信息检索综合报告
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信息检索综合报告汪傲真1.课题名称中文:人工关节用超高分子量聚乙烯的研究英文:The Research of Ultra High Molecular Weight Polyethylene for Artificial Joint2.检索词中文:超高分子量聚乙烯、人工关节英文:Ultra High Molecular Weight Polyethylene/UHMWPE,Artificial Joint3.数据库4.检索结果4.1 中国全文期刊数据库(CNKI)4.1.1题名:人工关节超高分子量聚乙烯磨损机制与研发现状作者:周磊,翁习生,李涛出处:中国矫形外科杂志,2014,16:1471-1475.摘要:超高分子量聚乙烯是目前人工关节载荷元件胫骨平台垫片和髋臼内衬的首选材料,然而其磨损不可避免,磨损碎屑继发假体周围骨溶解,严重影响假体使用寿命。
本文简要介绍了超高分子量聚乙烯独特的摩擦磨损机制和残留自由基氧化对其耐磨性的影响,最后阐述其研发现状和方向。
高交联聚乙烯可以显著降低人工关节假体的体内磨损率,目前得到了最广泛的临床应用。
而复合维生素E的高交联聚乙烯也可明显提高材料抗氧化性和耐磨性,近期随访证明了其安全有效,但仍有待大样本量长期的临床疗效观察。
4.1.2题名:超高分子量聚乙烯人工关节耐磨改性的研究进展作者:王东斌,李静,贺超峰,曹新鑫,何小芳出处:化工新型材料,2014,02:18-20+23.摘要:UHMWPE一直是常用作人工关节的轴承材料,在长期使用的情况下,因其受压力、润滑剂、对磨材料等因素的影响而产生的磨损最终导致人工关节失效。
简述了UHMWPE在人工关节中的磨损机理,重点介绍了其影响因素以及其摩擦磨损性能的改性方法,并对UHMWPE用于人工关节的研究及发展前景进行了展望。
4.1.3题名:超高分子量聚乙烯人工关节的摩擦学研究作者:薛茂权,黄之德出处:中国临床康复,2005,10:170-171摘要:超高分子量聚乙烯(UHMWPE)工程塑料具有优异的物理和机械性能、生物相容性和化学稳定性、抗冲击性及耐腐蚀性,普遍应用于人工关节软骨-关节臼材料。
然而在长期的使用过程中,其表面硬度低、耐磨性差、生物惰性等是其作为医用植入材料不容忽视的问题。
文章结合UHMWPE的磨损机制,综述了通过改性,如离子注入,填料改性等,提高UHMWPE的耐磨性研究,并对其发展方向进行了有益探讨。
4.1.4题名:超高分子量聚乙烯在人工髋关节中的摩擦磨损研究作者:黄捷,杨丹,屈树新出处:材料导报,2011,03:136-140摘要:超高分子量聚乙烯(Ultra-highmolecularweightpolyethylene,UHMWPE)的磨损是导致人工髋关节失效的重要原因之一。
介绍了UHMWPE体外摩擦的磨损机理和改性方法,阐述了一些研究摩擦磨损的试验手段,如髋关节模拟机的研究、润滑体系、磨损的测定、磨屑的评价、有限元分析等,提出了UHMWPE在目前临床应用上亟待解决的问题。
4.1.5题名:人工关节置换材料——超高摩尔质量聚乙烯改性研究的进展作者:黄孝龙,葛世荣出处:塑料工业,2006,11:1-3+16摘要:对目前国内外有关人工关节置换材料——超高摩尔质量聚乙烯改性研究的现状进行了分析和综述,并对未来研究中应注意的问题提出了一些看法。
4.2 中国科技期刊数据库(VIP)4.2.1题名:对偶件表面粗糙度对UHMWPE摩擦磨损性能的影响作者:李嫱,冷永祥出处:功能材料,2010,(6);931-934摘要:人工关节在服役过程中的磨损主要发生在超高分子量聚乙烯(UHMWPE)关节臼的表面。
UH-MWPE的磨擦磨损性能受多因素影响,其中与UHM-WPE对磨的硬质材料(对偶件)表面粗糙度是关键因素之一。
综述了近年来在对偶件表面粗糙度对UH-MWPE摩擦磨损性能影响方面的研究工作,结合UHMWPE的磨损机制,重点阐述对偶件表面粗糙度对UHMWPE磨损率、UHMWPE磨屑尺寸和人工关节润滑机制的影响。
4.2.2题名:UHMWPE在人工髋关节中的磨损机制及改性研究作者:白银龙,屈树新出处:工程塑料应用,2009,(11);76-79摘要:分析了超高分子量聚乙烯(UHMWPE)基人工髋关节假体松动失效的主要因素。
介绍了UHMWPE在人工关节中的磨损机制,以及降低UHMWPE磨损最常用的方法,包括辐射交联改性、α-维E抗氧化法、复合增强以及人工关节润滑等。
4.2.3题名:珊瑚粉填充改性UHMWPE的划痕试验作者:黄孝龙、葛世荣出处:塑料科技,2008,36(5);66-69摘要:将经过硅烷偶联剂处理的天然珊瑚(NC)粉末添加到超高分子量聚乙烯(UHMWPE)中,采用热压固化成型工艺制备出UHMWPE/NC复合材料,通过SEM、XRD 和划痕试验等方法对NC在复合材料中的分散性和复合材料的抗划伤性能进行了测定,结果表明:随着NC含量的提高,复合材料中NC的分散性提高;当NC含量为30%时,与纯UHMWPE相比,复合材料的硬度和抗划伤性能分别提高了84%和41%。
4.2.4题名:仿生UHMWPE软骨材料的制备和性能研究作者:吴刚,张文光,王成焘出处:功能材料,2007,38(10);1694-1697摘要:模拟天然软骨的“多孔渗透”和“梯度功能”特征,利用T-L法制备出多孔UHMWPE试样和梯度多孔UHMWPE/普通UHMWPE试样。
观察了试样表面和断面的形貌,并对试样的相关性能进行测试。
多孔UHMWPE仿生软骨材料具有与天然软骨材料类似的孔隙性质,孔径多分布在50-100μm左右,多孔UHMWPE的机械性能均不同程度低于普通UH-MWPE,且多孔结构能提高试样与水和牛血清之间的可润滑性能。
梯度UHMWPE仿生软骨材料的多孔层和实心层之间具有明显的梯度分界,但在界面连接处具有良好的融合性和结合强度。
4.2.5题名:具有规则表面织构的超高分子量聚乙烯髋臼表面温度分析作者:MENG Hua,董光能,李健出处:摩擦学学报,2005,25(1);45-49摘要:就人工关节中广泛使用的超高分子量聚乙烯(UHMWPE)髋臼在运行中的瞬态表面温度场进行了理论计算,与理想光滑表面对比考察了微球表面织构对接触压力分布的影响及其引起的表面温度变化.结果表明,基于光滑表面计算得到的髋臼表面温度偏低,而基于规则织构表面计算得到的温度与文献值接近;髋臼表面温度随摩擦系数和载荷增加而升高,随关节摆动而呈现周期性变化。
4.3Web of Science (SCI)4.3.1题名:Friction and wear properties of UHMWPE composites reinforced with carbon fiber作者:Xiong, DS (Xiong, DS)出处:MATERIALS LETTERS,卷:59,期: 2-3,页: 175-179摘要:The artificial joint acetabular material ultrahigh molecular weight polyethylene (UHMWPE) was reinforced with carbon fibers (CF) in different contents. The effects of CF content on hardness and tribological properties of the materials were studied. The morphologies of wear surfaces were examined with a Scanning Electron Microscope (SEM). The results show that the hardness and wear resistance ofCF-reinforced UHMWPE composites increased with CF content; the friction coefficients under distilled water lubrication were decreased greatly by the addition of CF; that adherence, plowing, plastic deformation and fatigue wear are dominant for the UHMWPE under dry sliding, and that abrasive wear and drawing out of CF from the wear surface of the composites are dominant for the CF-UHMWPE