宝丽亚 说明书
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2022年度Q2产品、合规及药物警戒知识考试您的姓名: [填空题] *_________________________________1. 以下哪项合规政策与RDPAC准则的相关规定最贴近?() [单选题] *A.《合规指导手册》B.《药品推广行为准则》(正确答案)C.《推广活动执行指南》D.《推广活动标准操作流程》2. 下列哪些人员不属于医疗卫生专业人士?() [单选题] *A.医疗、药剂或护理领域专业人员B.可开具处方的人员C.可推荐、采购、供应药品的人员D.医院的护工(正确答案)3. 新一代喹诺酮西他沙星的Slogan是:() [单选题] *A.新一代必杀G(正确答案)B.G+感染的理想新选择C.无氟,全新选择D.社区获得性感染治疗经验之选4. 西他沙星给药48小时内,约()的给药量以原型从尿液中排出 [单选题] *A.100%B.80%C.70%(正确答案)D.50%5. 奈诺沙星(太捷信)批准的适应症包括:() [单选题] *A.尿路感染B.AECOPDC.CAP(正确答案)D.其他选项都对6. 按常规治疗剂量,西他沙星和奈诺沙星的日治疗费用分别是?() [单选题] *A.9.8元和16.2元B.19.6元和32.4元(正确答案)C.9.8元和32.4元D.19.6元和16.2元7. 新一代喹诺酮西他沙星的对于AECOPD/支扩感染中哪一类主要致病菌的杀菌效果优于环丙沙星:() [单选题] *A.肺炎链球菌B.大肠杆菌C.铜绿假单胞菌(正确答案)D.肺炎支原体8. 西他沙星常见的不良反应不包括() [单选题] *A.腹泻B.QT间期延长(正确答案)C.头痛D.松软便9. 在感染领域,MIC通常指() [单选题] *A. 最小抑菌浓度(正确答案)B. 最小杀菌浓度C. 最大抑菌浓度D. 最小生长浓度10. 关于乐松®贴剂在人体的药代学情况,说法正确的是() [单选题] *A.乐松经皮吸收后,无法在皮肤和肌肉组织中转化为活性代谢物B.洛索洛芬钠进入血液循环后,大部分进入肾脏,之后以原型形式排出体外C.洛索洛芬钠及其活性代谢物在骨骼肌中的浓度比例高于皮肤(正确答案)D.治疗剂量下的洛索洛芬钠可能会抑制P450酶底物的代谢11. 关于乐松®贴剂的特殊人群用药,下列说法正确的是() [单选题] *A.8岁以上儿童可安全使用B.65岁以上老人使用时应密切注意贴敷部位的皮肤情况(正确答案)C.妊娠妇女可安全使用D.哺乳期妇女可安全使用12. 关于洛索洛芬钠,说法不正确的是() [单选题] *A.洛索洛芬钠为丙酸类前体药物B.洛索洛芬钠为非选择性NSAIDs类药物C.洛索洛芬钠具有抗炎、镇痛、解热等作用,尤其镇痛作用很强D.洛索洛芬钠在体内不经转化就可有抗炎、镇痛、解热等药理作用(正确答案)13. 乐松®的作用机制是在体内通过抑制()的活性起到镇痛、抗炎、解热作用的[单选题] *A.前列腺素B.环氧化酶(正确答案)C.白介素D.血栓素14. NSAIDs类药物的临床用途包括() [单选题] *A.风湿性疾病和慢性炎症性关节炎的治疗B.运动性损伤的治疗C.疼痛治疗和解热D.以上都是(正确答案)15. 使用乐松®贴剂1h后,哪种组织内的有效成分的浓度比例最高? [单选题] *A.皮肤B.真皮C.骨骼肌(正确答案)D.血液16. 以下对于2014 NICE骨关节炎指南描述正确的是() [单选题] *A.当提供口服NSAIDs药物治疗时,无论是传统NSAIDs还是COX-2I皆可作为首选(依托考昔除外)B.所有NSAIDs药物(包括COX-2)镇痛疗效相仿C.所有NSAIDs药物(包括COX-2)在胃肠道、肝脏、心-肾毒性方面各不相同D.以上都对(正确答案)17. 乐松贴剂的适应症为() [单选题] *A.骨关节炎B.肌肉痛C.外伤导致的肿胀或疼痛D.以上都是(正确答案)18. 下列关于宝丽亚®的儿童用法用量,正确的是() [单选题] *A.儿童:单剂量药瓶的一般剂量经雾化器给药,每次0.5支,每日1-3次, 使用前请充分摇匀B.儿童:单剂量药瓶的一般剂量经雾化器给药,每次1支,每日1-3次, 使用前请充分摇匀C.儿童:单剂量药瓶的一般剂量经雾化器给药,每次0.5支,每日1-2次, 使用前请充分摇匀(正确答案)D.儿童:单剂量药瓶的一般剂量经雾化器给药,每次1支,每日1-2次, 使用前请充分摇匀19. 启尔畅®的使用剂量因人而异,当用量为“每日二次 ,每次1或2揿。
新治疗性单抗Prolia(denosumab)注射剂使用说明书一般描述:Prolia (denosumab)是一种人IgG2单克隆抗体,对人RANKL(receptor activator of nuclear factor kappa-B ligand,即核因子κB配体受体激活剂)有亲和力和特异性。
Denosumab的分子量约为147 kDa和是在遗传工程哺乳动物(中国仓鼠卵巢)细胞中生产。
Prolia是一种消毒,无防腐剂,透明,无色至淡黄色溶液。
每1 mL单次-使用预装注射器的Prolia含60 mg denosumab(60 mg/mL溶液),4.7%山梨糖醇,17 mM醋酸盐, 0.01% 聚山梨醇20,注射用水(美国药典USP),和氢氧化钠至pH值5.2。
每1 mL单次-使用Prolia小瓶a含60 mg denosumab(60 mg/mL溶液),4.7%山梨糖醇,17 mM醋酸盐, 0.01% 聚山梨醇20,注射用水(美国药典USP),和氢氧化钠至pH值5.2。
1.适应证:Prolia是一种RANK配体(RANKL)抑制剂,适用于:治疗有骨质疏松高危骨折的绝经后妇女(1.1)。
2.剂量和给药方法:1) 应由卫生保健专业人员给予Prolia(2.1)。
2)每6个月在上臂、上大腿、或腹部皮下注射给予60 mg (2.1)。
3)指导患者每天服用钙1000 mg和每天至少400 IU维生素D (2.1)。
3.剂型和规格:1)单次使用预装注射器在1 mL溶液中含60 mg (3)。
2)单次使用小瓶在1 mL溶液中含60 mg (3)。
4.禁忌证:低钙血症(4.1,5.1)5. 警告和注意事项:1)低钙血症:开始用Prolia前必须纠正。
特别是肾损伤患者可能恶化。
充分补充患者钙和维生素D(5.1)。
2)严重感染包括皮肤感染:可能发生,包括那些导致住院。
忠告患者如他们发生感染的征象或症状,包括蜂窝织炎,寻求及时就医(5.2)。
3832 Bay Center Place TOLL FREE (800) 457-9444 **************** Hayward, CA 94545-3619PHONE (510) 638-6900 FAX (510) 638-6919CERTIFICATE OF ANALYSISPRODUCT NAME: GLYKO ® INSTANTAB™ A1F (G2FS1) PRODUCT CODE: GKIB-315GLYCAN NAME: Mono-sialylated, galactosylated biantennary, core-substituted with fucose (A1F) LOT NUMBER: DP18G0301aPACK SIZE: 60 pmol (qualitative standard for glycan identification) PURITY: ≥90% by UPLC ® FORM: Dry solidSTORAGE: Store at -20°C in the dark before and after reconstitution EXPIRATION:July 2023, may be used for 1 year after reconstitution STRUCTURE 1,2,3:Quality Control:Figure 1 - UPLC® Results: 2 - 4 pmol (1 μl, aqueous) of the InstantAB-labeled glycan was injected on a Waters ACQUITY UPLC® H Class System utilizing a 10-minute method under the conditions below:Time (min) Flow (ml/min) %ACN%Buffer00.0 1.0 75.0 25.08.0 1.0 60.0 40.08.1 0.5 40.0 60.08.5 0.5 40.0 60.08.6 1.0 40.0 60.08.8 1.0 75.0 25.010.0 1.0 75.0 25.0Column: Waters ACQUITY UPLC BEH Glycan Column (1.7 μm, 2.1 x 100 mm)ACN: AcetonitrileBuffer: 100 m M ammonium formate, pH 4.4Flow rate: As stated in table, in ml/minTemperature: 60° CMax Pressure:15,000 psiFluorescence Detection: λex = 278 nm, λem = 344 nmAverage Mass4: 2240.0Monoisotopic Mass4: 2238.8044 Structural Analysis: The identity of the unlabeled glycan is confirmed by MALDI-TOF5,6, ESI-MS or LC-MS. Agreement was found between the results from mass spectrometry and UPLC7.Application:•Qualitative standard for various analytical procedures•As a migration standard for liquidchromatography Handling & Reconstitution: The labeled oligo-saccharide is shipped as a dried solid. Use ultra-pure water or an aqueous buffer to dissolve the materials (see Directions for Use for suggested volumes).Allow the unopened vial to reach ambient temperature and tap on a solid surface to ensure that most of the material is at the bottom of the vial. Gently remove the cap, add the desired volume of ultra-pure water or aqueous buffer, re-cap and mix thoroughl y to redissolve all the material. For maximal recovery, ensure that the cap lining is also rinsed. Centrifuge the reconstituted vial briefly before use.Make sure that any glassware, plasticware, solvents or reagents used are free of glycosidases and carbohydrate contaminants. Minimize exposure to elevated temperatures or extremes of pH. Store the reconstituted glycan library at -20° C. Allow the vial to equilibrate to ambient temperature before use. Directions For Use: The amount of InstantAB-labeled glycan standard injected on a UPLC column is typically 2 - 4pmol of total glycan. For our Quality Control testing, one vial