Vortioxetine_HNMR_08966_MedChemExpress

Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Oct.-02-2018Print Date:Oct.-02-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :TUG-891Catalog No. :HY-100881CAS No. :1374516-07-01.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:TUG891;TUG 891Formula:C23H21FO3Molecular Weight:364.41CAS No. :1374516-07-04. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

科研热词 rna干扰 基因表达 转录因子 细胞凋亡 小鼠 受体 缺氧 基因表达调控 转染 胃癌 肺肿瘤 肝细胞 结缔组织生长因子 甲基化 凋亡 免疫组织化学 表达 胃肿瘤 细胞因子 细胞分化 癌 甲状腺激素 热休克蛋白70 激活蛋白-1 泡沫细胞 核转录因子κ b 心肌细胞 实时定量pcr 增殖 半定量rt-pcr 动脉粥样硬化 分化 克隆 乙型肝炎病毒 il-17 ghrelin 鼻咽肿瘤 黏蛋白类 雌激素 银屑病 重症肌无力 遗传转化 逆转录聚合酶链反应 过氧化物酶体增殖物激活受体γ 转移 转录调控 转录 转化生长因子β 1 质粒 调节性t细胞 血管内皮细胞生长因子 血管内皮细胞
科研热词 基因表达 rna干扰 细胞凋亡 大鼠 原位杂交 转录 猪 凋亡 免疫组织化学 转录因子 血管紧张素ⅱ 血管内皮生长因子 胰岛素样生长因子2 细胞增殖 小干扰rna sirna pou蛋白 阿霉素 铅 软骨细胞 转录调控 转化生长因子β 调节性t细胞 胰岛素 胃肿瘤 肌细胞,心脏 细胞分化 纤维化 神经毒性 甲基化 流式细胞术 活化蛋白-1 差异表达基因 基因表达调控 基因 哮喘 信号通路 信号转导 乳腺肿瘤 rt-pcr rna nf-κ b foxp3 dna甲基化 brn-3a 骨骼肌 骨肉瘤 钩藤碱 重症肌无力 醋酸铅 酶 过氧化物酶
2008年 序号 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52
卵巢肿瘤 2 剪接 2 前列腺素e2 2 内皮细 2 免疫耐受 2 信号传导通路 2 二噁英 2 二嘑英 2 乙型 2 乏氧 2 western blot 2 u937 2 t淋巴细胞 2 tgf-β 1 2 tcdd 2 smart技术 2 rna干涉 2 rnai 2 pgc-1α 2 northern杂交 2 lovo细胞系 2 l-02 northern blot 2 hepkt 2 鼠 1 黑素瘤分化相关基因(mda-7/il-24) 1 黏蛋白5b 1 黏蛋白5ac 1 黏膜上皮细胞 1 黏液高分泌 1 鸡端粒酶反转录酶 1 高迁移率族蛋白b1 1 高血压,肺性 1 高血压 1 高脂血症 1 高温胁迫 1 高压注射体内转染法 1 骨髓源性心肌干细胞 1 骨髓基质细胞 1 骨骼肌线粒体 1 骨转移 1 骨调素 1 骨桥蛋白 1 骨性关节炎 1 骨形态发生蛋白-2 1 骨发育 1 骨化三醇 1 骨保护素 1 马立克病 1 香加皮杠柳苷 1

名称
结构式非那雄胺杂质
A Finasteride Impurity A
CAS No. 98319-24-5B Finasteride Impurity B
非那雄胺是4-氮甾体激素化合物，为特异性Ⅱ型5α-还原酶抑制剂，抑制外周睾酮转化为二氢睾酮，降低血液和前列腺、皮肤等组织中二氢睾酮水平。

前列腺的生长发育和良性增生依赖于二氢睾酮，非那雄胺通过降低血液和前列腺组织中的二氢睾酮水平而抑制前列腺增生、改善良性前列腺增生的相关临床症状。

广州尤瓦化工产品有限公司，给大家整理非那雄胺杂质标准品。

非那雄胺杂质B
Finasteride Impurity B (Dutasteride Ester Impurity) CAS No. 103335-41-7
非那雄胺杂质C
Finasteride Impurity C
CAS No. 1329611-51-9。

药物沃替西汀（Vortioxetine）合成检索总结报告
一、沃替西汀（Vortioxetine）简介
沃替西汀（V ortioxetine）于2013年9月30日在美国上市。

沃替西汀（V ortioxetine）确切的作用机制尚不清楚，可能与抑制中枢神经系统的5-羟色胺(5-HT)再摄取相关。

沃替西汀（V ortioxetine）适应于重症抑郁障碍。

沃替西汀（V ortioxetine）不良反应：恶心、便秘和呕吐。

沃替西汀（V ortioxetine）分子结构式如下:
英文名称：V ortioxetine hydrobromide
中文名称：沃替西汀氢溴酸盐
本文主要对沃替西汀（V ortioxetine）的合成路线、关键中间体的合成方法及实验操作方法进行了文献检索并作出了总结。

二、沃替西汀（Vortioxetine）合成路线
三、沃替西汀（Vortioxetine）合成检索总结报告
(一) 沃替西汀（Vortioxetine）中间体3的合成方法一。