Lu AE58054_467459-31-0_DataSheet_MedChemExpress
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Q1126pis Rev 01/221Product InformationQ Sepharose ® Fast FlowQ1126Product DescriptionQ Sepharose ® Fast Flow is an ion exchangechromatography resin with a quaternary amine (Q) functional group [-CH 2-N +(CH 3)3] attached to Sepharose ® Fast Flow. The Q group serves as astrong anion exchanger, which is completely ionized over a broad pH range. The terms “s trong" and"weak" in ion exchange chromatography refer to the extent of ionization with pH, and not to the binding strength of the functional group to the target species. The parent Sepharose ® Fast Flow is a cross-linked derivative of Sepharose ®. The particle size range is 45-165 µm. The average bead diameter is ~90 µm. The counterion in the product is sulfate (SO 4-2). Recommended cation buffers to use with Q Sepharose ® Fast Flow include alkylamines,ammonium, ethylenediamine, imidazole, pyridine, or Tris. In terms of pH, it is suggested to operate within 0.5 pH unit of the buffer's pK a . With proteins, it is suggested to operate at least 1 pH unit above the pI of the protein, to facilitate binding. Oxidizing agents, and anionic detergents and buffers, should not be used with Q Sepharose ® Fast Flow. Likewise,extended exposure of Q1126 to pH < 4 should be avoided. Several publications 1,2 and dissertations 3-5 cite use of product Q1126 in their research.ReagentQ Sepharose ® Fast Flow is offered as a suspension in 20% ethanol.Approximate Exclusion Limit: average molecular mass of ~4 × 106 DaltonsIonic Capacity: 0.18-0.24 mmol Cl -/mL gel Binding Capacity: ~42 mg BSA per mL gel pH Stability: 2-12Working temperature: 4-40 °CPrecautions and DisclaimerFor R&D use only. Not for drug, household, or other uses. Please consult the Safety Data Sheet for information regarding hazards and safe handling practices. General Resin Preparation Procedure1. Allow the ion exchange medium and ~10 columnvolumes (CV) of buffer to equilibrate to thetemperature chosen for the chromatographic run. 2. Mix the pre-swollen suspension with startingbuffer to form a moderately thick slurry, which consists of ~75% settled gel and 25% liquid. 3. Degas the gel under vacuum at the temperatureof column operation.4. Mount the column vertically on a suitable stand,out of the way of direct sunlight or drafts, which may cause temperature fluctuations.5. Pour a small amount of buffer into the emptycolumn. Allow the buffer to flow through spaces to eliminate air pockets.6. Pour the suspension of ion exchange mediumprepared in Step 3 into the column by allowing it to flow gently down the side of the tube, to avoid bubble formation.7. For consistent flow rates and reproducibleseparations, connect a pump to the column. 8. Fill the remainder of the column to the top withbuffer. Allow ~5 CV of buffer to drain through the bed at a flow rate at least 133% of the flow rate to be used in the procedure. The bed height should have settled to a constant height.9. Using a syringe or similar instrument, apply thesample dissolved in starting buffer to the column. For isocratic separations, the sample volumeshould range from 1-5% of the column volume. If the chromatographic run involves elution with a gradient, the applied sample mass is of much greater importance than the sample volume, and the sample should be applied in a low ionicstrength medium. Ion exchange is used both to concentrate and to fractionate the sample. 10. Elution:• If only unwanted substances in the sample areadsorbed, or if sample components aredifferentially retarded under isocratic conditions, the starting buffer can also be used as the eluent.The life science business of Merck operates as MilliporeSigma in the U.S. and Canada.Merck and Sigma-Aldrich are trademarks of Merck KGaA, Darmstadt, Germany or its affiliates. All other trademarks are the property of their respective owners. Detailed information on trademarks is available via publicly accessible resources.© 2022 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved. Q1126pis Rev 01/22 JJJ,MAM,GCY2•Normally, however, separation and elution are achieved by selectively decreasing the affinity of the molecules for the charged groups on the resin by changing the pH and/or ionic strength of the eluent. This procedure is termed gradient elution. 11. Regeneration: •Either (a) washing the column with a high ionic strength salt solution, such as 1 M NaCl, or (b) changing the pH to the tolerable low and high pH extremes, is usually sufficient to remove reversibly bound material.• When needed, lipids and precipitated proteins canbe removed by washing with 1 CV of 1-2 M NaCl, followed by 1 CV of 0.1 M NaOH in 0.5 M NaCl. • Rinse with several CV of water. Thenre-equilibrate the resin with starting buffer.• If base such as NaOH was used, adjust the pH ofthe resin to neutral before storing or using.12. Storage: Q Sepharose ® Fast Flow may be storedat 2-8 °C in water with 20% ethanol added as an antibacterial agent.General NotesCation versus Anion Exchanger• If sample components are most stable below their pI values, a cation exchanger should be used. • If sample components are most stable above their pI values, an anion exchanger should be used. •If stability is good over a wide pH range on both sides of the pI, either or both types of ion exchanger may be used.Strong versus Weak Ion Exchanger•Most proteins have pI values within the range 5.5-7.5, and can thus be separated on both strong and weak ion exchangers.•When maximum resolution occurs at an extreme pH and the molecules of interest are stable at that pH, a strong ion exchanger should be used. Choice of Buffer, pH, and Ionic Strength• The highest ionic strength which permits binding should normally be used.•The required buffer concentration varies fromsubstance to substance. Usually, an ionic strength of at least 10 mM is required to ensure adequate buffering capacity.•As salts (such as buffers) help to stabilize proteins in solution, their concentration should be highenough to prevent denaturation and precipitation.References1. López, G. et al ., Eukaryot. Cell , 14(6), 564-577(2015).2. Bhargava, V. et al ., Dev. Cell., 52(1), 38-52.e10(2020).3. Fu , Yinan, “Structure and dynamics ofPseudomonas aeruginosa ICP”. University ofGlasgow, Ph.D. dissertation, p. 126 (April 2009). 4. Redmond, Miranda , “The Role of N-TerminalAcidic Inserts on the Dynamics of the Tau Protein ”. University of Vermont, Ph.D. dissertation, p. 22 (May 2017).5. Taylor-Whiteley, Teresa Rachel , “RecapitulatingParkinson’s disease pathology in athree-dimensional neural cell culture mode ”. Sheffield Hallam University, Ph.D. dissertation, p. 58 (September 2019).NoticeWe provide information and advice to our customers on application technologies and regulatory matters to the best of our knowledge and ability, but without obligation or liability. Existing laws and regulations are to be observed in all cases by our customers. This also applies in respect to any rights of third parties. Our information and advice do not relieve ourcustomers of their own responsibility for checking the suitability of our products for the envisaged purpose. The information in this document is subject to change without notice and should not be construed as acommitment by the manufacturing or selling entity, or an affiliate. We assume no responsibility for any errors that may appear in this document.Technical AssistanceVisit the tech service page at /techservice .Standard WarrantyThe applicable warranty for the products listed in this publication may be found at /terms .Contact InformationFor the location of the office nearest you, go to /offices .。
Product Name:Lu AE58054 Hydrochloride CAS No.:467458-02-2Cat. No.:HY-14338A Product Data SheetMWt:434.83Formula:C20H20ClF5N2O Purity :>98%Solubility:DMSO 11 mg/mL; Water <1 mg/mLMechanisms:Biological Activity:Lu AE58054hydrochloride is an in-vitro potency and selectivity in-vivo binding affinity and effect ofPathways:GPCR/G protein; Target:5-HT ReceptorPathways:Neuronal Signaling; Target:5-HT Receptor Lu AE58054 hydrochloride is an in-vitro potency and selectivity, in-vivo binding affinity and effect ofthe 5-HT(6)R antagonist with a Ki value of 0.83 nM.IC50 Value: 0.83 nm[1]Target: 5-HT(6)R in vitro: Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. In a 5-HT(6) GTPgammaS efficacy assay Lu AE58054 showed no agonist activity, but demonstrated potent inhibition of 5-HT-mediated activation. Besides medium affinity to adrenergic alpha(1A)- and alpha(1B)-adrenoreceptors, Lu AE58054 demonstrated >50-fold selectivity for morethan 70 targets examined[1].References:[1]. Arnt J, Bang-Andersen B, Grayson B, Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33.in vivo: Orally administered Lu AE58054 potently inhibited striatal in-vivo binding of the 5-HT(6)antagonist radioligand [(3)H]Lu AE60157, with an ED(50) of 2.7 mg/kg. Steady-state modelling of an acute pharmacokinetic/5-HT(6)R occupancy time-course experiment indicated...p y p p;()[2]. Witten L, Bang-Andersen B, Nielsen SM, Characterization of [?H]Lu AE60157 ([?H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine? (5-HT?) receptorsin vivo.Eur J Pharmacol. 2012 Feb 15;676(1-3):6-11.Caution: Not fully tested. For research purposes onlyMedchemexpress LLC18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AE m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。
RT8057®©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.Pin ConfigurationsOrdering InformationNote :Richtek products are :❝ RoHS compliant and compatible with the current require-ments of IPC/JEDEC J-STD-020.❝ Suitable for use in SnPb or Pb-free soldering processes.(TOP VIEW)WDFN-6SL 2x22.25MHz 1A Synchronous Step-Down ConverterGeneral DescriptionThe RT8057 is a high efficiency Pulse-Width-Modulated (PWM) step-down DC/DC converter, capable of delivering 1A output current over a wide input voltage range from 2.7V to 5.5V. The RT8057 is ideally suited for portable electronic devices that are powered from 1-cell Li-ion battery or from other power sources such as cellular phones, PDAs, hand-held devices, game console and related accessories.The internal synchronous rectifier with low R DS(ON)dramatically reduces conduction loss at PWM mode.No external Schottky diode is required in practical applications. The RT8057 enters Low Dropout Mode when normal Pulse -Width Mode cannot provide regulated output voltage by continuously turning on the upper P-MOSFET .The RT8057 enters shut-down mode and consumes less than 1μA when the EN pin is pulled low. The switching ripple is easily smoothed-ou t by small package filtering elements due to a fixed operating frequency of 2.25MHz.The RT8057 is available in a small WDFN-6SL 2x2 package.Features●2.7V to 5.5V Wide Input Operation Range●2.25MHz Fixed-Frequency PWM Operation ●Up to 1A Output Current ●Up to 90% Efficiency●0.6V Reference Allows Low Output Voltage ●Internal Soft-Start●No Schottky Diode Required●Internal Compensation to Reduce External Components●Low Dropout Operation : 100% Duty Cycle ●RoHS Compliant and Halogen FreeApplications●Portable Instruments●Game Console and Accessories●Microprocessors and DSP Core Supplies ●Cellular Phones●Wireless and DSL Modems ●PC CardsLXNC GND VIN ENFBJ7 : Product CodeW : Date CodeG : Green (Halogen Free and Pb Free)RT8057©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.Function Pin DescriptionFunction Block DiagramTypical Application CircuitOUT 2.3VRT8057©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.Absolute Maximum Ratings (Note 1)●Supply Input Voltage, V IN ------------------------------------------------------------------------------------------------6.5V ●Power Dissipation, P D @ T A = 25°CWDFN-6SL 2x2------------------------------------------------------------------------------------------------------------0.606W ●Package Thermal Resistance (Note 2)WDFN-6SL 2x2, θJA -------------------------------------------------------------------------------------------------------165°C/W WDFN-6SL 2x2, θJC ------------------------------------------------------------------------------------------------------8.2°C/W ●Lead Temperature (Soldering, 10 sec.)