was dissolved in 30 µl of water and 1 µl injected on the ACQUITY column. For larger injection volumes or other LC systems we recommend further dilution as necessary for compatibility with the mobile phase. For suggested methods see Rapid UPLC Methods for Screening Labeled N-Glycans at:/protocols/REFERENCES1. Ceroni A, Maass K, Geyer H, Geyer R, Dell A, Haslam SM.GlycoWorkbench: a tool for the computer-assistedannotation of mass spectra of glycans. J Proteome Res. 2008Apr; 7(4): 1650-9.2. Harvey DJ, Merry AH, Royle L, Campbell MP, Dwek RA, RuddPM. Proposal for a standard system for drawing structuraldiagrams of N– and O-linked carbohydrates and relatedcompounds. Proteomics 2009 Aug; 9(15): 3796-801.3. Harvey DJ, Merry AH, Royle L, Campbell MP, Rudd PM.Symbol nomenclature for representing glycan structures:Extension to cover different carbohydrate types. Proteomics2011 Nov;11(22):4291-5.4. Average mass and monoisotopic mass of the unlabeled glycanwere calculated using the ExPASy GlycanMass calculator:/glycanmass/The average mass of the InstantAB labeled glycan is obtainedusing the following formula:Average Mass Glycan + Average Mass InstantAB (161.1)The monoisotopic mass of the InstantAB labeled glycan isobtained using the following formula (result rounded to 4decimal places):Monoisotopic Mass Glycan + 161.058915. James DC, Jenkins N. Analysis of N-glycans by matrix-assistedlaser desorption/ionization mass spectrometry; in Alaboratory guide to glycoconjugate analysis. BioMethods (P.Jackson and J. T. Gallagher, ed) 1997; 9: 91-112.6. Papac DI, Wong A, Jones AJS. Analysis of acidicoligosaccharides by matrix-assisted laserdesorption/ionization time of flight mass spectrometry. AnalChem 1996 Sep 15; 68(18): 3215-3223.7. Ahn J, Bones J, Yu YQ, Rudd PM, Gilar M. Separation of 2-aminobenzamide labeled glycans using hydrophilicinteraction chromatography columns packed with 1.7 micromsorbent. J Chromatogr B Analyt Technol Biomed Life Sci.2010 Feb 1; 878(3-4): 403-8.Authorized SignatureDigitally signed by ShivaPourkavehDate: 2018.07.12 16:00:21 -07'00'。
2Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsFAILU RE OR IMPROPER SELECTION OR IMPROPER U CTS AND/OR SYSTEMS DESCRIBED HEREIN OR RELATED ITEMS CAN CAU PROPERTY DAMAGE.This document and other information from Parker Hannifin Corporation, its subsidiaries and authorized distributors provide product and/or system options for further investigation by users having technical expertise. It is important that you analyze all aspects of your application and review the information concerning the product or system in the current product catalog. Due to the variety of operating conditions and applications for these products or systems, the user, through its own analysis and testing, is solely responsible for making the final selection of the products and systems and assuring that all performance, safety and warning requirements of the application are met. The products described herein, including without limitation, product features, specifications, designs, availability and pricing, are subject to change by Parker Hannifin Corporation and its subsidiaries at any time without notice.WARNINGSALE CONDITIONSThe items described in this document are available for sale by Parker Hannifin Corporation, its subsidiaries or its authorized distributors. Any sale contract entered into by Parker will be governed by the provisions stated in Parker’s standard terms and conditions of sale (copy available upon request).Polycarbonate bowls and sight domes, being transparent and tough, are ideal for use with Filters and Lubricators. They are suitable for use in normal industrial environments, but should not be located in areas where they could be subjected to direct sunlight, an impact blow, nor temperatures outside of the rated range. As with most plastics, some chemicals can cause damage. Polycarbonate bowls and sight domes should not be exposed to chlorinated hydro-carbons, ketones, esters and certain alcohols. They should not be used in air systems where compressors are lubricated with fire-resistant fluids such as phosphate ester and di-ester types.Metal bowls are recommended where ambient and/or media conditions are not compatible with polycarbonate bowls. Metal bowls resist the action of most such solvents, but should not be used where strong acids or bases are present or in salt laden atmospheres. Consult the factory for specific recommendations where these conditions exist.TO CLEAN POL Metal bowl guards are recommended for all applications.REGULATOR PRESSURE ADJUSTMENT – the knob is not a limiting device. This is a common characteristic of most industrial regulators, and limiting devices may be obtained only by special design.3Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsTable of ContentsAir Line FiltersSeries 14F ................................................................................................................................................... 4 - 5Air Line Coalescing FiltersSeries 10F ................................................................................................................................................... 6 - 7Air Line RegulatorsSeries 14R ................................................................................................................................................... 