Automation Highlights from the Literature
L ABORATORY A UTOMATION AND
H IGH-T HROUGHPUT C HEMISTRY
Rapid Multistep Synthesis of1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence
A general method for the synthesis of bis-substituted1,2,4-oxadiazoles from readily available arylnitriles and activated carbonyls in a single con-tinuous microreactor sequence is described by N.D.P.Cosford et al.The synthesis incorporates three sequential microreactors to produce1,2,4-oxa-diazoles in approximately30min in quantities (40e80mg)sufficient for full characterization and rapid library supply(.Chem.2009,73, 7219e23).
Expanding the Chemical Space in Practice: Diversity-Oriented Synthesis
Diversity-oriented synthesis(DOS)aims to broaden the frontier of accessible collections of complex and diverse small molecules.M.Peuch-maur and Y.-S.Wong dissect the DOS concept through three elements of diversity:building block, stereochemistry,and skeleton.Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported(Comb.Chem.High Throughput Screen. 2008,11,587e601).
Selective Monolithiation of Dibromobiaryls Using Microflow Systems
Selective monolithiation of dibromobiaryls with one equivalent of n-butyllithium followed by the re-action with electrophiles is achieved by J.-I.Yoshida et ing a microflow system by virtue of fast mi-cromixing and precise temperature control.Sequen-tial introduction of two different electrophiles based on this method also is achieved using a microflow system composed of four micromixers and four mi-crotube reactors(Org.Lett.2008,10,3937e3940). Combinatorial Materials Research Applied to the Development of New Surface Coatings X: A High-Throughput Electrochemical Impedance Spectroscopy Method for Screening Organic Coatings for Corrosion Inhibition
J.He et al.report a high-throughput electrochem-ical impedance spectroscopy(HT-EIS)method for rapid and quantitative evaluation of corrosion pro-tective coatings.A12-element,spatially addressable electrochemical platform has been designed,fabri-cated,and validated.This platform is interfaced to a commercial electrochemical impedance spectros-copy(EIS)instrument through an automated elec-tronic switching unit.The HT-EIS system enables four parallel EIS measurements to be run simulta-neously,which significantly reduces characterization time compared to that of serial EIS measurements using a multiplexer.The performance of the HT-EIS system is validated using a series of model sys-tems,including a Randles equivalent circuit,an
Kerstin Thurow,
Ph.D.
Hilmar Weinmann,
Ph.D.
Correspondence:Hilmar Weinmann,Ph.D.,Bayer Schering Pharma
AG,Global Drug Discovery,Medicinal Chemistry Berlin,D-13342
Berlin,Germany;Phone:þ49.30.468.17892;Fax:
þ49.30.468.18170;E-mail:Hilmar.Weinmann@bayerhealthcare.
com;or Kerstin Thurow,Ph.D.,University of Rostock,Institute of
Automation,R.Wagner,Street31,18119Rostock,Germany;
Phone:þ49.381.498.7800;Fax:þ49.381.498.7802;E-mail:
Kerstin.Thurow@uni-rostock.de
JALA2009;14:1e5.
1535-5535/$36.00
Copyright c2009by The Association for Laboratory Automation
doi:10.1016/j.jala.2008.10.002
Literature Highlights
JALA February20091