-------------------------------------------------------------------------------260°C ●Junction T emperature -----------------------------------------------------------------------------------------------------150°C●Storage T emperature Range --------------------------------------------------------------------------------------------−65°C to 150°C ●ESD Susceptibility (Note 3)HBM --------------------------------------------------------------------------------------------------------------------------2kV MM ----------------------------------------------------------------------------------------------------------------------------200VRecommended Operating Conditions (Note 4)●Supply Input Voltage, V IN ------------------------------------------------------------------------------------------------2.7V to 5.5V ●Junction T emperature Range --------------------------------------------------------------------------------------------−40°C to 125°C ●Ambient T emperature Range --------------------------------------------------------------------------------------------−40°C to 85°CElectrical CharacteristicsRT8057©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.Note 1. Stresses beyond those listed “Absolute Maximum Ratings ” may cause permanent damage to the device. These are stressratings only, and functional operation of the device at these or any other conditions beyond those indicated in the operational sections of the specifications is not implied. Exposure to absolute maximum rating conditions may affect device reliability.Note 2. θJA is measured in natural convection at T A = 25°C on a low-effective thermal conductivity test board of JEDEC 51-3 thermalmeasurement standard. The measurement case position of θJC is on the exposed pad of the package.Note 3. Devices are ESD sensitive. Handling precaution is recommended.Note 4. The device is not guaranteed to function outside its operating conditions.Note 5. The reference voltage accuracy is ±2.5% at recommended ambient temperature range, guaranteed by design.RT8057©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.Typical Operating CharacteristicsOutput Voltage vs. Input Voltage2.222.242.262.282.302.322.342.362.382.53.03.54.04.55.05.5Input Voltage (V)O u t p u t V o l t a g e (V)Efficiency vs. Output Current01020304050607080901000.00.20.40.60.81.0Output Current (A)E f f i c i e n c y (%)Frequency vs. Input Voltage2.002.052.102.152.202.252.302.352.402.53.03.54.04.55.05.5Input Voltage (V)F r e q u e n c y(M H z )Output Current Limit vs. Input Voltage1.01.11.21.31.41.51.62.53.03.54.04.55.05.5Input Voltage (V)O u t p u t C u r r e n t l im i t (A )Frequency vs. Temperature1.901.952.002.052.102.152.202.252.30-50-25255075100125Temperature (°C)F r e q u e n c y (M H z )Output Current Limit vs. Temperature1.01.11.21.31.41.51.6-50-25255075100125Temperature (°C)O u t p u t C u r r e n t Li m i t (A )RT8057©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.Reference Voltage vs. Temperature0.5920.5940.5960.5980.6000.6020.6040.6060.608-50-25255075100125Temperature (°C)R e f e r e n c e V o l t a g e (V)Load Transient Response Time (100μs/Div)V IN = 5V, V OUT = 2.3V,I OUT = 0A to 1AI OUT(500mA/Div)V OUT(100mV/Div) Output RippleV IN = 3.3V, V OUT = 2.3V,I OUT = 1ATime (250ns/Div)V LX (5V/Div)V OUT (5mV/Div)Load Transient ResponseTime (100μs/Div)I OUT(500mA/Div)V OUT(100mV/Div)V IN = 5V, V OUT = 2.3V,I OUT = 0.4A to 1AOutput Voltage vs. Temperature2.252.262.272.282.292.302.312.322.332.342.35-50-25255075100125Temperature (°C)O u t p u t V o l t a g e (V)Output Ripple Time (250ns/Div)V LX (5V/Div)V OUT (5mV/Div)V IN = 5V, V OUT = 2.3V, I OUT = 1ART8057©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.En Threshold vs. Temperature0.600.620.640.660.680.700.720.740.760.780.80-50-25255075100125Temperature (°C)E N T h r e s h o l d (V )UVLO vs. Temperature1.51.61.71.81.92.02.12.22.32.4-50-25255075100125Temperature (°C)U V L O (V)Power On from ENTime (100μs/Div)V EN (2V/Div)V OUT (2V/Div)I OUT(500mA/Div)V IN = 5V, V OUT = 2.3V,I OUT = 1APower Off from ENTime (100μs/Div)V EN (2V/Div)V OUT (2V/Div)I OUT(500mA/Div)V IN = 5V, V OUT = 2.3V,I OUT = 1AOutput Voltage vs. Output Current2.262.272.282.292.302.312.322.332.340.00.10.20.30.40.50.60.70.80.91.0Output Current (A)O u t p u t V o lt a g e (V )RT8057©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.Application InformationThe basic RT8057 application circuit is shown in Typical Application Circuit. External component selection is determined by the maximum load current and begins with the selection of the inductor value and operating frequency followed by C IN and C OUT .Output Voltage SettingThe output voltage is set by an external resistive divider according to the following equation :OUT REFR1V V x (1)R2=+where VREF equals to 0.6V typical. The resistive divider allows the FB pin to sense a fraction of the output voltage as shown in Figure 1.Figure 1. Setting the Output VoltageSoft-StartThe RT8057 contains an internal soft-start clamp that gradually raises the clamp on the FB pin.100% Duty Cycle OperationWhen the input supply voltage decreases toward the output voltage, the duty cycle increases toward the maximum on-time. Further reduction of the supply voltage forces the main switch to remain on for more than one cycle,eventually reaching 100% duty cycle.The output voltage will then be determined by the input voltage minus the voltage drop across the internal P-MOSFET and the inductor.Low Supply OperationThe RT8057 is designed to operate down to an input supply voltage of 2.7V. One important consideration at low input supply voltages is that the R DS(ON) of the P-Channel and N-Channel power switches increases. The user should calculate the power dissipation when the RT8057 is used at 100% duty cycle with low input voltages to ensure that thermal limits are not exceeded.Under Voltage Protection (UVP)The output voltage can be continuously monitored for under voltage protection. When the output voltage is less than 33% of its set voltage threshold after OCP occurs, the under voltage protection circuit will be triggered to auto re-soft-start.Input Voltage Over Voltage protection (V IN OVP)When the input voltage (V IN ) is higher than 6V, V IN OVP will be triggered and the IC stops switching. Once the input voltage drops below 6V, the IC will return to normal operation.Output Over Voltage Protection (V OUT OVP)When the output voltage exceeds more than 5% of the nominal reference voltage, the feedback loop forces the internal switches off within 50μs. Therefore, the output over voltage protection is automatically triggered by the loop.Short Circuit ProtectionWhen the output is shorted to ground, the inductor current decays very slowly during a single switching cycle. A current runaway detector is used to monitor inductor current. As current increases beyond the control of current loop, switching cycles will be skipped to prevent current runaway from occurring.RT8057©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.C IN and C OUT SelectionThe input capacitance, C IN , is needed to filter the trapezoidal current at the source of the top MOSFET . To prevent large ripple voltage, a low ESR input capacitor sized for the maximum RMS current should be used. RMScurrent is given by :RMS OUT(MAX)I I =This formula has a maximum at V IN = 2V OUT , where I RMS =I OUT /2. This simple worst case condition is commonly used for design because even significant deviations do not result in much difference. Choose a capacitor rated at a higher temperature than required.Several capacitors may also be paralleled to meet size or height requirements in the design.The selection of C OUT is determined by the effective series resistance (ESR) that is required to minimize voltage ripple and load step transients, as well as the amount of bulk capacitance that is necessary to ensure that the control loop is stable. Loop stability can be checked by viewing the load transient response. The output ripple, ΔV OUT , is determined by :OUT L OUT 1V I ESR 8fC ⎡⎤∆≤∆+⎢⎥⎣⎦The output ripple is highest at maximum input voltagesince ΔI L increases with input voltage. Multiple capacitors placed in parallel may be needed to meet the ESR andRMS current handling requirements. Dry tantalum, special polymer, aluminum electrolytic and ceramic capacitors are all available in surface mount packages. Special polymer capacitors offer very low ESR, but have lower capacitance density than other types. Tantalum capacitors have the highest capacitance density, but it is important to only use types that have been surge tested for use in switching power supplies. Aluminum electrolytic capacitors have significantly higher ESR, but can be used in cost-sensitive applications provided that consideration is given to ripple current ratings and long term reliability. Ceramic capacitors have excellent low ESR characteristics, but can have a high voltage coefficient and audible piezoelectric effects.The high Q of ceramic capacitors with trace inductance can also lead to significant ringing.Using Ceramic Input and Output CapacitorsHigher value, lower cost ceramic capacitors are now becoming available in smaller case sizes. Their high ripple current, high voltage rating and low ESR make them ideal for switching regulator applications. However, care must be taken when these capacitors are used at the input and output. When a ceramic capacitor is used at the input and the power is supplied by a wall adapter through long wires, a load step at the output can induce ringing at the input, V IN . At best, this ringing can couple to the output and be mistaken as loop instability. At worst, a sudden inrush of current through the long wires can potentially cause a voltage spike at V IN large enough to damage the part.Table 2. Capacitors for C IN and C OUTRT8057©Copyright 2014 Richtek Technology Corporation. All rights reserved. is a registered trademark of Richtek Technology Corporation.Thermal ConsiderationsFor continuous operation, do not exceed absolute maximum junction temperature. The maximum power dissipation depends on the thermal resistance of the IC package, PCB layout, rate of surrounding airflow, and difference between junction and ambient temperature. The maximum power dissipation can be calculated by the following formula :P D(MAX) = (T J(MAX) − T A ) / θJAwhere T J(MAX) is the maximum junction temperature, T A is the ambient temperature, and θJA is the junction to ambient thermal resistance.For recommended operating condition specifications of the RT8057, the maximum junction temperature is 125°C and T A is the ambient temperature. The junction to ambient thermal resistance, θJA , is layout dependent. For WDFN-6SL 2x2 packages, the thermal resistance, θJA , is 165°C/W on a standard JEDEC 51-3 single-layer thermal test board. The maximum power dissipation at T A = 25°C can be calculated by the following formula :P D(MAX) = (125°C − 25°C) / (165°C/W) = 0.606W for WDFN-6SL 2x2 packageThe maximum power dissipation depends on the operating ambient temperature for fixed T J(MAX) and thermal resistance, θJA . For the RT8057 package, the derating curve in Figure 2 allows the designer to see the effect of rising ambient temperature on the maximum power dissipation.Figure 2. Derating Curve for the RT8057 PackageLayout ConsiderationsFollow the PCB layout guidelines for optimal performance of the RT8057.