8 - 9Air Line Filter / RegulatorsSeries 14E ............................................................................................................................................... 10 - 11Air Line LubricatorsSeries 04L ............................................................................................................................................... 12 - 13Mounting Bracket Kits . (14)4Parker Hannifin CorporationPneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs§L/s = 6.2 bar inlet and 0.3 bar pressure drop.‡ For polycarbonate bowl see Caution on page 2.14F FiltersOptions:Symbols• Excellent water removal efficiency.• Unique deflector plate that creates swirling of the air stream ensuring maximum water and dirt separation.• 5 micron element standard.• High Flow: 1/8” – 10 l/s §1/4” – 11 l/s§Manual drainAuto drain14F Series5Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs4mm 0/D x 0.75 I /D tubingAutomatic drainSpecifications5µ FilterAutomatic pulse drain tube barb 4mm O /D x 0.75 I /DBowl capacity 30 cm 3Operating temperature 0°C to 52°C Max supply pressurePolycarbonate bowl0 to 10.3 bar Automatic pulse drain0.7 to 17.2 barStandard filtration 5 micron Port size G1/8 / G1/4Weight0.180 gmFlow ChartsMaterials of ConstructionDimensionsAccessoriesBodyZincBowl - TransparentPolycarbonateDeflector, Element holder & Baffle Plastic DrainsTwist drainBody & Stem Plastic SealsNitrile Automaticpulse drainPiston & Seals NitrileStem, Seat,Adaptor & WashersAluminiumFilter elements 5 micron(standard)Plastic SealsNitrileBowl kits, Poly bowlAutomatic pulse drain PS408P Twist drainPS404P Filter element kits 5 micron PS403P Mounting bracket kitPS417BP2.4 bar 6.2 bar 10.3 barPrimary Pressure - bar P r e s s u r e d r o p - b a r.1.2.3.4.5.6Flow - dm 3/s2.4 bar 6.2 bar 10.3 barPrimary Pressure - bar P r e s s u r e d r o p - b a rFlow - dm 3/sFlow Characteristics - 1/8 Inch Ports14F01B*Flow Characteristics - 1/4 Inch Ports14F11B*14F Series6Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs10F Series§L/s = 6.2 bar inlet and 0.3 bar pressure drop.10F Coalescing FiltersOptions:Symbol• Removes liquid aerosols and sub-micron particles.• Liquids gravitate to the bottom of the element and will not re-enter the airstream.• Oil free air for critical applications, such as air gauging and pneumatic instrumentation and controls.• 99.97% DOP efficiency.• High Flow: Grade 6 Element1/8” – 8 l/s§1/4” –9 l/s§7Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs2.4 bar 6.2 bar 10.3 barPrimary Pressure - bar P r e s s u r e d r o p - b a r.1Flow - dm 3/s10F Series4mm 0/D x 0.75 I /D tubingAutomatic drainSpecificationsGrade 6Automatic pulse drain tube barb 4mm O /D x 0.75 I /DBowl capacity 30 cm 3OperationNormal pressure drop 0.1 bar Maximum recommended pres-sure drop0.7 barOperating temperature 0°C to 52°C Max supply pressure Polycarbonate bowl0 to 10.3 bar Standard filtration 0.01 micron Port size G1/8 / G1/4Weight0.180 gmFlow ChartsMaterials of ConstructionDimensionsAccessoriesBodyZincBowl - Transparent PolycarbonateDrainsTwist drainBody & Stem Plastic SealsNitrile Automaticpulse drainPiston & Seals Nitrile Stem, Seat,Adaptor & WashersAluminiumElement holder PlasticFilter element Borosilicate & felt glass fibers 99.97% DOP efficiencySealsNitrileBowl kits, Poly bowlAutomatic pulse drain PS408P Twist drainPS404P Filter element kits 0.01 micronPS446P Mounting bracket kitPS417BPto remove all bowls regardless of drain option2.4 bar 6.2 bar 10.3 barPrimary Pressure - bar P r e s s u r e d r o p - b a r.1Flow - dm 3/sFlow Characteristics - 1/8 Inch Ports10F01E*Flow Characteristics - 1/4 Inch Ports10F11E*8Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs14R RegulatorsOptions:• Unbalanced poppet standard.• Solid control piston with lip seal for extended life.• Non-rising adjusting knob.• Compact, 73,2mm high by 42mm wide.• High Flow: 1/8” – 6 l/s §1/4” – 7 l/s §SymbolNote: 31mm dia. hole required for panel mounting.§ L/s = 6.9 bar inlet, 6.2 bar no flow secondary setting and 0.7 barpressure drop.14R Series129Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsSpecificationsGauge ports G1/8Port sizeG1/8 / G1/4Operating temperature 0°C to 52°CMax supply pressure 0 to 20.7 bar Secondary pressure rangeStandard pressure 0 to 8 bar Medium pressure 0 to 4 bar Medium pressure0 to 2 bar Weight140 gmFlow ChartsMaterials of ConstructionDimensionsAccessoriesAdjusting nutBrass Adjusting stem & spring Steel BodyZinc Bonnet, Seat, Piston & Valve poppet PlasticSealsNitrileS e c o n d a r y p r e s s u r e - b a rFlow - dm 3/s14RMA 1.50B 1.50C 2.36D 0.50E 2.98F 1.188G 0.594H 0.325J 0.725Caution:Regulator pressure adjustment – The working range of knobadjustment is designed to permit outlet pressures within their full range. Pressure adjustment beyond this range is also possible because the knob is not a limiting device. This is a common characteristic of most industrial regulators, and limiting devices may be obtained only by special design.For best performance, regulated pressure should always be set by increasing the pressure up to the desired setting.Relief and Flow Characteristics14R013F*14R SeriesS e c o n d a r y p r e s s u r e - b a rFlow - dm 3/sRelief and Flow Characteristics14R113F*10Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs§L/s = 6.9 bar inlet, 6.2 bar no flow secondary setting and 0.7 bar pressure drop.