composites under both dry and distilled water lubrication conditions. (C) 2004 Elsevier B.V. All rights reserved.4.3.2题名:Nanometre size wear debris generated from crosslinked and non-crosslinked ultra high molecular weight polyethylene in artificial joints作者:Galvin, AL (Galvin, AL); Tipper, JL (Tipper, JL); Ingham, E (Ingham, E); Fisher, J (Fisher, J)出处:WEAR,卷: 259,页:977-983,子辑:2,特刊:SI摘要:Ultra high molecular weight polyethylene (UHMWPE) wear debris is a major cause of long term failure of total joint replacements. Recently, crosslinking has been introduced in order to reduce the wear of UHMWPE. In this study the wear and wear debris of noncrosslinked and two crosslinked UHMWPE's were compared. In particular this study has focused on the characterisation of nanometre size wear debris.The UHMWPE's were tested in a multidirectional pin on plate wear simulator against smooth and scratched counterfaces. The wear particles were isolated and imaged using a field emission gun scanning electron microscope (FEGSEM) at high resolution. The use of FEGSEM revealed nanometre size particles (less than 0.1 mu m) for the first time. No significant difference was found in the percentage number and percentage volume of the particles in different size ranges from any of the materials against any of the counterfaces. The specific biological activity (biological activity per unit value, SBA) was highest for the highly crosslinked material tested on the smooth counterfaces. The functional biological activity (FBA) which takes into account the wear volume and SBA showed that the highly crosslinked UHMWPE had a lower FBA for debris from both the smooth and scratched counterfaces. (c) 2005 Elsevier B.V. All rights reserved.4.3.3题名:Friction and wear properties of UHMWPE against ion implanted titanium alloy作者:Xiong, DS (Xiong, Dangsheng); Gao, Z (Gao, Zhan); Jin, ZM (Jin, Zhongmin)出处:SURFACE & COATINGS TECHNOLOGY,卷: 201,期: 15,页: 6847-6850摘要:In this study, a new two-step plasma immersion ion implantation technique was developed and applied for the modification of Ti6Al4V alloy; firstly ion implanting with nitrogen at high temperature and followed with oxygen in high dose.A graded titanium oxide-titanium nitride film was obtained on the surface of theTi6Al4V alloy. The contact angle and the microhardness of the modified alloys were measured. The friction and wear properties of UHMWPE rubbing against the modified alloys under lubrication of distilled water were investigated using apin-on-disc tribometer. The wettability and the microhardness of the alloy surfaces were found to be increased significantly after ion implantation. The friction coefficient decreased by nearly 5 times and the wear resistance of UHMWPE increased by about 40 times against the ion implanted Ti6Al4V alloy. Many deep furrows were found on the surface of the un-implanted alloy and were absent in the ion implanted surfaces of the alloy. (c) 2006 Elsevier B.V. All rights reserved.4.3.4题名:Effect of crosslinking and Pt-Zr quasicrystal fillers on the mechanical properties and wear resistance of UHMWPE for use in artificial joints作者:Schwartz, CJ (Schwartz, Christian J.); Bahadur, S (Bahadur, Shyam); Mallapragada, SK (Mallapragada, Surya K.)