不同程度老年慢性左心衰竭患者CD42b、hs-CRP和CD61的表达

医技与临床 Yijiyulinchuang 《中外医学研究》第19卷 第10期（总第486期）2021年4月- 90 -①厦门大学附属第一医院思明院区　福建　厦门　361000慢性心力衰竭患者血清hs-CRP表达水平与心功能的相关性林美英①　黄江山①　唐熟能①【摘要】　目的：探讨慢性心力衰竭患者血清超敏C 反应蛋白（hs-CRP）表达水平与心功能的相关性。

方法：选择2018年5月-2020年5月本院收治的75例慢性心力衰竭患者为研究对象，将其纳入CHF 组，选择本院同期收治的心功能正常患者75例，将其纳入对照组，CHF 组参照美国纽约心脏病协会（NYHA）分级分为NYHA Ⅰ+Ⅱ级组、NYHA Ⅲ级组、NYHA Ⅳ级组。

比较各组间心功能指标[左心室射血分数（LVEF）、左心室舒张末期内径（LVEDD）、6 min 步行试验（6MWT）]及hs-CRP 水平，并分析hs-CRP 表达水平与心功能的相关性。

结果：CHF 组LVEDD、hs-CRP 水平均高于对照组，LVEF、6MWT 低于对照组，差异有统计学意义（P <0.05）；NYHA Ⅰ+Ⅱ级组LVEF、6MWT 水平高于NYHA Ⅲ级组、NYHA Ⅳ级组，LVEDD、hs-CRP 水平低于NYHA Ⅲ级组、NYHA Ⅳ级组，差异有统计学意义（P <0.05）。

经Pearson 相关性分析结果显示，LVEF、6MWT 水平与血清hs-CRP 水平均呈负相关（r <0，P <0.05）；LVEDD 水平与血清hs-CRP 水平均呈正相关（r >0，P <0.05）。

结论：血清hs-CRP 与心功能具有一定相关性，可作为慢性心力衰竭患者诊断与判断预后的相关指标，值得临床推广。

【关键词】　慢性心力衰竭　超敏C 反应蛋白　心功能 doi：10.14033/ki.cfmr.2021.10.033文献标识码　B文章编号　1674-6805（2021）10-0090-03 Correlation between Serum hs-CRP Expression Level and Cardiac Function in Patients with Chronic Heart Failure/LIN Meiying, HUANG Jiangshan, TANG Shuneng. //Chinese and Foreign Medical Research, 2021, 19(10): 90-92 [Abstract]　Objective: To investigate the correlation between the expression level of serum high sensitive C reactive protein (hs-CRP) and cardiac function in patients with chronic heart failure. Method: A total of 75 patients with chronic heart failure admitted to our hospital from May 2018 to May 2020 were selected as the research subjects and included in the CHF group, 75 patients with normal cardiac function admitted to our hospital during the same period were selected and included in the control group, the CHF group was divided into the NYHA Ⅰ and Ⅱ group, NYHA Ⅲ group and NYHA Ⅳ group according to New York heart disease association (NYHA) classification. The cardiac function indexes [left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), 6 min walk test (6MWT)] and hs-CRP levels were compared among the groups, the correlation between the expression level of hs-CRP and cardiac function was analyzed. Result: The levels of LVEDD and hs-CRP in the CHF group were higher than those in the control group, LVEF and 6MWT in the CHF group were lower than those in the control group, the differences were statistically significant (P <0.05); the levels of LVEF and 6MWT in the NYHA Ⅰ and Ⅱ group were higher than those in the NYHA Ⅲ group and the NYHA Ⅳ group, LVEDD and hs-CRP levels were lower than those in the NYHA Ⅲ group and the NYHA Ⅳ group, the differences were statistically significant (P <0.05). Pearson correlation analysis showed that LVEF and 6MWT were negatively correlated with serum hs-CRP level (r <0, P <0.05); LVEDD level was positively correlated with serum hs-CRP level (r >0, P <0.05). Conclusion: Serum hs-CRP has a certain correlation with cardiac function, which can be used as a related index for the diagnosis and prognosis of patients with chronic heart failure, which is worthy of clinical promotion. [Key words]　Chronic heart failure　High sensitivity C reactive protein　Cardiac function First-author ’s address: Siming Branch, the First Affiliated Hospital of Xiamen University, Xiamen 361000, China 慢性心力衰竭属于临床常见心脑血管疾病，是心脏疾病发展至终末期的表现，患者主要表现为呼吸困难、食欲不振、咳嗽等临床症状，对患者生活质量影响较大。