‡ For polycarbonate bowl see Caution on page 2.Note: 31mm hole required for panel mounting.14E Filter / RegulatorsOptions:Symbols• Excellent water removal efficiency.• Unbalanced poppet standard.• Solid control piston for extended life.• Space saving package offers both filter and regulator features in one integral unit.• Non-rising adjustment knob.• Two full flow 1/8” gauge ports.• High Flow: 1/8” – 7 l/s §1/4” – 8 l/s§14E Series211Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsBowl kits, Poly bowlAutomatic pulse drain PS408P Twist drainPS404P Gauges - 1/80 to 2 bar P3D-KAB1AYN 0 to 4 bar P3D-KAB1ALN 0 to 10 barP3D-KAB1ANN Mounting bracket kit(Includes panel mount nut)PS417BP Panel mounts nuts Plastic P78652Service kitsNon-relieving PS422P RelievingPS423P4mm 0/D x 0.75 I /D tubingAutomatic drainregardless of drain optionAutomatic pulse drain tube barb 4mm O /D x 0.75 I /DBowl capacity30 cm 3Gauge ports (2) (can be used for full flow)G1/8Port sizeG1/8 / G1/4Operating temperature 0°C to 52°C Secondary pressure range Standard pressure 0 to 8 bar Medium pressure 0 to 4 bar Medium pressure0 to 2 bar Weight0.180 gm14E SeriesSpecificationsFlow ChartsMaterials of ConstructionDimensionsAccessoriesAdjusting nutBrass Adjusting stem & spring Steel BodyZinc Bonnet, Knob, Seat, Piston, Holder & Deflector PlasticBowl - Transparent PolycarbonateDrainsTwist drain Body & Stem Plastic Seals Nitrile Automatic pulse drainPiston & Seals Nitrile Stem, Seat,Adaptor & WashersAluminiumFilter elements - 5 micron (Standard)Plastic SealsNitrileS e c o n d a r y p r e s s u r e - b a rFlow - dm 3/sCaution:Regulator pressure adjustment – The working range of knobadjustment is designed to permit outlet pressures within their full range. Pressure adjustment beyond this range is also possible because the knob is not a limiting device. This is a common characteristic of most industrial regulators, and limiting devices may be obtained only by special design.For best performance, regulated pressure should always be set by increasing the pressure up to the desired setting.Relief and Flow Characteristics14E01B13F*S e c o n d a r y p r e s s u r e - b a rFlow - dm 3/sRelief and Flow Characteristics14E11B13F*12Parker Hannifin CorporationPneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs§L/s = 6.2 bar inlet and 0.3 bar pressure drop.‡ For polycarbonate bowl see Caution on page 2.04L Mist LubricatorsOptions:Symbol• Proportional oil delivery over a wide range of air flows.• Precision needle valve assures repeatable oil delivery and provides simple adjustment of delivery rate.• Ideal for low and high flow applications with changing air flow.• Transparent sight dome for 360° visibility.• High Flow: 1/8” – 9 l/s §1/4” – 10 l/s§04L Series13Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLs04L SeriesSpecificationsBowl capacity30 cm 3Minimum flow for lubrication 0.2 l/s at 6.9 barPort sizeG1/8 / G1/4Operating temperature 0°C to 52°C Max supply pressure Polycarbonate bowl0 to 10.3 barWeight0.180 gmFlow ChartsMaterials of ConstructionDimensionsAccessoriesBodyZincBowl - Transparent PolycarbonateSeals NitrileSight domePolycarbonateBowl kits, Poly bowl No drain PS421P Mounting bracket kitPS419Primary Pressure - barP r e s s u r e d r o p - b a rFlow - dm 3/s2.4 bar 6.2 bar 10.3 barPrimary Pressure - barP r e s s u r e d r o p - b a r0.1.2.3.4.5.6Flow - dm 3/sFlow Characteristics - 1/8 Inch Ports04L00G*Flow Characteristics - 1/4 Inch Ports04L10G*14Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsDimensions (mm)A B C D E F G H J K L M Kit4660233425135311461116PS417BP(10F , 14F , 14R, 14E)4655233425135311461116PS419(04L)PS417BP (Includes Panel Mount Nut)PS419Mounting Bracket KitsK Typ.K Typ.15Parker Hannifin Corporation Pneumatic Division - EuropePDE2591TCUKPrep-Air ®II Miniature FRLsCatalogue PDE2591TCUK - V3 - May 2020Your local authorized Parker distributor© 2020 Parker Hannifin Corporation. All rights reserved.Parker Hannifin Ltd. Tachbrook Park Drive Tachbrook Park, Warwick, CV34 6TU United KingdomTel.: +44 (0) 1926 317 878 Fax: +44 (0) 1926 317 855********************Parker WorldwideEurope, Middle East, AfricaAE – United Arab Emirates, DubaiTel: +971 4 8127100 ********************AT – Austria, St. Florian Tel: +43 (0)7224 66201 *************************AZ – Azerbaijan, Baku Tel: +994 50 2233 458****************************BE/NL/LU – Benelux, Hendrik Ido Ambacht Tel: +31 (0)541 585 000 ********************BG – Bulgaria, Sofia Tel: +359 2 980 1344**************************BY – Belarus, Minsk Tel: +48 (0)22 573 24 00 ************************CH – Switzerland, Etoy Tel: +41 (0)21 821 87 00*****************************CZ – Czech Republic, Klecany Tel: +420 284 083 111*******************************DE – Germany, Kaarst Tel: +49 (0)2131 4016 0*************************DK – Denmark, Ballerup Tel: +45 43 56 04 00*************************ES – Spain, Madrid Tel: +34 902 330 001 ***********************FI – Finland, Vantaa Tel: +358 (0)20 753 2500 *************************FR – France, Contamine s/Arve Tel: +33 (0)4 50 25 80 25 ************************GR – Greece, Piraeus Tel: +30 210 933 6450 ************************HU – Hungary, Budaörs Tel: +36 23 885 470*************************IE – Ireland, Dublin Tel: +353 (0)1 466 6370 *************************IL – IsraelTel: +39 02 45 19 21************************IT – Italy, Corsico (MI) Tel: +39 02 45 19 21 ***********************KZ – Kazakhstan, Almaty