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低频脉冲电磁场治疗原发性骨质疏松症的临床观察秦茵;李玲;张元菊【期刊名称】《中国骨与关节杂志》【年(卷),期】2007(006)006【摘要】目的观察低频脉冲电磁场对原发性骨质疏松症患者的治疗作用.方法对60例原发性骨质疏松症患者进行低频脉冲电磁场治疗,每次40min,1次/d,每周治疗5次,共24周为1个疗程,观察其治疗作用.结果治疗后在48例有疼痛症状的患者中,疼痛消失或缓解43例(P＜0.05),总有效率为89.6%.血清骨钙素水平提高5.8%.6个月后复查显示平均腰椎(L2-4)骨密度提高0.56%,平均股骨颈骨密度提高1.38%,平均大转子骨密度提高了1.29%,平均髋部Wards三角区骨密度提高1.87%(P均＜0.05).治疗过程中及治疗后无1例出现不良反应.治疗前后患者血常规、肝肾功能、血钙、血磷均在正常范围内.结论 PEMFs能缓解原发性骨质疏松症患者疼痛症状,改善骨代谢以及提高骨密度.【总页数】3页(P348-350)【作者】秦茵;李玲;张元菊【作者单位】350025,福州,南京军区福州总医院中医理疗科;解放军总医院第一附属医院康复理疗科;解放军总医院第一附属医院康复理疗科【正文语种】中文【中图分类】R6【相关文献】1.低频脉冲电磁场治疗原发性骨质疏松症的实验研究进展 [J], 夏璐;何成奇2.补肾益骨膏联合低频脉冲电磁场治疗老年原发性骨质疏松症临床观察 [J], 黄明炜;廖勇敢;李艳丽;陈思思;汪茜3.低频脉冲电磁场联合鲑鱼降钙素治疗原发性骨质疏松症 [J], 张捷;陈永茂;沈朝东4.低频脉冲电磁场治疗原发性骨质疏松症的临床观察 [J], 秦茵5.运用低频脉冲电磁场治疗原发性骨质疏松症 [J], 李小平因版权原因，仅展示原文概要，查看原文内容请购买。
脉冲电磁场合用钙剂治疗绝经后骨质疏松症的疗效观察
王玉英;李素梅;吴鸣
【期刊名称】《中国临床保健杂志》
【年(卷),期】2004(007)001
【摘要】目的对脉冲电磁场(PEMFs)治疗绝经后骨质疏松症疗效进行观察和探讨.方法确诊为绝经后骨质疏松症20例,采用磁振热机器(选用其主要的脉冲电磁场成分)加口服钙剂治疗,每次1 h,共30次,治疗50 d及治疗后6个月观察其自觉症状改善情况及骨密度(BMD)的变化,并与治疗前对比分析.结果 100%患者疼痛明显减轻,治疗50 d结束时平均BMD绝对增长0.048 g/cm2,治疗后6个月达0.083
g/cm2.结论 PEMFs治疗绝经后骨质疏松症可以有效控制疼痛,提高患者的生存质量,对患者BMD也有一定程度的提高.
