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<232>ELEMENTALIMPURITIES—LIMITSINTRODUCTIONThis general chapter specifies limits for the amounts of elemental impurities in drug products. Elemental impurities include catalysts and environmental contaminants that may be present in drug substances, excipients, or drug products. These impurities may occur naturally, be added intentionally, or be introduced inadvertently (e.g., by interactions with processing equipment and the container closure system). When elemental impurities are known to be present, have been added, or have the potential for introduction, assurance of compliance to the specified levels is required.A risk-based control strategy may be appropriate when analysts determine how to assure compliance with this standard. Due to the ubiquitous nature of arsenic, cadmium, lead,assessment. Regardless of the approach used, compliance with the limits specified is required for all drug products unless otherwise specified in an individual monograph or excluded in paragraph three of this introduction.The drug products containing purified proteins and polypeptides (including proteins and polypeptides produced from recombinant or non-recombinant origins), their derivatives, and products of which they are components (e.g., conjugates) are within the scope of this chapter, as are drug products containing synthetically produced polypeptides, polynucleotides, and oligosaccharides.This chapter does not apply to radiopharmaceuticals, vaccines, cell metabolites, DNA products, allergenic extracts, cells, whole blood, cellular blood components or blood derivatives including plasma and<232>元素杂质-限度介绍本通则规定了制剂中元素杂质的限度。
281RESIDUE ON IGNITION 炽灼残渣Portions of this general chapter have been harmonized with the corresponding texts of the European Pharmacopoeia and the Japanese Pharmacopoeia. The portions that are not harmonized are marked with symbols(◆◆). The harmonized texts of these pharmacopoeias are therefore interchangeable, and the methods of the European Pharmacopoeia and/or the Japanese Pharmacopoeia may be used for demonstration of compliance instead of the present United States Pharmacopoeia general chapter. These pharmocopoeias have been undertaken not to make any unilateral change to this harmonized chapter.此通则的各部分已经与欧洲药典和日本药典的对应部分做了协调。
不一致的部分用符号（◆◆）来标明。
因此，这些药典中协调一致的内容是可以互换的，欧洲药典和/或日本药典的方法可以替代美国药典的通则，用于显示符合性。
对于这个协调一致的章节，这些药典已经承诺不进行任何单方变更。
The Residue on Ignition / Sulfated Ash test utilizes a procedure to measure the amount of residual substance not volatilized from a sample when the sample is ignited in the presence of sulfuric acid according to the procedure described below. This test is usually used for determining the content of inorganic impurities in an organic substance.炽灼残渣/硫酸化灰分检测是当根据下面所述的步骤使样品在有硫酸的情况下灼烧后，测量未挥发的残留物质量的方法。
