医学论文英文参考文献.doc
- 格式:pdf
- 大小:75.31 KB
- 文档页数:2
医学论文英文参考文献
题目:干细胞帮助中风后脑功能恢复
A specific MicroRNA, a short set of RNA (ribonuclease)
sequences,naturally packaged into minute (50 nanometers) lipid
containers calledexosomes, are released by stem cells after a stroke and
contribute to betterneurological recovery according to a neal study by
Henry Ford Hospitalresearchers.
The important role of a specific microRNAtransferred from stem
cells to brain cells via the exosomes to enhancefunctional recovery after a
stroke ental ne cells affect injured tissue and alsooffers hope for
developing novel treatments for stroke and neurologicaldiseases, the
leading cause of long-term disability in adult humans.
The study, published in the journal Stem Cells, is noost stroke victims recover someability to voluntarily use their hands and other body
parts, nearly half areleft ber arepermanently disabled.
Currently no treatment exists for improving orrestoring this lost motor function in stroke patients, mainly because ofmysteries about
hoselves.
"This study may have solved one of thosemysteries by sho cells play a role in the brain's abilityto heal itself to differing
degrees after stroke or other trauma," saysstudy author Michael
Chopp, Ph.D., scientific director of the Henry FordNeuroscience Institute
and vice chairman of the department of Neurology atHenry Ford Hospital.
The researchers noted that Henry Ford'sInstitutional Animal
Care and Use Committee approved all the experimentalprocedures used
in the neent began by isolating mesenchymalstem cells (MSCs) from the
bone marroes that contain specific microRNAmolecules. The MSCs then
become "factories" producing exosomescontaining specific
microRNAs. These microRNAs act as master se that aspecific microRNA,
miR-133b, carried by these exosomes contributes tofunctional recovery
after a stroke.
The researchers genetically raised or loount of miR-133b in MSCs and, respectively, treated the rats. SCs are injected into the bloodstream
24 hours after stroke, they enter thebrain and release their exosomes. SCs
als and neurological recovery easured.
As a measure on neurological recovery, rats easure the normal
function of theirfront legs and paoval test" tomeasure ho to remove
a piece of tape stuck to their frontpaiR-133b, respectively. The tent.
The data demonstrated that the enriched miR-133bexosome
package greatly promoted neurological recovery and enhanced
axonalplasticity, an aspect of brain reinished miR-133b exosomepackage
failed to enhance neurological recovery
al study, its findings offer hope for nes as atic brain injury and spinal cord damage - regaining neurological function for a betterquality
of life.
(责任编辑:xzlunwen)