出处:WEAR,卷: 263,页:1072-1080,子辑:2,特刊:SI摘要:The use of artificial joints is common for restoration of comfort and functionality in joints that have been afflicted with cartilage loss due to disease or injury. These implants incorporate an articulating interface of ultra-high molecular weight polyethylene (UHMWPE) sliding against a polished metallic counterface such as 316L stainless steel. While the design of these joints has been refined over several decades, there are still significant limitations to their pain-free lifetime due to osteolysis induced by UHMWPE particulate. Crosslinking has been used recently to increase the wear resistance of the polymer, but there are significant tradeoffs involving reduced elastic modulus and impact toughness. The authors have proposed using Pt-Zr quasicrystals (QC) as fillers in UHMWPE as a method of increasing the wear resistance of the polymer while avoiding significant losses in mechanical properties. UHMWPE samples that had been irradiation crosslinked, filled with 20 wt.% Pt-Zr quasicrystals, or both, were tested in a dynamic mechanical analyzer to determine their viscoelastic properties. Furthermore, Charpy impact tests were performed on these materials. as well as multi-directional sliding wear tests in the dual axis wear simulator (DAWS), a machine designed to simulate in vivo joint wear conditions. It was found that while crosslinking reduced elastic modulus of UHMWPE over 30%, the use of QC fillers led to a slight increase. Additionally, the reduction inimpact toughness when using QC fillers was not as great as with crosslinking. Finally, it was found that both QC fillers and crosslinking provided the same significant reduction in wear amounts over untreated UHMWPE. The reduction in wear is explained in terms of the wear mechanisms. This involves inhibition of polymer chain orientation in the case of crosslinking, and shear load shielding effects of quasicrystals in the case of QC-filled polymer. These results suggest that Pt-Zr quasicrystal filler may be a desirable alternative to crosslinking when attempting to increase the wear resistance of UHMWPE for biomedical applications. (C) 2007 Elsevier B.V. All rights reserved.4.3.5题名:Tuning the Superstructure of Ultrahigh-Molecular-WeightPolyethylene/Low-Molecular-Weight Polyethylene Blend for Artificial Joint Application作者:Xu, L (Xu, Ling)[ 2,3 ] ; Chen, C (Chen, Chen)[ 1 ] ; Zhong, GJ (Zhong, Gan-Ji)[ 2,3 ] ; Lei, J (Lei, Jun)[ 2,3 ] ; Xu, JZ (Xu, Jia-Zhuang)[ 2,3 ] ; Hsiao, BS (Hsiao, Benjamin S.)[ 4 ] ; Li, ZM (Li, Zhong-Ming)[ 2,3 ]出处:ACS APPLIED MATERIALS & INTERFACES,卷:4,期:3,页:1521-1529摘要:An easy approach was reported to achieve high mechanical properties of ultrahigh-molecular-weight polyethylene (UHMWPE)-based polyethylene (PE) blend for artificial joint application without the sacrifice of the original excellent. wear and fatigue behavior of UHMWPE. The PE blend with desirable fluidity was obtained by melt mixing UHMWPE and low molecular weight polyethylene (LMWPE), and then was processed by a modified injection molding technology-oscillatory shear injection molding (OSIM). Morphological observation of the OSIM PE blend showed LMWPE contained well-defined interlocking shish-kebab self-reinforced superstructure. Addition of a small amount of long chain polyethylene (2 wt %) to LMWPE greatly induced formation of rich shish-kebabs. The ultimate tensile strength considerably increased from 27.6 MPa for conventional compression molded UHMWPE up to 78.4 MPa for OSIM PE blend along the flow direction and up to 33.5 MPa in its transverse direction. The impact strength of OSIM PE blend was increased by 46% and 7% for OSIM PE blend in the direction parallel and vertical to the shear flow, respectively. Wear and fatigue resistance were comparable to conventional compression molded UHMWPE. The superb performance of the OSIM PE blend was originated from formation of rich interlocking shish-kebab superstructure while maintaining unique properties of UHMWPE. The present results suggested the OSIM PE blend has high potential for artificial joint application.4.4Ei Compendex (Ei)4.4.1题名:Comparison of wear debris generated from ultra high molecular weight