❝ Connect the terminal of the input capacitor(s), C IN , asclose as possible to the VIN pin. This capacitor provides the AC current into the internal power MOSFETs.❝ LX node experiences high frequency voltage swing andshould be kept within a small area. Keep all sensitive small-signal nodes away from the LX node to prevent stray capacitive noise pick up.❝ Flood all unused areas on all layers with copper. Floodingwith copper will reduce the temperature rise of power components. Connect the copper areas to any DC net (V IN , V OUT , GND, or any other DC rail in the system).❝ Connect the FB pin directly to the feedback resistors.The resistive voltage divider must be connected between V OUT and GND.Figure 3. PCB Layout GuideINLX should be connected to inductor by wide and short trace. Keep sensitive 0.000.050.100.150.200.250.300.350.400.450.500.550.600.650255075100125Ambient Temperature (°C)M a x i m u m P o w e r D i s s i p a t i o n (W )W-Type 6SL DFN 2x2 PackageRichtek Technology Corporation14F, No. 8, Tai Yuen 1st Street, Chupei CityHsinchu, Taiwan, R.O.C.Tel: (8863)5526789Richtek products are sold by description only. Richtek reserves the right to change the circuitry and/or specifications without notice at any time. Customers should obtain the latest relevant information and data sheets before placing orders and should verify that such information is current and complete. Richtek cannot assume responsibility for use of any circuitry other than circuitry entirely embodied in a Richtek product. Information furnished by Richtek is believed to be accurate and reliable. However, no responsibility is assumed by Richtek or its subsidiaries for its use; nor for any infringements of patents or other rights of third parties which may result from its use. No license is granted by implication or otherwise under any patent or patent rights of Richtek or its subsidiaries.DS8057-04 February 11。
Dimensions: [mm]pl1 - Reflow2.8mmpl2 - Reflow1mmfw - Reflow1.3mmX7R0805334K025DFCT1S000885382207002X7R0805334K025DFCT1S000 885382207002T e m p e r a t u r eT pT LX7R0805334K025DFCT1S000885382207002Cautions and Warnings:The following conditions apply to all goods within the product series of MLCCs of Würth Elektronik eiSos GmbH & Co. KG:General:•This electronic component is designed and manufactured for use in general electronic equipment.•Würth Elektronik must be asked for a written approval (following the certain PPAP level procedure) before incorporating the components into any equipment in the field such as military, aerospace, aviation, nuclear control, submarine, transportation (automotive control, train control, ship control), transportation signal, disaster prevention, medical, public information network etc. where higher safety and reliability are especially required and/or if there is the possibility of direct damage or human injury.•Electronic components that will be used in safety-critical or high-reliability applications, should be pre-evaluated by the customer.•Direct mechanical impact to the product shall be prevented as material of the body, pins or termination could flake or in the worst case it could break.•Avoid any water or heavy dust on capacitors surface, which may cause electrical leakage, damage, overheating or corrosion.•Würth Elektronik products are qualified according to international standards, which are listed in each product reliability report. Würth Elektronik does not warrant any customer qualified product characteristic, beyond Würth Elektronik specifications, for its validity and sustainability over time.•The responsibility for the applicability of the customer specific products and use in a particular customer design is always within the authority of the customer. All technical specifications for standard products also apply to customer specific products.•The component is designed and manufactured to be used within the datasheet specified values. If the usage and operation conditions specified in the datasheet are not met, the body, pins or termination may be damaged or dissolved.•Do not apply any kind of flexural or compressive force onto soldered or unsoldered component.•The capacitance tolerance as specified within the datasheet is only valid on the date of delivery and according specified measurement criteria.Product specific:Storage conditions:• A storage of Würth Elektronik products for longer than 12 months is not recommended. Within other effects, the terminals may suffer degradation, resulting in bad solderability. Therefore, all products shall be used within the period of 12 months based on the day of shipment.•Do not expose the components into direct sunlight.•The storage condition in the original packaging is defined according to DIN EN 61760-2.•The environment in which the capacitors are operated and stored has to have atmospheric characteristics and must be free of dew condensation and toxic gases (e.g. chlorine, ammonia, sulfur, hydrogen sulphide and hydrogen sulfate).Operating climatic conditions:•Do not exceed the lower nor the upper specified temperature under no circumstances.•Be aware that the specified capacitance tolerance is only valid at the date of delivery.•Do not use the capacitors under high humidity, high temperature nor under high or low atmospheric pressure which may affect capacitors reliability.•Surface temperature including self-heating must be kept below the maximum operating temperature.•The temperature rise of the capacitor´s temperature compared to ambient temperature shall be below 20°C.Operating load conditions:•Operating voltage across the terminals including AC and DC peaks and AC or pulse overshooting, Vp-p, as well as irregular voltage because of resonance or switching must be below the rated voltage.•Due to self-heating the reliability of the capacitor may be reduced, if high frequency AC or pulse is applied.•Consider carefully possible specific changes of electrical characteristics like capacitance over temperature, voltage and time as well as the specific performance over frequency for the actual use conditions.Design of the PCB:•The chip capacitor shall be located to minimize any possible mechanical stress from deflection or board wrap.•It is recommended to position the chip capacitor in parallel to slits and perforations and as far away from slits, perforations, separation points, screw holes, frames and edges of the PCB to avoid mechanical stress.•The PCB design (e.g. land pattern design and grounding planes) must be evaluated for each individual circuit to achieve the optimal soldering results.Mounting:•Adjust the bottom dead center of the mounting head not to press on the PCB surface.•Provide support from the bottom side of the PCB by a support pin for minimizing the impact energy from the mounting head. Adhesive:•The adhesive should have sufficient coating and viscosity and should harden rapidly.•The adhesive should be strong enough to hold parts on the board during the mounting and solder process and should have sufficient strength at high temperatures.•The adhesive should have corrosion resistance, excellent insulation characteristics and no emission of toxic gasses nor any effect on the human body.•Do not use too much adhesive to avoid pollution of the soldering pads.Würth Elektronik eiSos GmbH & Co. KGEMC & Inductive SolutionsMax-Eyth-Str. 174638 WaldenburgGermanyTel. +49 (0) 79 42 945 - 0*******************CREATED CHECKED GENERAL TOLERANCE PROJECTIONMETHODKaS PSL DIN ISO 2768-1mDESCRIPTION TECHNICAL REFERENCEWCAP-CSST Soft TerminationMLCCX7R0805334K025DFCT1S000ORDER CODE885382207002SIZE REVISION STATUS DATE (YYYY-MM-DD)BUSINESS UNIT PAGESoldering:•The solder profile must comply with the Würth Elektronik technical soldering specification. All other profiles will void the warranty.•All other soldering methods are at the customer’s own risk.•Strong forces which may affect the coplanarity of the component’s electrical connection with the PCB (i.e. pins), can damage the part, resulting in avoid of the warranty.•Customer needs to ensure that the applied solder paste, the paste thickness and solder conditions are applicable to guarantee a sufficient solder result according to the relevant criteria of IPC-A-610.•Excessive amount of solder may lead to higher tensile force and chip cracking. Insufficient amount of solder may detach the capacitor due to defective contacts.•Do not use excessive nor insufficient flux.•Provide enough washing when water-soluble flux is used.•For reflow soldering, two times limitation is recommended.•Wave soldering is recommended only for the following case sizes: 0603 and 0805, thicknessCleaning and Washing:•Washing agents used during the production to clean the customer’s application, might damage or change the characteristics of the wire insulation body, the marking or the plating. Washing agent could have a negative effect on the long term functionality of the product.•Avoid Halogen in the flux or any contaminated flux as well as excessively high ultrasonic cleaning.Coating, molding and potting of the PCB:•If the product is potted in the costumer’s application, the potting material might shrink or expand during and after hardening. Shrinking could lead to an incomplete seal, allowing contaminants into the body and termination. Expansion could damage the body ortermination. We recommend a manual inspection after potting to avoid these effects.•When coating and molding the PCB, verify the quality influence on the capacitor.•Verify the curing temperature and assure that there is no harmful decomposing or reaction gas emission during curing.•Do not exceed the maximal temperature rise of 20°C.Handling:•After soldering, please pay attention not to bend, twist or distort the PCB in handling and storage.•Avoid excessive pressure during the functional check of the PCB.•Avoid bending stress while breaking the PCB.