BMS-754807_HNMR_08106_MedChemExpress

ｔｈｅｉｍｍｕｎｏｆｌｕｏｒｅｓｃｅｎｃｅｒｅｓｕｌｔｓａｌｓｏｒｅｖｅａｌｅｄｔｈｅａｐ ｐｅａｒａｎｃｅｏｆｉｎｓｕｌｉｎａｎｄｇｌｕｃａｇｏｎｃｏ ｌｏｃａｌｉｚｅｄｃｅｌｌｓｉｎｐａｎｃｒｅａｓｏｆｔｈｅｍｆａｔ １ｇｒｏｕｐａｎｄｄｉｅｔｉｎｔｅｒｖｅｎｔｉｏｎｇｒｏｕｐｍｉｃｅ．Ｃｏｎｃｌｕｓｉｏｎｓ　Ｉｔｈａｓｂｅｅｎｐｒｅｌｉｍｉｎａｒｉｌｙｄｅｍｏｎｓｔｒａｔｅｄｔｈａｔω ３ＰＵＦＡｓｃａｎａｍｅｌｉｏｒａｔｅｔｙｐｅ１ｄｉ ａｂｅｔｉｃｍｉｃｅｗｉｔｈｈｙｐｅｒｇｌｙｃｅｍｉａｓｙｍｐｔｏｍｓｂｙｅｎｃｏｕｒａ ｇｉｎｇｉｎｓｕｌｉｎｐｒｏｄｕｃｔｉｏｎｂｙｐａｎｃｒｅａｔｉｃαｃｅｌｌｓ．Ｋｅｙｗｏｒｄｓ：ω ３ｐｏｌｙｕｎｓａｔｕｒａｔｅｄｆａｔｔｙａｃｉｄｓ；ｔｙｐｅ１ｄｉａｂｅｔｅｓｍｅｌｌｉｔｕｓ；ｐａｎｃｒｅａｔｉｃαｃｅｌｌｓ；ｐａｎｃｒｅａｔｉｃβｃｅｌｌｓ；ｔｒａｎｓ ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ；ｍｆａｔ １ｔｒａｎｓｇｅｎｉｃｍｉｃｅ网络出版时间：２０２３－１１－０２０９：１６：５８　网络出版地址：ｈｔｔｐｓ：／／ｌｉｎｋ．ｃｎｋｉ．ｎｅｔ／ｕｒｌｉｄ／３４．１０８６．Ｒ．２０２３１１０１．１５５５．００６◇药物代谢动力学◇基于ＵＰＬＣ Ｑ／ＴＯＦ ＭＳ的甘草酸单铵和甘草酸二铵在大鼠体内移行成分表征虞　娉１，庄让笑１，席建军１，何亮亮２（１．杭州市西溪医院药学部，浙江杭州　３１００２３；２．暨南大学药学院中药及天然药物研究所，广东广州　５１０６３２）ｄｏｉ：１０．１２３６０／ＣＰＢ２０２３０２０２７文献标志码：Ａ文章编号：１００１－１９７８（２０２３）１１－２１４８－０８中国图书分类号：Ｒ ３３２；Ｒ２８２ ７１；Ｒ２８４；Ｒ４４６ ９摘要：目的　采用超高效液相色谱－四极杆／飞行时间高分辨质谱技术（ＵＰＬＣ Ｑ／ＴＯＦ ＭＳ）对甘草酸单铵和甘草酸二铵在大鼠体内的代谢轮廓进行表征，探讨两者可能的代谢途径。

网络出版时间：２０２３－１１－０７１１：０１：２１　网络出版地址：ｈｔｔｐｓ：／／ｌｉｎｋ．ｃｎｋｉ．ｎｅｔ／ｕｒｌｉｄ／３４．１０８６．Ｒ．２０２３１１０６．１７２３．０１０芝麻酚通过ＡＭＰＫ信号通路调控巨噬细胞极化减轻脂肪组织炎症刘　瞩，程明慧，张劝劝，秦　虹（中南大学湘雅公共卫生学院营养与食品卫生学教研室，湖南长沙　４１００７８）收稿日期：２０２３－０３－２７，修回日期：２０２３－０６－２９基金项目：国家自然科学基金面上项目（Ｎｏ８２０７３５５６）作者简介：刘　瞩（１９９６－），女，硕士生，研究方向：植物化学物与慢性病防治，Ｅ ｍａｉｌ：ｌｉｕｚｈｕｃｓｕ＠１６３．ｃｏｍ；秦　虹（１９８２－），女，博士，教授，博士生导师，研究方向：植物化学物与慢性病防治，通信作者，Ｅ ｍａｉｌ：ｑｉｎｈｏｎｇ＠ｃｓｕ．ｅｄｕ．ｃｎｄｏｉ：１０．１２３６０／ＣＰＢ２０２３０２０６３文献标志码：Ａ文章编号：１００１－１９７８（２０２３）１１－２０８２－０７中国图书分类号：Ｒ ３３２；Ｒ３２９ ２４；Ｒ３６４ ５；Ｒ３４５ ５７；Ｒ９１６ ４摘要：目的　探讨芝麻酚（ｓｅｓａｍｏｌ，ＳＥＭ）对高脂饮食诱导的肥胖小鼠脂肪组织炎症的影响及对脂多糖（ｌｉｐｏｐｏｌｙｓａｃｃｈａ ｒｉｄｅ，ＬＰＳ）诱导的ＲＡＷ２６４ ７巨噬细胞极化的调控分子机制。

方法　将Ｃ５７ＢＬ／６Ｊ小鼠随机分成正常对照组、肥胖模型对照组和ＳＥＭ干预组。

干预结束后取小鼠血清和脂肪组织，ＥＬＩＳＡ法测定小鼠血清和脂肪组织中炎症因子、抗炎因子及趋化因子的分泌水平，Ｗｅｓｔｅｒｎｂｌｏｔ法测定脂肪组织巨噬细胞Ｍ１型极化标志物的蛋白表达水平。

以ＬＰＳ刺激ＲＡＷ２６４ ７巨噬细胞诱导炎症模型并用ＳＥＭ进行干预，使用ＡＭＰＫ抑制剂ｃｏｍｐｏｕｎｄＣ进行机制探讨和验证，Ｗｅｓｔｅｒｎｂｌｏｔ法检测巨噬细胞极化标志物及ＡＭＰＫ信号通路相关蛋白表达水平，ＥＬＩＳＡ法检测巨噬细胞炎症相关因子。

第18卷 第5期 中国药剂学杂志 Vol. 18 No.5 2020年9月 Chinese Journal of Pharmaceutics Sep. 2020 p.244 收稿日期：2019-11-24作者简介：张德广(1985-)，男(汉族)，安徽宣城人，大学专科生, E-mail ***********************；*通信作者：王启帅(1973-)，男(汉族)，江苏泰州人，硕士研究生，主要从事医药研发及生产管理，Tel. 138****6658，文章编号：2617–8117（2020）05–0244–06 DOI:10.14146/ki.cjp.2020.05.002高效液相色谱法测定硼替佐米中异戊醛含量张德广1，李 贞1，刘 霞1，王启帅2*（1. 扬子江药业集团上海海尼药业有限公司，上海 浦东 201318；2. 扬子江药业集团，江苏 泰州 225321）摘 要：目的 建立高效液相色谱法测定硼替佐米原料药中异戊醛含量。

方法 硼替佐米中的异戊醛用 2,4-二硝基苯肼衍生化，采用 Waters symmetry C 18 色谱柱（250 mm × 4.6 mm ，5 µm ），以乙腈（体积分数 0.1% 甲酸）-水（体积分数 0.1% 甲酸）为流动相进行线性梯度洗脱，流速为 1.0 mL•min -1，检测波长为 364 nm ，柱温为 30 ℃。

结果 异戊醛质量浓度在 0.015～2.998 mg•L -1 内与峰面积呈良好线性关系（r = 1.000 0），平均回收率为 101.1%，RSD 为 1.4%。

结论 该方法准确灵敏、线性范围宽，可以用于稳定性过程中潜在基因毒性杂质异戊醛的评估。

关键词：硼替佐米；异戊醛；高效液相色谱；衍生化中图分类号：R94 文献标志码：A多发性骨髓瘤主要是因为骨髓浆细胞异常克隆增殖所致的一种恶性浆细胞病，在造血系统肿瘤中发病率占比约为 13%，且具有临床治疗效果差，治疗后复发率高等特点[1]。

Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Nov.-23-2018Print Date:Nov.-23-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Gelucire 14/44Catalog No. :HY-Y1892CAS No. :121548-04-71.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:N/AMolecular Weight:N/ACAS No. :121548-04-74. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Pure form-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Oil)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

基于多种内参物的一测多评法测定金莲清热颗粒中6种成分含量Δ和敏 1＊，毛姗 1，李琳 2，倪海峰 2，都青钰 1，于永杰 1， 3， 4，张霞 1， 3， 4 #（1.宁夏医科大学药学院，银川　750004；2.宁夏启元药业有限公司，银川　750011；3.宁夏药物创制与仿制药研究重点实验室，银川　750004； 4.宁夏少数民族医药现代化教育部重点实验室，银川　750004）中图分类号 R 917 文献标志码 A 文章编号 1001-0408（2023）17-2069-05DOI 10.6039/j.issn.1001-0408.2023.17.04摘要 目的 建立基于多种内参物的一测多评法测定金莲清热颗粒中芒果苷、荭草素-2″-O-β-L-半乳糖苷、荭草苷、藜芦酸、牡荆苷和哈巴俄苷6个成分的含量。

方法 以Agilent Eclipse Plus C 18为色谱柱，以乙腈-0.1%磷酸溶液为流动相（梯度洗脱），流速为1 mL/min ，柱温为30 ℃，检测波长为270 nm 。

分别以荭草苷、牡荆苷、荭草素-2″-O-β-L-半乳糖苷为内参物，采用一测多评法建立另外5个待测成分与内参物的相对校正因子，然后计算21批金莲清热颗粒样品中6个成分的含量，并与外标法测定结果进行比较。

结果 一测多评法测得21批金莲清热颗粒样品中芒果苷、荭草素-2″-O-β-L-半乳糖苷、荭草苷、藜芦酸、牡荆苷和哈巴俄苷的含量范围分别为0.234～0.516、1.804～2.270、2.143～2.606、0.190～0.223、0.594～0.782、0.080～0.152 mg/g ，外标法测定结果分别为0.235～0.523、1.798～2.265、2.137～2.599、0.190～0.224、0.597～0.786、0.077～0.151 mg/g ，2种方法所测结果的差异百分比不大于4.00%。