Tel: +7 7273 561 000****************************NO – Norway, Asker Tel: +47 66 75 34 00************************PL – Poland, Warsaw Tel: +48 (0)22 573 24 00 ************************PT – PortugalTel: +351 22 999 7360**************************RO – Romania, Bucharest Tel: +40 21 252 1382*************************RU – Russia, Moscow Tel: +7 495 645-2156************************SE – Sweden, Borås Tel: +46 (0)8 59 79 50 00 ************************SK – Slovakia, Banská Bystrica Tel: +421 484 162 252**************************SL – Slovenia, Novo Mesto Tel: +386 7 337 6650**************************TR – Turkey, Istanbul Tel: +90 216 4997081 ************************UA – Ukraine, Kiev Tel: +48 (0)22 573 24 00 ************************UK – United Kingdom, Warwick Tel: +44 (0)1926 317 878 ********************ZA – South Africa, Kempton Park Tel: +27 (0)11 961 0700*****************************North AmericaCA – Canada, Milton, Ontario Tel: +1 905 693 3000US – USA, Cleveland Tel: +1 216 896 3000Asia PacificAU – Australia, Castle Hill Tel: +61 (0)2-9634 7777CN – China, Shanghai Tel: +86 21 2899 5000HK – Hong Kong Tel: +852 2428 8008IN – India, MumbaiTel: +91 22 6513 7081-85JP – Japan, Tokyo Tel: +81 (0)3 6408 3901KR – South Korea, Seoul Tel: +82 2 559 0400MY – Malaysia, Shah Alam Tel: +60 3 7849 0800NZ – New Zealand, Mt Wellington Tel: +64 9 574 1744SG – Singapore Tel: +65 6887 6300TH – Thailand, Bangkok Tel: +662 186 7000TW – Taiwan, Taipei Tel: +886 2 2298 8987South AmericaAR – Argentina, Buenos Aires Tel: +54 3327 44 4129BR – Brazil, Sao Jose dos Campos Tel: +55 800 727 5374 CL – Chile, Santiago Tel: +56 2 623 1216MX – Mexico, Toluca Tel: +52 72 2275 4200。
Page 1 of 2 ColiComplete ®AOAC Official Method 992.30General DescriptionColiComplete ® contains 5-bromo-4-chloro-3-indolyl-ß-Dgalactopyranoside (X-Gal) and 4-methyl umbelliferyl-ß-D-glucuronide (MUG). Discs are added to LST inoculated with selected dilutions of samples. Samples are incubated at 35–37 °C and examined after 24 and 48 ±2 h for confirmed total coliforms and after 30 ±2 h for confirmed E. coli results. ß-Galactosidase, from coliforms present in samples, cleaves X-Gal into 5-bromo-4-chloro-indoxyl intermediate which undergoes oxidation to yield water-insoluble blue dimer, visually detectable on disc or in surrounding medium as confirmed positive result for total coliform activity. ß-Glucuronidase, from E. coli present in samples, cleaves MUG into glucuronide and methyl umbelliferone which fluoresces under long wave UV light (366 nm) as confirmed positive result for E. coli presence.NOTE : As E. coli O157:H7 does not produce ß-glucuronidase, ColiComplete ® is not suitable for the detection of E. coli O157:H7.A. Sample PreparationPrepare appropriate serial dilutions as indicated in FDA Bacteriological Analytical Manual (BAM), or AOAC Official Methods of Analysis according to sample type.B. InoculationInoculate LST tubes with appropriate sample dilution series selected to determine MPN levels or presence/absence of total coliforms and E. coli in sample. Aseptically add a single ColiComplete ® disc to each tube. Incubate at 35–37 °C.C. Reading ColiComplete ®a. For total coliforms — After at least 24 h incubation, examine each tube for visually detectable blue color on disc or in surrounding medium. Presence of blue color indicates confirmed positive result for total coliforms.NOTE: A wide range of blue color intensity may be expected, depending on sample composition and microflora. All blue reactions are positive regardless of intensity of color.Reincubate at 35–37 °C. After additional 24 ±2 h re-examine. Continued absence of blue indicates negative result; presence of blue indicates confirmed positive result for total coliforms. Read and record the MPN code or presence/absence of total coliforms in the sample.b. For E.coli — After 30 ±2 h from start of initial incubation, examine tubes under long-wave UV light (366 nm). Fluorescent tubes indicate confirmed positive result for E. coli. Read and record the MPN code or presence/absence of E. coli in the sample.D. CONTROLSPositive and negative controls should be used to facilitate interpretation of MUG fluorescent reaction. Use one known positive E. coli tube and two negative controls - one non -E. coli /coliform tube (e.g., Klebsiella spp.) and one uninoculated media tube.NOTE: Use borosilicate glass tubes, flint glass gives fluorescence that may be misinterpreted for a positive result.Lit. No. MK_UG4655EN Merck KGaAFrankfurter Strasse 25064293 DarmstadtGermanyPage 2 of 2 E. Method Modification for Certain JuicesApplicable to juice products/processors which rely on treatments that do not come into direct contact with all parts of the juice, as contained in 21 CFR Part 120: Rules and Regulations. Hazard Analysis and Critical Control Point (HAACP); Procedures for the Safe and Sanitary Processing and Importing of Juice; Final Rule. Vol 66 No. 13. 6137-6202. Use the modified method “Analysis for Escherichia coli in Citrus Juices - Modifi cation of AOAC Official Method 992.30” as stated in Section 120.25 (a).F. StorageStore unused discs at 2–8 °C (36–46 °F) in a sealed container, with desiccant.G. DisposalAfter use, all tubes must be steam-sterilized at 121 °C for at least 30 min before discarding. For in-vitro diagnostic use only.Manufacturing EntityBioControl Systems, Inc, 12822 SE 32nd St, Bellevue, WA 98005, USA.BioControl Systems, Inc is an affiliate of Merck KGaA, Darmstadt, Germany.。