【总页数】2页(P25-26)
【作者】王玉英;李素梅;吴鸣
【作者单位】安徽省立医院,康复医学科,合肥,230001;安徽省立医院,内分泌科,合肥,230001;安徽省立医院,康复医学科,合肥,230001
【正文语种】中文
【中图分类】R454.1;R591.44
【相关文献】
1.低频脉冲电磁场治疗绝经后骨质疏松症的临床疗效观察 [J], 姜俊良;梁邱;杨浩伦;何成奇;杨霖
2.雌激素加钙剂与钙剂对比治疗绝经后妇女骨质疏松症的骨密度测定分析 [J], 张宏红;吴春维;何秀华
3.雌激素辅以钙剂治疗绝经后骨质疏松症疗效观察 [J], 董利;郭厉华
4.雌激素、乐力钙联合用药治疗绝经后骨质疏松症 [J], 张玉霞;尹玉香
5.淫羊藿总黄酮联合钙剂和维生素D治疗绝经后骨质疏松症的临床疗效观察 [J], 金雨
因版权原因，仅展示原文概要，查看原文内容请购买。
脉冲电磁场治疗绝经后骨质疏松症的Meta分析徐换;郝赤子;郑俊;廖维靖【摘要】Objective: To systematically review the effectiveness and safety of pulsed electromagnetic fields (PEMFs) in treating patients with postmenopausal osteoporosis (PMO), so as to provide a basis for clinical treatment and further study.Method: The randomized controlled trials (RCTs) on PEMFs in treating patients with PMO were searched on China National Knowledge Internet (CNKI), Wanfang Data medical information system (WF), VIP information resource system (VIP), Chinese Biomedical Literature Database (CBM), PubMed, The Cochrane Library and Web of Science from inception to August 2016.Two reviewers independently screened articles according to the inclusion and exclusion criteria, extracted data and assessed the risk of bias of included studies.Then meta-analysis was performed using RevMan 5.3 software.Results: A total of 12 RCTs involving 1134 patients were included.The results of meta-analysis showed that there was statistically significant difference in VAS (SMD=-2.07, 95% CI-2.74 to-1.40, P<0.01) between the two groups, but there was no statistically significant difference in BMD of the lumbar spine(SMD=0.79, 95% CI 0.00 to 1.57, P=0.05) and femoral neck (SMD=0.77, 95% CI-0.04 to 1.57, P=0.06), and the adverse events (RR=0.33, 95% CI 0.09 to 1.20, P=0.09) between the two groups.Conclusion: Actual clinical evidence indicates that PEMFs are effective and safe for PMO to a certainrge-sample, multi-center and high-quality studies are still neededfor validation because of the limitation of the quantity and quality of the included studies.%目的:系统评价脉冲电磁场(PEMFs)治疗绝经后骨质疏松症(PMO)的有效性和安全性,为临床治疗和进一步的研究提供参考依据.方法:计算机检索中国知网(CNKI)、万方数据库、维普数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、The Cochrane Library和Web of Science数据库,搜集有关PEMFs治疗PMO患者的随机对照试验(RCT),检索时限为从建库至2016年8月.由2名研究者按照纳入与排除标准独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析.结果:共纳入12个RCT,合计患者1134例.Meta分析结果显示,VAS评分[SMD=-2.07,95%CI(-2.74,-1.40),P<0.01]2组间差异具有统计学意义,腰椎BMD[SMD=0.79,95%CI(0.00,1.57),P=0.05]、股骨颈BMD[SMD=0.77,95%CI(-0.04,1.57),P=0.06]、不良反应率[RR=0.33,95%CI(0.09,1.20),P=0.09]方面,2组间差异均无统计学意义.结论:现有临床证据表明,PEMFs对PMO的治疗有一定疗效,安全性较好,但受纳入研究数量和质量限制,尚需大样本、多中心、高质量的研究加以验证.【期刊名称】《中国康复》【年(卷),期】2017(032)003【总页数】5页(P230-234)【关键词】脉冲电磁场;绝经后骨质疏松症;系统评价;Meta分析;随机对照试验【作者】徐换;郝赤子;郑俊;廖维靖【作者单位】武汉大学中南医院康复医学科,武汉 430071;武汉大学中南医院康复医学科,武汉 430071;武汉大学中南医院康复医学科,武汉 430071;武汉大学中南医院康复医学科,武汉 430071【正文语种】中文【中图分类】R49;R681早期有效预防和治疗骨质疏松症(Osteoporosis，OP)对提高绝经后妇女生活质量、改善其预后、减轻家庭及社会精神压力及经济负担有重要意义[1]。
