医学论文英文参考文献.doc

  • 格式:pdf
  • 大小:75.31 KB
  • 文档页数:2

医学论文英文参考文献

题目:干细胞帮助中风后脑功能恢复

A specific MicroRNA, a short set of RNA (ribonuclease)

sequences,naturally packaged into minute (50 nanometers) lipid

containers calledexosomes, are released by stem cells after a stroke and

contribute to betterneurological recovery according to a neal study by

Henry Ford Hospitalresearchers.

The important role of a specific microRNAtransferred from stem

cells to brain cells via the exosomes to enhancefunctional recovery after a

stroke ental ne cells affect injured tissue and alsooffers hope for

developing novel treatments for stroke and neurologicaldiseases, the

leading cause of long-term disability in adult humans.

The study, published in the journal Stem Cells, is noost stroke victims recover someability to voluntarily use their hands and other body

parts, nearly half areleft ber arepermanently disabled.

Currently no treatment exists for improving orrestoring this lost motor function in stroke patients, mainly because ofmysteries about

hoselves.

"This study may have solved one of thosemysteries by sho cells play a role in the brain's abilityto heal itself to differing

degrees after stroke or other trauma," saysstudy author Michael

Chopp, Ph.D., scientific director of the Henry FordNeuroscience Institute

and vice chairman of the department of Neurology atHenry Ford Hospital.

The researchers noted that Henry Ford'sInstitutional Animal

Care and Use Committee approved all the experimentalprocedures used

in the neent began by isolating mesenchymalstem cells (MSCs) from the

bone marroes that contain specific microRNAmolecules. The MSCs then

become "factories" producing exosomescontaining specific

microRNAs. These microRNAs act as master se that aspecific microRNA,

miR-133b, carried by these exosomes contributes tofunctional recovery

after a stroke.

The researchers genetically raised or loount of miR-133b in MSCs and, respectively, treated the rats. SCs are injected into the bloodstream

24 hours after stroke, they enter thebrain and release their exosomes. SCs

als and neurological recovery easured.

As a measure on neurological recovery, rats easure the normal

function of theirfront legs and paoval test" tomeasure ho to remove

a piece of tape stuck to their frontpaiR-133b, respectively. The tent.

The data demonstrated that the enriched miR-133bexosome

package greatly promoted neurological recovery and enhanced

axonalplasticity, an aspect of brain reinished miR-133b exosomepackage

failed to enhance neurological recovery

al study, its findings offer hope for nes as atic brain injury and spinal cord damage - regaining neurological function for a betterquality

of life.

(责任编辑:xzlunwen)