药物分析专业词汇中英文对照绪论释药系统（drug delivery system，DDS）中国药典（Chinese Pharmacopoeia,ChP）美国药典（The United States Pharmacopoeia,USP）美国国家处方集（The National Formulary,NF）英国药典（British Pharmacopoeia,BP）欧洲药典（European Pharmacopoeia,Ph.Eup）国际药典（The International Pharmacopoeia,Ph.Int）良好药品实验研究规范（Good Laboratory Practice,GLP）良好药品生产规范(Good Manufacture Practice,GMP)良好药品供应规范(Good Supply Practice,GSP)良好药品临床试验规范(Good Clinical Practice,GCP)分析质量管理(Analytical Quality Control,AQC)第1章药物的鉴别试验药物的鉴别试验identification test一般鉴别试验general identification test专属鉴别试验specific identification test灵敏度sensitivity最低检出量minimum detectable quantity最低检出浓度minimum detectable concentration第2章药物的杂质检查巯基醋酸mercaptoacetic acid古蔡氏Gutzeit二乙基二硫代氨基甲酸银siliver diethyldithio-carbamate硫酸灰分sulphated ash炽灼残渣residue on ignition热重分析法thermogravimetric analysis,TGA差示热分析法differential thermal analysis,DTA差示扫描量热法differential scanning calorimetry,DSC碱性酒石酸铜试验Fehling’s reagent异红紫酸盐isopurpurate2，3-二氨基萘2,3-diaminonaphthalene4，5-苯并苯硒二唑4，5-benzopiazselenol第3章定量分析样品前处理与测定方法的效能指标汞齐化法amalgamation method氧瓶燃烧法oxygen flask combustion method葡萄糖醛酸甙glucuronides硫酸酯sulphates血浆plasma血清serum全血whole blood治疗药物浓度监测therapeutic drug monitoring,TDM结合bound游离free缀合物conjugate l液-液提取法liquid-liquid extraction,LLE离子对试剂ion pair reagent离子对提取法ion pair extraction method反离子counter液-固提取法liquid-solid extraction LSE半自动样品制备系统advanced automated sample processor,AASP 烷基化alkylations酰基化acylations L硅烷化silylations精密度precision标准差standard deviation,SD orS相对标准差relative standard deviation变异系数coefficient of variation,批内精密度within-run precision日内精密度within-day precision批间精密度between-run precision日间精密度day to day precision准确度accuracy定量限limit of quantitation,LOQ检测限limit of detection,LOD选择性selectivity专属性specificity线性与范围linearity and range重现性ruggedness耐用性robustness散布图scatter diagram+y r:L!z7\9^'T3l'h*M荧光偏振免疫测定法fluorescence polarization immunoassay第4章巴比妥类药物的分析溴化十六烷基三甲基苄铵cetyltrimethylbenzylammonium bromide，CTMA 氯化四癸基二甲基苄铵T etradacyldimethybenzylammonium chloride，TDBA第5章芳酸及其酯类药物的分析苯甲酸及其钠盐benzoic acid and sodium benzoate布美他尼bumetanide羟苯乙酯ethylparoben丙磺舒probenecid酚黄乙胺etamsylate第6章胺类药物的分析第7章杂环类药物的分析二硝基氯苯反应Vongerichten反应戊烯二醛反应反应第8章生物碱类药物的分析生物碱alkaloids阿片gum opium扫尾剂tailing-suppressing reagent蒂巴因thebaine诺司卡品noscapine竞争离子competing ions亲脂性lipophicity拖尾因子tailing factor金刚烷adamantane第9章维生素类药物的分析维生素vitamin去氢维生素A dehydroretinol去水维生素A anhydroretinol鲸醇kitol三氯化锑反应Carr-Price反应维生素B1 thiamine hydrochloride；盐酸硫胺2，3，5-三苯基氯化四氮唑2，3，5-triphenyltetrazolium chlorid，TTC红四氮唑red tetrazoline，RT蓝四氮唑blue tetrazoline，BT3，3’-二甲基氧苯基-双-4，4’-（3，5-二苯基）氯化四氮唑{3，3’-dianisole-bis[4，4’-（3，5-dipheny）tetrazolium chloride]}有色甲……formazan铁-酚试剂iron-phenol reagente铁-柯柏试剂iron-Kober reagent南药07药理复试题一、名词解释（5分*10）1、一级动力学消除；2、非竞争性拮抗剂；3、动作电位时程；4、前致癌物；5、初次接触效应；6、synergism；7、mutation；8、GLP；9、acute toxicity；10、uptake1。