宝丽操作说明:1 冲机开机1 检查冲机曹里的药水DEVELOPER(彩显) BLEACH(漂定)STABILIZER(稳定)药面是否到了流出的费药水口面。
(如果底于费药水口面就会导制药水不会加温)2 盖好冲机过桥盖。
3 打开稳压电源开关。
4 打开冲机后面电源开关。
5 等一分钟,看前面控制面板上的电源指示灯由绿色变成红色时按下控制面板上的ON 按钮打开冲纸机。
开机等待冬天大约要1小时到1个半小时的机器升温时间。
夏天大约要半小时到1小时的机器升温时间。
2打开空压机。
3打开ups电源。
电脑会自动启动。
注:用户名:administrator 密码:poli4 启动冲印软件:Lmagelab v5启动好该软件的工作界面:注:DEVELOPER(彩显) 设定温度:37.8度BLEACH(漂定)设定温度:34度STABILIZER(稳定)设定温度:34度Drier (风箱) 设定温度:75度确定彩显和漂定温度显示是否到达设定温度。
温度到了值会是白色底显示。
如果温度没到会是红色底显示。
前面两个温度到了温度设定值后就可以做早调。
如过开机后温度长时间都没到达设定的温度,表示机器没有加温。
打开冲机打印软件界面右上脚冲机状态按钮查看药水补充液位是否过低。
弹出冲机状态对话窗口。
如下图:上图有两个红色的框表示彩显液和稳定液低手动补充药液。
点击对应的手动补充液按钮。
补充完成后等待温度到达做早调。
5早调前检查1 检查机器里装的是什么纸。
点击打印软件界面上的早调按钮() 弹出窗口:检查纸通道是否和装的纸是一样的。
2 检查冲机设置是否正确。
3 点击打印软件的工作界面右下脚Setup 冲机设置弹出设置窗口如下图:注意:彩显补充量:120 漂定补充量:180 稳定补充量:300特别说明:富士绒面纸和乐凯绸面纸输出时传动速度设置:为82柯达金属纸输出时传动速度设置:为42(解决金属纸两头有严重偏蓝色的问题这样基本可以解决)其他设置不变6 早调1如果是新装上的纸箱在打试条前先打张纸头。
Check our knowledge base at/supportCopyright 2015 Paralinx LLC All Rights ReservedTABLE OF CONTENTS PARALINX TRITONImportant Notice Safety Instructions Overview Package Contents Transmitter Receiver Quick-Start Guide 1234579LCD Screen Indicators Specifications Troubleshooting Available Frequency Channels Triton Accessories1011121416171IMPORTANT NOTICE PARALINX TRITONIMPORTANT NOTICE Paralinx reserves the right to make corrections, modifica-tions, enhancements, improvements, and other changesto its products and services at any time and to discontinueany product or service without notice. Customers shouldobtain the latest relevant information before placingorders and should verify that such information is currentand complete. All products are sold subject to Paralinx’sterms and conditions of sale supplied at the time of orderacknowledgment.Paralinx warrants performance of its hardware productsto the specifications applicable at the time of sale inaccordance with Paralinx’s standard warranty. Testing andother quality control techniques are usedto the extent Paralinx deems necessary to supportthis warranty. Except where mandated by governmentrequirements, testing of all parameters of each productis not necessarily performed.Paralinx assumes no liability for applications assistanceor customer product design. Customers are responsiblefor their products and applications using Paralinx com-ponents. To minimize the risks associated with customerproducts and applications, customers should provideadequate design and operating safeguards.Paralinx does not warrant or represent that any license,either express or implied, is granted under any Paralinxpatent right, copyright, mask work right, or other Paralinxintellectual property right relating to any combination,machine, or process in which Paralinx products or ser-vices are used. Information published by Paralinx regard-ing third-party products or services does not constitute alicense from Paralinx to use such products or services ora warranty or endorsement thereof. Use of such informa-tion may require a license from a third party under thepatents or other intellectual property of the third party, ora license from Paralinx under the patents or other intel-lectual property of Paralinx.Reproduction of information in Paralinx data booksor data sheets is permissible only if reproduction is with-out alteration and is accompanied by all associatedwarranties, conditions, limitations, and notices. Repro-duction of this information with alteration is an unfair anddeceptive business practice. Paralinx is not responsible orliable for such altered documentation.Resale of Paralinx products or services with state-ments different from or beyond the parameters statedby Paralinx for that product or service voids all expressand any implied warranties for the associated Paralinxproduct or service and is an unfair and deceptive businesspractice. Paralinx is not responsible or liable for any suchstatements.All company, brand, product, and service namesare trademarks or registered trademarks of their respec-tive holders.2 SAFETY INSTRUCTIONS PARALINX TRITONSAFETY INSTRUCTIONS When operating this equipment, read and follow all theinstructions in this manual.Keep these instructions in a safe and accessible place forfuture reference.Do not use this apparatus near water.Clean only with a dry cloth.Do not install near any heat sources such as radiators,heat registers, stoves, or other apparatus (including am-plifiers) that produce heat.Use only accessories specified or recommended byParalinx.Do not defeat the safety purpose polarized or ground-ing-type plug. A polarized plug has two blades with onewider than the other. A grounding-type plug has twoblades and a third grounding prong. The wide blade orthe third prong is provided for your safety. If the providedplug does not fit into your outlet, consult an electrician forreplacement of your obsolete outlet. Caution! To reducethe risk of electrical shock, grounding of the center pin ofthis plug must be maintained.Protect the power cord from being walked on orpinched--particularly at the plugs, convenience recepta-cles, and the point where they exit from the apparatus.Do not block the air ventilation openings. Airflow is re-quired in order to maintain proper operating temperatureof the device.Unplug this apparatus during lightning storms or whenunused for long periods of time.Caution! Shock Hazard. Do not open the unit or this willvoid your