di s e a s e a nd p r e v en t join t d a m a ge a nd p a in.I n t en s i v e c oll ab o r a t ion w i t h p a t ien t o r g a ni s a t ion sI t i s impo rt a n t t o us t o g a in a g r e a t e r u nde rst a nding of w h a t i t i s like t o li v e w i t h t hi s a nd o t he r di s e a s e s ,a nd t o c omp r ehend t he c h a llenge s f ac ing p a t ien ts a nd t hei r f a milie s .T h a t ’s w h y w e c oll ab o r a t e c lo s el y w i t h diffe r en t p a t ien t o r g a ni s a t ion s –t o g a in kno w -ledge ,fo r e x a mple ,ab o ut di s e a s e-r el a t ed p r o b lem s o r t he us e r -f r iendline ss of d ru g s w hi c h onl y t he y ca n su ppl y .T hi s c oope r a t ion a l s o en ab le s R o c he t o g a t he r e x pe r ien c e t h a t i s c h a nnelled in t o su ppo rt fo r do c t o rs a nd n urs ing st a ff ,a nd in t hi s w a y b ene-fits p a t ien ts .R o c he goe s t o t he r oo t of t he di s e a s eO ur r e s e a r c he rs a r e looking t o deepen t hei r u nde r -st a nding of t he imm u ne syst em a nd pinpoin t t he ca us e s a nd c o urs e of a rt h r i t i s .T hei r di s c o v e r ie s h a v e a l r e a d y r e su l t ed in ne w d ru g s offe r ing r e a l p a t ien t b enefits .B ioph a r m ac e ut i ca l s su c h a s MabT he r a /R i tux a n in r he u m a t oid a rt h r i t i s s ele c t i v el y in t e rv ene in t he mole c u l a r c o urs e of t he di s e a s e w i t ho ut w e a k-ening t he imm u ne syst em a s a w hole.T hi s ne w me c h a ni s m of ac t ion a lle v i a t e s p a in a nd hold s t he di s e a s e in c he c k.T he e a r lie r t he di a gno s i s ,t he b e tt e rC urr en t l y do c t o rs r el y on a c on st ell a t ion of s ign s a nd sy mp t om s t o m a ke a fir m di a gno s i s of r he u m a -t oid a rt h r i t i s .B y t h a t t ime m a n y p a t ien ts a r e a l r e a d y di s ab led b y t hei r d a m a ged join ts .O ur go a l i s e a r lie r de t e c t ion us ing a r eli ab le di s e a s e indi ca t o r in t he fo r m of a b iom a r ke r in c o r po r a t ed in a di a gno st i c t e st .O nl y t hen w ill do c t o rs b e ab le t o in t e rv ene e a r l y eno u gh t o p r e v en t join t d a m a ge a nd di s ab ili ty .W e s pe a k of a n a ut oimm u ne di s e a s e w hen t he b od y tur n s on i ts elf a nd t he imm u ne syst em mi st a ke s “s elf”fo r “non-s elf”.I nno v a t i v e b ioph a r m ac e ut i ca l s offe r a defen c e a g a in st t hi s a ut oimm u ne a tt ac k.O ur c on tr i b ut iont o enh a n c ing q u a li ty of lifeC en tr a l ne rv o us syst em di s o r de rs a r e a mong t he w o r ld’s g r e a t e st u n r e s ol v ed he a l t h p r o b lem s ,a nd A l z heime r ’s di s e a s e i s one of t he b igge st t h r e a ts f ac ing a ging ind ustr i a l s o c ie t ie s .T he r e i s c urr en t l y no p r o s pe c t of a c ur e fo r A l z heime r ’s ,onl y t he po ss i b ili ty of s lo w ing i ts p r og r e ss ion.R e s pon s i b le ac t ionR e s e a r c h en t a il s r e s pon s i b ili ty .T h a t ’s w h y w e’v e a l w a ys a pplied t he highe st e t hi ca l st a nd a r d s in r e-s e a r c h a nd de v elopmen t ,r efle c t ed fo r e x a mple in o ur g u ideline s go v e r ning gene t i c r e s e a r c h o r c lini ca l tr i a l s .B efo r e a d ru g c ome s t o m a r ke t a r eg u l a t o ry a ut ho r i ty m ust a pp r o v e i t .T hi s a pp r o v a l p r o c e ss in-c l u de s p r e-c lini ca l l ab o r a t o ry a nd a nim a l stu die s ,a s w ell a s c lini ca l tr i a l s t o demon str a t e t he s a fe ty a nd efficac y of t he d ru g.W e b elie v e t h a t w e h a v e a n e t hi-ca l o b lig a t ion t o info r m t he p u b li c ab o ut o ur