F. 砷盐检查法 标准砷溶液的制备 称取三氧化⼆砷0.132g，置1000ml量瓶中，加20％氢氧化钠溶液5ml溶解后，⽤适量的稀硫酸中和，再加稀硫酸10ml，⽤⽔稀释⾄刻度，摇匀,作为贮备液。
临⽤前，精密量取贮备液10ml，置1000ml量瓶中，加稀硫酸10ml,⽤⽔稀释⾄刻度,摇匀，即得（每1ml相当于1µg的As）。
第⼀法(古蔡⽒法) 仪器装置 如图1。
A为100ml标准磨⼝锥形瓶；B为中空的标准磨⼝塞，上连导⽓管C(外径8.0mm，内径6.0mm),全长约180mm；D 为具孔的有机玻璃旋塞,其上部为圆形平⾯,中央有⼀圆孔，孔径与导⽓管C的内径⼀致，其下部孔径与导⽓管C的外径相适应，将导⽓管C的顶端套⼊旋塞下部孔内，并使管壁与旋塞的圆孔适相吻合。
粘合固定，E为中央具有圆孔(孔径6.0mm)的有机玻璃旋塞盖，与D紧密吻合。
测试时，于导⽓管C中装⼊醋酸铅棉花60mg(装管⾼度为60～80mm)，再于旋塞D的顶端平⾯上放⼀⽚溴化汞试纸（试纸⼤⼩以能覆盖孔径⽽不露出平⾯外为宜），盖上旋塞盖E并旋紧，即得。
标准砷斑的制备 精密量取标准砷溶液2ml，置A瓶中,加盐酸5ml与⽔21ml，再加碘化钾试液5ml与酸性氯化亚锡试液5滴，在室温放置10分钟后，加锌粒2g，⽴即将照上法装妥的导⽓管C密塞于A瓶上,并将A瓶置25～40℃⽔浴中，反应45分钟,取出溴化汞纸试,即得。
若供试品需经有机破坏后再⾏检砷，则应取标准砷溶液代替供试品，照各药品项下规定的⽅法同法处理后，依法制备标准砷斑。
检查法 取照各药品项下规定⽅法制成的供试液，置A瓶中,照标准砷斑的制备，⾃“再加碘化钾试液5ml”起，依法操作。
将⽣成的砷斑与标准砷斑⽐较，不得更深。
第⼆法(⼆⼄基⼆硫代氨基甲酸银法) 仪器装置 如图2。
A为100ml标准磨⼝锥形瓶；B为中空的标准磨⼝塞，上连导⽓管C（⼀端的外径为8mm，内径为6mm；另⼀端长180mm, 外径4mm，内径1.6mm，尖端内径为1mm）。
目的：建立砷盐检查标准操作规程,规范砷盐检查标准操作。
适用范围：本法适用于砷盐检查法。
责任：QC质检员实施本操作规程，QC负责人、QA质监员实施监督。
程序：1. 技术依据：《中华人民共和国药典》2000年版一部，附录IX F。
2简述：2.1砷盐检查法适用于药品中微量砷盐（以As计算）的限量检查。
2.2砷盐检查法中的第一法（古蔡氏法）用作药品中砷盐的限量检查；第二法（二乙基二硫代氨基甲酸银法）既可检查药品中砷盐限量，又可测定含量；两法并列，可根据需要选用。
2.3古蔡氏法是利用金属锌与酸作用产生新生态的氢与药品中微量亚砷酸盐反应生成具有挥发性的砷化氢，遇溴化汞试纸产生黄色至棕色的砷斑，与同一条件下定量标准砷溶液所产生的砷斑比较，以判定砷盐的限量。
2.4二乙基二硫代氨基甲酸银法是将生成的砷化氢气体导入盛有二乙基二流代氨基甲酸银试液的管中，使之还原为红色胶态银，与同一条件下定量的标准砷溶液所制成的对照液比较，或在510nm波长处测定吸收度，以判定含砷盐的限度或测定含量。
3 仪器与用具3.1第一法（古蔡氏法）按药典规定。
有机玻璃塞D和E的孔径应与导气管C内径一致，以免生成的色斑直径不同，影响比色的准确度；B磨口塞，C管顶端与D、E有机玻璃旋塞塞盖间应紧密吻合，以防砷化氢泄漏。
3.2第二法（二乙基二硫代氨基甲酸银法）按药典规定。
B磨口塞应密闭，以防砷化氢泄漏；与标准磨口塞B相连的导气管C一端长度应不低于80mm，便于装醋酸铅棉花达80cm，另一端长度应不低于180mm，尖端内径不可超过lmm，以保证产生的砷化氢吸收完全；D管的标准管与样品管要一致，管内径，色泽，刻线要相同。
4 试药与试液4.1标准砷溶液：精密称取105℃干燥至恒重的三氧化二砷0.132g，置1000ml量瓶中，加20％氢氧化钠溶液5ml溶解后，用适量的稀硫酸中和，再加稀硫酸10ml，用水稀释至刻度，摇匀，作为贮备液。
临用前，精密量取贮备液10ml，置1000ml量瓶中，加稀硫酸10ml，用水稀释至刻度，摇匀，即得（每lml相当于1.0um的As）。
美国药典－中英文对照译文美国药典中记载的辣椒碱资料辣椒碱（辣椒素）分子结构式：C18H27NO3，分子量：305.41，化学名：（反）－N－[（4－N－羟基－3－甲氧基苯基）－甲基]－8－甲基－6－壬烯基酰胺以干燥提取物计算，辣椒碱含辣椒二萜类化合物总量为标示量的90％－100%,其中辣椒素的含量达到50％以上，辣椒素和二氢辣椒素总量超过75％，其它辣椒素类化合物总量不足15％。
注意事项：小心处置辣椒碱，谨防吸入辣椒碱微粒，勿使身体接触辣椒碱。
包装贮藏：密封包装，置避光，阴凉处保存。
标示量：以辣椒二萜类化合物总百分含量表示。
美国药典参考标准：美国药典辣椒素标准规范，美国药典二氢辣椒素标准规范。
鉴别：配制1.0mg/ml辣椒碱甲醇溶液，配制符合美国药典标准的辣椒碱1.0mg/ml甲醇溶液作为对照液，分别点样于0.25mm厚硅胶、凝胶混合薄层板上，点样量为10礚，将薄层板放于乙醚－甲醇（19:1）展开剂中展开，待展开剂前沿至薄层板3/4处时将薄层板取出，晾干，用0.5% 2,6-二溴苯醌-氯化亚胺甲醇溶液喷雾显色，放于氨气中片刻，取出，鉴别色谱图：供试液主要斑点颜色（兰色）及R值与对照液主要斑点颜色（兰色）及R值一致。
熔点〈741〉: 57°－66°, 一般熔融起始温度至结束温度温差不超过5°。
干燥失重〈731〉: 置40°P2O5真空干燥器中干燥5小时，失重不超过1.0%。
灼烧残渣：≤1.0％。
辣椒素，二氢辣椒素及其它辣椒二萜类化合物含量测定：流动相：磷酸水溶液（l ：1000，V/V）：乙腈(600:400)混匀，0.5祄微孔滤膜滤过，脱气。
流动相视色谱行为可作适当调整。
辣椒素对照液：精密称取美国药典标准的辣椒碱适量溶于甲醇中，配制约0.1 mg/mL的辣椒甲醇溶液。
二氢辣椒素对照液：精密称取美国药典标准的辣椒碱适量溶于甲醇中，配制约0.025mg/mL的辣椒甲醇溶液。