Warranty. Refer to qualified service personnel.All repairs must be performed by a Certified Paralinx***************************************************mation.Servicing is required when the apparatus has beendamaged in any way, such as power-supply cord or plugis damaged, liquid has been spilled or objects have falleninto the apparatus, the apparatus has been exposed torain or moisture, does not operate normally, or has beendropped or damaged in any way.3OVERVIEW PARALINX TRITONOVERVIEW The Paralinx Triton System is a compact HD Video Transmissionsystem offering realtime uncompressed wireless HD with robustlong range, capable of sending full-HD video with a range of upto 450 feet (140m) while maintaining less than 1ms latency.POWER INPUT WARNING!The Triton system accepts 6-17 volts DC maximum inputcurrent. Subjecting the system to higher voltage will result indamage or destruction!4PACKAGE CONTENTS PARALINX TRITONPACKAGE CONTENTSHDMI wireless video transmitter 1x 12v Adapter 2x 2dBi OMNI directional antennas for Tx HDMI wireless video receiver Please verify the following items are in the shipping box, prior to installation of the Triton transmitter or Triton receiver:Please contact sales @should you find any items missing from yourpackage.18” PTap power cable 1x1x Cold Shoe Mounting Bracket 1x Antenna MountingTool5TRANSMITTER PARALINX TRITONTRANSMITTER Model No. TR888TDC INConnect to power adapterHDMI INConnect to HD video device for signal inputMINI USBSoftware upgrade onlyAUDIO IN (3.5mm)Connect to active microphone or other audio sourcePOWER ON/OFFPress for 2 seconds to power on the transmitterPress again for 2 seconds to Power OFF.*(The transmitter does not charge external batterywhen connected to a DC power source)SELECT BUTTONPush to confirm selection on LCD screenCHANNEL BUTTONPress to switch between the 8 frequency channels1234567LCD SCREENDisplays the operating status of transmitter (networkvideo status, channel, mode, battery charge)POWER INDICATOROn: power supply is normalOff: power supply is OFF or abnormalLOW-BATTERY INDICATORFlashes when the battery charge is low.SCREW HOLE MOUNTING1/4 20” threaded mounting insertCOLD SHOE MOUNTFor mounting transmitter to a DSLR/DV cameraBATTERY (*NOT INCLUDED)LP-E6 style and other compatible types2dBi ANTENNAS (2)RP-SMA typeBATTERY CLIPPush to release external battery89101112131415*The battery is not included. Available for purchase at/store6 TRANSMITTER PARALINX TRITON7RECEIVER PARALINX TRITONRECEIVER Model No. TR888RDC INConnect to power adapterHDMI OUTConnected to HD display devices for video output.MINI USBUsed for Software upgradePOWER ON/OFFPress for 2 seconds to power on the receiver.Press again for 2 seconds to Power OFF.Note: (The transmitter does not charge externalbattery when connected to a DC power source)CHANNEL BUTTONPress to switch between the 8 frequency channelsSELECT BUTTONPush to confirm selection on LCD screenLCD SCREENDisplays the operating status of receiver (networkvideo status, channel, mode, battery charge)1234567POWER INDICATOROn: power supply is normalOff: power supply is OFF or abnormalLOW BATTERY INDICATORFlashes when the battery charge is lowSCREW HOLE FOR MOUNTING1/4 20” threaded mounting insertBATTERY (*NOT INCLUDED)NP-F styleTally feature availability TBD89101112*The battery is not included. Available forpurchase at /store8 RECEIVER PARALINX TRITON9QUICK-START GUIDE PARALINX TRITONQUICK-START GUIDE1234TRANSMITTER Install antennas and rotate clockwise to tighten. Donot over-tighten.Connect LP-E6 battery or external 6-17V DC powersource.Connect a video source via HDMI cablePress ON/OFF button to turn on transmitter RECEIVER 121Connect NP-F battery or external 6-17v DC powersourceConnect receiver to monitor via HDMI cable, poweron receiver and monitorSelect same channel on transmitter and receivers.Wait up to 10 seconds for ‘VIDEO’ icon to display onLCD and video will display on monitor LINKINGIMPORTANT NOTE:For best results, when using multiple systems in close quarters, select channel with at least a one-number gap. For instance: Camera A on channel 1 and Camera B on channel 3.10LCD SCREEN PARALINX TRITONLCD SCREENBATTERY CHARGE INDICATOR SIGNAL STRENGTH INDICATOR CURRENT CHANNEL SELECTION NETWORK STATUS ‘LINK’ means unit is linkedVIDEO STATUS‘VIDEO’ means video is transmittingB MEANS BROADCAST MODEMICROPHONE INPUT INDICATOR (WHEN EXTERNAL AUDIO IS BEING USED]1234567TIPS*All operations should be saved and implemented by pressing the SELECT button*If the SELECT button is not pressed after chang-ing a setting, the system will revert to its originalstatus after about 10 seconds and the LCD back-light will turn off*When the LCD backlight is off, press any key toilluminate LCD *To turn the device on or off, press and hold the ON/OFF button until the device turns on or off123411PARALINX TRITONINDICATORSINDICATORS12PARALINX TRITONSPECIFICATIONSSPECIFICATIONS Transmitter5.10-5.80GHzMIMOOFDM±20PPM40MHzHMDI 1.3, HDCP 1.2≤ 1ms2 External Antennas14dBmUp to 450ft / 140m, line of sight1. DC (6V~17V)2. Li-battery (LP-E6, or other compatible types)4.65 x 2.13 x 1.69 (in) / 118 x 54 x 43 (mm)14~122˚F / -10~50˚CWith Li- Battery: 32~104˚F / 0~40˚C Transmission FrequencyVideo CommunicationModulation ModeFrequency StabilityBandwidthStandard ProtocolSystem LatencyAntennasTransmission PowerTransmission DistancePower Supply optionsDimensions (W x D