发病机理 Pathogenesis
发病机理 Pathogenesis
➢ 致热源机制 ➢ 非致热源机制
病理生理机制
外源性致热原
(exogenous pyrogen )
机体 产热>散热
内源性致热原
(endogenous pyrogen)
发热
致热源性 Pyrogen
外源性致热源
通过激活 白细胞
内源性致热源
➢ Muscle activity:Exercise ➢ Age: very young> adult> elderly ➢ Others:Stress、having meal、environment
Body temperature change < 1℃/24Hr
Body temperature
如中暑
➢ 植物神经功能紊乱:
感染后低热、神经功能性低热
Non-infective fever
➢ Absorption of aseptic necrosis substance ➢ Antigen and antibody reaction ➢ Endocrine and metabolic disease ➢ Decrease of heat loss through skin ➢ Abnormity of heat regulating center ➢ Abnormal automatic nerve function
Cold stimulus
Blood cooler than set point
Body temperature
increases
Skin blood vessels constrict
Skeletal muscles activated, shivering begins