美国药典中191 、197、221、231、2021、281、467、726、791这几章的中文翻译<231> 重金属本试验系在规定的试验条件下，金属离子与硫化物离子反应显色，通过制备的标准铅溶液目视比较测定，以确证供试品中重金属杂质含量不超过各论项下规定的限度（以供试品中铅的百分比表示，以重量计）。
（见分光光度法和光散射项下测定法目视比较法<851>）[ 注意:对本试验有响应的典型物质有铅、汞、铋、砷、锑、锡、镉、银、铜和钼等]。
除各论另有规定外，按第一法测定重金属。
第一法适用于在规定试验条件下，能产生澄清、无色溶液的物质。
第二法适用于在第一法规定试验条件下不能产生澄清、无色溶液的物质，或者适用于由于性质复杂，易干扰硫化物离子与金属离子形成沉淀的物质，或者是不易挥发的和易挥发的油类物质。
第三法为湿消化法，仅用于第一法、第二法都不适合的情况。
特殊试剂硝酸铅贮备液—取硝酸铅159.8mg，溶于100ml水中，加1ml硝酸，用水稀释至1000ml。
制备和贮存本溶液的玻璃容器应不含可溶性铅。
标准铅溶液—使用当天，取硝酸铅贮备液10.0ml，l标准铅溶液制备的对照溶液，μg的铅。
按每克供试品取100μ用水稀释至100.0ml。
每1ml的标准铅溶液含相当于10 相当于供试品含百万分之一的铅。
方法IpH3.5醋酸盐缓冲液—取醋酸铵25.0g溶于25ml水中，加6N盐酸液38.0ml，必要时，用6N氢氧化铵液或6N盐酸液调节pH至3.5，用水稀释至100ml，混匀。
g的Pb），μ标准溶液准备—精密量取标准铅溶液2ml，（相当于20 置50ml比色管中，加水稀释至25ml，以精密pH试纸作为外指示剂，用1N醋酸液或6N氢氧化铵液调节pH至3.0~4.0，用水稀释至40ml，混匀。
供试品溶液制备—取各论项下规定的供试品溶液25ml，置50ml比色管中，或用各论项下规定用量的酸溶解样品，再用水稀释至25ml，供试品以g计，按下式计算：2.0/（1000L）式中L是重金属限度（%）。
281RESIDUE ON IGNITION 炽灼残渣Portions of this general chapter have been harmonized with the corresponding texts of the European Pharmacopoeia and the Japanese Pharmacopoeia. The portions that are not harmonized are marked with symbols(◆◆). The harmonized texts of these pharmacopoeias are therefore interchangeable, and the methods of the European Pharmacopoeia and/or the Japanese Pharmacopoeia may be used for demonstration of compliance instead of the present United States Pharmacopoeia general chapter. These pharmocopoeias have been undertaken not to make any unilateral change to this harmonized chapter.此通则的各部分已经与欧洲药典和日本药典的对应部分做了协调。
不一致的部分用符号（◆◆）来标明。
因此，这些药典中协调一致的内容是可以互换的，欧洲药典和/或日本药典的方法可以替代美国药典的通则，用于显示符合性。
对于这个协调一致的章节，这些药典已经承诺不进行任何单方变更。
The Residue on Ignition / Sulfated Ash test utilizes a procedure to measure the amount of residual substance not volatilized from a sample when the sample is ignited in the presence of sulfuric acid according to the procedure described below. This test is usually used for determining the content of inorganic impurities in an organic substance.炽灼残渣/硫酸化灰分检测是当根据下面所述的步骤使样品在有硫酸的情况下灼烧后，测量未挥发的残留物质量的方法。
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文档下载后可定制修改，请根据实际需要进行调整和使用，谢谢!并且，本店铺为大家提供各种类型的经典范文，如英语单词、英语语法、英语听力、英语知识点、语文知识点、文言文、数学公式、数学知识点、作文大全、其他资料等等，想了解不同范文格式和写法，敬请关注!Download tips: This document is carefully compiled by this editor.I hope that after you download it, it can help you solve practical problems. The document can be customized and modified after downloading, please adjust and use it according to actual needs, thank you!In addition, this shop provides various types of classic sample essays, such as English words, English grammar, English listening, English knowledge points, Chinese knowledge points, classical Chinese, mathematical formulas, mathematics knowledge points, composition books, other materials, etc. Learn about the different formats and writing styles of sample essays, so stay tuned!arsenic的用法总结大全arsenic的意思arsenic的简明意思n. 