结论 建立了基于多种内参物同时测定金莲清热颗粒中6种成分含量的一测多评法，该方法与外标法所得结果无明显差异，可用于金莲清热颗粒的质量控制。

中国饲料2016年第17期DOI：10.15906/11-2975/s.20161711高效液相色谱紫外检测法测定饲料中N-氨甲酰谷氨酸的含量李裕（湖南省兽药饲料监察所，湖南长沙410006）N-氨甲酰谷氨酸是N-乙酰谷氨酸的稳定结构类似物，能激活动物体内氨甲酰磷酸合成酶-Ⅰ和二氢吡咯-5-羧酸合成酶，从而促进精氨酸的生成。

精氨酸在调控动物机体营养代谢和免疫反应方面有重要作用，可提高多胎动物窝产仔数和初生重、促进幼龄动物生长和发育（Wu等，2004）。

N-氨甲酰谷氨酸的成本仅为精氨酸的1/10（冯涛等，2012）。

目前含有N-氨甲酰谷氨酸的饲料产品主要有饲料添加剂和配合饲料两大类。

目前报道的检测饲料中N-氨甲酰谷氨酸的方法有高效液相色谱电喷雾串联质谱法（梁婧等，2015；唐圣芸等，2014）。

相比常见的高效液相色谱紫外检测法，串联质谱法对色谱条件、样品净化容忍度较高，而且灵敏度高、定性更准确，常用于复杂基质中极痕量物质的检测。

但串联质谱仪器昂贵，运行和维护成本也较高，大部分饲料企业尚未配备。

而且对于含量较高样品的检测，由于串联质谱上机的稀释倍数大、离子源的离子化效率及稳定性等因素，定量可能不如高效液相色谱紫外检测法准确。

因此，本实验旨在建立一种适用于大多数饲料企业实验室使用，能准确测定饲料中N-氨甲酰谷氨酸含量的方法。

1材料与方法1.1仪器Waters2695高效液相色谱仪配2489型紫外检测器、2998型二极管阵列检测器（美国Waters公司）；Delta320型pH计（梅特勒-托利多公司）；OASIS MAX固相萃取柱（150mg，6cc，美国Waters公司）。

