门诊胃镜检查患者中焦虑抑郁状态与消化不良症状相关性的研究*贺甜1闵秀君1孙喆1仇宇悦1徐佳军2刘苓1#四川大学华西医院消化内科1（610041）四川大学华西医院心理卫生中心2背景：消化不良患者是消化科门诊就诊的最主要人群，消化不良症状与焦虑抑郁密切相关。
但焦虑抑郁状态与门诊胃镜检查患者消化不良症状的关系及其特点目前仍不清楚。
目的：探讨门诊胃镜检查患者中焦虑抑郁的患病率及其与消化不良症状严重程度之间的相关性。
方法：收集2021年11月—2021年12月于四川大学华西医院内镜中心行胃镜检查的患者，使用7项广泛性焦虑障碍量表（GAD‑7）和9项患者健康问卷（PHQ‑9）分别评估患者焦虑、抑郁状态，功能性胃肠病罗马Ⅳ诊断性问卷、消化不良症状严重程度问卷和内脏敏感性指数评估消化不良症状，并分析焦虑抑郁状态与消化不良症状严重程度的相关性。
结果：最终有效回收458份问卷，其中焦虑抑郁患者146例（31.9%）。
与非焦虑抑郁组相比，焦虑抑郁组既往胃镜检查次数显著升高（P<0.05）。
焦虑抑郁组极轻/轻度消化不良症状发生率、中等/严重上腹部饱胀、餐后饱胀、上腹部疼痛、嗳气发生率明显高于非焦虑抑郁组（P<0.05）。
焦虑抑郁状态与消化不良症状严重程度和内脏敏感性显著相关（r=0.421，r=0.143；P<0.05）。
结论：门诊胃镜检查患者普遍存在焦虑抑郁状态；焦虑抑郁状态可能导致反复多次的内镜检查；焦虑抑郁状态与消化不良症状和内脏敏感性存在显著相关性。
关键词胃镜检查；焦虑；抑郁；消化不良Study on Relationship of Anxiety and/or Depression With Dyspepsia in Outpatients Undergoing Gastroscopy HE Tian1,MIN Xiujun1,SUN Zhe1,QIU Yuyue1,XU Jiajun2,LIU Ling1.1Department of Gastroenterology and Hepatology, West China Hospital,Sichuan University,Chengdu(610041);2Mental Health Center,West China Hospital,Sichuan University,ChengduCorrespondence to:LIU Ling,Email:********************Background:Patients with dyspepsia are the major group of outpatient department of gastroenterology.Dyspeptic symptoms are closely related to anxiety and/or depression.However,the relationship of anxiety and/or depression to dyspeptic symptoms in outpatients undergoing gastroscopy is still unclear.Aims:To investigate the incidence of anxiety and/or depression in outpatients undergoing gastroscopy and its correlation with the severity of dyspepsia.Methods: Outpatients underwent gastroscopy from November2021to December2021at West China Hospital,Sichuan University were recruited.Generalized anxiety disorder‑7(GAD‑7),patient health questionnaire‑9(PHQ‑9)were used to evaluate anxiety and depression,respectively.RomeⅣdiagnostic questionnaire for functional gastrointestinal disorders,severity of dyspepsia assessment questionnaire,visceral sensitivity index were used to evaluate dyspepsia.The correlation of anxiety and/or depression with dyspepsia was analyzed.Results:A total of458questionnaires were collected effectively,including 146(31.9%)patients with anxiety and/or pared with the non‑anxiety and depression group,the number of gastroscopy in the anxiety and/or depression group was significantly higher(P<0.05).Compared with the non‑anxiety and depression group,the incidences of extremely mild/mild dyspepsia,moderate/severe epigastric fullness,postprandial fullness,epigastric pain and belching were significantly increased in the anxiety and/or depression group(P<0.05).Anxiety and/or depression was significantly correlated with the severity of dyspepsia and visceral sensitivity(r=0.421,r=0.143;P<0.05).Conclusions:Anxiety and/or depression is common in outpatients undergoing gastroscopy;anxiety and/or depressionmay lead to repeated endoscopic examinations;anxiety and/or depression is significantly correlated with dyspepsia andDOI：10.3969/j.issn.1008‑7125.2022.07.003*基金项目：四川大学“医学+信息”中心融合创新项目（YGJC005）；四川大学华西医院临床研究孵化重点项目（2020HXFH040）#本文通信作者，Email:********************visceral sensitivity.Key words Gastroscopy;Anxiety;Depression;Dyspepsia消化不良症状主要包含上腹部疼痛、上腹部烧灼感、餐后饱胀、早饱、反酸、嗳气、恶心等，在一般人群中的患病率约为20%[1]。