砷；砒霜adj. 砷的；含砷的英式发音 ['ɑːsnɪk] 美式发音 ['ɑːrsnɪk]arsenic的具体用法如：Like when she bought the rat poison, the arsenic.比如说,她那次买老鼠药、砒霜的情况.在此句中arsenic表示砒霜的意思Major treatment methods for arsenic include sulfide precipitation, or complexation with polyvalent heavy metals.砷的主要处理方法有硫化物沉淀法, 或与多价重金属络合.在此句中arsenic表示砷的的意思arsenic的用法例句Objective To investigate the irradiation enhancement effect of arsenic trioxide ( As 2 O 3 ) on human cervical squamous carcinoma cells.目的探讨三氧化二砷 ( As2O3 ) 对人宫颈癌Hela细胞系的放射增敏作用.在此句中arsenic表示三氧化二砷的意思Conclusion Arsenic trioxide inhibits cell proliferation, induces apoptosis in ovarian cancer cell.结论三氧化二砷能诱导卵巢癌细胞凋亡,抑制卵巢癌细胞增殖.在此句中arsenic表示三氧化二砷的意思Objective To evaluate telomerase activity and effect of arsenic trioxide on acute leukemia.目的观察白血病端粒酶活性与三氧化二砷的治疗效果.在此句中arsenic表示砷的的意思Objective To find out if there are arsenic pollution and harm in Wushan type fluorosis area.目的了解燃煤氟污染较为严重的巫山县是否存在砷的污染与危害.在此句中arsenic表示砷的的意思His wife poisoned him with arsenic.他的妻子用砒霜把他毒死了.在此句中arsenic表示砒霜的意思。
This procedure is designe arsenic (As) by converting which is then passed throu a red complex. The red co spectrophotometrically, to an amount of arsenic equi Limits are stated in terms exceed the limit given in th Two methods are provided treatment of the test subst for inorganic materials, whApparatus—The apparatus (see illustra scrubber unit (c) and an ab ball-and-socket joints ( apparatus, embodying the may be used. 211ARSENICsigned to determine the presence of trace amo erting the arsenic in a substance under test to through a solution of silver diethyldithiocarbam ed color so produced is compared, either visu ly, to the color produced similarly in a control c equivalent to the limit given in the individual m erms of arsenic (As). The content of arsenic do n in the individual monograph.ovided, the methods differing only in the prelim substance and the standard. Generally, Metho s, while Method II is used for organic materlustration) consists of an arsine generator (an absorber tube (e) with standard-taper or grb and d) between the units. However, any ot g the principle of the assembly described andArsenic Test ApparatusArsenic Trioxide Stock So previously dried at 105 hydroxide solution (1 in 5) solution with 2 N sulfuric a recently boiled and cooledStandard Arsenic Solution Solution to a 1000-mL volu add recently boiled and co Arsenic Solution contains solution in an all-glass conStandard Preparation—generator flask, and dilute Test Preparation— Unless transfer to the generator fl calculated by the formula:in which