•After mounting, avoid piling up PCBs to avoid hitting the chip capacitor of another board.These cautions and warnings comply with the state of the scientific and technical knowledge and are believed to be accurate and reliable. However, no responsibility is assumed for inaccuracies or incompleteness.Würth Elektronik eiSos GmbH & Co. KGEMC & Inductive SolutionsMax-Eyth-Str. 174638 WaldenburgGermanyTel. +49 (0) 79 42 945 - 0*******************CREATED CHECKED GENERAL TOLERANCE PROJECTIONMETHODKaS PSL DIN ISO 2768-1mDESCRIPTION TECHNICAL REFERENCEWCAP-CSST Soft TerminationMLCCX7R0805334K025DFCT1S000ORDER CODE885382207002SIZE REVISION STATUS DATE (YYYY-MM-DD)BUSINESS UNIT PAGEImportant NotesThe following conditions apply to all goods within the product range of Würth Elektronik eiSos GmbH & Co. KG:1. General Customer ResponsibilitySome goods within the product range of Würth Elektronik eiSos GmbH & Co. KG contain statements regarding general suitability for certain application areas. These statements about suitability are based on our knowledge and experience of typical requirements concerning the areas, serve as general guidance and cannot be estimated as binding statements about the suitability for a customer application. The responsibility for the applicability and use in a particular customer design is always solely within the authority of the customer. Due to this fact it is up to the customer to evaluate, where appropriate to investigate and decide whether the device with the specific product characteristics described in the product specification is valid and suitable for the respective customer application or not.2. Customer Responsibility related to Specific, in particular Safety-Relevant ApplicationsIt has to be clearly pointed out that the possibility of a malfunction of electronic components or failure before the end of the usual lifetime cannot be completely eliminated in the current state of the art, even if the products are operated within the range of the specifications.In certain customer applications requiring a very high level of safety and especially in customer applications in which the malfunction or failure of an electronic component could endanger human life or health it must be ensured by most advanced technological aid of suitable design of the customer application that no injury or damage is caused to third parties in the event of malfunction or failure of an electronic component. Therefore, customer is cautioned to verify that data sheets are current before placing orders. The current data sheets can be downloaded at .3. Best Care and AttentionAny product-specific notes, cautions and warnings must be strictly observed. Any disregard will result in the loss of warranty.4. Customer Support for Product SpecificationsSome products within the product range may contain substances which are subject to restrictions in certain jurisdictions in order to serve specific technical requirements. Necessary information is available on request. In this case the field sales engineer or the internal sales person in charge should be contacted who will be happy to support in this matter.5. Product R&DDue to constant product improvement product specifications may change from time to time. As a standard reporting procedure of the Product Change Notification (PCN) according to the JEDEC-Standard inform about minor and major changes. In case of further queries regarding the PCN, the field sales engineer or the internal sales person in charge should be contacted. The basic responsibility of the customer as per Section 1 and 2 remains unaffected.6. Product Life CycleDue to technical progress and economical evaluation we also reserve the right to discontinue production and delivery of products. As a standard reporting procedure of the Product Termination Notification (PTN) according to the JEDEC-Standard we will inform at an early stage about inevitable product discontinuance. According to this we cannot guarantee that all products within our product range will always be available. Therefore it needs to be verified with the field sales engineer or the internal sales person in charge about the current product availability expectancy before or when the product for application design-in disposal is considered. The approach named above does not apply in the case of individual agreements deviating from the foregoing for customer-specific products.7. Property RightsAll the rights for contractual products produced by Würth Elektronik eiSos GmbH & Co. KG on the basis of ideas, development contracts as well as models or templates that are subject to copyright, patent or commercial protection supplied to the customer will remain with Würth Elektronik eiSos GmbH & Co. KG. Würth Elektronik eiSos GmbH & Co. KG does not warrant or represent that any license, either expressed or implied, is granted under any patent right, copyright, mask work right, or other intellectual property right relating to any combination, application, or process in which Würth Elektronik eiSos GmbH & Co. KG components or services are used.8. General Terms and ConditionsUnless otherwise agreed in individual contracts, all orders are subject to the current version of the “General Terms and Conditions of Würth Elektronik eiSos Group”, last version available at .Würth Elektronik eiSos GmbH & Co. KG EMC & Inductive SolutionsMax-Eyth-Str. 174638 WaldenburgGermanyTel. +49 (0) 79 42 945 - 0*******************CREATED CHECKED GENERAL TOLERANCE PROJECTIONMETHODKaS PSL DIN ISO 2768-1mDESCRIPTION TECHNICAL REFERENCEWCAP-CSST Soft TerminationMLCCX7R0805334K025DFCT1S000ORDER CODE885382207002SIZE REVISION STATUS DATE (YYYY-MM-DD)BUSINESS UNIT PAGE。
1Does not qualify for DLC4 Cannot be used w/ FMB, HUB, or HOOKOne needed per project Must be used with FSIR for commissioningSensor Mounted on centerAvailable for EDV-8L–24L only 5Mounted externally to fixture 8Must be used with ES/PCD Only available with FRL driver channelAvailable for EDV-30L–60L onlyMust be used with ES/PCD and ES/IR 9 Reduces published performance by 16%Sensor Mounted off end cap of fixtureConsult Factoryoptions for commissioningSUITABLE APPLICATIONS • Gymnasiums • Manufacturing Plants • Warehouses • Distribution CentersIK10RATING Project Name:Part Number:Type:FEATURES• Sleek Curved Polycarbonate Injection Molded End Caps • Aluminum Body with steel channel for added rigidity • Toolless Hinged Driver Access • Wide & Narrow Distributions• Impact Resistant and IP5X Rated Lens Options:- Frosted Acrylic (FRL)- Frosted Polycarbonate (PFL) IK10 Impact Rated • V-Clips for dual point chain or cable hanging (std.)• Advanced and Basic Controls Options • -40˚F –122˚F Ambient Temperature Range • 3000K - 5000K CCT • Uplight Options• >80 Color Rendering Index (CRI)• Calculated L 70 >100,000 hrs• 0-10V Dimmable Driver (100%–10%)• 120-277V Universal Voltage • 5 Year Warranty• ETL Listed for Damp Location• DesignLights Consortium ® Premium Qualified LuminaireFixtures shown with Frosted Lens (FRL)1 2 3SPECIFICATIONSCONSTRUCTIONAluminum body with steel driver channel for maximum rigidity and thermal properties. Sleek curved polycarbonate injection moldedend caps provide a modern finish while adding rigidity and durability. Toolless hinged driver door access for ease of maintenance and installation. Power access plate mounted on back of center driver channel for easy access to wiring. Product proudly assembled in the United States of America.ELECTRICALClass 2 LED light engine for high efficacy and long life.Calculated L70 > 100,000 hrs. LED Lumen Maintenance Estimates based on TM-21 projections for the light source at 25˚C ambient. Power Factor > 0.90. Standard 120-277 Vac 0-10V dimmable (10%-100%) with optional 347-480 Vac step down transformer. Optional emergency battery backups and generator transfer device available to meet critical life safety lighting requirements. Fixture reduced maximum ambientfor emergency battery backup and step down options. Optional uplight wired to sensor it ordered together.MOUNTINGOptions include suspension chain, aircraft cables, hook, single pendant (HUB), surface mount (SMZBKIT). Reduced maximum ambient range for surface mount.WARRANTY5 Year Warranty (Terms and Conditions apply)OPTICSStandard without lens. Optional frosted acrylic (FRL) and frosted polycarbonate (PFL) lenses available for added LED protection and glare reduction. Both optics are IP5X rated; protected against dust intrusion. Frosted Polycarbonate lens (PFL) is IK10 Impact Rated; highest impact rating available. Wide (std.) & Narrow (ND) Distribution options available for all lumen packages.THERMALAmbient temperature range -40°F to 122°F (-40°C to 50°C). Fixtureto be mounted at a minimum plenum height of 18" to maintain maximum ambient temperature. Reduced maximum ambient for surface mounting.CONTROLSFactory installed Advanced and Basic integral occupancy sensor options available. All Basic sensors are end mounted. Advanced EasySense sensor is end mounted. All other Advanced sensors are center driver cover mounted. Inquire with manufacturer for additional controls options, including customer supplied items. CERTIFICATIONSETL listed to US and Canadian safety standards. Suitable for damp locations. American Recovery and Reinvestment Act Funding Compliant. DLC (DesignLights Consortium) Premium Qualified, with some Standard Qualified configurations. Please refer to the DLC Qualified Products List at /QPL to confirm specific product qualifications.FIOSStandard on/off motion sensor. Comes with 360 degree high bay lens, 360 degree low bay lens & aisle lens. 360 degree high bay lens factory installed, unless notified otherwise. Sensor mounted off end cap of fixture. Inquire for mounting on center of driver cover.Philips ES/HBEasySense sensor combines occupancy sensing, daylight harvesting and institutional tuning in one compact solution. This is an ideal control for any high bay application. Each device allows you to turn on/off occupancy and/or daylight harvesting functions as well as set the full light output, background light level, occupancy prolong time, occupancy grace fading time & occupancy time out/hold time. Requires use of EasySense Pre-Programmed Control Device (ES/PCD) & Commissioning IR Blaster (ES/IR); one of each needed per project. (Sold separately). Sensor mounted off end cap of fixture.USBDUser Selectable Bi-Level Dimming. Allows the end user to manually select the unoccupied dimming level. Once motion is detected, the fixture will return to 100% light output. Sensor mounted off end cap of fixture.Enlighted 5S/CU/CLBundled System with Enlighted 5E sensor (SU-5S-H-CL), Control Unit (CU-4E-FM) & Cable (CBL-5E-CU4-30N). Fixtures are controlled based on occupancy & ambient light. Includes individual lighting control plus connection to Enlighted Energy Manager. The Energy Manager provides data analysis for all data collected by the Enlighted Smart Sensors for energy, occupancy & environment. Provided factory installed components only. Enlighted system provided by others. Contact factory for more information. Sensor mounted on center driver channel.FIOSPCMotion sensor with the