脉冲电磁场对老年大鼠关节软骨及软骨下骨凋亡蛋白的影响李萌萌;尹林伟;牛尚博;刘静;黄夏荣;王金玲;孙光华;钟培瑞;彭婷;曾国锋;周君【期刊名称】《风湿病与关节炎》【年(卷),期】2024(13)5【摘要】目的:探讨脉冲电磁场对老年大鼠关节软骨及软骨下骨凋亡蛋白的影响。
方法:采用随机抽样法将16只24月龄SD自然衰老雄性大鼠随机等分为老年组和脉冲电磁组,8只6月龄SD青年雄性大鼠作为青年组。
脉冲电磁组予脉冲电磁场干预,频率为8 Hz,强度为3.82 mT,每日40 min,每周5 d,持续8周。
青年组和老年组固定于脉冲电磁场下,仪器不通电。
8周后取材,ELISA法检测血清Ⅱ型胶原C 端肽(CTX-Ⅱ)含量;显微CT检测左侧胫骨软骨下骨微结构并分析骨组织形态量化指标;番红O-固绿染色观察大鼠左侧胫骨平台软骨组织形态结构,改良Mankin's评分评估大鼠膝关节软骨组织退行性变化程度。
RT-qPCR、Western blot检测半胱氨酸天冬氨酸蛋白酶-3(Caspase-3)、半胱氨酸天冬氨酸蛋白酶-8(Caspase-8)、血小板反应蛋白解整合素金属蛋白酶-4(ADAMTS-4),以及血小板反应蛋白解整合素金属蛋白酶-5(ADAMTS-5)的mRNA与蛋白表达水平。
结果:①与青年组比较,老年组大鼠软骨胶原分解产物CTX-Ⅱ水平升高(P<0.05);骨密度、骨体积分数、骨小梁数量均降低(P<0.05),骨小梁厚度、骨小梁间距均增大(P<0.05);番红O-固绿染色显示,大鼠软骨表面粗糙有裂隙,软骨与软骨下骨界限模糊不清,且有潮线,低细胞化,细胞形态结构不规则,蛋白多糖丢失且红染变淡;改良Mankin's评分增加(P<0.05);Caspase-3、Caspase-8、ADAMTS-4、ADAMTS-5的mRNA及蛋白表达升高(P<0.05)。
②与老年组比较,脉冲电磁组大鼠软骨胶原分解产物CTX-Ⅱ水平降低(P<0.05);左侧胫骨软骨下骨的骨密度、骨体积分数升高,骨小梁数量增加(P<0.05),骨小梁间距减小(P<0.05),骨小梁厚度有降低趋势(P>0.05);番红O-固绿染色显示,大鼠软骨表面较为平整,软骨与软骨下骨界限分明,细胞形态较规则、数量较多,蛋白多糖丰富且染色均匀;改良Mankin's评分较小(P<0.05);Caspase-3、Caspase-8、ADAMTS-4、ADAMTS-5的mRNA及蛋白表达降低(P<0.05)。
低频脉冲电磁场联合阿仑膦酸钠治疗绝经后骨质疏松骨密度及骨代谢的影响郑黎勤 郑衍庆广东省佛山市中医院三水医院，广东佛山 528100[摘要] 目的 观察低频脉冲电磁场联合阿仑膦酸钠治疗绝经后骨质疏松的疗效和安全性。
方法 将78例绝经后骨质疏松患者按随机数字表法分为试验组和对照组，对照组患者给予阿仑膦酸钠治疗，试验组在对照组的基础上加用低频脉冲电磁场，比较两组患者治疗效果。
结果 治疗4个月后，两组患者股骨颈、股骨粗隆、Wards三角和腰椎BMD水平，血清TRACP-5b、BAP、BGP水平以及VAS评分均较治疗前改善（P＜0.05），试验组改善幅度大于对照组（P＜0.05）；试验组有效率明显高于对照组（P＜0.05）；两组不良反应发生率比较无统计学意义（P＞0.05）。
结论 低频脉冲电磁场联合阿仑膦酸钠治疗绝经后骨质疏松效果肯定，安全性较好。
[关键词] 低频脉冲电磁场；阿仑膦酸钠；绝经后骨质疏松[中图分类号] R580 [文献标识码] A [文章编号] 2095-0616（2018）07-247-04 Effects of low frequency pulsed electromagnetic fields combined with alendronate on bone mineral density and bone metabolism in postmenopausal osteoporosisZHENG Liqin ZHENG YanqingSanshui Hospital,Foshan Hospital of Traditional Chinese Medicine,Guangdong province,Foshan 528100,China [Abstract] Objective To observe the efficacy and safety of low frequency pulsed electromagnetic fields combined with alendronate in the treatment of postmenopausal osteoporosis. Methods Seventy-eight cases of postmenopausal osteoporosis were randomly divided into the experimental group and the control group.The patients in the control group were treated with alendronate,while the experimental group was added low frequency pulsed electromagnetic fields on the basis of the control group.The therapeutic effects of two groups were compared. Results After 4 months of treatment,the levels of