c lini ca l tr i a l s a nd t hei r r e su l ts s o t h a t t hi s info r m a t ion ca n b e helpf u l t o p a t ien ts a nd ph ys i c i a n s .F igh t ing fo r ge t f u lne ss w i t h t he r a pe ut i c a n t i b odie sW e’r e t hinking o uts ide t he b o x t o a tt ac k t he di s -e a s e a t i ts r oo t .W e’r e r e s e a r c hing v a r io us str a t egie s fo r di ss ol v ing t he b r a in depo s i ts ,kno w n a s pl a q u e s ,t h a t a r e c h a r ac t e r i st i c of A l z heime r ’s di s e a s e.O ne p r omi s ing a pp r o ac h ,iden t ified in c oll ab o r a t ion w i t h a p a rt ne r ,i s ba s ed on a h u m a n t he r a pe ut i c a n t i b od y t h a t i s c ust om-de s igned fo r t hi s p ur po s e.Pa t ien ts w ill b enefit b e ca us e r emo v a l of t he depo s i ts h a s b een linked t o imp r o v ed c ogni t i v e f u n c t ioning.N e w pe rs pe c t i v e s fo r s c hi z oph r eni a p a t ien ts Y e a rs of r e s e a r c h on t he c en tr a l ne rv o us syst em i s le a ding us in ne w di r e c t ion s a nd t o w a r d s inno v a t i v e a pp r o ac he s t o t he tr e a t men t of s c hi z oph r eni a .W e h a v e di s c o v e r ed c ompo u nd s t h a t diffe r in t hei r me c h-a ni s m of ac t ion f r om t he c l a ss i ca l a n t ip sy c ho t i c s c urr en t l y us ed t o tr e a t s c hi z oph r eni a .T hi s m a y b r ing f r e s h hope t o p a t ien ts w i t h p sy c hi a tr i c di s o r de rs .D e v eloping effe c t i v e d ru g s fo r di s e a s e s su c h a s A l z heime r ’s ,s c hi z oph r eni a o r dep r e ss ion i s a m a jo r c h a llenge.N e v e rt hele ss ,r e s e a r c h in t he s e a r e a s h a s p r og r e ss ed eno r mo us l y in t he l a st fe w de ca de s .T he mo st effe c t i v e d ru gw hen i t c ome s t o t he b r a inO ur a im i s t o c on t in u e t a ilo r ing medi c ine a s c lo s el y a s po ss i b le t o p a t ien ts ’need s .A s one of t he w o r ld’s le a ding he a l t h ca r ec omp a nie s ,a nd gi v en o ur c om b ined str eng t h s in ph a r m ace ut i ca l s a nd di a gno st i c s ,t he r e’s no one b e tt e r su i t ed fo r t he t a s k of de v el-oping pe rs on a li s ed medi c ine.M edi c ine i s b e c oming in c r e a s ingl y pe rs on a li s ed O v e r t he l a st fe w y e a rs R o c he h a s gi v en v a r io us e x a mple s in t he field s of ca n c e r tr e a t men t a nd v i r a l di s e a s e s of ho w t he in t e rw e a v ing of di a gno st i c a nd ph a r m ac e ut i ca l e x pe rt i s e p a v e s t he w a y fo r pe rs on-a li s ed medi c ine.O ur a im i s t o p r o v ide he a l t h ca r e p r ofe ss ion a l s w i t h mo r e po w e r f u l di a gno st i c t ool s a nd t a r ge t ed tr e a t men ts ba s ed on t he ne w in s igh ts in t o ho w di s e a s e s a r i s e a t t he mole c u l a r le v el.S e tt ing o ur s igh ts on t he f utur eW e’r e c on v in c ed t h a t onl y inno v a t ion ca n m a in t a in t he r eq u i s i t e q u a li ty of he a l t h ca r e o v e r t he long t e r m.I nno v a t ion i s t he c o r e of o ur str a t eg y a nd t he ke y t o s a fe r ,mo r e c o st -effe c t i v e a nd mo r e people-f r iendl y medi c ine s .P eople a r e diffe r en t a nd s o a r e di s e a s e sI ndi v id u a l s r e ac t diffe r en t l y t o s pe c ific medi ca t ion s d u e t o t he v a r i a t ion s in t hei r gene s .M o r eo v e r ,m a n y di s e a s e s o cc ur in gene t i ca ll y di st in c t su b ty pe s t h a t v a ry in t hei r c lini ca l c o urs e a nd p r ogno s i s .T h us ,tw o p a t ien ts w ho s eemingl y h a v e t he s a me di s e a s e a nd a r e tr e a t ed w i t h t he s a me medi c ine m a y r e s pond in r a di ca ll y diffe