L is the arsenic lim 35 mL.Procedure— Treat the Sta as follows. Add 20 mL of 7 mL of stronger acid stanno mix. Allow to stand at room tube (c) with two pledgets acetate solution, freed from vacuum at room temperatuic trioxide,n 5 mL of sodium tralize theacid, then addxide Stockuric acid, thenh mL of Standard s). Keep thisution into amonograph, bstanceute with water toparation similarly iodide TS, 0.5 pyl alcohol, and the scrubber saturated leadd dried inthe two pledgets.Lubricate the joints (b and d) with a suitable stopcock grease designed for use with organic solvents, and connect the scrubber unit to the absorber tube (e). Transfer 3.0 mL of silver diethyldithiocarbamate TS to the absorber tube. Add 3.0 g of granular zinc (No. 20 mesh) to the mixture in the flask, immediately connect the assembled scrubber unit, and allow the evolution of hydrogen and the color development to proceed at room temperature for 45 minutes, swirling the flask gently at 10-minute intervals. Disconnect the absorber tube from the generator and scrubber units, and transfer the absorbing solution to a 1-cm absorption cell. Any red color produced by the Test Preparation does not exceed that produced by the Standard Preparation. If necessary or desirable, determine the absorbance at the wavelength of maximum absorbance between 535 and 540 nm, with a suitable spectrophotometer or colorimeter, using silver diethyldithiocarbamate TS as the blank.Interfering Chemicals— Metals or salts of metals, such as chromium, cobalt, copper, mercury, molybdenum, nickel, palladium, and silver, may interfere with the evolution of arsine. Antimony, which forms stibine, produces a positive interference in the color development with silver diethyldithiocarbamate TS; when the presence of antimony is suspected, the red colors produced in the two silver diethyldithiocarbamate solutions may be compared at the wavelength of maximum absorbance between 535 and 540 nm, with a suitable colorimeter, since at this wavelength the interference due to stibine is negligible.METHOD IINOTES—(1) Caution—Some substances may react with explosive violence when digested with hydrogen peroxide. Exercise safety precautions at all times. (2) If halogen-containing compounds are present, use a lower temperature while heating the test specimen with sulfuric acid, avoid boiling the mixture,and add the hydrogen pero loss of trivalent arsenic.