femoral neck,trochanter,Wards triangle and lumbar BMD,the serum levels of TRACP-5b,BAP,BGP and VAS scores in the two groups were better than before treatment (P＜0.05).The improvement of the experimental group was greater than that of the control group (P＜0.05).The effective rate of the experimental group was significantly higher than that of the control group (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Low frequency pulsed electromagnetic field combined with alendronate sodium in the treatment of postmenopausal osteoporosis is effective and safe.[Key words] Low frequency pulsed electromagnetic field;Alendronate sodium;Postmenopausal osteoporosis骨质疏松是一种老年人易患的全身代谢性骨病，以严重的全身疼痛为主要表现，并严重影响患者的生活质量，造成极大的不便。
两种干预周期脉冲电磁场对原发性骨质疏松症的疗效比较田永芝;田发明;张柳;程爱国;梁春雨【期刊名称】《中国骨质疏松杂志》【年(卷),期】2015(21)1【摘要】Objective To compare the efficacy of different treatment periods with pulse electromagnetic fields ( PEMFs ) on primary osteoporosis. Methods A total of 124 cases of osteoporosis in our hospital from October 2010 to January 2012 were enrolled in this study. They were divided into whole period group and half period group. The patients in whole period group ( 62 cases) received 60 times PEMFs treatment, with 6⁃12Hz frequency and 9⁃11mT intensity, using a TY⁃PEMF A2 ( Tong⁃Ye Company, Tianjin) . Each treatment lasted for 40 minutes. The total course was 5 months. The patients in the half period treatment group received 30 times treatment. The total course was two and half months. All patients received calcium carbonate and vitamin D 300mg twice a day, alfacalcidol 1 ug once a day, and alendronate sodium pill 70 mg once a week. The bone mineral density of the total hip, femoral neck, and lumbar vertebral ( L2⁃L4 ) was detected before and after the treatment. Results The BMD of the total hip, femoral neck, and lumbar vertebral L2⁃L4 in both groups markedly increased after the treatment comparing to that before the treatment. The increasing rates of BMD in whole period group and half period group were 8�31 ± 1�01 and 5�45 ± 1�17 in the total hip, 8�58 ± 1�40 and 5�44± 1�52 in the femoral neck, and 8�02 ± 0�63 and 4�97 ± 0�49 in the lumbar vertebrae, respectively. The difference among them was statistically significant. Conclusion PEMFs combined with anti⁃osteoporosis drugs can increase the BMD of osteoporosis patients. The whole period of PEMFs has better efficacy than half period treatment.%目的：比较脉冲电磁场（ pulsed electric⁃magnetic fields， PEMFs）在原发性骨质疏松症骨重建周期全程干预和半程干预的疗效。