addition of photocell control. When installed, fixture will not activate unless 1.motion is detected and 2.light levels are below the preset level. When activated, fixture will turn on to 100% light output & will only shut off when one of the two levels mentioned above are met. If no motion is detected & light levels fall below preset level the fixture remains off. Sensor mounted off end cap of fixture.Legrand FSP-211FSP-211 offers fully adjustable high and low dimmed light levels with optional photocell. Hold off setpoint with automatic calibration option. Adjustable time delay and cut off delay. Sensor adjustable programming with handheld wireless configuration tool; FSIR-100. (Sold separately. One needed per project). Sensor mounted on center driver channel.BDxxFactory set Bi-Level Dimming. Sensor is set to dim level, as indicated in the “xx” portion of the part number, when the area is unoccupied. Example: BD20 sets the fixture to dim down to 20% lumen output when the area is unoccupied. Once motion is detected, the fixture will return to 100% light output. Sensor mounted off end cap of fixture.Sensor mounted off end cap of fixture.Enlighted 5S/CU/IOTBundled System with Enlighted 5E sensor (SU-5S-H-IOT), Control Unit (CU-4E-FM) and Cable (CBL-5E-CU4-30N). Fixtures are controlled based on occupancy and ambient light. Includes individual lighting control plus connection to Enlighted Energy Manager. The Energy Manager provides data analysis for all data collected by Enlighted Smart Sensors for energy, occupancy & environment. Additionally, the IOT functionality takes the data access and function beyond just lighting to a wide range of applications beyond the standard connected lighting controls. Provided factory installed components only. Enlighted system provided by others.Contact factory for more information. Sensor mounted on center driver channel.FIOSPC/DLHFactory installed motion sensor with the addition of photocell control that will allow for daylight harvesting. When installed, fixture will not activate unless 1.motion is detected & 2.light levels are below the preset level. When activated, fixture will turn on only enough to meet the preset light levels and will adjust as the amount of light in the space adjusts between 100%-10%. If light levels are adequate the fixture will remain off. Sensor mounted off end cap of fixture.Legrand FSP-311FSP-311 offers fully adjustable high and low dimmed light levels with optional photocell. Hold off setpoint with automatic calibration option. Adjustable time delay and cut off delay. Sensor adjustable programming via iOS ®or Android ®'Sensor Configuration' App.Sensor mounted on center driver channel. Sensor mounted on center driver channel.BDxxPCFactory set Bi-Level Dimming with motion and photocell. Sensor is set to dim level, as indicated in the “xx” portion of the part number, when the area is unoccupied and will not return to 100% light output unless 1.motion is detected and 2.the light level is below the preset level. Example: BD20PC sets the fixture to dim down to 20% lumen output when the area is unoccupied and will not return to 100% light output unless the above conditions are met for both motion and light level readings. Sensor mounted off end cap of fixture.DHPCDaylight Harvesting off photocell. Fixtures will continually dim up/down throughout the day based on light level readings taken from the photocell control. Sensor mounted off end cap of fixture.Enlighted 5S/CU/ILBundled System with Enlighted 5E sensor (SU-5S-H-IL), Control Unit (CU-4E-FM) and Cable (CBL-5E-CU4-30N). Fixtures are controlled based on occupancy and ambient light. Includes ability to group fixtures together and connect to a switch to zone fixtures for group operation. Provided factory installed components only. Enlighted system provided by others. Contact factory for more information. Sensor mounted on center driver channel.CONTROLS OPTIONSBASICADVANCEDHUB 3/4Conduit Hub 3/4" for Pendant MountingHOOKCast Iron Hook for SinglePoint MountingSMBZKITSurface Mount Bracket Kit providesa 2" space above the fixtureHB-XX-18Y-PADIncludes 2 adjustable cable hangers. Available in 60", 120", 180" & 240"FMBIncludes rigid box to attach to the fixture, provides for single point mounting to accept a pendant, hook or conduit hub(sold separately)CORDxCords available in 6ft, 10ft, 12ft & 20ft (Inquire for additional options) Plugoptions availableQDCxQuick Disconnect Cords available in 6ft, 10ft, 12ft & 20ft (Inquire foradditional options) Plugoptions available.WC11 GA Wire CageOPTIONSLINE DRAWINGS8L - 24L30L36L - 60LQuadralaterally Sy mmetric Solid: 0 DegreesSm all Dash: 45 Degrees Large Dash: 90 DegreesQuadralaterally Sy mmetric Solid: 0 DegreesSm all Dash: 45 Degrees Large Dash: 90 DegreesQuadralaterally Sy mmetric Solid: 0 DegreesSm all Dash: 45 Degrees Large Dash: 90 Degrees。
Specification Approval Sheet Name:Polymer Lithium-Ion BatteryModel: CELLEVIA BATTERIES LP103035SPEC:3.7V/ 1050mAhNumber: 103035Specification Modification RecordsContent1.Scope:This specification describes the Product Specification of chargeable Polymer Lithium-IonBattery produced by Cellevia.Any copies are invalid without our company’s approval2.Model :3.Cell parameters Index:3.2 Parameters of batterythe temperature.4.Electronic Characteristics test and inspection:4.1 Standard testing environmentUnless special stated, tests should be done within one month of delivery and thecharging-recharging times is less than 5 times. The following is test conditions: Ambient Temperature: 25℃±0.5℃Ambient Humidity: 65 ±20%4.2 The requirement of measure instrument(1) The measure instrument is passed tested by qualified institute.(2) The accuracy of the size instrument is not more than 0.01mm.(3) The accuracy of multimeter is not less than 0.5%. while measure the voltage, theinternal resistance mustn’t less than 10KΩ.(4) The principal of the internal resistance is 1KHz LCR, the accuracy is 0.2%.(5) The internal resistance is changeable, it varies according to the temperature and thecharging mode. And it is relevant to the PTC and the length and the Capacity of the drawing line.(6) The current accuracy of the battery test system is more than ±0.1%,isobaricallyaccuracy is ±0.5%, timer accuracy is less than ±0.1%.(7) The accuracy of the temperature meter is less than ±0.5℃.4.3 Visual inspectionAny visual inspection defects will affect the electronic characteristics, such as cracks,leakage, and flaw, are not inexistence.Notes: The Max. voltage while charging is not more than 4.25V.The Max.protective voltage designed on PCB board should not more than4.3V.5. Storage and others5.1 Long Period StorageIf the cell has been stored for 3 month, it should be transfer to a dry and cool environment. Storage Voltage is between 3.6V and 3.9V and the storage conditions as Item 4.1.5.2Any matters that this specification does not cover should be conferred between theSpecification Approval sheet6.Drawing6.1 Assembly diagram(not in scale)Model :LP10303531.0MAX30adhesive wire black AWG2660wire red (+)AWG26507030351050m A hE V I A B A T T E R I E S 3,7 V! Danger●Strictly prohibits heat or throw cell into fire.●Strictly prohibits throw and wet cell in liquid such as water, gasoline or drink etc.●Strictly prohibits use leave cell close to fire or inside of a car where temperature may be above60°C. Also do not charge / discharge in such conditions.●Strictly prohibits put batteries in your pockets or a bag together with metal objects such asnecklaces. Hairpins,coins, or screws. Do not store or transportation batteries with such objects.●Strictly prohibits short circuit the (+) and (-) terminals with other metals.●Do not place Cell in a device with the (+) and (-) in the wrong way around.●Strictly prohibits pierce Cell with a sharp object such as a needle.●Strictly prohibits disassemble or modify the cell.●Strictly prohibits welding a cell directly.●Do not use a Cell with serious scar or deformation.●Thoroughly read the user’s manual before use, inaccurate handling of lithium ion rechargeablecell may cause leakage, heat, smoke, an explosion, or fire, capacity decreasing.! Warning●Strictly prohibits put cell into a microwave oven, dryer, or high-pressure container.●Strictly prohibits use cell with dry cells and other primary batteries, or new and old battery orbatteries of a different package, type, or brand.●Stop charging the Cell if charging is not completed within the specified time.●Stop using the Cell if abnormal heat, odor, discoloration, deformation or abnormal condition isdetected during use, charge, or storage.●Keep away from fire immediately when leakage or foul odor is detected.●If liquid leaks onto your skin or clothes, wash well with fresh water immediately.●If liquid leaking from the Cell gets into your eyes, do not rub your eyes. Wash them well with cleanedible oil and go to see a doctor immediately.! Caution●Before using the Cell, be sure to read the user’s manual and cautions on handling thoroughly.●Charging with specific charger according to product specification. Charge with CC/CV method.Strictly prohibits revered charging. Connect cell reverse will not charge the cel. At the sametime, it will reduce the charge-discharge characteristics and safety characteristics, this will leadto product heat and leakage.●Store batteries out of reach of children so that they are not accidentally swallowed.●If younger children use the Cell, their guardians should explain the proper handling.●Before using the Cell, be sure to read the user’s manual and cautions on handling thoroughly.●Batteries have life cycles. If the time that the Cell powers equipment becomes much shorter thanusual, the Cell life is at an end. Replace the Cell with a new same one.●When not using Cell for an extended period, remove it from the equipment and store in aplace with low humidity and low temperature.●While the Cell pack is charged, used and stored, keep it away from objects or materials with staticelectric charges.●If the terminals of the Cell become dirty, wipe with a dry clothe before using the Cell.●Storage the cells in storage temperature range as the specifications, After full discharged, wesuggest that charging to 3.9~4.0V with no using for a long time.●Do not exceed these ranges of the following temperature ranges.Charge temperature range : 0 °C to 45 °C;Discharge temperature range : -20 °C to 60 °C.