(3) If the test substance re sulfuric acid before heating in 2), and add a few drops Standard Preparation—generator flask, add 2 mL percent hydrogen peroxide mixture to strong fuming, c to strong fumes. Repeat th any traces of hydrogen pe Test Preparation— Unless transfer to a generator flas by the formula:in which L is the arsenic lim beads, and digest in a fum temperature not exceeding may be necessary to wet s added should not exceed hydrogen peroxide, allowin between drops. Add the fir order to prevent a rapid re excessive. When the reac occasionally to prevent the heating unit. Maintain oxid adding small quantities of mixture turns brown or dar is destroyed, gradually rais n peroxide with caution, before charring begins nic.ce reacts too rapidly and begins charring with eating, use instead 10 mL of cooled dilute sulf rops of the hydrogen peroxide before heating — Pipet 3.0 mL of Standard Arsenic Solution 2 mL of sulfuric acid, mix, and add the total am roxide used in preparing the Test Preparation ing, cool, add cautiously 10 mL of water, and eat this procedure with another 10 mL of wate en peroxide. Cool, and dilute with water to 35 m nless otherwise directed in the individual mon or flask the quantity, in g, of the test substance 3.0 / Lnic limit in ppm. Add 5 mL of sulfuric acid and a fume hood, preferably on a hot plate and at eding 120, until charring begins. (Additional s wet some specimens completely, but the tota ceed 10 mL.) Cautiously add, dropwise, 30 per llowing the reaction to subside and again hea the first few drops very slowly with sufficient m pid reaction. Discontinue heating if foaming be reaction has abated, heat cautiously, rotating nt the specimen from caking on glass exposed n oxidizing conditions at all times during the dig es of the hydrogen peroxide solution wheneve or darkens. Continue the digestion until the org ly raising the temperature of the hot plate unti egins, to prevent g with 5 mL of e sulfuric acid (1 eating.ution into aal amount of 30 ation . Heat the and again heat water to remove o 35 mL. monograph, tance calculated d and a few glass nd at aonal sulfuric acid e total volume 30 percent n heatingent mixing, in ng becomes ating the flask posed to the he digestion by never thehe organic matter e until fumes ofsulfur trioxide are copiously evolved, and the solution becomes colorless or retains only a light straw color. Cool, add cautiously 10 mL of water, mix, and again evaporate to strong fuming, repeating this procedure to remove any trace of hydrogen peroxide. Cool, add cautiously 10 mL of water, wash the sides of the flask with a few mL of water, and dilute with water to 35 mL. Procedure— Proceed as directed for Procedure under Method I.Interfering Chemicals— See Interfering Chemicals under Method I.Auxiliary Information— Staff Liaison : Kahkashan Zaidi, Ph.D., Senior Scientist Expert Committee : (GC05) General Chapters 05USP31–NF26 Page 131Phone Number : 1-301-816-8269本过程用于确定微量的后将其通过二乙基二硫代氨觉对照或者风光光度计两种限量的砷盐的红色。