x H)Operating TemperatureBoth units should be stored between -40~80˚C (-40~176˚F) Both units have an operating humidity level of 15~85%13SPECIFICATIONS PARALINX TRITONSPECIFICATIONS Receiver5.10-5.80GHzMIMOOFDM±20PPM40MHz≤-70dBm≤ 1msBuilt-in AntennaHDMI 1.3, HDCP 1.2Up to 450ft / 140m, line of sight1. DC (6V~17V)2. Li-battery (NP-F style)4.65 x 2.36 x 1.77 (in) / 118 x 60 x 45 (mm)14~104˚F / -10~40˚C Transmission FrequencyVideo CommunicationModulation ModeFrequency StabilityBandwidthReceiving SensitivitySystem LatencyAntennasStandard ProtocolTransmission DistancePower SupplyDimensions (W x D x H)Operating Temperature14PARALINX TRITONTROUBLESHOOTINGTROUBLE- SHOOTING123“LINK” Icon is Not Displaying- Make sure transmitter and receiver are powered ON-Make sure both units are on the same channel- Make sure the transmitter and receiver are within range. Ideal range for linking is within 2 50 feet (75 meters)-If problem persists, power c ycle both transmitter and receiver“VIDEO” Icon is Not Displaying on LCD Screen-Make sure transmitter and receiver(s) are powered ON-Make sure all units are on the same channel (1 -8)-Make sure the transmitter and receiver are within range. Maximum range is 450 feet (140 meters)-Check the HDMI cable from the video source into the transmitter. Unplug and plug it back in again. Try a different HDMI cable if the problem persists.-If you have changed framerates on your video source, you may need to power c ycle the transmitter and receiver(s) for the video signal to be sent.-If problem persists, check that your video source supports HDCP authentication.“VIDEO” Icon is ON, but Video Signal Will Not Display on Monitor-Make sure your monitor is powered ON and not in standby mode-Make sure your HDMI cable is plugged into the selected video input-Make sure the transmitter and receiver are within range. Maximum range is 450 feet (140 meters)-Check the HDMI cable from receiver to the monitor. Unplug and plug it back in again. -Try a different HDMI cable if the problem persists.-Check to see that your monitor supports the video framerate being sent from source15PARALINX TRITONTROUBLESHOOTING 456 Abnormal Color/Tint on Video Signal- Unplug the HDMI cables on the transmitter & receiver and plug them back in again.- Power c ycle the transmitter and receiver - Try different HDMI cables Digital Noise on the Image- Make sure the transmitter and receiver are within range (maximum 450 ft/140m). - Bring them closer together to see if the problem persists- If there are several walls or obstacles in between the transmitter and receiver , try to remove them or raise the units to send the signal over them Video Signal is Fine but There is No Audio - Make sure the video source is not muted- Make sure the volume on your monitor is turned up- Check to make sure your monitor supports the audio format sent by the video source.- Change audio format if necessary. If audio format has been changed, power c ycle both transmitter and receiver- Try different HDMI cables on your receiver and transmitter in case it is a problem with the cable(s)- If the Microphone icon is displayed on the transmitter LCD, make sure an audio signal is being sent through the 3.5mm audio input on the transmitter- If the Microphone icon is NOT displayed on the transmitter LCD, make sure an audio signal is being sent through the HDMI cable TROUBLE- SHOOTINGFOR ADDITIONAL INFORMATION ANDSUPPORT VISIT OUR KNOWLEDGE BASE AT:/SUPPORTIMPORTANT NOTE:For best results, when using multiple systems in close quarters, select channel with at least a one-number gap. For instance: Camera A on channel 1 and Camera B on channel 3.16SUPPORTED FRAMERATES/ RESOLUTIONS 1080/60p1080/50p1080/30p1080/29.97p1080/25p1080/24p1080/23.98p720/60p720/59.94720/50p480p1080/60i1080/59.94i1080/50i576i480i720/59.94i720/50iAVAILABLE FREQUENCY CHANNELS1 - 5150mhz2 - 5190mhz3 - 5210mhz4 - 5230mhz5 - 5735mhz6 - 5755mhz7 - 5775mhz8 - 5795mhz576i480iPARALINX TRITON AVAILABLE FREQUENCY CHANNELS17PARALINX TRITONTRITON ACCESSORIESOPTIONAL ACCESSORIES GO TO /STORE TO CHECK OUT ALL TRITON ACCESSORIES AND BUILD YOUR OWN CUSTOMIZED KITCONTACT US AT SALES@ SHOULD YOU REQUIRE ANY ASSISTANCE WITH YOUR PURCHASECONTACT SUPPORT@ SHOULD YOU REQUIRE ASSISTANCE WITH TROUBLESHOOTING YOUR SYSTEMTABLE OF CONTENTS PARALINX TRITON21。
宝丽亚说明书
【药品名称】通用名称:吸入用丙酸倍氯米松混悬液商品名称:宝丽亚【主要成份】本品主要成分为丙酸倍氯米松,化学名称为:16β-甲基-11β,17α,21-三羟基-9α-氯孕甾-1,4-二烯-3,20-二酮-17,21-二丙酸酯。
【成份】分子式:C28H37ClO7 分子量:521.05
【性状】本品在耐压容器中的药液为白色或微黄色混悬液,揿压阀门,药液即呈雾粒喷出。
【适应症/功能主治】因本品局部用于肺无明显全身作用,可用气雾吸入法以缓解哮喘症状和过敏性鼻炎的治疗,本品有治疗和预防作用。
【规格型号】2ml*20支
【用法用量】成人一般一次喷药0.05-0.1mg(每揿一次约喷出主药0.05mg )一日3~4次。
重症用全身性皮质激素控制后再用本品治疗,每日最大量不超过1mg。
儿童用量按年龄酌减每日最大量不超过0.8mg。
症状缓解后逐渐减量。
【不良反应】气雾剂对个别人有刺激感,咽喉部出现白色念球菌感染。
但吸后立即漱口可减轻刺激感,并可用局部抗菌药物控制感染。
无钠水潴留作用。
偶见声嘶或口干,少数可因变态反应引起皮疹。
【禁忌】对本品过敏者禁用。
【注意事项】
1.本气雾剂适用于轻症哮喘,急性发作时应加用其它平喘药。
2.用药后应在哮喘控制良好的情况下逐渐停用口服皮质激素,一般在本气雾剂治4-5天后才慢慢减量停用。
3.当药品性状发生改变时,禁止使用。
【儿童用药】婴儿慎用。
【老年患者用药】尚不明确。
【孕妇及哺乳期妇女用药】孕妇慎用。
【药物相互作用】 1.本品可能对人甲状腺对碘的摄取、清除和转化率有影响。
2.胰岛素能与本品产生拮抗作用,糖尿病患者应注意调整用药剂量。
【药物过量】本品用量过大(>0.8mg/d),可出现糖皮质激素的一系列全身性不良反应。
【药理毒理】丙酸倍氯米松为人工合成的强效外用肾上腺皮质激素类药物。
丙酸倍氯米松气雾剂外用具有。
(1)抗炎、抗过敏、止痒及减少渗出作用,能抑制支气管渗出物,消除支气粘膜肿胀,解除支气管痉挛。
(2)可以减轻和防止组织对炎症的反应,能消除局部非感染性炎症引起的发热、发红及肿胀,从而减轻炎症的表现。
(3)免疫抑制作用:防止或抑制细胞中介的免疫反应,延迟性过敏反应,并减轻原发免疫反应的扩展。
(4)本品局部应用,对钠潴留及肝糖原异生作用很弱,也无雄性、雌性及蛋白同化激素样的作用,对体温和尿也无明显影响,吸入给药对支气管喘息的疗效比口服更有效。
【药代动力学】本品亲脂性较强,易渗透,约吸入量的25%到达肺部。
【贮藏】密封。
【包装】每盒20支。
【有效期】24 月。