论著•DOI：10.3969/j.issn.1672-7770.2020.06.015*基于生物电阻抗技术的无创脑水肿动态监护仪在獄猴脑出血及血肿扩大模型中的监测研究邹永杰，张超，陈蔚翔，葛红飞，张水仙，刘丹，何明莲，谭彬彬，陈渝杰，冯华，胡荣，文唐敏【摘要】目的应用獗猴脑出血（ICH）模型,观察基于生物电阻抗技术的无创脑水肿动态监护仪对病情变化的监测能力，明确该仪器在颅脑岀血及后续血肿扩大过程中的数据变化规律，为其在临床脑岀血患者病情监测中的应用奠定基础。
方法健康成年雄性獄猴3只，通过股动脉抽取自体血5mL,采用二次注入法制备獄猴脑出血及血肿扩大模型。
应用有创颅内压监测仪和无创脑水肿动态监护仪同时对造模动物进行病情动态监测，术后通过MRI确认脑出血造模情况。
结果獄猴在脑出血造模后，出现了相应的神经损伤症状,MRI可见脑内血肿位置、大小固定,表明该造模方法较为稳定。
另外,有创颅内压监测指标与无创脑水肿监护仪扰动系数、相位斜率的变化趋势基本一致。
结论本研究建立的獄猴脑出血模型，可以较稳定、可靠地模拟脑出血和血肿扩大的病情及其变化。
无创脑水肿动态监护仪可以比较直观地反映脑内血肿变化情况，结合其操作方法简单、无创伤和可以持续动态监测的优点，为该设备用于临床脑出血患者的病情监测和临床治疗指导提供了重要的实验依据。
【关键词】脑出血；生物电阻抗;獄猴；血肿扩大；病情监测【中图分类号】R-332；R743.34【文献标志码】A【文章编号】1672-7770（2020）064）675亠5Monitorii^study of non-invasive cerebral edema dynamic monitor based on bioelectrical impedance technique in rhesus monkey intracerebral hemorrhage and hematoma enlargementmodel ZOU Yong-jie,ZHANG Chao,CHEN Wei-xiang,et al.Department of Neurosurgery,SouthwestHospital,Army Medical University,Chongqing400038,ChinaCorresponding authors:FENG Hua,HU RongAbstract:Objective The rhesus monkey intracerebral hemorrhage（ICH）model was used toobserve the monitoring ability of non-invasive cerebral edema monitor based on bioelectrical impedance technique.To clarify the change rule of the instrument in the process of ICH and subsequent hematoma enlargement.To lay a foundation for its application in clinical monitoring ofpatients with ICH.Methods In3healthy adult male rhesus monkeys,5mL of autologous bloodwas extracted from the femoral artery.The model of ICH and hematoma enlargement in rhesusmonkey was established by secondary injection.Invasive intracranial pressure monitor and non-invasive cerebral edema monitor were used to continuously mon让or the condition of the model,andthe condition of model was confirmed by MRI after operation.Results The corresponding neurological symptoms appeared after the establishment of the model.MRI showed that the locationand size of ICH were fixed,indicating that the modeling approach was relatively viable.In addition,the changing trends of disturbance coefficient and phase slope of invasive intracranial pressuremonitoring instrument was broadly consistent with that of noninvasive brain edema monitor. Conclusions The study indicates that rhesus monkey model can reliably simulate the condition ofcerebral hemorrhage and hematoma enlargement.The noninvasive dynamic monitor of cerebral基金项目：国家重点研发计划（2017YFC0111900）作者单位：400038重庆,陆军军医大学第一附属医院（西南医院）神经外科（邹永杰，张超，陈蔚翔，葛红飞,张水仙，刘丹，何明莲，谭彬彬,陈渝杰，冯华，胡荣）；中国人民解放军联勤保障部队第908医院神经外科（邹永杰）；重庆市长寿区人民医院神经外科（文唐敏）通信作者:冯华，胡荣edema can directly reflect the changes of bined with the advantages of simple,noninvasive and continuous dynamic monitoring,it provides a basis for the clinical application.Key words:intracerebral hemorrhage；bioelectrical impedance；rhesus monkey；hematoma enlargement;clinical monitoring脑卒中是脑血管循环功能障碍导致以局部中枢神经系统功能缺失为特征的一类疾病，可分为缺血性和出血性脑卒中两大类。