1.2试剂N-氨甲酰谷氨酸（纯度≥98%，Sigma 公司）；甲醇（色谱纯，德国Merck公司）；磷酸（优级纯，国药集团化学试剂有限公司）。

N-氨甲酰谷氨酸标准储备液：准确称取N-氨甲酰谷氨酸对照品102mg置于100mL容量瓶中，用水溶解，定容至刻度，摇匀。

Rank ISSN Abbreviated Journal Title40001-0782COMMUN ACM50001-1452AIAA J60001-1541AICHE J70001-2491ASHRAE J80001-253X ASLIB PROC320001-5903ACTA INFORM600001-9240AERONAUT J850002-8711J AM HELICOPTER SOC 1660003-6870APPL ERGON2000004-3702ARTIF INTELL 2020004-5411J ACM2210005-1098AUTOMATICA2220005-1144AUTOMATIKA2270005-6650BAUINGENIEUR-GERMANY 2820007-215X BRODOGRADNJA 2930007-8506CIRP ANN-MANUF TECHN 3040008-4034CAN J CHEM ENG 3370009-2460CHEM ENG-NEW YORK 3380009-2509CHEM ENG SCI 3470009-286X CHEM-ING-TECH 3500009-3092CHEM TECH FUELS OIL+ 3790010-2180COMBUST FLAME 3800010-2202COMBUST SCI TECHNOL 3870010-4485COMPUT AIDED DESIGN 3880010-4620COMPUT J3910010-485X COMPUTING4360012-7361DYNA-BILBAO4370012-7515EDN4490013-5194ELECTRON LETT 4500013-5585BIOMED ENG-BIOMED TE 4570013-8029ENG J AISC5110015-7899FORSCH INGENIEURWES 5140016-0032J FRANKLIN I 5150016-1136FREQUENZ5160016-2361FUEL5440016-8505GEOTECHNIQUE 5590017-9310INT J HEAT MASS TRAN 5780018-8646IBM J RES DEV 5790018-9162COMPUTER5810018-9200IEEE J SOLID-ST CIRC 5820018-9219P IEEE5830018-9235IEEE SPECTRUM 5860018-9286IEEE T AUTOMAT CONTR 5870018-9294IEEE T BIO-MED ENG 5890018-9340IEEE T COMPUT 5900018-9359IEEE T EDUC5930018-9391IEEE T ENG MANAGE 5940018-9448IEEE T INFORM THEORY 5950018-9456IEEE T INSTRUM MEAS 5970018-9480IEEE T MICROW THEORY 5980018-9499IEEE T NUCL SCI 5990018-9529IEEE T RELIAB 6010019-0578ISA T6200020-0190INFORM PROCESS LETT 6210020-0255INFORM SCIENCES 6320020-4412INSTRUM EXP TECH+ 6390020-7209INT J ELEC ENG EDUC 6400020-7217INT J ELECTRON 6410020-7225INT J ENG SCI 6450020-7403INT J MECH SCI 6500020-7543INT J PROD RES 6810021-8502J AEROSOL SCI 6850021-8669J AIRCRAFT7080021-9290J BIOMECH7100021-9487J CAN PETROL TECHNOL 7170021-9568J CHEM ENG DATA 7190021-9592J CHEM ENG JPN 7340022-0000J COMPUT SYST SCI 7510022-0833J ENG MATH7730022-1481J HEAT TRANS-T ASME 8560022-4502J SHIP RES8600022-460X J SOUND VIB8610022-4650J SPACECRAFT ROCKETS 8690022-4898J TERRAMECHANICS 8920023-5954KYBERNETIKA9290025-3324MAR TECHNOL SOC J 9470025-6501MECH ENG9730026-2692MICROELECTRON J 10060028-1425NAV ENG J10370029-5981INT J NUMER METH ENG 10470029-8018OCEAN ENG10810031-3203PATTERN RECOGN 11090031-9155PHYS MED BIOL 11420032-5910POWDER TECHNOL 11480033-0337PROGRAM-ELECTRON LIB 11520033-2496PRZEM CHEM11970034-7752REV CHIM-BUCHAREST 12070035-4066REV ROUM SCI TECH-EL 12410036-8792IND LUBR TRIBOL 12530037-5497SIMUL-T SOC MOD SIM 12630038-0741SOIL MECH FOUND ENG+ 12790038-9145STAHLBAU12830039-2480STROJ VESTN-J MECH E 13120040-5795THEOR FOUND CHEM EN+13370042-3114VEHICLE SYST DYN 13760044-7447AMBIO13860045-7825COMPUT METHOD APPL M 14160049-4488TRANSPORTATION 14270065-2156ADV APPL MECH 14350065-2458ADV COMPUT15110079-6727PROG QUANT ELECTRON 15410090-6964ANN BIOMED ENG 15700093-3651SEA TECHNOL 15790093-9994IEEE T IND APPL 15810094-114X MECH MACH THEORY 15870094-5765ACTA ASTRONAUT 15930094-9930J PRESS VESS-T ASME 16190098-2202J FLUID ENG-T ASME 16240098-5589IEEE T SOFTWARE ENG 16250098-6445CHEM ENG COMMUN 16300098-9886INT J CIRC THEOR APP 16680104-6632BRAZ J CHEM ENG 16910120-5609ING INVEST17030127-9084MALAYS J COMPUT SCI 17050129-0541INT J FOUND COMPUT S 17070129-0657INT J NEURAL SYST 17170138-9130SCIENTOMETRICS 17270140-7007INT J REFRIG 17320141-0296ENG STRUCT17350141-1187APPL OCEAN RES 17400141-6359PRECIS ENG17450141-9331MICROPROCESS MICROSY 17460141-9382DISPLAYS17570142-694X DESIGN STUD 17580142-727X INT J HEAT FLUID FL 17690143-3369INT J VEHICLE DES 17800143-974X J CONSTR STEEL RES 17820143-991X IND ROBOT17860144-5154ASSEMBLY AUTOM 18020145-7632HEAT TRANSFER ENG 18030145-8876J FOOD PROCESS ENG 18100146-4833ACM SIGCOMM COMP COM 18320148-0731J BIOMECH ENG-T ASME 18420148-9267COMPUT MUSIC J 18520149-6395SEP SCI TECHNOL 18610160-564X ARTIF ORGANS 18770161-7346ULTRASONIC IMAGING 18870162-8828IEEE T PATTERN ANAL 18960163-5808SIGMOD REC19060164-0925ACM T PROGR LANG SYS 19070164-1212J SYST SOFTWARE 19180165-1684SIGNAL PROCESS19270165-5515J INF SCI19400166-3615COMPUT IND19430166-4972TECHNOVATION 19450166-5316PERFORM EVALUATION 19560167-4730STRUCT SAF19660167-6105J WIND ENG IND AEROD 19700167-6393SPEECH COMMUN 19710167-6423SCI COMPUT PROGRAM 19800167-7055COMPUT GRAPH FORUM 19840167-739X FUTURE GENER COMP SY 19910167-8191PARALLEL COMPUT 19920167-8299REV CHEM ENG 19940167-8442THEOR APPL FRACT MEC 19950167-8655PATTERN RECOGN LETT 19990167-9260INTEGRATION 20090168-1699COMPUT ELECTRON AGR 20170168-7433J AUTOM REASONING 20330169-2607COMPUT METH PROG BIO 20370169-3913TRANSPORT POROUS MED 20510169-8141INT J IND ERGONOM 20900177-0667ENG COMPUT-GERMANY 21000178-2770DISTRIB COMPUT 21010178-2789VISUAL COMPUT 21340191-2615TRANSPORT RES B-METH 21810196-9722CYBERNET SYST 21880197-6729J ADV TRANSPORT 21940199-6231J SOL ENERG-T ASME 21970208-189X OIL SHALE21990208-5216BIOCYBERN BIOMED ENG 22000208-6425CHEM PROCESS ENG-INZ 22160213-1315REV INT METOD NUMER 22340218-0014INT J PATTERN RECOGN 22350218-1266J CIRCUIT SYST COMP 22370218-1940INT J SOFTW ENG KNOW 22400218-2130INT J ARTIF INTELL T 22470218-4885INT J UNCERTAIN FUZZ 22490218-8430INT J COOP INF SYST 22530219-1377KNOWL INF SYST 22550219-4554INT J STRUCT STAB DY 22590219-5194J MECH MED BIOL 22650219-6913INT J WAVELETS MULTI 22690219-8762INT J COMP METH-SING 22900239-7528 B POL ACAD SCI-TECH 23200253-3839J CHIN INST ENG 23440255-2701CHEM ENG PROCESS 23480256-1115KOREAN J CHEM ENG 23500256-2499SADHANA-ACAD P ENG S 23610257-9731J CHIN SOC MECH ENG23710260-8774J FOOD ENG23830262-8856IMAGE VISION COMPUT 23870263-2241MEASUREMENT 23960263-8231THIN WALL STRUCT 24030264-4401ENG COMPUTATION 24120265-2048J MICROENCAPSUL 24240266-4720EXPERT SYST 24330267-5730INT J TECHNOL MANAGE 24340267-6192COMPUT SYST SCI ENG 24410268-0033CLIN BIOMECH 24490268-2575J CHEM TECHNOL BIOT 24530268-3768INT J ADV MANUF TECH 24540268-3962J INF TECHNOL 24650269-2821ARTIF INTELL REV 24760269-8889KNOWL ENG REV 25000272-1716IEEE COMPUT GRAPH 25010272-1732IEEE MICRO25120272-6343ELECTROMAGNETICS 25130272-6351PARTICUL SCI TECHNOL 25380276-7783MIS QUART25530278-0046IEEE T IND ELECTRON 25550278-0070IEEE T COMPUT AID D 25560278-0097IEEE TECHNOL SOC MAG 25610278-081X CIRC SYST SIGNAL PR 25710278-6125J MANUF SYST 25730278-6826AEROSOL SCI TECH 25890288-3635NEW GENERAT COMPUT 26650301-679X TRIBOL INT26670301-7516INT J MINER PROCESS 26990304-3886J ELECTROSTAT 27000304-3894J HAZARD MATER 27030304-3975THEOR COMPUT SCI 27300305-215X ENG OPTIMIZ 27410306-2619APPL ENERG27440306-4379INFORM SYST 27550306-8919OPT QUANT ELECTRON 27630307-904X APPL MATH MODEL 27660308-0161INT J PRES VES PIP 27710308-1079INT J GEN SYST 27910315-1468CAN J CIVIL ENG 27950315-8977T CAN SOC MECH ENG 28030324-5853PERIOD POLYTECH-CHEM 28050324-8828ENVIRON PROT ENG 28110327-0793LAT AM APPL RES 28140332-1649COMPEL28150332-7353MODEL IDENT CONTROL 28300340-1200BIOL CYBERN 28560342-5622OIL GAS-EUR MAG28680350-2465GRADEVINAR28730352-9568CHEM BIOCHEM ENG Q 28820360-0300ACM COMPUT SURV 28850360-1285PROG ENERG COMBUST 28880360-1323BUILD ENVIRON 28960360-7275CHEM ENG PROG 29010361-0853MANUF ENG29040361-2317COLOR RES APPL 29050361-5219SOLID FUEL CHEM+ 29110361-7688PROGRAM COMPUT SOFT+ 29180362-1340ACM SIGPLAN NOTICES 29260362-5915ACM T DATABASE SYST 29520364-9059IEEE J OCEANIC ENG 29680367-598X HEM IND29750368-492X KYBERNETES29970373-4633J NAVIGATION 30140376-0421PROG AEROSP SCI 30150376-4265ESA BULL-EUR SPACE 30460378-3820FUEL PROCESS TECHNOL 30470378-3839COAST ENG30640378-7788ENERG BUILDINGS 30650378-7796ELECTR POW SYST RES 30880386-216X KAGAKU KOGAKU RONBUN 31070391-3988INT J ARTIF ORGANS 31380424-7760ELECTR ENG JPN 31600543-1972MEAS TECH+31620549-3811T JPN SOC AERONAUT S 31660553-6626PERIOD POLYTECH-CIV 31710567-7718ACTA MECH SINICA-PRC 31800578-5634COAST ENG J 32150718-915X REV CONSTR32210721-3115PROPELL EXPLOS PYROT 32330723-4864EXP FLUIDS32390730-0301ACM T GRAPHIC 32500731-5090J GUID CONTROL DYNAM 32730733-9364J CONSTR ENG M 32740733-9372J ENVIRON ENG 32750733-9399J ENG MECH32760733-9402J ENERG ENG 32790733-9445J STRUCT ENG 32800733-9453J SURV ENG32810733-947X J TRANSP ENG 32820733-9488J URBAN PLAN DEV 32880734-2071ACM T COMPUT SYST 32910734-743X INT J IMPACT ENG 33080736-2501NOISE CONTROL ENG J 33130736-5845ROBOT CIM-INT MANUF 33200737-0024HUM-COMPUT INTERACT33240737-3937DRY TECHNOL 33260737-6782J PROD INNOVAT MANAG 33310738-4602AI MAG33340739-0572J ATMOS OCEAN TECH 33430740-722X AEROSPACE AM 33440740-7459IEEE SOFTWARE 33450740-817X IIE TRANS33500741-3106IEEE ELECTR DEVICE L 33570742-1222J MANAGE INFORM SYST 33640742-4787J TRIBOL-T ASME 33650742-4795J ENG GAS TURB POWER 33660742-597X J MANAGE ENG 33720743-7315J PARALLEL DISTR COM 33850748-4658J PROPUL POWER 33860748-5492ISSUES SCI TECHNOL 33900748-8017QUAL RELIAB ENG INT 34150765-0019TRAIT SIGNAL 34490824-7935COMPUT INTELL-US 34610840-8688CAN J ELECT COMPUT E 35000883-7554IEEE ELECTR INSUL M 35070883-9514APPL ARTIF INTELL 35140884-8173INT J INTELL SYST 35180885-2308COMPUT SPEECH LANG 35190885-3010IEEE T ULTRASON FERR 35280885-6125MACH LEARN35310885-7024CIVIL ENG35330885-7458INT J PARALLEL PROG 35380885-8950IEEE T POWER SYST 35390885-8969IEEE T ENERGY CONVER 35400885-8977IEEE T POWER DELIVER 35410885-8985IEEE AERO EL SYS MAG 35420885-8993IEEE T POWER ELECTR 35490886-7798TUNN UNDERGR SP TECH 35570887-3801J COMPUT CIVIL ENG 35590887-3828J PERFORM CONSTR FAC 35600887-4417J COMPUT INFORM SYST 35710887-8722J THERMOPHYS HEAT TR 35770888-3270MECH SYST SIGNAL PR 35810888-613X INT J APPROX REASON 35940889-504X J