r en t w a ys .O ne m a y b enefit f u ll y f r om tr e a t men t ,w hile t he o t he r e x pe r ien c e s u n w a n t ed s ide effe c ts o r de r i v e s no c lini ca l b enefit a t a ll.Va r i a t ion s in o ur gene sH o w w ell c e rt a in d ru g s w o r k depend s in m a n y ca s e s on s pe c ific gene v a r i a t ion s in p a t ien ts .A mode r n DNA c hip (A mpli C hip CYP 450t e st )en ab le s do c t o rs t o iden t if y t he s e v a r i a t ion s in a min ut e a mo u n t of DNA .Ba s ed on t hi s kno w ledge ,t he y ca n t hen a dj ust tr e a t men t acc o r dingl y .A s a r e su l t p a t ien ts r e c ei v e t he r igh t do s a ge of t he r igh t d ru g ,w hi c h le a d s t o a b e tt e r tr e a t men t o ut c ome.E v e ry p a t ien t e x pe c ts t he b e st po ss i b le tr e a t men t .Sc ien c e help s t o p r o v ide i t .G r o w ing in s igh ts in t o t he ca us e s a nd p r og r e ss ion of di s e a s e s on a mole c u l a r le v el offe r t he oppo rtu ni ty t o imp r o v e t he w a y w e di a gno s e a nd tr e a t di s e a s e.P eople a r e diffe r en t ,a nd fo r t h a t r e a s on one s i z e doe s no t fit a ll.T hi s mole c u lem a ke s t he diffe r en c eT he r e a r e a s m a n y a n sw e rs a s people.W e c on t in u e t o r e s e a r c h indi v id u a l s ol ut ion s. 58R o c he W e I nno v a t e H e a l t h ca r e R o c he W e I nno v a t e H e a l t h ca r e59P u b li s hed b yF.H offm a nn-La R o c he L t dC o r po r a t e C omm u ni ca t ion s4070Ba s el,S w i tz e r l a nd©2008A ll tr a dem a r k s men t ioned enjo y leg a l p r o t e c t ion. T hi s b r o c h ur e i s a v a il ab le inG e r m a n,E ngli s h,S p a ni s h a nd F r en c h.P r in t ed on FSC-c e rt ified p a pe rC on c ep t a nd de s ignI n t e r b r a nd Z in tz me y e r&L ux,Z ur i c hP r in t ed in S w i tz e r l a nd b yB i r khäus e r+GBC,R ein ac h BLW o r ld W ide W e bh tt p://www.r o c he.c om60R o c he W e I nno v a t e H e a l t h ca r eP u b li s hed b yF.H offm a nn-La R o c he L t dC o r po r a t e C omm u ni ca t ion s4070Ba s el,S w i tz e r l a nd©2008A ll tr a dem a r k s men t ioned enjo y leg a l p r o t e c t ion.7000798RocheWeInnovateHealthcare。

L a b X S o f t w a r e S o l u t i o n sapplicable regulations. Among the list of many require-ments, the most relevant include:a permanently filtered atmosphere, ventilated cabinets, dedicated analytical equipment, easy to clean sur-faces, validated software installations, carefully trained personnel, special clothes and limited time spent in the lab…Additionally, it has been established that paper can easily be contaminated. In principle, paper has to be avoided or must be thrown away in the HAS lab and destroyed according to special procedures. Moreover, the HAS lab is a regulated area. Consequently, the dataLabX combined with the large XP display is the perfect solution for supporting both the weighing pro-cess and the strict requirements of a traceable documentation system“The METTLER TOLEDO balances operate under stringent con-ditions in ventilated cabinets.The weighing process is especially critical because the substances are used in their pure form. The handling of these substances is strictly controlled by external re-gulations and company dependant standard operating Traceable weighing in the Highly Active Substance At Roche Pharma Development Center in Basel (Swit-zerland), a brand new HAS lab (Highly Active Sub-stances lab) has been constructed to handle Category 4 active substances. This lab fully complies with the©07/2006 Mettler-Toledo AG Printed in Switzerland LabX Competence Center 11795851Quality certificate ISO9001Environment certificate ISO14001Internet: Worldwide service/LabXVisit for more informationlarge XP display is very easy to use and gives clear instructions to the user to guide him/her through thedefined procedures.