氯法齐明治疗耐多药结核病有效性与不良反应的研究进展桂敏陈敬芳邓国防付亮曾谷清【摘要】氯法齐明是治疗耐多药结核病领域中老药新用的代表性药品，可有效增加耐多药结核病的痰菌阴转 率、病灶吸收率及空洞缩小率，且不增加药物不良反应发生率，是世界卫生组织推荐治疗耐多药结核病的重要药 品作者对氯法齐明治疗耐多药结核病的临床有效性和不良反应进行简要综述.旨在为临床用药和临床研究提供参考。
【关键词】结核，抗多种药物性；氯法齐明；药物毒性Research progress on the effectiveness and adverse reactions of clofazimine in the treatment of multidrug-resistant tuIxTculosis GUI M i n', CHEN J in g-fm ig1'2 ■,DENG G uo-fang1. FU L ia n g1, ZENG G u-qitig1. 1School o f N ursing, University o f South China , H unan Province, H mgyan^ 421001. China-, ' C rude/ff Hospitals Create O ffice, Nfiliiimil Clinical Resemrh Center for Infectious Disease, the Third Pm lilp's Husliilal o f Shenzhen , Shenzhen 5hS112, China-, 1the Sm m d Department of Pulmonary Diseases, the Third People' s Hospital o f Shenzhen, Shenzhen ^1SI I2,ChinaCm'mpmiding uuttwr:CHEN Jing-j'm g, Em nil:138****9640@163.cum【Abstract】Clofazimine is a representative repurposed drug in the field of multidrug-resistant tuberculosis (MDR-TB). Clofazimine can effectively increase the sputum negative conversion, lung lesion absorption, and cavity reduction of MDR-TB, without increasing the incidence of adverse reactions. It is an important drug recommended by the WHO guidelines. We briefly reviewed the clinical application progress and adverse reaction management of clofazimine in the treatment of MDR-TB. in order to provide references for clinical medication and clinical research.【Key words】Tuberculosis，multidrug-resistant; Clofazimine; Drug toxicity耐药结核病疗程长、治愈率低.已成为重大公共卫生问 题•研发抗结核新药和探索治疗新方案迫在眉睫。
中国组织工程研究与临床康复第13卷第48期 2009–11–26出版Journal of Clinical Rehabilitative Tissue Engineering Research November 26, 2009 Vol.13, No.48 ISSN 1673-8225 CN 21-1539/R CODEN: ZLKHAH9567 Medical School of Yangtze University, Jingzhou 434023, Hubei Province, ChinaShu Xian-tao, Professor, Medical School of Yangtze University, Jingzhou 434023, Hubei Province, China85sxt@ Supported by: a grant from Education Department of Hubei Province, No.B20091202* Received: 2009-09-21 Accepted: 2009-10-24长江大学医学院，湖北省荆州市434023舒先涛，男，1951年生，湖北省荆州市人，1999年武汉大学毕业，教授，主要从事应用解剖学方面的研究。
85sxt@湖北省教育厅资助课题(B2009 1202)*中图分类号:R318文献标识码:B文章编号:1673-8225 (2009)48-09567-03收稿日期：2009-09-21 修回日期：2009-10-24 (20090921020/G•A)胸腰椎压缩性骨折患者过伸复位过程中前纵韧带动态力学的有限元分析*舒先涛，李孝林Dynamic biomechanics of anterior longitudinal ligament in the treatment of thoracolumbar spine compression fracture by hyperextending: A finite element analysisShu Xian-tao, Li Xiao-linAbstract: Reconstructing the three-dimensional finite element model of compression fracture of T12 based on the 210-layerconsecutive CT DICOM format images from one patient of compression fracture of T12 to simulate the hyperextending. Bound thelower of T12, a vertical traction at the top of T11 and a 3.0 cm-displacement toward the vertebra by three steps at the top of spinousprocess of T11, T12 and L1 was provided. The procedure began computing to read the results about dynamic biomechanicalcharacteristics of anterior longitudinal ligament. A realistic appearance and full biomechanical properties 3D finite element modelof thoracolumbar spine compression fracture was established. The anterior longitudinal ligament was changed from relaxation totension after hyperextending. The stresses of anterior longitudinal ligament were different when the hyperextending fulcrum wasdifferent. The treatment effect of thoracolumbar spine compression fracture by hyperextending is exact. The anterior longitudinalligament plays an important role in the treatment. Finite element analysis of mechanism of traditional practices has manyadvantages, such as reliable experimental results, direct displaying results, saving resources and accurate simulation.Shu XT, Li XL.Dynamic biomechanics of anterior longitudinal ligament in the treatment of thoracolumbar spine compressionfracture by hyperextending: A finite element analysis. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2009;13(48):9567-9569. [ ]摘要：依据1例T12椎体单纯压缩性骨折患者的210层Dicom 3.0标准的CT图片建立T12椎体单纯压缩性骨折的有限元模型，在对建立模型的有效性进行验证后模拟过伸复位手法，约束L2下端所有面，给T11椎体上端一个纵向牵引力，分别于T11，T12，L1椎骨棘突顶点给予一个方向垂直朝向椎体、大小为3.0 cm的位移。
糖尿病酮症酸中毒疑难病例讨论今天我们讨论的病例是一位26岁男性患者，因多饮多尿伴乏力消瘦10余天入院。
经检查诊断为糖尿病酮症酸中毒、2型糖尿病、脂肪肝、肾功能异常和高脂血症。
入院后，患者接受了对症支持治疗，包括胰岛素泵降血糖、补液等，同时采取一级护理、糖尿病饮食等措施。
近三日血糖控制在12.0-26.8mmol/L之间。
在护理过程中，患者出现了低钾血症，予以补钾治疗后症状得到缓解。
最终，患者无明显症状，血糖控制较好出院。
在讨论中，我们了解到糖尿病酮症酸中毒是由于胰岛素不足及升糖激素不适当升高，引起代谢紊乱，导致水、电解质、酸碱平衡紊乱，以高血糖、高血酮和代谢性酸中毒为主要表现的临床综合征。
在护理中，我们应该采取针对性的措施，包括胰岛素治疗、补液、补钾等，同时注意监测患者的酸碱平衡和电解质水平，及时发现并处理低钾血症等并发症。
最后，我们还讨论了糖尿病酮症酸中毒的诱因，包括胰岛素不足、感染、手术、创伤、饮食不当等。
对于患者，我们应该加强宣教，提高其自我管理水平，避免糖尿病酮症酸中毒的发生。
Nurse XXX: The most common cause of XXX (30%-50%)。
with XXX being the most common。
Other XXX (21%-49%)。
newly diagnosed diabetes (20%-30%)。
XXX。
stroke。
acute pancreatitis。
trauma。
surgery。
alcohol abuse。
use of steroids。
thiazide diuretics。
sympathomimetic drugs。
alpha- and beta-receptor blockers。
etc。
In n。
2%-10% of cases have no XXX.Nurse XXX: What are the clinical XXX?XXX。
