Aliskiren hemifumarate_173334-58-2_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening

Safety Data SheetRevision Date:Oct.-05-2018Print Date:Oct.-05-2018

1. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Alarelin (Acetate)

Catalog No. :HY-17405

CAS No. :79561-22-11.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USA

Tel:609-228-6898

Fax:609-228-5909

E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-6898

2. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.

Inhibitors, Agonists, Screening Data SheetBIOLOGICAL ACTIVITY: Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively.target: SGLT2IC50: 5.6 μM (SGLT1)/ 2 nM (SGLT2)1) In normal rats and dogs a saturable urinary glucose excretion was produced with an ED50 of 0.38 and 0.09 mg/kg, respectively.2) EGT1442 significantly prolonged the median survival of SHRSP rats.3) EGT1442 dose–dependently reduced HbA1c and blood glucose concentration without affecting body mass or insulin level.References: [1]. Zhang W et al. EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival ofstroke–prone rats. Pharmacol Res. 2011 Apr;63(4):284–93.Product Name:BexagliflozinCat. No.:HY-17604CAS No.:1118567-05-7Molecular Formula:C24H29ClO7Molecular Weight:464.94Target:SGLTPathway:Membrane Transporter/Ion ChannelSolubility:10 mM in DMSOCaution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852,

Product Name:PentamidineCAS No.: 100-33-4Cat.No.:HY-B0537Product Data Sheet

Cat. No.:HYB0537MWt:340.42Formula:C19H24N4O2Purity :>98%

Solubility:

Mechanisms:

Biological Activity:() Pathways:Anti-infection; Target:Antiparasitic

DMSO

Pentamidine(MP-601205) is an antimicrobial agent. Target: AntiparasiticPentamidine has a potent in vitro antiprotozoal activity. Pentamidine displays cytotoxic activityagainst L. infantum promastigotes with IC50 of 2.5 μM. 2.5 μM Pentamidine induces earlyprogrammed cell death in 49.6% of L. infantum promastigotes. 2.5 μM Pentamidine induces anotorious decrease in promastigotes in both G1 and S phases relative to the control-untreatedsamples (G1:77.0 vs 15.0%; S:11.0 vs 2.4% for control- and pentamidine-treated promastigotes,resp). Pentamidine is able to bind with calf-thymus DNA (CT-DNA) and induces conformationalchangesintheDNAdoublehelixPentamidinealsobindswithubiquitintomodifiythe-clusterof

Inhibitors, Agonists, Screening Libraries

Data Sheet

BIOLOGICAL ACTIVITY: 

Pyrantel tartrate is an antinematodal thiophene; nicotinic receptor agonist and can elicit spastic muscle paralysis in parasitic worms

due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle.

References:

[1]. Aceves J, et al. The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle. Br J Pharmacol. 1970 May;38(3):602–7.

[2]. Aubry ML, et al. Aspects of the pharmacology of a new anthelmintic: pyrantel. Br J Pharmacol. 1970 Feb;38(2):332–44.Product Name:Pyrantel (tartrate)

Cat. No.:HY-12641

CAS No.:33401-94-4

Molecular Formula:C

15H

20N

2O

6S

Molecular Weight:356.39

Target:Parasite

Pathway:Anti–infection

Solubility:

DMSO: ≥ 34 mg/mL

Caution: Product has not been fully validated for medical applications. For research use only.