进展性卒中患者血小板膜糖蛋白CD41和CD61及CD62P的表达邵良;季美华;陶国华;谢玮;丁莉;张丽华;朱震勤;姚鸿莉【期刊名称】《中国脑血管病杂志》【年(卷),期】2007(4)4【摘要】目的观察进展性卒中(progressive stroke,PS)患者外周血中血小板膜糖蛋白CD41、CD61和CD62P的表达及其临床意义.方法应用流式细胞仪,采用单克隆抗体分子探针分别测定37例PS患者(Ⅰ组)、40例稳定型脑梗死患者(Ⅱ组)和45名对照组(Ⅲ组,为健康体检正常者)外周血血小板膜糖蛋白CD41、CD61和CD62P的阳性表达率,并进行组间比较.其中Ⅰ组:男20例,女17例,年龄30～73岁;Ⅱ组:男25例,女15例,年龄31～70岁;Ⅲ组:男24例,女21例,年龄28～69岁.结果①Ⅰ组:CD41、CD61和CD62P表达分别为(97±13)%、(86±8)%和(87±6)%;Ⅱ组:CD41、CD61和CD62P表达分别为(92±12)%、(72±6)%和(78±9)%;Ⅲ组:CD41、CD61和CD62P表达分别为(85±10)%、(67±7)%和(67±7)%.②Ⅰ组和Ⅱ组比较,差异有统计学意义(P＜0.05),Ⅰ组明显高于Ⅱ组;Ⅱ组和Ⅲ组比较,差异有统计学意义(P＜0.05),Ⅱ组明显高于Ⅲ组.结论 PS与血小板膜糖蛋白密切相关,CD41、CD61和CD62P的检测可作为脑血管病发生、发展演变的观察指标,对预后评估及指导治疗有重要帮助.【总页数】4页(P156-159)【作者】邵良;季美华;陶国华;谢玮;丁莉;张丽华;朱震勤;姚鸿莉【作者单位】226001,江苏省,南通大学第二附属医院神经科;226001,江苏省,南通大学第二附属医院神经科;226001,江苏省,南通大学第二附属医院神经科;226001,江苏省,南通大学第二附属医院神经科;226001,江苏省,南通大学第二附属医院神经科;226001,江苏省,南通大学第二附属医院神经科;226001,江苏省,南通大学第二附属医院神经科;226001,江苏省,南通大学第二附属医院神经科【正文语种】中文【中图分类】R743;R446.1【相关文献】1.类风湿关节炎患者CD62P、CD41/CD61的表达及意义 [J], 王利军;杨林花;李小峰;朱镭2.2型糖尿病患者血小板CD41、CD61、CD62p的表达及意义 [J], 张义东;施锦杰3.血小板膜糖蛋白CD41/CD61基因多态性及表达率与脑梗死的关系 [J], 李洪波;朱辛明;宋玉国;熊英;王萍4.外源性一氧化碳释放分子对脓毒症小鼠血小板膜糖蛋白CD41、CD61和CD62p表达的影响 [J], 杨国涛;孙炳伟;邹向前;王敏5.血小板膜糖蛋白CD41/CD61基因多态性及其表达率与动脉粥样硬化性急性脑梗死的关系 [J], 陈云; 周元林; 蒋辉华; 柯绍发; 陈葆国; 朱敏; 韩文胜因版权原因，仅展示原文概要，查看原文内容请购买。

cTnI、hs—CRP和BNP在心力衰竭患者治疗前后的变化及其对诊断和预后判断的价值目的探究在心力衰竭患者治疗前后，cTnI、hs-CRP和BNP的变化情况，同时总结其对于患者诊断和预后判断的价值。

方法选取我院2015年1月～12月收治心力衰竭患者40例治疗前后的cTnI、hs-CRP和BNP水平均进行观察，同时选取健康志愿者40例进行cTnI、hs-CRP和BNP水平的测量，探究其预后判断和诊断的价值。

结果针对心力衰竭患者治疗前后的cTnI、hs-CRP和BNP 水平和志愿者水平进行比较，治疗前各项指标水平均明显较高，经过治疗均出现不同程度降低的情况，而健康的志愿者各项水平均明显较低，比较可见差异有统计学意义（P＜0.05）。

结论cTnI、hs-CRP和BNP在心力衰竭患者治疗前后会出现明显的变化，因此在患者诊断时各项水平如果出现明显升高的现象，即可对患者进行诊断，而经过治疗如果患者的相关水平出现下降现象，则意味着患者情况好转，可积极对患者进行预后的判断。

标签：cTnI、hs-CRP和BNP；心力衰竭；诊断；预后判断；价值Changes of cTnI，hs-CRP and BNP in patients with heart failure before and after treatment and their value in diagnosis and prognosisDING Jing（Dantu District People’s Hospital of Zhenjiang，Jiangsu Zhenjiang 212000，China）【Abstract】Objective To explore in heart failure patients before and after treatment，cTnI，hs CRP and the change of the BNP，and summarize the diagnostic and prognostic value for patients.Methods 40 cases of heart failure patients before and after treatment of cTnI，hs CRP and BNP levels were observed，at the same time we do cTnI on 40 cases of healthy volunteers，hs CRP and BNP level measurement，to explore the prognostic and diagnostic value；80 cases of the researchers are from January 2015 to December 2015 were analyzed.Results In 40 patients before and after treatment of cTnI，hs CRP and BNP level and the level of 40 volunteers comparison，discovered the existence of significant differences，including patients with each index levels were significantly higher before treatment，after treatment in different degree lower，the condition of the patients and healthy volunteers with various levels were significantly lower，more visible differences statistically significant （P＜0.05）.Conclusion CTnI，hs CRP and BNP in patients with heart failure will appear obvious change before and after the treatment，so if a significant rise in all levels in the patients with diagnosis of phenomenon，can be carried out on the patients with diagnosis，but after treatment if the patient’s level of related decline phenomenon，which means that the patient is better，can be a positive judgment of prognosis ofpatients.【key words】CTnI、hs CRP and BNP；Heart failure；Diagnosis；Prognostic judgment；The value of心力衰竭在臨床中较为常见，其是不同心血管疾病发展至中末端而产生的一种情况，对于患者的健康会产生较大程度的影响，因此如何能够对患者及时进行准确的诊断，同时对患者积极进行治疗，对于患者预后同样做出及时的判断，就成为我们共同关注的问题。