polyethylene in vivo and in artificial joint simulator作者:Hongtao, Liu1; Shirong, Ge2; Shoufan, Cao1; Shibo, Wang2出处:Wear,2011,卷:271,期:5-6,页:647-652,摘要:The artificial joint simulator is designed to simulate the complicated movement and environment of the artificial joint in vivo. Although the wear loss of materials evaluated on the artificial joint simulator under ISO standard is found to conform to that in vivo, there is a significant difference in the morphology of the wear debris obtained from the tester and human body. It is well known that the wear debris plays an important role in aseptic loosening of the artificial joint, and its morphology indicates the working conditions of the artificial joint. Therefore, it is necessary to distinguish the two kinds of wear debris. In this paper, the comparative study of ultra high molecular weight polyethylene (UHMWPE) wear debris from the implanted artificial joint and hip joint tester was performed on their size distribution,shape, 3-D feature, and thickness. Results show that the wear debris from joint simulator have different sizes and shapes such as strip, block, plate, and spherical etc., their average diameter is 7.54 μm, and its medium diameter is 6.89 μm. The most wear debris from artificial joint have the spherical or subsphaeroidal shapes, and a small amount of the debris have the unbroken plate structure, the average diameter is 1.33 μm, is about 18% of the wear debris' from joint simulator, and the medium diameter of 2.95 μm, is about 43% of the wear debris' from joint simulator. The results are expected to provide both experimental and theoretical foundationfor improving the artificial joint simulator and optimizing the evaluation standards of the artificial joint materials. © 2011 Elsevier B.V.4.4.2题名:Biotribological properties of UHMWPE grafted with AA under lubrication as artificial joint作者:Deng, Yaling1; Xiong, Dangsheng1; Wang, Kun1出处:Journal of Materials Science: Materials in Medicine,2013,卷:24,期:9,页:2085-2091摘要:Osteolysis caused by wear particles from polyethylene in the artificial hip joints is a serious issue. In order to endow the low friction and wear of the bearing surface of ultra-high molecular weight polyethylene (UHMWPE) artificial joint for a longer term, hydrophilic acrylic acid (AA) was grafted on UHMWPE powders with the method of ultraviolet irradiation and then the modified powders were hot pressed. The tribological properties of modified UHMWPE sliding against CoCrMo metallic plate on reciprocating tribometer under calf serum, saline and distilled water lubrication during a long-term friction were investigated. The measurement of Fourier-transform infrared spectroscopy indicates that AA is successfully grafted on the surface of UHMWPE powders by photo-induced graft polymerization. Contact angles of UHMWPE are decreased from 83 to 35 by grafting and the surface wettability is effectively improved. The tensile strength of modified sample decreases. The friction coefficient and wear rate of UHMWPE-g-PAA under calf serum, saline and distilled water lubrication are lower than that of untreated UHMWPE. With the increase of grafting ratio, the wear rate of UHMWPE-g-PAA decreases firstly and then increases. The modified UHMWPE with grafting ratio of 3.5 % has the lowest wear rate, which is just quarter of the untreated UHMWPE. The hydrated PAA polymer brushes enclosed in the UHMWPE bulk material provide continuous lubrication during long term sliding. © 2013 Springer Science+Business Media New York.4.4.3题名:An activated energy approach for accelerated testing of the deformation of UHMWPE in artificial joints作者:Galetz, Mathias Christian1; Glatzel, Uwe1出处:Journal of the Mechanical Behavior of