TURBOMACH 36050889-9746J FLUID STRUCT 36070890-0604AI EDAM36160890-6327INT J ADAPT CONTROL 36270891-2017COMPUT LINGUIST 36350891-6152EXP HEAT TRANSFER 36460892-6875MINER ENG36500892-7219J OFFSHORE MECH ARCT 36550893-1321J AEROSPACE ENG36620893-6080NEURAL NETWORKS 36790894-3214PACKAG TECHNOL SCI 36810894-3370INT J NUMER MODEL EL 36830894-4393SOC SCI COMPUT REV 36940895-2477MICROW OPT TECHN LET 37010895-6111COMPUT MED IMAG GRAP 37020895-6308RES TECHNOL MANAGE 37410899-7667NEURAL COMPUT 37560905-6947INDOOR AIR38100920-4105J PETROL SCI ENG 38150920-5691INT J COMPUT VISION 38170920-654X J COMPUT AID MOL DES 38180920-8542J SUPERCOMPUT 38260921-3449RESOUR CONSERV RECY 38320921-7126AI COMMUN38360921-8831ADV POWDER TECHNOL 38430922-6443REAL-TIME SYST 38490923-4748J ENG TECHNOL MANAGE 38510923-5965SIGNAL PROCESS-IMAGE 38520923-6082MULTIDIM SYST SIGN P 38540923-8174J ELECTRON TEST 38570924-090X NONLINEAR DYNAM 38580924-1868USER MODEL USER-ADAP 38630924-4247SENSOR ACTUAT A-PHYS 38640924-6495MIND MACH38720925-1030ANALOG INTEGR CIRC S 38730925-2312NEUROCOMPUTING 38840925-7535SAFETY SCI38870925-8574ECOL ENG38900925-9856FORM METHOD SYST DES 38930925-9902J INTELL INF SYST 38980926-5805AUTOMAT CONSTR 39030926-8782DISTRIB PARALLEL DAT 39110927-6467RUSS J NUMER ANAL M 39280928-8910AUTOMAT SOFTW ENG 39360929-5585DES AUTOM EMBED SYST 39430929-8215J NEW MUSIC RES 39680932-4194MATH CONTROL SIGNAL 39720932-8092MACH VISION APPL 39730932-8351BAUTECHNIK39740933-2790J CRYPTOL39750933-3657ARTIF INTELL MED 39860934-5043FORM ASP COMPUT 39890934-9839RES ENG DES 40110938-0108MICROGRAVITY SCI TEC 40280939-8368EPE J40430942-4962MULTIMEDIA SYST 40660947-3602REQUIR ENG40790948-3349INT J LIFE CYCLE ASS 40800948-4280J MAR SCI TECH-JAPAN 40830948-695X J UNIVERS COMPUT SCI 40840948-7921ELECTR ENG40940949-8036GEFAHRST REINHALT L 41070950-4230J LOSS PREVENT PROC 41090950-5849INFORM SOFTWARE TECH 41110950-7051KNOWL-BASED SYST 41140951-192X INT J COMPUT INTEG M 41250951-8339MAR STRUCT41260952-1976ENG APPL ARTIF INTEL 41450953-5438INTERACT COMPUT 41540954-0075LUBR SCI41560954-0091CONNECT SCI 41630954-4054P I MECH ENG B-J ENG 41640954-4062P I MECH ENG C-J MEC 41650954-4070P I MECH ENG D-J AUT 41660954-4089P I MECH ENG E-J PRO 41670954-4097P I MECH ENG F-J RAI 41680954-4100P I MECH ENG G-J AER 41690954-4119P I MECH ENG H 41710954-4828J ENG DESIGN 41790954-898X NETWORK-COMP NEURAL 41850955-5986FLOW MEAS INSTRUM 41870955-792X J LOGIC COMPUT 41880955-7997ENG ANAL BOUND ELEM 41920956-053X WASTE MANAGE 41960956-5515J INTELL MANUF 42000956-7968J FUNCT PROGRAM 42040957-4158MECHATRONICS 42060957-4174EXPERT SYST APPL 42140957-5820PROCESS SAF ENVIRON 42150957-6509P I MECH ENG A-J POW 42270959-1524J PROCESS CONTR 42310959-3020ISOKINET EXERC SCI 42420959-6526J CLEAN PROD 42540960-085X EUR J INFORM SYST 42550960-1295MATH STRUCT COMP SCI 42620960-3085FOOD BIOPROD PROCESS 43120963-8687J STRATEGIC INF SYST 43150963-9314SOFTWARE QUAL J 43280965-089X P I CIVIL ENG-CIV EN 43290965-0903P I CIVIL ENG-MUNIC 43300965-0911P I CIVIL ENG-STR B 43310965-092X P I CIVIL ENG-TRANSP 43400965-9978ADV ENG SOFTW 43530967-0661CONTROL ENG PRACT 43570967-3334PHYSIOL MEAS43960971-457X INDIAN J CHEM TECHN 44110972-5768ADV VIB ENG 44320988-3754RAIRO-THEOR INF APPL 44491000-9000J COMPUT SCI TECH-CH 44511000-9361CHINESE J AERONAUT 44701003-2169J THERM SCI 44741004-4132J SYST ENG ELECTRON 44761004-9541CHINESE J CHEM ENG 45271016-2364J INF SCI ENG 45291016-3328COMPUT COMPLEX 45331016-8664STRUCT ENG INT 45571021-2019J S AFR INST CIV ENG 45781022-4653CHINESE J ELECTRON 45851023-2796J MAR SCI TECH-TAIW 45921023-8883TRIBOL LETT 45941024-123X MATH PROBL ENG 46021025-5842COMPUT METHOD BIOMEC 46091026-3098SCI IRAN46231028-6608CIV ENG ENVIRON SYST 46461040-2004TRIBOL T46781041-4347IEEE T KNOWL DATA EN 46961042-9247EMJ-ENG MANAG J 47071043-7398J ELECTRON PACKAGING 47201044-7318INT J HUM-COMPUT INT 47301045-9219IEEE T PARALL DISTR 47311045-9243IEEE ANTENN PROPAG M 47321045-926X J VISUAL LANG COMPUT 47381046-8188ACM T INFORM SYST 47401047-3203J VIS COMMUN IMAGE R 47481048-9002J VIB ACOUST 47521049-331X ACM T SOFTW ENG METH 47571049-8923INT J ROBUST NONLIN 47611050-0472J MECH DESIGN 47741051-2004DIGIT SIGNAL PROCESS 47771051-8215IEEE T CIRC SYST VID 47941053-5381INT J OFFSHORE POLAR 47951053-587X IEEE T SIGNAL PROCES 47961053-5888IEEE SIGNAL PROC MAG 48101054-7460PRESENCE-TELEOP VIRT 48311057-7149IEEE T IMAGE PROCESS 48321057-7157J MICROELECTROMECH S 48371058-0530INFORM SYST MANAGE 48401058-2916ASAIO J48441058-6180IEEE ANN HIST COMPUT 48481058-9244SCI PROGRAMMING-NETH 48541059-1478PROD OPER MANAG 48561059-7123ADAPT BEHAV 48991063-293X CONCURRENT ENG-RES A49071063-6536IEEE T CONTR SYST T 49081063-6560EVOL COMPUT 49101063-6706IEEE T FUZZY SYST 49261063-8016J DATABASE MANAGE 49271063-8210IEEE T VLSI SYST 49401064-2307J COMPUT SYS SC INT+ 49421064-5462ARTIF LIFE49581065-5131J ENHANC HEAT TRANSF 49621065-8483J APPL BIOMECH 49721066-8527PROCESS SAF PROG 49731066-8888VLDB J49961069-2509INTEGR COMPUT-AID E 50161070-9622SHOCK VIB50181070-986X IEEE MULTIMEDIA 50201070-9908IEEE SIGNAL PROC LET 50311071-5819INT J HUM-COMPUT ST 50441073-0516ACM T COMPUT-HUM INT 50751076-0342J INFRASTRUCT SYST 50851076-9757J ARTIF INTELL RES 50881077-2618IEEE IND APPL MAG 50891077-2626IEEE T VIS COMPUT GR 50901077-3142COMPUT VIS IMAGE UND 51131079-8587INTELL AUTOM SOFT CO 51451083-4435IEEE-ASME T MECH 51571084-0702J BRIDGE ENG 51591084-4309ACM T DES AUTOMAT EL 51621084-8045J NETW COMPUT APPL 51701086-055X SPE J51711086-4415INT J ELECTRON COMM 51781087-1357J MANUF SCI E-T ASME 51901088-467X INTELL DATA ANAL 52011089-778X IEEE T EVOLUT COMPUT 52031089-7801IEEE INTERNET COMPUT 52181091-028X J POROUS MEDIA 52241091-6466PETROL SCI TECHNOL 52271091-9392J ORG COMP ELECT COM 52371092-8758ENVIRON ENG SCI 52411093-4529J ENVIRON SCI HEAL A 52461093-9687COMPUT-AIDED CIV INF 52501094-3420INT J HIGH PERFORM C 52531094-6136J SCHEDULING 52601094-9224ACM T INFORM SYST SE 52631095-4244WIND ENERGY 52691096-4290INT J RF MICROW C E 52821098-1241SYSTEMS ENG 53501134-3060ARCH COMPUT METHOD E 53801176-2322APPL BIONICS BIOMECH 54131210-0552NEURAL NETW WORLD54141210-2512RADIOENGINEERING 54451225-4568STRUCT ENG MECH 54501226-086X J IND ENG CHEM 54591226-6116WIND STRUCT 54611226-7988KSCE J CIV ENG 54701229-9138INT J AUTO TECH-KOR 54821230-6169OCHR SR54871233-2585POL MARIT RES 55051270-9638AEROSP SCI TECHNOL 55141290-0729INT J THERM SCI 55331300-0527TURK J CHEM 55341300-0632TURK J ELECTR ENG CO 55391300-1884J FAC ENG ARCHIT GAZ 55411300-3453TEK DERGI55421300-3615ISI BILIM TEK DERG 55731310-4772J BALK TRIBOL ASSOC 56191335-3632J ELECTR ENG-SLOVAK 56211335-9150COMPUT INFORM 56361341-7215SOLVENT EXTR RES DEV 56381341-7649J HARD TISSUE BIOL 56731346-8804J JPN PETROL INST 56841349-2543IEICE ELECTRON EXPR 56951350-6501P I MECH ENG J-J ENG 57051351-3249NAT LANG ENG 57131353-3452SCI ENG ETHICS 57521358-8265INT J CRASHWORTHINES 57591359-4311APPL THERM ENG 57611359-5113PROCESS BIOCHEM 57781361-4568NEW REV HYPERMEDIA M 57791361-8415MED IMAGE ANAL 57981364-7830COMBUST THEOR MODEL 58021365-1609INT J ROCK MECH MIN 58091366-5545TRANSPORT RES E-LOG 58351369-4332ADV STRUCT ENG 58411369-703X BIOCHEM ENG J 58461370-4621NEURAL PROCESS LETT 58531380-7501MULTIMED TOOLS APPL 58571381-1231J HEURISTICS 58601381-298X COMPUT MATH ORGAN TH 58661382-3256EMPIR SOFTW ENG 58791383-5866SEP PURIF TECHNOL 58801383-7133CONSTRAINTS 58821383-7621J SYST ARCHITECT 58861384-5810DATA MIN KNOWL DISC 58991385-8947CHEM ENG J59021386-145X WORLD WIDE WEB 59081386-4564INFORM RETRIEVAL 59141386-7857CLUSTER COMPUT59191387-2176BIOMED MICRODEVICES 59201387-2532AUTON AGENT MULTI-AG 59221387-3326INFORM SYST FRONT 59391389-0417COGN SYST RES 59451389-2576GENET PROGRAM EVOL M 59461389-4420OPTIM ENG59601392-1215ELEKTRON ELEKTROTECH 59611392-124X INF TECHNOL CONTROL 59651392-3730J CIV ENG MANAG 59681392-8716J VIBROENG60001420-326X INDOOR BUILT ENVIRON 60341432-4350THEOR COMPUT SYST 60361432-7643SOFT COMPUT 60421433-2833INT J DOC ANAL RECOG 60481433-7541PATTERN ANAL APPL 60671434-7229J ARTIF ORGANS 61851464-4177STRUCT CONCRETE 61861464-4193P I MECH ENG K-J MUL 62201468-0874INT J ENGINE RES 62231468-4527ONLINE INFORM REV 62481471-0684THEOR PRACT LOG PROG 63281473-8716INFORM VISUAL 63311474-0346ADV ENG INFORM 63421475-0902P I MECH ENG M-J ENG 63511475-472X INT J AEROACOUST 63561475-9217STRUCT HEALTH MONIT 63571475-925X BIOMED ENG ONLINE 63631476-1548J MAR ENG TECHNOL 63641476-3141SPORT BIOMECH 63721476-9271COMPUT BIOL CHEM 63931478-4629P I CIVIL ENG-ENG SU 64081479-8751INT J MARIT ENG 64271509-409X ACTA BIOENG BIOMECH 64281509-8117POL J CHEM TECHNOL 64881523-9829ANNU REV BIOMED ENG 64891524-0703GRAPH MODELS 64951524-9050IEEE T INTELL TRANSP 65511529-3785ACM T COMPUT LOG 65701530-9827J COMPUT INF SCI ENG 65741531-1309IEEE MICROW WIREL CO 65771531-636X IEEE CIRC SYST MAG 65871532-2882J AM SOC INF SCI TEC 65891532-3641INT J GEOMECH 65901532-4435J MACH LEARN RES 66001533-5399ACM T INTERNET TECHN 66031534-4320IEEE T NEUR SYS REH 66391536-9323J ASSOC INF SYST 66601539-2791NEUROINFORMATICS66681539-9087ACM T EMBED COMPUT S 66751540-7489P COMBUST INST 66801540-9589J WEB ENG66821541-0161SOUND VIB66831541-1672IEEE INTELL SYST 66921541-7794STRUCT DES TALL SPEC 67021542-3980J MULT-VALUED LOG S 67061543-1649INT J MULTISCALE COM 67191544-3558ACM T APPL PERCEPT 67201544-3566ACM T ARCHIT CODE OP 67291545-5971IEEE T DEPEND SECURE 67311545-7362INT J WEB SERV RES 67431546-2234J ORGAN END USER COM 67441546-4261COMPUT ANIMAT VIRT W 67551547-5816J IND MANAG OPTIM 67611548-0992IEEE LAT AM T 67651548-3924INT