• The LabX server and 4 Client PCs are located in several offices. From any office, the users can access reports or administrate methods, depending on theirrights defined in the user manager. Both software architecture and use of the balance display as a terminal limit the time spent in the HAS lab to the weighing tasks only. All data is securely kept in an SQL database and changes can only be carried out by defined users. The LabX system supports Roche Pharma in their regulatory requirements – 21 CFRPart 11 and GMP and was validated by METTLERTOLEDO validation specialists using the LabX Valida-tion Manuals.produced must be fully traceable and the electronicrecords generated in the lab fall under FDA 21 CFR Part 11. The installation and use of a data capture systemmust be validated.Therefore the task of Roche became challenging to findways to completely abolish paper documentation in the HAS lab and keep total traceability of all weighing andanalytical data. Roche was confronted with the uniquechance to enforce a 100% paperless policy!The METTLER TOLEDO weighing solution and itsbenefits• For weighing in the HAS lab, Roche uses oneAX205DR and one MX5. Both balances are con-nected to the company network with the METTLERTOLEDO e-Link RS-Ethernet converter. No PC isrequired for the LabX application in the HAS lab. Theoperator logs-in on the balance display and is guided through the weighing procedure, step by step. Data is collected automatically, thanks to the LabX PCsoftware controlling the balance in the background.The weighing procedures are purposely kept simple, including back weighing. • In 2 other labs, several of the latest generation of Excellence Plus XP balances are linked to LabX. They are connected directly to the company network with a simple Ethernet plug-in option, which means less cable. The balance and its immediate environment become extremely easy to clean. Additionally, the …Electronic weighing data contri-butes to both employee safety and data security “The flexible software architecture allows installation on multiple computers in diffe-rent rooms. LabX controls multiple balan-ces directly over the network.LabXRoche Ethernetoffice PC server for database and administrationMETTLER TOLEDOAX205METTLER TOLEDOXP205METTLER TOLEDOXP205METTLER TOLEDOMX5UHAS labAll managers, lab assistants and technicians who work in the HAS environment have been trained on the LabX system. The system is periodically exten-ded to add new balances or to accommodate new customer applications. Following this successful pilot installation, LabX balance is currently under evaluati-on in several other Roche Pharma departments.。

兽用抗生素加米霉素研究进展向蓉;杨大伟;岳磊;尹烨华【摘要】加米霉素(Gamithromycin)是一种新型的半合成大环内酯类(Marolides)兽用抗生素,通过抑制细菌RNA依赖性蛋白合成而起到抑菌和杀菌的作用.加米霉素对引起牛呼吸系统疾病(BRD)的溶血性曼氏杆菌、多杀性巴氏杆菌及牛支原体等均有较高的抗菌活性,其动力学特点优良,吸收快,达峰时间短,生物利用度较高,可以在肺组织达到较高的组织浓度;加米霉素毒性低,在动物的可食性组织中残留较少,治疗无副作用,国外已广泛应用于牛的呼吸系统疾病临床治疗.因此,在我国兽医临床上具有广阔的应用前景.为了促进其在我国兽医临床上的合理应用、研制与开发,现对其抗菌活性、药动学、毒性及残留、临床应用等相关研究进展进行综述.【期刊名称】《广东农业科学》【年(卷),期】2015(042)016【总页数】5页(P79-83)【关键词】加米霉素;抗菌活性;动力学;毒性及残留【作者】向蓉;杨大伟;岳磊;尹烨华【作者单位】广东省农科院动物卫生研究所/广东省畜禽疫病防治研究重点实验室,广东广州510640;中国兽医药品监察所,北京100081;广东省农科院动物卫生研究所/广东省畜禽疫病防治研究重点实验室,广东广州510640;广东省农科院动物卫生研究所/广东省畜禽疫病防治研究重点实验室,广东广州510640【正文语种】中文【中图分类】S859.79+6加米霉素（Gamithromycin）属氮杂内酯类抗生素，是由法国梅里亚公司研发的第二代大环内酯类抗生素的代表药物之一。

目前梅里亚公司生产的以加米霉素为主要有效成分的注射剂ZACTRAN，经欧盟药品监督管理局兽药署的审核，已经实现市场化生产和销售。

其抗菌谱广、抗菌活性强，具有吸收快、体内分布广泛、体内残留低、安全性高等优点，暂无不良反应报道，国外已广泛应用于溶血性巴斯德菌、出血败血性巴斯德菌、嗜组织菌等细菌病原体导致的牛呼吸系统疾病临床治疗。