Biomedical Materials,2010,卷:3,期:4,页:331-338摘要:The deformation behavior of ultrahigh molecular polyethylene (UHMWPE) is studied in the temperature range of 23-80 °C. Samples are examined in quasi-static compression, tensile and creep tests to determine the accelerated deformation of UHMWPE at elevated temperatures. The deformation mechanisms under compression load can be described by one strain rate and temperature dependent Eyring process. The activation energy and volume of that process do not change between 23 °C and 50 °C. This suggests that the deformation mechanism under compression remains stable within this temperature range. Tribological tests are conducted to transfer this activated energy approach to the deformation behavior under loading typical for artificial knee joints. While this approach does not cover the wear mechanisms close to the surface, testing at higher temperatures is shown to have a significant potential to reduce the testing time for lifetime predictions in terms of the macroscopic creep and deformation behavior of artificial joints. ©2010.4.4.4题名:Elementary study of modifying UHMWPE with schiff base copper complex for the use as an artificial hip joint material作者:Gao, Xinlei1; Hua, Meng2; Li, Jian3; Gao, Wanzhen3出处:Journal of Dispersion Science and Technology,2009,卷:30,期:7,页:1059-1066摘要:Elementary micro-tribological test for UHMWPE modified with 15 wt% of Schiff base copper complex (Cu(II) chelate of bissalicylaldehyde-ethylenediamine rubbed by titanium alloy showed that a reduction of 20% friction coefficient when compared with the pure UHMWPE/titanium alloy pair under the condition of dry friction. Under a simulating loading level of an artificial hip joint, the highest frication coefficient of the modified UHMWPE pairing with steel was 15% lower than its pure UHMWPE/steel pairing counterpart. Furthermore, wear of the modified UHMWPE was very mild almost without any sign of worn debris even being run for a sufficiently long period, while the pure UHMWPE could run only for a very short period. Test results confirmed that the Cu(II) chelate ofbissalicylaldehyde-ethylenediamine modifying UHMWPE was able to reduce friction, wear and debris during application. Besides excellent tribological characteristics, good biocompatibility of the modified UHMWPE was also demonstrated by a cell toxicity test in vitro. T Consequently, attempts to develop this modified UHMWPE for artificial joint is obviously beneficial. © Taylor & Francis Group, LLC.4.4.5题名:Molecular deformation mechanisms in UHMWPE during tribological Loading in Artificial Joints作者:Galetz, Mathias Christian1; Glatzel, Uwe1出处:Tribology Letters,2010,卷:38,期:1,页:1-13摘要:No clear picture of the deformation and wear mechanisms of Ultra High Molecular Weight Polyethylene (UHMWPE) in artificial knee joints exists up to today. Tri-bological tests were conducted under relevant loads and the worn samples were extensively studied by XRD, DSC, Raman, and SEM. It was shown that stresses close to the surface in areas where high relative velocity in combination with high normal loads are applied are most effective in changing the microstructure and therefore most detrimental to produce wear particles, while in the depth the same deformed structure as under unidirectional cyclic loading is found. A model was proposed which reflects the deformation at different zones in the depth of a tribologically loaded UHMWPE sample. This model shows amazing analogy to the orientation of collagen fibrils in natural cartilage. © Springer Science+Business Media, LLC 2010. 4.5国家知识产权局专利数据库4.5.1发明名称:一种人工关节用可熔体加工的超高分子量聚乙烯复合材料公开(公告)号:CN103751849A申请(专利权)人:四川大学发明人:李忠明;黄妍斐;雷军;钟淦基;徐家壮;徐玲摘要:本发明涉及一种人工关节用可熔体加工的超高分子量聚乙烯复合材料。