J DATA WAREHOUS 67691548-7199INT J UNCONV COMPUT 67781549-7747IEEE T CIRCUITS-II 67791549-8328IEEE T CIRCUITS-I 67891550-4832ACM J EMERG TECH COM 68031551-6857ACM T MULTIM COMPUT 68191552-6283INT J SEMANT WEB INF 68211553-3077ACM T STORAGE 68381555-1423J COMPUT NONLIN DYN 68481556-4665ACM T AUTON ADAP SYS 68491556-4681ACM T KNOWL DISCOV D 68511556-6013IEEE T INF FOREN SEC 68521556-603X IEEE COMPUT INTELL M 68531556-6056IEEE COMPUT ARCHIT L 68571556-7036ENERG SOURCE PART A 68721557-5969J CELL AUTOM 68741558-3058INT J ARCHIT HERIT 68781558-7916IEEE T AUDIO SPEECH 68851559-1131ACM T WEB68971559-9612INT J OPTOMECHATRONI 69061562-2479INT J FUZZY SYST 69191566-2535INFORM FUSION 69321567-4223ELECTRON COMMER R A 69391567-7818NAT COMPUT69401567-8326J LOGIC ALGEBR PROGR 69461568-4946APPL SOFT COMPUT 69551569-190X SIMUL MODEL PRACT TH 69741570-5838APPL ONTOL69801570-7873J GRID COMPUT 69811570-8268J WEB SEMANT 69931573-2479STRUCT INFRASTRUCT E 70071574-020X LANG RESOUR EVAL70261582-7445ADV ELECTR COMPUT EN 70501598-2092J POWER ELECTRON 70521598-2351INT J STEEL STRUCT 70781609-0985J MED BIOL ENG 70841610-3653ENVIRON CHEM LETT 71051615-147X STRUCT MULTIDISCIP O 71081615-5262INT J INF SECUR 71091615-5289UNIVERSAL ACCESS INF 71121615-7591BIOPROC BIOSYST ENG 71231617-7959BIOMECH MODEL MECHAN 71321618-954X CLEAN TECHNOL ENVIR 71331619-1366SOFTW SYST MODEL 72161665-2738REV MEX ING QUIM 72181671-3664EARTHQ ENG ENG VIB 72241672-5107PETROL SCI72681678-5878J BRAZ SOC MECH SCI 72741679-7825LAT AM J SOLIDS STRU 72931687-4722EURASIP J AUDIO SPEE 73021687-6180EURASIP J ADV SIG PR 73071687-8132ADV MECH ENG 73471726-4529INT J SIMUL MODEL 73661735-0522INT J CIV ENG 73861738-1584SMART STRUCT SYST 73911738-494X J MECH SCI TECHNOL 74061741-1106INT J WEB GRID SERV 74071741-2560J NEURAL ENG 74101741-5977INVERSE PROBL SCI EN 74201742-2876DIGIT INVEST 74391743-0003J NEUROENG REHABIL 74421743-4440EXPERT REV MED DEVIC 74551744-232X INT J HEAVY VEH SYST 74611744-5302SHIPS OFFSHORE STRUC 74771745-1353IEICE T ELECTRON 74781745-1361IEICE T INF SYST 74991746-8094BIOMED SIGNAL PROCES 75281748-8842AIRCR ENG AEROSP TEC 75461750-5836INT J GREENH GAS CON 75551751-5254EUR J IND ENG 75671751-8601IET COMPUT DIGIT TEC 75681751-8628IET COMMUN75691751-8644IET CONTROL THEORY A 75701751-8660IET ELECTR POWER APP 75721751-8709IET INFORM SECUR 75771751-8806IET SOFTW75811751-9632IET COMPUT VIS 75821751-9659IET IMAGE PROCESS 75831751-9675IET SIGNAL PROCESS 75881752-1416IET RENEW POWER GEN76011753-3309INT J OIL GAS COAL T 76281755-4535IET POWER ELECTRON 76481756-8277INT J SPRAY COMBUST 76491756-8293INT J MICRO AIR VEH 76681758-0366INT J BIO-INSPIR COM 77491810-2328J ENG THERMOPHYS-RUS 77661820-0214COMPUT SCI INF SYST 77671822-427X BALT J ROAD BRIDGE E 78011854-0171ACTA GEOTECH SLOV 78031857-5552MACED J CHEM CHEM EN 78081860-5974LOG METH COMPUT SCI 78131861-1125ACTA GEOTECH 78591866-9956COGN COMPUT 79141875-5100J NAT GAS SCI ENG 79161875-6891INT J COMPUT INT SYS 79191876-1070J TAIWAN INST CHEM E 79371877-7503J COMPUT SCI-NETH 79581881-3054J ADV MECH DES SYST 79911931-4973IEEJ T ELECTR ELECTR 80021932-2135ASIA-PAC J CHEM ENG 80041932-4529IEEE IND ELECTRON M 80051932-4545IEEE T BIOMED CIRC S 80061932-4553IEEE J-STSP 80581936-6582FLEX SERV MANUF J 80591936-7406ACM T RECONFIG TECHN 80691937-8629ENG STUD80771939-1374IEEE T SERV COMPUT 80781939-1382IEEE T LEARN TECHNOL 80811939-1412IEEE T HAPTICS 80901939-8018J SIGNAL PROCESS SYS 80971940-3151J AEROSP INFORM SYST 81261942-9533ELECTR COMMUN JPN 81311943-068X IEEE T COMP INTEL AI 81331943-670X INT J IND ENG-THEORY 81691949-3029IEEE T SUSTAIN ENERG 81701949-3045IEEE T AFFECT COMPUT 81711949-3053IEEE T SMART GRID 81761959-0318IRBM82091991-3761INT J DES82151994-2060ENG APPL COMP FLUID 83062047-7473J SOFTW-EVOL PROC 83142049-825X GEOTECH LETT 83202050-7038INT T ELECTR ENERGY 84092154-2287IEEE PULSE84272157-6904ACM T INTEL SYST TEC 84442162-237X IEEE T NEUR NET LEAR 84672168-2216IEEE T SYST MAN CY-S 84682168-2267IEEE T CYBERNETICS84692168-2291IEEE T HUM-MACH SYST 85072194-5748INT J CHEM REACT ENG 85542224-7890S AFR J IND ENG 85572228-6160IJST-T CIV ENG 85632234-7593INT J PRECIS ENG MAN 86098755-2930EARTHQ SPECTRASubcategory Country total Cites IF 2014-2015IF 2013-2014IF 2012-2013计算机：理论方法UNITED STATES11320 3.621 2.863 2.511工程：宇航UNITED STATES12214 1.207 1.165 1.080工程：化工UNITED STATES19462 2.748 2.581 2.493工程：机械UNITED STATES5470.1900.1240.260计算机：信息系统ENGLAND3270.6760.5750.432计算机：信息系统GERMANY5530.5000.4050.474工程：宇航ENGLAND5500.4050.3360.311工程：宇航UNITED STATES6150.7960.6270.514工程：工业ENGLAND3629 2.023 1.332 1.728计算机：人工智能NETHERLANDS6137 3.371 2.709 2.194计算机：理论方法UNITED STATES4883 1.394 2.939 2.370工程：电子与电气UNITED STATES20482 3.020 3.132 2.919 ENGINEERING, ELECTRICAL & E CROATIA810.3070.3020.349工程：土木GERMANY2410.5110.2070.196CROATIA410.2940.3000.133工程：工业SWITZERLAND6790 2.542 2.541 2.251工程：化工CANADA3937 1.231 1.313 1.003工程：化工UNITED STATES3330.3300.3560.284工程：化工UNITED STATES29067 2.337 2.613 2.386工程：化工GERMANY14510.6580.6610.698工程：化工RUSSIA2090.1330.1410.116工程：化工UNITED STATES12685 3.082 3.708 3.599工程：化工UNITED STATES31350.9910.976 1.011计算机：软件工程ENGLAND3543 1.801 1.515 1.264计算机：软件工程ENGLAND25850.7870.8880.755计算机：理论方法AUSTRIA12720.593 1.0550.807工程：综合SPAIN650.1790.2000.237工程：电子与电气UNITED STATES720.0210.0350.168工程：电子与电气ENGLAND143490.930 1.068 1.038 MEDICAL INFORMATICS GERMANY631 1.4580.0370.000工程：土木UNITED STATES2140.143 1.3710.227工程：机械GERMANY1970.3810.1380.243工程：电子与电气UNITED STATES3029 2.395 2.260 2.418工程：电子与电气GERMANY1620.3930.3400.168工程：化工ENGLAND28939 3.520 3.406 3.357地球科学综合ENGLAND7006 1.868 1.670 1.481工程：机械ENGLAND29586 2.383 2.522 2.315计算机：硬件UNITED STATES27900.6880.5040.688计算机：软件工程UNITED STATES4235 1.443 1.438 1.675工程：电子与电气UNITED STATES13775 3.009 3.106 3.063工程：电子与电气UNITED STATES21017 4.934 5.466 6.911工程：电子与电气UNITED STATES10120.7820.936 1.322工程：电子与电气UNITED STATES27226 2.779 3.167 2.718工程：生物医学UNITED STATES14435 2.347 2.233 2.348工程：电子与电气UNITED STATES5706 1.659 1.473 1.379工程：电子与电气UNITED STATES9690.842 1.2210.950工程：工业UNITED STATES1799 1.1030.9380.893工程：电子与电气UNITED STATES30514 2.326 2.650 2.621工程：电子与电气UNITED STATES7576 1.790 1.710 1.357工程：电子与电气UNITED STATES15375 2.243 2.943 2.229工程：电子与电气UNITED STATES10640 1.283 1.455 1.219工程：电子与电气UNITED STATES3270 1.934 1.657 2.293工程：综合UNITED STATES1691 2.984 2.256 1.626计算机：信息系统NETHERLANDS30020.5460.4790.488计算机：信息系统UNITED STATES15616 4.038 3.893 3.643工程：综合RUSSIA6780.3310.3490.330工程：电子与电气ENGLAND1030.0770.1180.041工程：电子与电气ENGLAND9220.4590.7510.509工程：综合ENGLAND5498 2.668 2.291 1.691工程：机械ENGLAND5829 2.034 2.061 1.613工程：工业ENGLAND9095 1.477 1.323 1.460工程：化工ENGLAND5894 2.236 2.705 2.686工程：宇航UNITED STATES33600.5560.4880.632工程：生物医学ENGLAND24787 2.751 2.496 2.716工程：化工CANADA12560.7440.6170.451工程：化工UNITED STATES17706 2.037 2.045 2.004工程：化工JAPAN20560.6440.6090.616计算机：理论方法UNITED STATES2824 1.138 1.091 1.000工程：综合NETHERLANDS13130.803 1.069 1.075工程：机械UNITED STATES9187 1.450 2.055 1.718工程：海洋UNITED STATES5810.8210.8780.628工程：机械UNITED STATES22682 1.813 1.857 1.613工程：宇航UNITED STATES22710.5330.4740.489工程：环境ENGLAND716 1.417 1.2360.803计算机：控制论CZECH REPUBLIC6320.5410.5630.619工程：大洋UNITED STATES5540.4340.7570.678工程：机械UNITED STATES7350.4030.0000.407工程：电子与电气ENGLAND21960.8360.9240.912工程：海洋UNITED STATES1670.0740.0840.105工程：综合ENGLAND13768 2.055 1.961 2.056工程：大洋ENGLAND3891 1.351 1.337 1.161工程：电子与电气ENGLAND16200 3.096 2.584 2.632工程：生物医学ENGLAND20131 2.761 2.922 2.701工程：化工SWITZERLAND13626 2.349 2.269 2.024计算机：信息系统ENGLAND2800.6510.5000.377工程：化工POLAND7580.3990.3670.344工程：化工ROMANIA12690.8100.6770.538工程：电子与电气ROMANIA890.3330.3680.337工程：机械ENGLAND3540.4440.3160.402计算机：跨学科应用ENGLAND9110.8180.6560.692RUSSIA770.1580.1410.190工程：土木GERMANY3400.2190.2250.256工程：机械SLOVENIA3540.8210.7760.883工程：化工RUSSIA6210.5760.3760.360工程：机械ENGLAND2267 1.0610.8720.766工程：环境NORWAY5182 2.289 2.973 2.295工程：综合NETHERLANDS18357 2.959 2.626 2.617工程：土木NETHERLANDS1945 2.358 1.617 1.657工程：机械UNITED STATES1206 1.429 1.20011.333计算机：软件工程UNITED STATES2170.3020.4890.389工程：电子与电气ENGLAND912 3.778 4.6889.786工程：生物医学UNITED STATES8154 3.195 3.231 2.575工程：大洋UNITED STATES1440.1010.0450.068工程：电子与电气UNITED STATES10577 1.756 2.046 1.672工程：机械ENGLAND3747 1.660 1.310 1.214工程：宇航UNITED STATES3470 1.1220.8160.701工程：机械UNITED STATES11950.3570.2700.441工程：机械UNITED STATES41220.9320.9390.886工程：电子与电气UNITED STATES3943 1.614 2.292 2.588工程：化工UNITED STATES1828 1.1040.788 1.052工程：电子与电气ENGLAND911 1.254 1.210 1.293工程：化工BRAZIL1041 1.0430.9120.894 ULTIDISCIPLINARY COLOMBIA540.1930.0940.000 COMPUTER SCIENCE, THEORY & Malaysia740.4050.5000.161计算机：理论方法SINGAPORE4350.2960.3260.420计算机：人工智能UNITED STATES1154 6.507 6.056 5.054计算机：跨学科应用NETHERLANDS5805 2.183 2.274 2.133工程：机械ENGLAND5969 2.241 1.702 1.793工程：土木ENGLAND9954 1.838 1.767 1.713工程：大洋ENGLAND1245 1.287 1.262 1.072工程：制造UNITED STATES1922 1.517 1.403 1.393工程：电子与电气NETHERLANDS3360.4300.5980.549工程：电子与电气NETHERLANDS768 1.033 1.205 1.101工程：制造ENGLAND1224 1.295 1.304 1.545工程：机械UNITED STATES4519 1.596 1.777 1.581工程：机械SWITZERLAND5380.4050.2390.509工程：土木ENGLAND3910 1.321 1.370 1.327工程：工业ENGLAND5510.6350.6220.690工程：制造ENGLAND4460.9130.7110.603工程：机械UNITED STATES15240.8140.9020.694工程：化工UNITED STATES9760.6750.6260.558 CE, INFORMATION SYSTEMS UNITED STATES3678 1.116 1.1020.000工程：生物医学UNITED STATES6639 1.780 1.748 1.519计算机：跨学科应用UNITED STATES2490.4740.4100.756工程：化工UNITED STATES5093 1.171 1.200 1.164工程：生物医学UNITED STATES3132 2.050 1.870 1.964工程：生物医学UNITED STATES8610.912 1.156 1.583工程：电子与电气UNITED STATES29822 5.781 5.694 4.795计算机：软件工程UNITED STATES1198 1.0540.9550.462计算机：软件工程UNITED STATES10110.8970.800 1.026计算机：理论方法UNITED STATES2721 1.352 1.245 1.135工程：电子与电气NETHERLANDS7150 2.209 2.238 1.851。