(When using equipment)Handling Precaution and GuidelineFor LIP (Lithium-Ion Polymer) Rechargeable BatteriesPrefaceThis document of ‘Handling Precautions and Guideline LIP Rechargeable Batteries’shall be applied to the battery cells manufactured by CELLEVIA.Note (1): The customer is requested to contact CELLEVIA in advance, if and when the customer needs other applications of operating conditions than those described in this document. Additional experimentation may be required to verify performance and safety under such condition.Note (2): CELLEVIA will take no responsibility for any accident when the cell is used under other condition.Note (3): CELLEVIA will inform, in a written form, the customer of improvement(s) regarding proper use and handling of the cell, if it is deemed necessary.1. Charging 1.1ChargingCurrent:Charging current should be less than maximum charge current specified in theSpecification Approval Sheet.1.2 Charging Voltage:Charging voltage should be less than the maximum nominal voltage 4.2V, andthe charging voltage upper limited is 4.30V(single pack).1.3 Charging Temperature:The cell should be charged within the range specified in this Specification ApprovalSheet.1.4 Notes:Since charging with constant current or constant voltage, reverse charging isprohibited. In case of the cell is connected improperly, the cell cannot be charged.Simultaneously, the reverse charging may cause damaging to the cell whichmay lead to degradation of cell performance and damage the cell safety, andcould cause heat generation or leakage.2. Discharging Current:The cell shall be discharged at less than the maximum discharge current specified in the Specification Approval Sheet. High discharging current may reduce the discharging capacity significantly or cause over-heat.3. Discharging TemperatureDischarging Temperature should be within the range specified in this Specification Approval Sheet.4.Over-DischargeOver-discharging will cause cell low-performance and function loss. The cell would be in a over-discharged state by its self-discharge characteristic. In order to prevent over-discharging, the cell shall be charged periodically to maintain between 3.6V and 3.9V.5. Protective Circuit Module5.1 The cell / battery pack shall be with a PCM that can protect cell / battery packproperly. PCM shall have functions of(1) Overcharging prevention(2) Over-discharging prevention(3) Over current prevention to maintain safety and prevent significant deteriorationof cell performance. The over current can occur by external short circuit.5.2 Overcharging ProtectionOvercharging prevention function shall stop charging if any cell of the battery packreaches 4.30V.5.3 Over-discharging protectionOver-discharging protection function shall monitor the voltage of every cell in the pack, and work to avoid further drop in the cell voltage of 2.5V or less.6. StorageCells should be stored in proper temperature specified in Specification ApprovalSheet.7. AppearanceIt shall be free from any defects such as remarkable scratches, breaks, cracks,discoloration, leakage or deformation .8. Notice△!8.1 Handling of cells:Avoid any short-circuit, it will caused the pole hot and lost electronic functions.Soft packing is very damaged by sharp edge parts such as needles and knives.Avoid cells touch with sharp edge part, when handling and storage.Beside the poles is the sealed edge. Don’t bend or fold dealing edge, for it is a sensitive part.Don’t open the folding edge on both sides of the cells.Don’t bend the tabs, for the tabs are not so stubborn.Avoid mechanical shock to the cells.Don’t put the cells into the heater, washing machine or high-voltage container.Don’t use the charger without any safety guarantee, and recommend you use specified charger.You should immediately stop charging, as cell is overheating, delivery any smell, changed color, distortion etc.Before Children use batteries, adults should explain the usage first.Before use batteries, please read the handling guideline carefully and fully understand.Away from the static-electronic field, while using, charging and storing cells.Don’t put the cells together with metal conductors such as chains, barrette, bolt into the pocket or stored them together.Don’t use metal conductor to shortcut the positive and negative poles.Don’t mis-assemble the positive pole with the negative one.8.2 Notice for Designing Battery Pack8.2.1 Package DesignBattery pack should have sufficient strength and battery should be protected from mechanical shock.No sharp edge components should be inside the pack containing the battery.5The overcharge threshold voltage should not be exceed 4.30V (single pack) The over-discharge threshold voltage should not be lower than 2.V (singlepack)The PCM should have short protection built inside.8.3 Notice for Assembling Battery Pack8.3.2 Tab connectionUltrasonic welding or spot welding is recommended to connect battery withPCM or other parts. If apply manual solder method to connect tab with PCM, below notice is veryimportant to ensure battery performance.8.3.2.1 The solder iron should be temperature controlled and ESDsafe.8.3.2.2 Soldering temperature should not exceed 350℃. 8.3.2.3 Soldering time should not be longer than 3 seconds . 8.3.2.4 Keep battery tab cold down before next time soldering.8.3.2.5 Directly heat cell body is strictly prohibited. Battery shouldbe damaged by heat above approx. 60℃.8.3.3 Cell fixingThe battery should be fixed to the battery pack by its large surface area. No sharp edge at the assembling position.No cell movement in the battery pack should be allowed.9.Others9.1 The disassembling may generate internal shout circuit in the cell, which may causegassing, firing, or other problem.9.2 Prohibition of dumping of cells into fireNever incinerate or dispose the cells in fire, for these may cause firing of the cells. 9.3 The cells should never be soaked with liquids such as water, drinks or oil.9.4 Prohibit using the cells mixed with different manufactories. Prohibit using new cellsmixed with old ones.▲Special Notice: If the cell isn’t used for a long time, Please Keep the cells in half-charged state, which is keeping them unfully charged or incompletely discharged. Recharge the cells and use half of the power after 2-3months. Store the cells in cool and dry place. It will protect the cell from damage effectively and long-term.10. StatementIf our specifications material, product process or product control system has changed, the information will be transmitted to consumer by way of written with quality and reliability data.。
Supertex inc.AN-H59Application NoteApplication CircuitHigh Voltage DC/DC Converter forSupertex Ultrasound Transmitter DemoboardsBy Afshaneh Brown, Applications Engineer,and Jimes Lei, Applications ManagerIntroductionThe Supertex AN-H59DB1 demoboard is a high voltage DC/DC converter. It can provide up to +90V voltage supply for V PP and -90V for V NN . It also provides +8.0 to +10V voltage supply for V DD , floating power supplies of V NN +8.0 to V NN +10V for V NF and V PP -8.0 to V PP -10V for V PF . The input supply voltage is 12V.The AN-H59DB1 circuitry consists of two high voltage PWM Current-Mode controllers, a DC/DC transformer driver, and three low dropout regulators. The Supertex AN-H59DB1 uses a high-voltage, current mode, PWM controller boost topology to generate +15 to +90V and a high-voltage current mode PWM controller buck-boost topology to generate -15 to -90V power supply voltage for Supertex HV738DB1 and HV748DB1 ultrasound transmitter demoboards.Each of the transmitter demoboards has slightly different operating voltages as summarized below.To accommodate all three demoboards, the AN-H59DB1 demoboard has adjustable V PP , V NN , V DD , V PF and V NF . The purpose of the AN-H59DB1 is to aid in the evaluation of the three transmitter demoboards. The intention of this application note is to provide a general circuit description on how each of the output voltages is generated.The VSUB pin on the HV738DB1 and HV748DB1 can either be connected to the most positive supply voltage on the demoboard, or can be left floating.To power up the AN-H59DB1, ensure that the 3.3V power supply will be powered up first, and then the 12V power supply. The sequences on the HV738DB1 and HV748DB1 took into consideration using the protection diodes on each power line.The circuit is shown in Figure 6, the component placement in Figure 5, and the bill of materials is at the end of thisapplication note.PP The circuit in Figure 1 shows U5, the Supertex high volt -age current mode PWM controller, being used to generate the high voltage power supply for V PP . The maximum output power for V PP was set for 10mA at 90V, which is 900mW. With an input voltage of 12V, a converter frequency of 110 kHz with a 100µH inductor was chosen to provide the de -sired output power.The converter frequency is set by an external resistor, R20, across OSC IN and OSC OUT pins of U5. A 154kΩ resistor will set the frequency to about 110 kHz. R24 is the current sense resistor. 2.2Ω was used to set the maximum peak current limit to about 450mA. An RC filter, R23 and C15, is added between the current sense resistor and the current sense terminal pin 3 of U5. This reduces the leading edge spike on R24 from entering the current sense pin.Inductor L1 is being charged from the 12V input by M3. When M3 turns off, the energy in L1 is discharged into C16, which is the V PP output through D8. The V PP voltage is di-vided down by feedback resistors R25, R26, and R27. The wiper of R26 is connected to pin 14 of U5. The overall con -verter will regulate the voltage on pin 14 to 4.0V. Different V PP output voltages can be obtained by adjusting R26.When the wiper for R26 is set to the top, V PP can be calcu-lated as:where V FB is 4.0VWhen the wiper for R26 is set to the bottom, V PP can be calculated as:By adjusting potentiometer R26, V PP meets the adjustable target range of 15 to parator U6 will turn on LED D7 when the V PP output is out of regulation due to excessive load. During initial power up, C16 will be at 0V. D7 is therefore expected to be on until C16 is charged to the desired regulation voltage.Figure 1: Adjustable V PP Power SupplyV PPGNDV PP = 4.0V x ( 232k + 100k + 14.3k )= 12.1V 100k + 14.3k V PP= V FBx ( R25 + R26 + R27 )R26 + R27V PP = 4.0V x ( 232k + 100k + 14.3k )= 96.9V 14.3kV PP = V FBx ( R25 + R26 + R27 )R27NN The circuit in Figure 2 shows U7, the Supertex high voltage current mode PWM controller, being used to generate the high voltage power supply for V NN . The function of U7 is very similar to what was described in the V PP circuit description for U5. However, in this circuit a negative voltage is gener -ated from a positive input voltage source, therefore requir-ing a buck-boost topology. The maximum output power for V NN was set for -10mA at -90V which is 900mW. With an input voltage of 12V, a converter frequency of 110 kHz with a 100µH inductor was chosen to provide the desired output power.Inductor L2 is being charged from the 12V input by the par-allel combination of M6 and M7. When M6 and M7 turn off, the energy in L2 is discharged into C23, which is the V NNoutput through D10. M6 and M7 are high voltage P-channel MOSFETs. U7 is designed to drive a high voltage N-chan -nel MOSFET. The drive output for U7 therefore needs to be inverted. This is accomplished by M4 and M5.The feedback voltage that U7 detects on pin 14 is +4.0V. The V NN that needs to be sensed is a negative voltage. A cir-cuit is needed to make sure the feedback voltage is positive. This is consists of Q4, Q5, R33, R34, R35, R37, and R38. Q4 becomes a constant current sink set by the V NN voltageand R35. The same current will be flowing through R33 and R34.The voltage on the base of Q5 will be V IN minus the voltage drop across the sum of R33 and R34. By varying R34, the base voltage on Q5 will change. Q5 