低频脉冲磁场对兔膝关节软骨细胞人白介素1β、肿瘤坏死因子α表达与分泌的影响刘明晖;窦逾常;晋学飞;丁保冬【期刊名称】《中国医药导报》【年(卷),期】2012(9)29【摘要】目的探讨低频脉冲磁场对兔膝关节软骨细胞人白介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)表达与分泌的影响.方法选择40只健康成年新西兰白兔建立兔膝关节软骨损伤模型,把右膝关节设为治疗组(n = 20),每日给予低频脉冲磁场治疗;左膝关节为对照组(n = 20),给予假磁场治疗,治疗后1、4周深麻醉处死动物,观察相关指标的变化.结果在同一观察时间点,IL-1β和TNF-α表达量治疗组均明显少于对照组,差异均有统计学意义(均P < 0.05).治疗组软骨损伤程度较对照组轻微,关节活动度明显大于对照组,outerbridge积分也少于对照组,差异均有统计学意义(均P < 0.05).结论低频脉冲磁场治疗骨性关节炎具有简便易行,安全无创等优点,可有效遏制IL-1β、TNF-α的释放,调节分泌作用,从而对骨性关节炎软骨损伤修复具有促进作用.%Objective To investigate the effects of expression and secretion of human interleukin 1(3 (TL 1 (5), tumor necrosis factor α (TNF-α) in rabbit articular cartilage cells by the low-frequency pulsed magnetic field. Methods 40 healthy adult New Zealand white rabbits were selected to construct the articular cartilage injury model, the right knees were chosen as the treatment group (n - 20) and given daily low-frequency pulsed magnetic field therapy; the left knees in - 20) were chosen as the control group and given false magnetic field therapy, after the treatment of 1 and4 weeks, the rabbits were given deep anesthesia and sacrificed to observe the changes of the relevant indicators. Results A.E ihe same time points, the expression of IL-1β and TNF-α in the treatment gro up were lower than those in control group, the differences were all statistically significant (all P ＜ 0.05). The degree of cartilage damage in treatment group was less than that in control group, the outerbridge points in treatment group were less than that in control group, the joint activity of the treatment group were better than that of the control group, the differences were all statistically significant (all P ＜ 0.05). Conclusion The low-frequency pulse magnetic field therapy for treating osteoarthritis is simple, safe and non-invasive which can effectively curb the release and regulate the secretion of IL-1β and TNF-α, thus it can promote the repair of the osieoarthritis cartilage injury.【总页数】3页(P32-33,36)【作者】刘明晖;窦逾常;晋学飞;丁保冬【作者单位】吉林大学中日联谊医院中医科,吉林长春,130033;吉林大学中日联谊医院中医科,吉林长春,130033;吉林大学中日联谊医院泌尿外科,吉林长春,130033;吉林大学中日联谊医院急诊科,吉林长春,130033【正文语种】中文【中图分类】R683【相关文献】1.体外冲击波对兔膝关节炎软骨细胞丝裂原活化蛋白激酶表达的影响 [J], 刘洪柏;侯晓东2.丹参注射液对骨性关节炎模型兔膝关节软骨细胞p-IκBα表达影响的实验研究[J], 徐西林;张晓峰;吕航;夏联恒;李小东;宿慧;刘沛然;王顺3.硫酸氨基葡萄糖胶囊对兔膝关节软骨细胞凋亡基因Bcl-2与Bax表达的影响 [J], 林宗汉;郑铁牛;黎强;覃学流;容向宾;龙飞攀;梁庆华;王永乐4.低频脉冲磁场对兔膝关节软骨细胞白介素-1β、肿瘤坏死因子-α表达与分泌的影响 [J], 张志刚;曹成;王根林;朱雪松;耿德春;施勤;毛海青;邹俊5.伸筋易骨矫形手法对兔膝关节软骨细胞代谢及Sox9表达的影响 [J], 赵强;王一洲因版权原因，仅展示原文概要，查看原文内容请购买。