基于HITEMP数据库的分子吸收光谱高精度快速建模方法钱宝健，蔡静*，常海涛，高一凡（航空工业北京长城计量测试技术研究所，北京 100095）摘要：为解决高温环境下分子吸收光谱精确计算的时间复杂性，满足宽光谱测量领域对理论吸收光谱计算的需求，本研究利用Python语言以逐线计算为基础，结合线型函数的简化、线翼截止准则和谱线数据库的优化，建立了基于高温分子吸收参数数据库（High⁃Temperature molecular spectroscopic absorption parameters data⁃base，HITEMP）的分子吸收光谱精确快速计算模型。

以Hartmann⁃Tran线型函数作为吸收光谱标准线型编写部分相关二次速度依赖硬碰撞函数（partially⁃Correlated quadratic⁃Speed⁃Dependent Hard⁃Collision Profile，pCqSDHC），结合复概率函数（Complex Probability Function，CPF）简化模型实现了线型函数的精确快速计算，相较于理论计算模型计算速度提高了20倍。

按照光谱计算残差在10-5量级确定了固定波数截断结合谱线半宽等倍数截断的线翼截止准则。

以阈值线强度10-25 cm-1/(mol∙cm-2)为标准筛选了每100 K温度梯度时的光谱数据，整合得到优化数据库。

在6 500 ~ 8 000 cm-1范围内对水分子的吸收光谱进行计算，并与“”分子气体集成光谱建模网站仿真结果对比，逐线模型的计算误差在10-7量级，优化模型的计算误差在10-5量级，计算速度平均提升25倍。

该模型满足吸收光谱测量中对于理论吸收光谱的高效准确计算，为复杂环境中基于宽调谐、超连续激光吸收光谱的测量研究提供了理论模型基础。

关键词：吸收光谱；HITEMP数据库；线型函数；线翼截止中图分类号：TB9；O433 文献标志码：A 文章编号：1674-5795（2023）05-0039-10Modeling molecular absorption spectra based on the HITEMP databaseQIAN Baojian, CAI Jing*, CHANG Haitao, GAO Yifan(Changcheng Institute of Metrology & Measurement, Beijing 100095, China)Abstract: To address the computational complexity of accurately calculating molecular absorption spectra in high⁃temperature environments and meet the demand for theoretical absorption spectrum calculations in broad⁃spectrum mea⁃surement fields, this study developed a precise and fast calculation model for molecular absorption spectra based on the High⁃Temperature molecular spectroscopic absorption parameters database (HITEMP). The model was implemented us⁃ing Python language, employing a line⁃by⁃line calculation approach combined with simplification of line shape functions, line wing truncation criteria, and optimization of spectral line databases. The Hartmann⁃Tran line shape function was used as the standard absorption spectrum line shape, and partially⁃Correlated quadratic⁃Speed⁃Dependent Hard⁃Collision Pro⁃file (pCqSDHC) was developed for relevant second⁃order velocity⁃dependent hard⁃collision functions. By incorporating the doi：10.11823/j.issn.1674-5795.2023.05.06收稿日期：2023-09-26；修回日期：2023-10-08基金项目：国家“十三五”计量技术基础科研项目（JSJL2020205A003）引用格式：钱宝健，蔡静，常海涛，等.基于HITEMP数据库的分子吸收光谱高精度快速建模方法［J］.计测技术，2023，43（5）：39-48.Citation：QIAN B J，CAI J，CHANG H T，et al.Modeling molecular absorption spectra based on the HITEMP database［J］.Metrology & Measurement Technology，2023，43（5）：39-48.Complex Probability Function (CPF) and simplifying the model, the line shape functions were calculated accurately and rapidly, resulting in a 20⁃fold increase in computational speed compared to theoretical models. The line wing truncation criteria were determined based on the spectral calculation residual at the level of 10-5 and involved the truncation of fixed wavenumbers combined with equal multiple truncations of spectral line half widths. Spectral data for each temperature gradient of 100 K were selected using a threshold line intensity of 10-25 cm-1/(mol∙cm-2) and integrated to create an opti⁃mized database. The absorption spectra of water molecules were calculated within the range of 6 500 ~ 8 000 cm-1 and compared with the simulation results from "", a molecular gas integrated spectral modeling website. The calculation error of the line⁃by⁃line model was at the level of 10-7, while the optimized model achieved a calculation error at the level of 10-5, with an average speed improvement of 25 times. This model enables efficient and accurate calculation of theoretical absorption spectra for absorption spectral measurements and provides a theoretical foundation for measuring studies based on wide⁃tunable and supercontinuum laser absorption spectra in complex environments.Key words: absorption spectrum; HITEMP database; line shape functions; line wing cutoff0　引言分子吸收光谱是一种描述物质分子对特定波长光的吸收能力的图谱，通过测量物质对不同波长光的吸收程度，可以推断物质的组成、浓度、结构和化学性质等重要信息，从而在燃烧诊断［1-2］、温度测量［3-4］、污染物监测［5］等领域中进行定性和定量分析。