becomes a constant current source with a value set by its base voltage and R37. The current source of Q5 is going into R38, which creates a positive voltage that is now proportional to the magnitude of V NN .where V BE = 0.6V, V FB = 4.0V.When R34 is set to 100k, V NN is calculated to be:= -4.0VWhen R34 is set to 0k, V NN is calculated to be:= -97.4V By adjusting potentiometer R34, V NN meets the adjustable target range of -15 to parator U8 will turn on LED D9 when the V NN output isout of regulation due to excessive load. During initial power up, C23 will be at 0V. D9 is therefore expected to be on until C23 is charged to the desired regulation voltage.Figure 2: Adjustable V NN Power SupplyVNN-15V to -90V GNDV NN = V BE - ( R35 ) x (V BE + V FB x R37 ), R33 + R34 R38V NN = 0.6V - ( 273k) x (0.6V + 4.0V x 14.7k ) 4.99k + 100k 40.2k V NN = 0.6V - ( 273k ) x (0.6V + 4.0V x 14.7k )4.99k + 0k 40.2kVPF and VNF Circuit DescriptionThe three transmitter demoboards require two floating low voltage supplies, V PF and V NF . The floating supplies need to be adjustable to accommodate the different operating re-quirements for the three different boards. The V PF is 8.0 to 10V below the high voltage V PP positive supply. The V NF is 8.0 to 10V above the high voltage V NN negative supply. The two floating supplies are generated by using two isolated transformers, T1 and T2, and an isolated transformer driver, U1, as shown in Figure 4. Both outputs utilize adjustable low dropout linear regulators, U2 and U3, as shown in Figure 3. U2 and U3 are both Linear Technology LT1521, which has a reference voltage of 3.75V on the ADJ pin. For V PF , resistors R6, R7, and R8 set the output V PF voltage. R7 is a potentiom -eter for adjusting V PF . V PF can be calculated with the following equation:When R7 is set to 20kΩ, V PF becomes:When R7 is set to 0Ω, V PF becomes:Please note that the OUT pin on U2 is referenced to V PP , thereby setting V PF to be 8.0 to 10V below V PP . V NF can also be calculated in a similar manner using resistors R12, R13, and R14. Please note that the GND pin on U3 is referenced to V NN thereby setting V NF to be 8.0 to 10V above V NN .LED indicators, D5 and D11, start to turn on when the input current to U2 and U3 reaches an arbitrary value of 40mA. This is set by Q1 and R3 for V PF and Q2 and R9 for V NF . The input current can be calculated with the following equation: Input current = V EB = 0.5V = 41.3mA R 12.1Ω50mA current limits are added to protect against output shorts. The current limiter is consists of a depletion-mode MOSFET and a series source resistor. The resistor sets the current limit and can be estimated with the following equa -tion:R SERIES = V TH x ( √I LIM / I DSS - 1) where, I LIMV TH = pinch-off voltage for M1 and M2: -2.5V I LIM = desired current limit: 50mAI DSS = saturation current for M1 and M2: 1.1A R SERIES = 39.3Ω. A 40.2Ω resistor was used.Figure 3: Adjustable V PF and V NF Power SupplyV VNFVFPV PF = 3.75V x ( 45.3k + 20k + 24.9k )= 7.53V 20k + 24.9kV PF = 3.75V x ( 45.3k + 0k + 24.9k )= 10.6V 0 +24.9kV PF= V ADJx ( R6 + R7 + R8 )R7 + R8V DD Circuit DescriptionThe V DD output voltage utilizes an adjustable low dropout lin -ear regulator, U4 LT1521, as shown in Figure 4. The desiredadjustable output voltage range is 8.0 to 10V to accommo-date the different operating V DD voltages for the three differ-ent transmitter demoboards.The LT1521 has a reference voltage of 3.75V on the adj pin. Resistors R17, R18, and R19 set the output V DD voltage. R18 is a potentiometer for adjusting V DD . V DD can be calcu-lated with the following equation:When R18 is set to 20kΩ, V DD becomes:When R18 is set to 0Ω, V DD becomes:An LED indicator, D6, is included in case of excessive input,I IN, current. D6 is starts to turn on when the input currentreaches an arbitrary value of 20mA. This is set by Q3 and R15. When the emitter-base junction of Q3 is forward biased (0.5V), Q3 will start to turn on, thereby forward biasing D6.The I IN value to turn D6 on can be calculated with the follow -ing equation: I IN = V EB = 0.5V= 20.6mAR1524.3Ω 3.3V Input TerminalThe AN-H59DB1 has a 3.3V input terminal that is directly connected to the output terminal, V CC . There is no circuitry on this board that uses the 3.3V supply. It is only there as a convenient connection to the 8-pin header. V CC is the logic supply voltage for HV738DB1 and HV748DB1 and can oper-ate from 1.2 to 5V. However, most users will operate V CC at either 3.0 or 3.3V.Input and Output PowerThe output voltages from the AH-H59DB1 are all generated from the 12V input line. With no load on the outputs, the measured input current was about 70mA. This input current can vary from board to board due to variations in the isolated transformer.The maximum output power is:P OUT(MAX) = P VPP(MAX) + P VNN(MAX) + P VPF(MAX) + P VNF(MAX) + P VDD(MAX)P OUT(MAX) = 0.9W + 0.9W + 0.4W + 0.4W + 0.2W P OUT(MAX) = 2.8WUnder this condition, the 12V input current was measured to be 340mA. Input power is therefore 4.08W. This gives an approximate overall efficiency of 69% at full load.Figure 4: Adjustable V DD Power SupplyV IN = 12VVDD+8.0 to 10V GNDV DD = 3.75V x ( 45.3k + 20k + 24.9k )= 7.53V20k + 24.9kV DD = 3.75V x ( 45.3k + 0k + 24.9k )= 10.6V 0 + 24.9k V DD = V ADJ x ( R17 + R18 + R19 )R18 + R19VPF and VNF Output CurrentThe AN-H59DB1 can supply more than 40mA of current for the V PF and V NF outputs. The I NF and I PF input currents for the HV738 or the HV748 can be found in their respective datasheet but are summarized below:This is for continuous 5.0 MHz operation. For ultrasound, thehigh voltage transmitter is operating at very low duty cycles; 1% or lower. At a 1% duty cycle, the average current is ex -pected to be a 100 times lower. The 40mA output current ca -pability on the AN-H59DB1 is more than sufficient to power up the HV738 or the HV748.ConclusionThe main purpose of AN-H59DB1 power supply demoboard is to help the evaluation of the Supertex HV738DB1 and HV748DB1 demoboards by reducing the number of power supplies needed. The AN-H59DB1 was designed to operate from a single 12V input which should be commonly available in any engineering laboratory.The five on-board LEDs allow the user to quickly determine whether there is an overload condition on each of the supplylines. The five potentiometers allow the user to easily adjust each supply to meet their particular needs.Figure 5: AN-H59 Component PlacementFigure 6: AN-H59 Circuit SchematicVPPVPFVNFSupertex inc. does not recommend the use of its products in life support applications, and will not knowingly sell them for use in such applications unless it receives an adequate “product liability indemnification insurance agreement.” Supertex inc. does not assume responsibility for use of devices described, and limits its liability to the replacement of the devices determined defective due to workmanship. No responsibility is assumed for possible omissions and inaccuracies. Circuitry and specifications are subject to change without notice. For the latest product specifications refer to the Supertex inc. (website: http//)©2012 Supertex inc. All rights reserved. Unauthorized use or reproduction is prohibited.Supertex inc.1235 Bordeaux Drive, Sunnyvale, CA 94089。
USA SAFETY DATA SHEET300000002744 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATIONProduct name:CHEMLOK 459XProduct Use/Class:Primer for AdhesiveLORD Corporation 111 LORD Drive Cary, NC 27511-7923 USATelephone: 814 868-3180Non-Transportation Emergency: 814 763-2345 Chemtrec 24 Hr Transportation Emergency No. 800 424-9300 (Outside Continental U.S. 703 527-3887)EFFECTIVE DATE : 11/23/20202. HAZARDS IDENTIFICATIONGHS CLASSIFICATION :Flammable liquids Category 3 Skin corrosion/irritation Category 2 Serious eye damage/eye irritation Category 2A Carcinogenicity Category 2 Reproductive toxicity Category 2Specific target organ systemic toxicity (single exposure) Category 1 Central nervous system, Kidney, Liver, Respiratory systemSpecific target organ systemic toxicity (single exposure) Category 3 Specific target organ systemic toxicity (repeated exposure) Category 1 Nervous system, Respiratory system Specific target organ systemic toxicity (repeated exposure) Category 2 Ears Aspiration hazard Category 1Hazardous to the aquatic environment - acute hazard Category 2GHS LABEL ELEMENTS : Symbol(s)Signal WordD ANGERHazard StatementsFlammable liquid and vapor. Causes skin irritation.Causes serious eye irritation. Suspected of causing cancer.Suspected of damaging fertility or the unborn child. May cause harm to breast -fed children. Causes damage to organs.(Central nervous system, Kidney, Liver, Respiratory system ) May cause drowsiness or dizziness. May cause respiratory irritation.Causes damage to organs through prolonged or repeated exposure.(Nervous system, Respiratory system ) May cause damage to organs through prolonged or repeated exposure.(Ears ) May be fatal if swallowed and enters airways. Toxic to aquatic life.Precautionary StatementsPrevention- No smoking.Keep away from heat/sparks/open flames/hot surfaces.Ground/Bond container and receiving equipment.Use explosion-proof electrical/venti lating/lighting equipment.Use only non-sparking tools.Take precautionary measures against static discharge.Obtain special instructions before use.Do not handle until all safety precautions have been read and understood.e clothing/eye protection/face protection.Wear protective gloves/protectivUse personal protective equipment as required.Do not breathe dust/fume/gas/mist/vapors/spray.Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Use only outdoors or in a well-ven tilated area.Avoid release to the environment.ResponseIn case of fire: refer to section 5 of SDS for extinguishing media.Call a POISON CENTER or doctor/physician if you feel unwell.IF exposed: Call a POISON CENTER or doctor/physician.Specific treatm ent (see supplemental first aid instructions on this label).IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing..IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/showerIf skin irritation occurs: Get medical advice/attention.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.Continue rinsing.IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.Do NOT induce vomiting.StorageStore in a well-ventilated place. Keep cool.Store in a well-ventilated place. Keep container tightly closed.Store locked up.Disposal:Dispose of contents/container in accordance with waste/disposal laws and regulations of your country or particular locality.Other Hazards:This product contains component(s) which have the following warnings; however based on the GHS classification criteria of your country or locale, the product mixture may be outside the respective category(s).Acute: Vapor harmful; may affect the brain or nervous system causing dizziness, headache or nausea. Possibleng a variety of symptoms such as dryness of the throat, tightness of irritation of the respiratory system can occur causithe chest, and shortness of breath. May cause central nervous system depression characterized by the followingiousness or coma. This product contains a progressive steps: headache, dizziness, staggering gait, confusion, unconscresidual amount of a chemical substance that may cause an allergic skin and/or respiratory reaction.May be harmful if swallowed. Ingestion is not an expected route of entry in industrial or commercial uses.