复方中药侯氏黑散发挥维持神经血管单元内环境稳定的作用途径脑缺血不仅损伤神经元，而且会累及对神经元起支持作用的胶质细胞及为神经组织供能的微血管。
因此，要使神经功能恢复，不能仅局限于单一神经元保护，而应着眼于对整个“神经血管单元”功能的维护。
中药复方侯氏黑散是治疗脑卒中的有效复方中药之一，全方由风药（菊花、防风、细辛、桂枝、川芎、桔梗）和补虚药（人参、当归、白术、茯苓、干姜）组成。
首都医科大学中医药学院王海征所在课题组进行的一项研究显示，侯氏黑散方中的“风药”、“补虚药”相辅相成，可通过下调β淀粉样蛋白的表达，抑制淀粉样前体蛋白异常积聚，减少淀粉样物质沉积，维持神经血管单元内环境的稳定，从而保护神经血管单元。
文章发表在《中国神经再生研究（英文版）》杂志2014年4月第7期。
苏木精伊红染色显示，侯氏黑散灌胃脑缺血大鼠模型，脑缺血半暗带区神经细胞数量明显增多，有少量炎细胞浸润Article: " Houshiheisan compound prescription protects neurovascular units after cerebral ischemia," by Haizheng Wang, Lei Wang, Nan Zhang, Qi Zhang, Hui Zhao, Qiuxia Zhang (School of Traditional Chinese Medicine, Capital Medical University, Beijing, China)Wang HZ, Wang L, Zhang N, Zhang Q, Zhao H, Zhang QX. Houshiheisan compound prescription protects neurovascular units after cerebral ischemia. Neural Regen Res. 2014;9(7):741-748.欲获更多资讯：Neural Regen ResHoushiheisan maintains stabilization of the internal environment of neurovascular unitsCerebral ischemia not only injuries neurons, but also involves the glial cells that provide a supportive scaffold to which the neurons are attached and the microvessels that provide energy for nervous tissue. Therefore, protection of a single neuron is not sufficient to recover nervous function, and more attention should be paid to maintenance of the function of entire neurovascular units. Houshiheisan compound is one of effective traditional Chinese compound prescriptions for stroke. The prescription is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drugs. Haizheng Wang and his team, School of Traditional Chinese Medicine, Capital Medical University in China, performed a study on Houshiheisan and found that the wind-dispelling and deficiency-nourishing drugs in the compound prescription Houshiheisan are complementary to each other, effectively suppress abnormal amyloid precursor protein accumulation, reduce amyloid substance deposition, maintain stabilization of the internal environment of neurovascular units, and minimize injury to neurovascular units in the ischemic penumbra by downregulating the amyloid-βexpression. Their findings were published in Neural Regeneration Research (Vol. 9, No. 7, 2014).Hematoxylin-eosin staining revealed that after intragastric administration of Houshiheisan, the number of nerve cells was visibly increased and there was infiltration of a small number of inflammatory cells in the ischemic penumbra of rats with cerebral ischemia.Article: " Houshiheisan compound prescription protects neurovascular units after cerebral ischemia," by Haizheng Wang, Lei Wang, Nan Zhang, Qi Zhang, Hui Zhao, Qiuxia Zhang (School of Traditional Chinese Medicine, Capital Medical University, Beijing, China)Wang HZ, Wang L, Zhang N, Zhang Q, Zhao H, Zhang QX. Houshiheisan compound prescription protects neurovascular units after cerebral ischemia. Neural Regen Res. 2014;9(7):741-748.。