USA SAFETY DATA SHEET1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATIONProduct name: CHEMLOK 8560S-1Product Use/Class: Aqueous AdhesiveLORD Corporation111 LORD DriveCary, NC 27511-7923 USATelephone: 814 868-3180Non-Transportation Emergency: 814 763-2345 Chemtrec 24 Hr Transportation Emergency No.800 424-9300 (Outside Continental U.S. 703 527-3887)EFFECTIVE DATE: 12/20/20212. HAZARDS IDENTIFICATIONGHS CLASSIFICATION:Serious eye damage/eye irritation Category 2B Skin sensitization Category 1A Carcinogenicity Category 2Specific target organ systemic toxicity (single exposure) Category 2 blood system Specific target organ systemic toxicity (repeated exposure) Category 2 blood system Hazardous to the aquatic environment - acute hazard Category 2 Hazardous to the aquatic environment - chronic hazard Category 2GHS LABEL ELEMENTS:Symbol(s)Signal WordW ARNINGHazard StatementsCauses eye irritation.May cause an allergic skin reaction. Suspected of causing cancer.May cause damage to organs.(blood system)May cause damage to organs through prolonged or repeated exposure.(blood system) Toxic to aquatic life.Toxic to aquatic life with long lasting effects.Precautionary Statements PreventionObtain special instructions before use.Do not handle until all safety precautions have been read and understood. Wear protective gloves.Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Wash thoroughly after handling.Do not eat, drink or smoke when using this product.Contaminated work clothing should not be allowed out of the workplace. Avoid release to the environment.Product: CHEMLOK 8560S-1, Effective Date: 12/20/2021ResponseGet medical advice/attention if you feel unwell.Call a POISON CENTER or doctor/physician if exposed or you feel unwell.Specific treatment (see supplemental first aid instructions on this label).IF ON SKIN: Wash with plenty of soap and water.If skin irritation or rash occurs: Get medical advice/attention.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.Continue rinsing.If eye irritation persists: Get medical advice/attention.Wash contaminated clothing before reuse.Collect spillage.StorageStore locked up.Disposal:Dispose of contents/container in accordance with waste/disposal laws and regulations of your country or particular locality.Other Hazards:This product contains component(s) which have the following warnings; however based on the GHS classification criteria of your country or locale, the product mixture may be outside the respective category(s).Acute: May cause mild skin irritation. In elevated-temperature applications, product may release vapors that may produce cyanosis in the absence of sufficient ventilation or adequate respiratory protection. 4,4'-Diphenylmethane bis-maleimide is harmful by inhalation. Avoid breathing sanding dust from this product. May be harmful ifswallowed. Ingestion is not an expected route of entry in industrial or commercial uses.Chronic: Prolonged or repeated contact may result in dermatitis. The nitrogen substituted aromatic in this product gave positive results for mutagenicity in an Ames Assay study while two other mutagenicity studies proved negative.IARC has designated carbon black as Group 2B - inadequate evidence for carcinogenicity in humans, but sufficient evidence in experimental animals. In 2006 IARC reaffirmed its 1995 finding that there is "inadequate evidence"from human health studies to assess whether carbon black causes cancer in humans. Further, epidemiologicalevidence from well-conducted investigations has shown no causative link between carbon black exposure and the risk of malignant or non-malignant respiratory disease in humans. IARC has identified the proprietary curative in this product as an "animal suspected" carcinogen, Group 3, which downgrades a previous NCI report of it as an "animal positive" carcinogen.3. COMPOSITION/INFORMATION ON INGREDIENTSChemical Name CAS Number RangeNitrogen substituted aromatic PROPRIETARY15 - 20%Zinc compound PROPRIETARY 5 - 10%4,4'-Diphenylmethane bis-maleimide13676-54-5 1 - 5%Carbon black1333-86-4 1 - 5%Nonylphenol ethoxylate compound PROPRIETARY0.9 - 1%Curative PROPRIETARY0.1 - 0.9%Any "PROPRIETARY" component(s) in the above table is considered trade secret, thus the specific chemical and its exact concentration is being withheld.4. FIRST AID MEASURESFIRST AID - EYE CONTACT: Flush eyes immediately with large amount of water for at least 15 minutes holding eyelids open while flushing. Get prompt medical attention.FIRST AID - SKIN CONTACT: Flush contaminated skin with large amounts of water while removing contaminated clothing. Wash affected skin areas with soap and water. Get medical attention if symptoms occur.FIRST AID - INHALATION: Move person to fresh air. Restore and support continued breathing. If breathing is difficult, give oxygen. Get immediate medical attention.Product: CHEMLOK 8560S-1, Effective Date: 12/20/2021FIRST AID - INGESTION: If swallowed, do not induce vomiting. Call a physician or poison control center immediately for further instructions. Never give anything by mouth if victim is rapidly losing consciousness, unconscious or convulsing.5. FIRE-FIGHTING MEASURESSUITABLE EXTINGUISHING MEDIA: Carbon Dioxide, Dry Chemical, Foam, Water FogUNSUITABLE EXTINGUISHING MEDIA: Not determined for this product.SPECIFIC HAZARDS POSSIBLY ARISING FROM THE CHEMICAL: Keep containers tightly closed. Closed containers may rupture when exposed to extreme heat. Use water spray to keep fire exposed containers cool. WARNING: Due to the combustible nature of the dried film of this product and the potential for smoldering or fire, the accumulation and buildup of the dried film on spray booth walls and floors, spindles, fixtures and other surfaces should be avoided, and any buildup should be removed. Keep the dried film accumulations away from sparks, friction, impact, high heat (>235 F/>112 C) or other sources of ignition. These conditions could cause the dried film to ignite very readily and quickly, and the resulting smoldering or fire may be difficult to extinguish. During removal of accumulation/buildup of this product, take precautions to avoid heat, friction and impact during the cleaning process. Use paint stripper, brass brush, or plastic scraper for cleaning. In the event of smoldering or a fire involving the dried product, Cold Fire®** fire suppressing agent is preferred as the extinguishing medium. If Cold Fire® is not available, use water spray as the extinguishing medium. Take efforts to ensure that these agents reach the base of the smoldering or fire. Parker-LORD Corporation will not be responsible for personal injuries, property damage or any other damages arising from the accumulation (buildup, cleaning/removal or any related smoldering or fire) resulting from the use of this product. Refer to the Chemlok® Safe Handling Guide for additional information. **NOTE: Parker-LORD Corporation has determined Cold Fire® fire suppressing agent to be effective in extinguishing fires involving dried Chemlok® adhesives. Parker-LORD does not recommend any particular equipment or system for use in delivering or applying Cold Fire® products. Customer is responsible for determining that Cold Fire® products and any delivery equipment or system is appropriate and effective for customer's specific needs. During a fire, irritating and/or toxic gases and particulate may be generated by thermal decomposition or combustion. SPECIAL PROTECTIVE EQUIPMENT AND PRECAUTIONS FOR FIRE-FIGHTERS: Wear full firefighting protective clothing, including self-contained breathing apparatus (SCBA). If water is used, fog nozzles are preferable.6. ACCIDENTAL RELEASE MEASURESPERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES: Avoid breathing vapors. Avoid contact. Use appropriate respiratory protection for large spills or spills in confined area. See Section 5 for cautionary information on the dried residue of this product.ENVIRONMENTAL PRECAUTIONS: Do not contaminate bodies of water, waterways, or ditches, with chemical or used container.METHODS AND MATERIALS FOR CONTAINMENT AND CLEANUP: Notify appropriate authorities if necessary. Contain and remove with inert absorbent material. Avoid contact. Keep non-essential personnel away from spill area. Before attempting cleanup, refer to hazard caution information in other sections of this Safety Data Sheet.7. HANDLING AND STORAGEHANDLING: Keep closure tight and container upright to prevent leakage. Avoid skin and eye contact. Wash thoroughly after handling. Do not handle until all safety precautions have been read and understood. Empty containers should not be re-used. Use with adequate ventilation. See Section 5 for cautionary information on handling of the dried residue of this product. Avoid breathing sanding dust from this product.STORAGE: Store only in well-ventilated areas. Keep from freezing. Keep container closed when not in use. INCOMPATIBILITY: Strong acids, bases, and strong oxidizers.8. EXPOSURE CONTROLS/PERSONAL PROTECTIONCOMPONENT EXPOSURE LIMIT Chemical Name ACGIH TLV-TWA ACGIH TLV-STELOSHA PEL-TWAOSHA PEL-CEILINGSkinProduct: CHEMLOK 8560S-1, Effective Date: 12/20/2021Nitrogen substituted aromatic N.E.N.E.N.E. N.E. N.A. Zinc compound2 mg/m3 10 mg/m3 5 mg/m3 N.E. N.A. 4,4'-Diphenylmethane bis-maleimide N.E. N.E. N.E. N.E. N.A. Carbon black3 mg/m3 N.E. 3.5 mg/m3 N.E. N.A. Nonylphenol ethoxylate compound N.E. N.E. N.E. N.E. N.A. CurativeN.E.N.E.N.E.N.E.N.A.N.A. - Not Applicable, N.E. - Not Established, S - Skin DesignationEngineering controls: Sufficient ventilation in pattern and volume should be provided in order to maintain air contaminant levels below recommended exposure limits.PERSONAL PROTECTION MEASURES/EQUIPMENT:RESPIRATORY PROTECTION: Use a NIOSH approved chemical/mechanical filter respirator designed to remove a combination of particulates and organic vapor if occupational limits are exceeded. For emergencysituations, confined space use, or other conditions where exposure limits may be greatly exceeded, use an approved air-supplied respirator. For respirator use observe OSHA regulations (29CFR 1910.134) or use in accordance with applicable laws and regulations of your country or particular locality.SKIN PROTECTION: Use neoprene, nitrile, or rubber gloves to prevent skin contact.EYE PROTECTION: Use safety eyewear including safety glasses with side shields and chemical goggles where splashing may occur.OTHER PROTECTIVE EQUIPMENT: Remove and wash contaminated clothing before reuse.HYGIENIC PRACTICES: Wash hands before eating, smoking, or using toilet facility. Do not smoke in any chemical handling or storage area. Food or beverages should not be consumed anywhere this product is handled or stored. Wash thoroughly after handling.9. PHYSICAL AND CHEMICAL PROPERTIESTypical values, not to be used for specification purposes.ODOR:Odorless VAPOR PRESSURE:N.D.APPEARANCE: Green/BlackVAPOR DENSITY:Heavier than Air PHYSICAL STATE:Thixotropic liquid LOWER EXPLOSIVE LIMIT: Not Applicable FLASH POINT: ≥ 201 °F, 93 °C Setaflash Closed Cup UPPER EXPLOSIVE LIMIT:Not Applicable BOILING RANGE:100 °CEVAPORATION RATE: Slower than n-butyl-acetateAUTOIGNITION TEMPERATURE: N.D. DENSITY:1.2 g/cm3 (10.00 lb/gal) DECOMPOSITION TEMPERATURE:N.D. VISCOSITY, DYNAMIC: ≥50 mPa.s @ 25 °C ODOR THRESHOLD: N.D.VISCOSITY, KINEMATIC: ≥42 mm2/s @ 25 °C SOLUBILITY IN H2O:Water Dispersible VOLATILE BY WEIGHT: 56.93 % pH:6.0 VOLATILE BY VOLUME:66.72 % FREEZE POINT:N.D. VOC CALCULATED: 0.02 lb/gal , 3 g/l COEFFICIENT OF WATER/OILDISTRIBUTION:N.D.LEGEND: N.A. - Not Applicable, N.E. - Not Established, N.D. - Not Determined10. STABILITY AND REACTIVITYHAZARDOUS POLYMERIZATION: Hazardous polymerization will not occur under normal conditions.STABILITY: Product is stable under normal storage conditions.Product: CHEMLOK 8560S-1, Effective Date: 12/20/2021CONDITIONS TO AVOID: High temperatures.; For dried product issues, refer to Section 5 of the (M)SDS.; DO NOT ALLOW THIS MATERIAL TO DRY OUT. As a solid, p-benzoquinone dioxime is flammable, and it may explode if exposed to shock, friction or heat.INCOMPATIBILITY: Strong acids, bases, and strong oxidizers.HAZARDOUS DECOMPOSITION PRODUCTS: Decomposition due to high temperatures or a fire causes the formation of irritating and/or toxic gases, organic vapors or fumes., May contain CO, CO2, oxides of nitrogen, oxides of sulfur, halogenated by-products, Carbon dioxide, carbon monoxide, chlorine, hydrogen chloride, Phosgene, Metal oxides11. TOXICOLOGICAL INFORMATIONEXPOSURE PATH: Refer to section 2 of this SDS.SYMPTOMS: Refer to section 2 of this SDS.TOXICITY MEASURES:Chemical NameLD50/LC50 Nitrogen substituted aromatic Oral LD50: rat 1,100 mg/kgZinc compoundOral LD50: Rat > 5,000 mg/kg Dermal LD50: Rat > 2,000 mg/kgGHS LC50 (vapour): Acute toxicity point estimate 55 mg/l Inhalation LC50: Rat > 5,700 mg/m3 /4 h 4,4'-Diphenylmethane bis-maleimide Oral LD50: Rat > 5 g/kgDermal LD50: rat > 5,400 mg/kgGHS LC50 (dust and mist): rat 0.52 mg/l Inhalation ATE: 11 mg/l Carbon blackOral LD50: Rat > 15,400 mg/kg Dermal LD50: Rabbit > 3 g/kgGHS LC50 (vapour): Acute toxicity point estimate 55 mg/l : Nonylphenol ethoxylate compound N.D.CurativeOral LD50: Rat 464 mg/kgGHS LC50 (vapour): Acute toxicity point estimate 55 mg/l Inhalation LC50: Rat > 5 mg/l /4 hGerm cell mutagenicity: No classification proposedCarcinogenicity: Category 2 - Suspected of causing cancer. Components contributing to classification: Curative.Reproductive toxicity: No classification proposed12. ECOLOGICAL INFORMATIONECOTOXICITY:Chemical NameEcotoxicityNitrogen substituted aromatic N.D. Zinc compoundN.D.4,4'-Diphenylmethane bis-maleimide Fish: Oncorhynchus mykiss (rainbow trout) > 0.145 mg/l96 hCarbon blackN.D. Nonylphenol ethoxylate compound N.D.CurativeFish: Danio rerio (zebra fish) 24 mg/l96 h Static Invertebrates: Daphnia magna (Water flea) 3.5 mg/l48 h StaticPERSISTENCE AND DEGRADABILITY: Not determined for this product.BIOACCUMULATIVE: Not determined for this product.MOBILITY IN SOIL: Not determined for this product.OTHER ADVERSE EFFECTS: Not determined for this product.13. DISPOSAL CONSIDERATIONSDISPOSAL METHOD: Disposal should be done in accordance with Federal (40CFR Part 261), state and local environmental control regulations. If waste is determined to be hazardous, use licensed hazardous waste transporter and disposal facility. Waste streams, including the dried adhesive residue, resulting from the use of this product should be tested for RCRA characteristics, including ignitability, to determine any applicable waste classifications.14. TRANSPORT INFORMATIONUS DOT RoadProper Shipping Name: Environmentally hazardous substances, liquid, n.o.s.Hazard Class: 9SECONDARY HAZARD: NoneUN/NA Number: 3082Packing Group: IIIEmergency Response Guide Number: 171For US DOT non-bulk road shipments this material may be classified as NOT REGULATED. For the mostaccurate shipping information, refer to your transportation/compliance department regarding changes inpackage size, mode of shipment or other regulatory descriptors.IATA CargoPROPER SHIPPING NAME: Environmentally hazardous substance, liquid, n.o.s.Hazard Class: 9HAZARD CLASS: NoneUN NUMBER: 3082PACKING GROUP: IIIEMS: 9LIMDGPROPER SHIPPING NAME: Environmentally hazardous substance, liquid, n.o.s.Hazard Class: 9HAZARD CLASS: NoneUN NUMBER: 3082PACKING GROUP: IIIEMS: F-AThe listed transportation classification applies to non-bulk shipments. It does not address regulatory variations due to changes in package size, mode of shipment or other regulatory descriptors. For the most accurate shipping information, refer to your transportation/compliance department.15. REGULATORY INFORMATIONU.S. FEDERAL REGULATIONS: AS FOLLOWS:SARA SECTION 313This product contains the following substances subject to the reporting requirements of Section 313 of Title III of the Superfund Amendment and Reauthorization Act of 1986 and 40 CFR part 372.:Chemical Name CAS Number Weight % Less ThanZinc compound PROPRIETARY10.0%TOXIC SUBSTANCES CONTROL ACT:INVENTORY STATUSThe chemical substances in this product are on the active TSCA Section 8 Inventory or exempt.EXPORT NOTIFICATIONThis product contains the following chemical substances subject to the reporting requirements of TSCA 12(B) if exported from the United States:None16. OTHER INFORMATIONUnder HazCom 2012 it is optional to continue using the HMIS rating system. It is important to ensure employees have been trained to recognize the different numeric ratings associated with the HazCom 2012 and HMIS schemes.HMIS RATINGS - HEALTH: 2* FLAMMABILITY: 1 PHYSICAL HAZARD: 0* - Indicates a chronic hazard; see Section 2Revision: New GHS SDS FormatEffective Date: 12/20/2021DISCLAIMERThe information contained herein is, to the best of our knowledge and belief, accurate. However, since the conditions of handling and use are beyond our control, we make no guarantee of results, and assume no liability for damages incurred by use of this material. It is the responsibility of the user to comply with all applicable federal, state and local laws and regulations.。

Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Oct.-10-2018Print Date:Oct.-10-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :BMS-986205Catalog No. :HY-101560CAS No. :1923833-60-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Skin irritation (Category 2), H315Serious eye damage (Category 1), H318Respiratory sensitisation (Category 1), H334Skin sensitisation (Category 1), H317Germ cell mutagenicity (Category 2), H341Reproductive toxicity (Category 2), H361Specific target organ toxicity - single exposure (Category 1), H370Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335Chronic aquatic toxicity (Category 4), H4132.2 GHS Label elements, including precautionary statementsPictogramSignal word DangerHazard statement(s)H315: Causes skin irritation.H317: May cause an allergic skin reactionH318: Causes serious eye damage.H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled.H335: May cause respiratory irritation.H341: Suspected of causing genetic defects.H361: Suspected of damaging fertility or the unborn child.H370: Causes damage to organs.H413: May cause long lasting harmful effects to aquatic life.Precautionary statement(s)P201: Obtain special instructions before use.P202: Do not handle until all safety precautions have been read and understood.P260: Do not breathe dust ⁄ fume ⁄ gas ⁄ mist ⁄ vapors ⁄ spray.P264: Wash skin thoroughly after handling.P270: Do not eat, drink or smoke when using this product.P271: Use only outdoors or in a well-ventilated area.P272: Contaminated work clothing should not be allowed out of the workplace.P273: Avoid release to the environment.P280: Wear protective gloves ⁄ eye protection ⁄ face protection.P302 + P352: IF ON SKIN: Wash with plenty of soap and water.P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do.Continue rinsing.P310: Immediately call a POISON CENTER ⁄doctor.P321: Specific treatment (see supplemental first aid instructions on this label).P333 + P313: If skin irritation or rash occurs: Get medical advice ⁄ attention.P362: Take off contaminated clothing and wash before reuse.P403 + P233: Store in a well-ventilated place. Keep container tightly closed.P405: Store locked up.P501: Dispose of contents ⁄ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:C24H24ClFN2OMolecular Weight:410.91CAS No. :1923833-60-64. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 2Additional informationRTECS No.: DA8340700Alopecia., Liver injury may occur., Kidney injury may occur., Nausea, Headache, Vomiting, bone marrow depressionThis information is based on our current knowledge. However the chemical, physical, and toxicological properties have not been completely investigated.12. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 ComponentsNo chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 ComponentsNo chemicals in this material are subject to the reporting requirements of SARA Title III, Section 313.SARA 311/312 HazardsAcute Health Hazard, Chronic Health Hazard16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

迪信泰检测平台
哌啶酸检测
哌啶酸（Pipecolic acid），又称2-哌啶甲酸，是一种重要的刚性环状非蛋白质氨基酸，它既可以限定多肽的构象，还可作为不同化合物合成库中的多功能骨架，所以广泛用于许多手性药物和生物活性物质的制备。

哌啶酸的合成方法主要分为生物催化合成、化学不对称合成和光催化合成。

迪信泰检测平台采用液相质谱联用(LC-MS)的方法，使用Thermo Scientific的
U3000快速液相色谱对样品进行分离，Thermo Scientific™ Q Exactive™对样品进行鉴定，可高效、精准的检测哌啶酸的含量变化。

此外，我们还提供其他极性小分子系列检测服务，以满足您的不同需求。

LC-MS测定哌啶酸样本要求：
1. 请确保样本量大于0.2g或者0.2mL。

周期：2~3周。

项目结束后迪信泰检测平台将会提供详细中英文双语技术报告，报告包括：
1. 实验步骤（中英文）。

2. 相关参数（中英文）。

3.质谱图片。

4. 原始数据。

5. 哌啶酸含量信息。

迪信泰检测平台可根据需求定制其他物质测定方案，具体可免费咨询技术支持。

2-c-甲基-d-赤藓糖醇4-磷酸胞苷酰转移酶作用引言是一篇文章的开头部分，用于介绍研究主题、概述研究背景，并阐明研究的目的和意义。

本文的主题是关于2-c-甲基-d-赤藓糖醇4-磷酸胞苷酰转移酶作用的研究，下面将详细说明引言部分的内容。

1.1 概述在本部分，将对整篇文章要涉及的主题进行简单概括。

首先可以介绍2-c-甲基-d-赤藓糖醇4-磷酸胞苷酰转移酶（以下称为XMT）这个酶类以及其在生物体内中起到的重要作用。

也可以简要描述该酶与底物之间发生转化反应的过程。

1.2 研究背景在此部分，需要回顾现有文献和相关实践工作，探讨当前对于XMT已有的了解以及相关领域中可能存在的问题或待解决的挑战。

可以描述近年来该领域内XMT相关研究成果，提出已知问题或待解答之难点，并指明目前对于XMT催化机制和功能特点等方面的研究现状。

1.3 目的和意义本部分应明确本文的研究目标以及对于科学领域和应用领域的重要意义。

可以论述研究XMT催化机制相关问题的重要性，以及深入理解XMT酶类活性对于生物医药、工业生产等方面带来的潜在益处。

同时，也可以展望XMT酶类相关研究在未来可持续发展领域中所能发挥的作用，包括但不限于新药开发、底物转化等方面。

以上内容可以根据实际情况进行适当调整和补充，以完整而清晰地介绍2-c-甲基-d-赤藓糖醇4-磷酸胞苷酰转移酶作用这一主题，并为读者提供足够的背景信息和动机理解接下来文章将涉及到的内容。

2. 2-c-甲基-d-赤藓糖醇4-磷酸胞苷酰转移酶的结构特点2-c-甲基-d-赤藓糖醇4-磷酸胞苷酰转移酶（简称MTDGP）是一种关键酶，参与细菌中碳代谢和能量产生的过程。

该酶具有特定的结构特点，决定了其催化活性和底物特异性。

结构分析表明，MTDGP是一个多亚基复合物，由多个蛋白质亚基组成。

每个亚基都包含一个活性位点，其中存在着底物结合和催化反应所需的氨基酸残基。

这些亚基通过非共价相互作用保持在一起，并形成一个稳定的三维空间结构。