實驗材料及方法:
1. 取週齡於12至16週之雄性大白鼠(Wistar)，體重約250+330克。 2.平均動脈血壓之測量 注射urethane (1.4g/kg, I.P.)，將其全身麻醉後進行股動靜脈插管。將內含heparin (100 U/ml)之polyethylene導管(PE50)插入股動脈，並連接壓力轉換器與放大器，以偵測血壓與心跳之變化。
研究成果發表
1. Chu, C.-M.; Gao, S.; Sastry, M. N. V.; Yao, C.-F. “Iodine-catalyzed Michael addition of mercaptans to a,b-unsaturated ketones under solvent-free conditions” Tetrahedron Lett, 2005, 46, 4971-4974. (SCI ) 2. Ko, S.; Sastry, M. N. V.; Lin, C.; Yao, C.-F. ” Molecular iodine-catalyzed one-pot synthesis of 4-substituted-1,4-dihydropyridine derivatives via Hantzsch reaction” Tetrahedron Lett, 2005, 46, 5771-5774. (SCI) 3. Shivaji, V. M.; Sastry, M. N. V.; Wang, C.-C.; Yao, C.-F. “Molecular iodine: A powerful catalyst for the easy and efficient synthesis of quinoxalines” Tetrahedron Lett, 2005, 46, 6345-6348. (SCI) 4. Tu, Z.; Jang, Y.; Lin, C.; Liu, J.-T.; Hsu, J.; Sastry, M. N. V. N.; Yao, C.-F. “The study of reaction mechanism for the transformation of nitronate into nitrile by phosphorus trichloride” Tetrahedron 2005, 61, 10541-10551. (SCI) 5. Lin, C.; Hsu, J.; Sastry, M. N. V.; Fang, H.; Tu, Z.; Liu, J.-T.; Yao, C.-F. “I2-catalyzed Michael addition of indole and pyrrole to nitroolefins” Tetrahedron 2005, 61, 11751-11757. (SCI) 6. More, S. V.; Sastry, M. N. V.; Yao, C.-F. “Cerium (IV) ammonium nitrate (CAN) as a catalyst in tap water : A simple, proficient and green approach for the synthesis of quinoxalines”Green Chem., 2006, 8, 91-95. (SCI) 7. Ko, S.; Lin, C.; Tu, Z.; Wang, Y.-F.; Wang, C.-C.; Yao, C.-F. “CAN and iodine-catalyzed reaction of indole or 1-methylindole with a,b-unsaturated ketone or aldehyde” Tetrahedron Lett, 2006, 47, 487-492. (SCI) 8. Gao, S.; Tzeng, T.; Chu, C.-M.; Liu, J.-T.; Lin, C.; Sastry, M. N. V.; Yao, C.-F. “Iodine Catalyzed Conjugate Addition of Mercaptans to α,β-Unsaturated Carboxylic Acids under Solvent–free condition” Tetrahedron Lett, 2006, 47, 1889-1892. (SCI) 9. More, S. V.; Sastry, M. N. V.; Yao, C.-F. “TMSCl Catalyzed Aza-Diels-Alder Reaction: A Simple and Efficient Synthesis of Pyrano- and Furanoquinoline” Synlett. 2006, xxxx-xxxx. (SCI) 10. Shen, K.-H.; Yao, C.-F. “A Novel and Efficient Method for the Allylation of Carbonyl Compounds and Imines using Triallylaluminum” J. Org. Chem. 2006, 71, xxxx-xxxx. (SCI) 11. Kulkarni, N. A. and Chen, K* “Excellent diastereoselective allylation of camphor derived glyoxylic oxime ethers mediated by a Lewis acid” Tetrahedron Lett. 2006, 47, 611-613. (SCI) 12. Kulkarni, N. A.; Wang, S. G.; Lee, L. C.; Tsai, H. R.; Venkatesham, U. and Chen, K.* “Highly diastereoselective allylation and reduction of chiral camphor-derived a-ketoamides” Tetrahedron: Aymmetry 2006, 17, 336-346. (SCI) 13. Chen, J. H.; Venkatesham, U.; Lee, L. C. and Chen, K.* “Diastereoselective Allylation of -Ketoamides Bearing amphor N-Tosylpyrazolidinone Auxiliary: Efficient Synthesis of Highly Optically Active Two Stereoisomers” Tetrahedron 2006, 62, 887-893. (SCI) 14. Lu, K. T.; Chiou, R. Y. Y.; Chen, L. G.; Chen, M. H.; Tseng, W. T.; Hsieh, H. T. and Yang, Y. L. “Neuroprotective effects of resveratrol on cerebral ischemia-induced neuro loss mediated by free radical scavenging and cerebral blood flow elevation” J. Agricultural and Food Chem. 2006, xxxx-xxxx. (SCI 2.327) (SCI) 15. Yang, Y. L.; Su, Y. W.; Ng, M. C.; Chao, P. K.; Tung, L. C. and Lu, K. T. “Extract of Gingo biloba Egb761 facilitates extinction of conditioned fear measured by fearpotentiated startle” Neuropsychopharmacology 2006, xxxx-xxxx. (SCI 4.941)