低频脉冲电磁场治疗绝经后骨质疏松症的临床疗效观察姜俊良;梁邱;杨浩伦;何成奇;杨霖【期刊名称】《中国康复医学杂志》【年(卷),期】2017(032)002【摘要】目的:采用低频脉冲电磁场(pulsed electromagnetic fields,PEMFs)对绝经后骨质疏松症患者进行干预,观察其临床疗效并进行为期1年的疗效观察,以探讨PEMFs对骨质疏松患者的短期和远期疗效.方法:将纳入研究的绝经后骨质疏松患者60例分为对照组和研究组.对照组接受为期12个月的常规骨质疏松治疗,包括钙剂、维生素D和二膦酸盐;研究组接受常规治疗的基础上增加30次(1个月)的PEMFs治疗.所有患者在治疗前和治疗后第1、3、6和12个月接受疗效评估,包括疼痛、功能受限指数.腰椎骨密度检查在治疗前,治疗后3、6和12个月接受检查.结果:纳入患者基线水平无显著性差异(P＞ 0.05).治疗后1、3、6和12个月,研究组患者疼痛和功能受限的水平显著低于对照组;治疗后3个月研究组患者骨密度(bone mass density,BMD)改善明显高于对照组,而治疗后6和12个月两组的BMD没有显著性差异.结论:在常规药物治疗的基础上配合PEMFs治疗可在短期内增加对骨质疏松症患者疼痛和运动功能的改善作用且具有较好的远期疗效;对于腰椎骨密度的影响具有较好的效果,但是远期效果不明显.【总页数】3页(P192-194)【作者】姜俊良;梁邱;杨浩伦;何成奇;杨霖【作者单位】四川大学华西医院康复医学科,康复医学四川省重点实验室,成都,610000;四川大学华西医院康复医学科,康复医学四川省重点实验室,成都,610000;四川大学华西医院康复医学科,康复医学四川省重点实验室,成都,610000;四川大学华西医院康复医学科,康复医学四川省重点实验室,成都,610000;四川大学华西医院康复医学科,康复医学四川省重点实验室,成都,610000【正文语种】中文【中图分类】R685;R493【相关文献】1.鲑鱼降钙素联合低频脉冲电磁场治疗绝经后妇女骨质疏松症的临床观察 [J], 梁莉萍;王立2.低频脉冲电磁场与雌激素联合应用治疗绝经后骨质疏松症 [J], 黄姝;孟萍;蔡红卫3.阿仑膦酸钠治疗绝经后骨质疏松症的临床疗效观察 [J], 王笑哥4.淫羊藿总黄酮联合钙剂和维生素D治疗绝经后骨质疏松症的临床疗效观察 [J], 金雨5.阿仑膦酸钠治疗绝经后骨质疏松症的临床疗效观察 [J], 李禹潼;程之强因版权原因，仅展示原文概要，查看原文内容请购买。
低频脉冲电磁场联合运动、针灸治疗类风湿性关节炎并发骨质疏松症的临床研究2佛山复星禅诚医院康复医学科广东省佛山市 528300【摘要】目的：探讨低频脉冲电磁场联合运动、针灸治疗在炎症相关骨质疏松症（类风湿性关节炎（RA）并发骨质疏松）的疗效。
方法：选取60例RA并发骨质疏松症女性患者，随机分为空白组、干预组1、干预组2。
空白组仅服用抗RA药物以及常规的补钙治疗；干预组1在服用药物基础上接受低频脉冲电磁场治疗；干预组2在服用药物基础上接受低频脉冲电磁场联合运动、针灸治疗。
干预24周后比较干预前后的腰椎、股骨颈的骨密度、骨痛程度（VAS评分）及生活质量（SF-36）。
结果：两个干预组的腰椎、股骨颈的骨密度及生活质量评分均较空白组明显增加、骨痛程度则较空白组明显减低。
干预组2的股骨颈骨密度和骨痛程度的改善较干预组1显著。
结论：低频脉冲电磁场联合运动、针灸治疗能有效增加RA并发骨质疏松症患者的骨密度，明显提升该类患者的生活质量。
【关键词】炎症相关骨质疏松症；低频脉冲电磁场；骨密度；VAS评分；SF-36Therapeutic Efficacy of LF-PMF combined with Physical Therapy and Acupuncture Treatment in Rheumatoid Arhritis Patients with Osteoporosis: A case-control studyXiaolin TANG1 Xiaohua YAN 2 Dequan DING3Department of Medical Science, Shunde Polytechnic, Foshan 528300 , China【Abstract】Objective: To evaluate the therapeutic efficacy oflow-frequency pulsed electromagnetic field (LF-PMF) combined with physical therapy (PT) and acupuncture treatment in inflammation associated osteoporosis (rheumatoid arthritis (RA) with osteoporosis). Methods: 60 females with RA and osteoporosis were randomly and equally pided into control group and intervention group (IG)1 and IG2.The control group was given anti-RA medicine and calcium; the IG1 was treated with LF-PMF;the IG2 was treated with LF-PMF combined with PT and acupuncture treatment. Results: Compared with control group, the BMD of lumber spine and femoral neck, and the score of SF-36 in IG1and IG2 increased remarkably,and scale of pain decreased significantly in IG1 and IG2. The BMD of femoral neck and the scale of pain in IG2 improved more than IG1. Conclusions: The combined therapy of LF-PMFwith PT and acupuncture could significantly increase BMD, relieve pain and improve quality of life in RA patients with osteoporosis.【Key words】inflammation associated osteoporosis;LF-PMF;BMD;VAS;SF-36骨质疏松症是一种常见的骨代谢疾病，是一种以骨量低、骨组织微结构破坏，导致骨脆性增加，易发生骨折为特征的全身性骨病。