-forming organs. Prolonged or Chronic: May affect the gastrointestinal system. May affect the blood and bloodrepeated contact may result in dermatitis. Ethylbenzene has been classified by IARC as a possible human carcinogenw clear evidence for carcinogenicity in animals.(Group 2B) and reported by NTP to showithheld.FIRST AID - EYE CONTACT: Flush eyes immediately with large amount of water for at least 15 minutes holding eyelids open while flushing. Get prompt medical attention.FIRST AID - SKIN CONTACT: Flush contaminated skin with large amounts of water while removing contaminated clothing. Wash affected skin areas with soap and water. Get medical attention if symptoms occur.FIRST AID - INHALATION: Move person to fresh air. Restore and support continued breathing. If breathing is difficult,ion.give oxygen. Get immediate medical attentFIRST AID - INGESTION: If swallowed, do not induce vomiting. Call a physician or poison control center immediatelyfor further instructions. Never give anything by mouth if victim is rapidly losing consciousness, unconscious or convulsing.SUITABLE EXTINGUISHI NG MEDIA: Carbon Dioxide, Dry Chemical, Foam, Water FogUNSUITABLE EXTINGUIS HING MEDIA: Not determined for this product.SPECIFIC HAZARDS POSSIBLY ARISING FROM T HE CHEMICAL: Flammable liquid and vapor. Keep containers tightly closed. Isolate from heat, electrical equipment, sparks, open flame, and other sources of ignition. Closed containersners cool. During a fire, irritatingmay rupture when exposed to extreme heat. Use water spray to keep fire exposed contaiand/or toxic gases and particulate may be generated by thermal decomposition or combustion.SPECIAL PROTECTIVE E QUIPMENT AND PRECAUT IONS FOR FIRE-FIGHTE RS: Wear full firefightingprotective clothing, including self-contained breathing apparatus (SCBA).If water isWater spray may be ineffective.used, fog nozzles are preferable.PERSONAL PRECAUTIONS, PROTECTIV E EQUIPMENT AND EMER GENCY PROCEDURES: Remove all.sources of ignition (flame, hot surfaces, and electrical, static or frictional sparks). Avoid contact. Avoid breathing vapors Use self-contained breathing equipment.ENVIRONMENTAL PREC AUTIONS: Do not contaminate bodies of water, waterways, or ditches, with chemical or used container.METHODS AND MATERIAL S FOR CONTAINMENT AN D CLEANUP: Keep non-essential personnel a safeorities if necessary. Avoid contact. Before attempting cleanup, refer distance away from the spill area. Notify appropriate auth-to hazard caution information in other sections of the SDS form. Contain and remove with inert absorbent material and non sparking tools.HANDLING: Keep closure tight and container upright to prevent leakage. Ground and bond containers when transferring material. Avoid skin and eye contact. Wash thoroughly after handling. Avoid breathing of vapor or spray mists. Do not-used. Use withhandle until all safety precautions have been read and understood. Empty containers should not be readequate ventilation. Because empty containers may retain product residue and flammable vapors, keep away from heat, puncture or weld on or near the empty container. Do not smoke where this product is used or sparks and flame; do not cut,stored.-ventilated areas. Do not puncture, drag, STORAGE: Do not store or use near heat, sparks, or open flame. Store only in welltainer closed when not in use. Refer to OSHA 29CFR Part 1910.106 "Flammable andor slide container. Keep conCombustible Liquids" for specific storage requirements.INCOMPATIBILITY: Strong oxidizers, acids, bases, water.Engineering controls: Sufficient ventilation in pattern and volume should be provided in order to maintain airposure limits. Caution: Solvent vapors are heavier than air and collect in lower contaminant levels below recommended ex-proof equipment) should be provided to prevent flammable levels of the work area. Sufficient ventilation (using explosionvapor/air mixtures from accumulating.PERSONAL PROTECTION MEASURES/EQU IPMENT:RESPIRATORY PROTECTION: Use a NIOSH approved chemical/mechanical filter respirator designed toremove a combination of particulates and organic vapor if occupational limits are exceeded. For emergencysituations, confined sp ace use, or other conditions where exposure limits may be greatly exceeded, use an approved air-supplied respirator. For respirator use observe OSHA regulations (29CFR 1910.134) or use in accordance witharticular locality.applicable laws and regulations of your country or pSKIN PROTECTION: Use neoprene, nitrile, or rubber gloves to prevent skin contact.EYE PROTECTION: Use safety eyewear including safety glasses with side shields and chemical goggles where splashing may occur.OTHER PROTECTIVE EQUIPMENT: Use disposable or impervious clothing if work clothing contamination is likely. Remove and wash contaminated clothing before reuse.HYGIENIC PRACTICES: Wash hands before eating, smoking, or using toilet facility. Do not smoke in anyche mical handling or storage area. Food or beverages should not be consumed anywhere this product is handled or stored. Wash thoroughly after handling.Typical values, not to be used for specification purposes.ODOR: Solvent VAPOR PRESSURE:N.D.APPEARANCE: Clear VAPOR DENSITY:Heavier than AirPHYSICAL STATE:Liquid LOWER EXPLOSIVE LIMIT: 1 %(V)UPPER EXPLOSIVE LIMIT:7 %(V)FLASH POINT: 81 °F, 27 °C SetaflashClosed CupBOILING RANGE: 136 - 141 °C EVAPORATION RATE:Not Applicable AUTOIGNITION TEMPERA TURE:N.D.DENSITY:0.85 g/cm3 (7.08 lb/gal)DECOMPOSITION TEMPER ATURE:N.D. VISCOSITY, DYNAMIC:≥10 mPa.s @ 25 °C ODOR THRESHOLD:N.D.VISCOSITY, KINEMATIC: ≥12 mm2/s@ 25 °CSOLUBILITY IN H2O:Insoluble VOLATILE BY WEIGHT:96.50 %pH: N.A.VOLATILE BY VOLUME:97.18 %FREEZE POINT:N.D. VOC CALCULATED: 6.83 lb/gal, 819 g/lN.D. METHOD 24: 7.03 lb/gallon COEFFICIENT OF WATER/OILDISTRIBUTION:LEGEND: N.A. - Not Applicable, N.E. - Not Established, N.D. - Not DeterminedHAZARDOUS POLYMERIZATION: Hazardous polymerization will not occur under normal conditions.STABILITY: Product is stable under normal storage conditions.CONDITIONS TO AVOID: High temperatures. Sources of ignition.INCOMPATIBILITY: Strong oxidizers, acids, bases, water.HAZARDOUS DECOMPOSITION PRODUCTS: Carbon dioxide, carbon monoxide, chlorine, hydrogen chloride, PhosgeneEXPOSURE PATH: Refer to section 2 of this SDS.SYMPTOMS:Refer to section 2 of this SDS.TOXICITY MEASURES:Germ cell mutagenicity: No classification proposedCarcinogenicity: Category 2- Suspected of causing cancer.Components contributing to classification:Ethyl benzene.-Reproductive toxicity: Category 2- Suspected of damaging fertility or the unborn child. May cause harm to breast fed children.Components contributing to classification:Xylene. Ethyl benzene. Toluene.PERSISTENCE AND DEGRADABILITY:Not determined for this product.BIOACCUMULATIVE: Not determined for this product.MOBILITY IN SOIL: Not determined for this product.OTHER ADVERSE EFFECTS: Not determined for this product.DISPOSAL METHOD: Disposal should be done in accordance with Federal (40CFR Part 261), state and localIf waste is determined to be hazardous, use licensed hazardous waste transporter and environmental control regulations.disposal facility.US DOT RoadProper Shipping Name: AdhesivesHazard Class: 3SECONDARY HAZARD: NoneUN/NA Number: 1133Packing Group: IIIEmergency Response Guide Number: 128IATA CargoPROPER SHIPPING NAME: AdhesivesHazard Class: 3HAZARD CLASS: NoneUN NUMBER: 1133PACKING GROUP: IIIEMS: 3LIMDGPROPER SHIPPING NAME: AdhesivesHazard Class: 3HAZARD CLASS: NoneUN NUMBER: 1133PACKING GROUP: IIIEMS: F-E-bulk shipments. It does not address regulatory variations due toThe listed transportation classification applies to nonchanges in package size, mode of shipment or other regulatory descriptors. For the most accurate shipping information, refer to your t ransportation/compliance department.U.S. FEDERAL REGULATIONS: AS FOLLOWS:SARA SECTION 313This product contains the following substances subject to the reporting requirements of Section 313 of Title III of the:Superfund Amendment and Reauthorization Act of 1986 and 40 CFR part 372.Chemical Name CAS Number Weight % Less ThanXylene1330-20-780.0%Ethyl benzene100-41-420.0%TOXIC SUBSTANCES CONTROL ACT:INVENTORY STATUSThe chemical substances in this product are on the TSCA Section 8 Inventory.EXPORT NOTIFICATIONThis product contains the following chemical substances subject to the reporting requirements of TSCA 12(B) if:exported from the United StatesNoneUnder HazCom 2012 it is optional to continue using the HMIS rating system. It is important to ensure employees have been trained to recognize the different numeric ratings associated with the HazCom 2012 and HMIS schemes.HMIS RATINGS - HEALTH: 2* FLAMMABILITY: 3 PHYSICAL HAZARD: 0* - Indicates a chronic hazard; see Section 2Revision: Section 1Effective Date: 11/23/2020The information contained herein is, to the best of our knowledge and belief, accurate. However, since the conditions of handling and use are beyond our control, we make no guarantee of results, and assume no liability for damages incurred byuse of this material. It is the responsibility of the user to comply with all applicable federal, state and local laws and regulations.。
Product Name:
Lu AE58054CAS No.:
467459-31-0Cat. No.:
HY-14338
Product Data Sheet
MWt:
398.37Formula:
C20H19F5N2O Purity :>98%
Solubility:
25°C: DMSO
Mechanisms:Biological Activity:
Description:
Pathways:Neuronal Signaling; Target:5-HT Receptor Pathways:GPCR/G protein; Target:5-HT Receptor p
IC50 Value: 0.83 nm[1]Lu AE58054 is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R
antagonist.in vitro: Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. In a 5-HT(6) GTPgammaS efficacy assay Lu AE58054 showed no agonist activity, but demonstrated potent inhibition of 5-HT-mediated activation. Besides medium affinity to adrenergic alpha(1A)- and alpha(1B)-adrenoreceptors, Lu AE58054 demonstrated >50-fold selectivity for more
than 70 targets examined[1].i i O ll d i i t d L AE58054t tl i hibit d t i t l i i bi di f th 5HT(6)
References:
[1]. Arnt J, Bang-Andersen B, Grayson B, Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol 2010Sep;13(8):1021-33in vivo: Orally administered Lu AE58054 potently inhibited striatal in-vivo binding of the 5-HT(6)antagonist radioligand [(3)H]Lu AE60157, with an ED(50) of 2.7 mg/kg. Steady-state modelling of an acute pharmacokinetic/5-HT(6)R occupancy time-course experiment indicated a plasma EC(50)value of 20 ng/ml. Administ...
Neuropsychopharmacol. 2010 Sep;13(8):1021-33.
[2]. Witten L, Bang-Andersen B, Nielsen SM, Characterization of [?H]Lu AE60157 ([?H]8-(4-
methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine? (5-HT?) receptors
in vivo.Eur J Pharmacol. 2012 Feb 15;676(1-3):6-11.Caution: Not fully tested. For research purposes only
Medchemexpress LLC
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