HEALTH REPORT - Anti-Aging Research

手掌参延缓衰老及临床应用研究进展作者：刘散丹春香马秀艳麦拉苏刘彩虹斯钦图来源：《中国美容医学》2022年第02期[摘要]手掌参具有补精华、固精、滋补，生津壮阳，增力生精，强身健体，神志清爽阳力强，抗老增力，可抗疲劳，强身益髓等功效。

通过研究表明，手掌参具有氨基酸类化合物、菲类化合物，芳香族类化合物，二苯乙烯（芪）类等化合物，具有抗过敏、抗氧化及抗衰老等作用。

在蒙医临床上运用手掌参的滋补、壮阳、增强体力等作用，主要用于手掌参-37味丸、巴萨姆酥油丸、手掌参-6、手掌参合剂等处方中。

本文对手掌参抗衰老研究及临床应用进行综述，以便为今后蒙药养生研究提供借鉴及参考价值。

[关键词]手掌参;滋补;壮阳;蒙药;养生;抗衰[中图分类号]R339.3+8 [文献标志码]A [文章编号]1008-6455（2022）02-0178-04Research Progress on Anti-aging and Clinical Application of Palmistra ChinensisLIU Sandan1，2， CHUN Xiang1， MA Xiuyan2， MAI Lasu2， LIU Caihong3， SI Qintu2（1.Inner Mongolia Minzu University， Tongliao 028000，Inner Mongolia，China;2.Affiliated Hospital of Inner Mongolia Minzu University，Tongliao 028000，Inner Mongolia，China;3.Tongliao Institute of Mongolian Medicine， Tongliao 028000， Inner Mongolia， China）Abstract： Handicapped ginseng was first recorded in the Tibetan medicine book "Four Medical Codes"， which has the functions of replenishing essence， solidifying essence， nourishing，promoting salivation， strengthening body， producing essence， refreshing mind， strengthening yang，resisting aging， strengthening fatigue，strengthening yang， solidifying essence，strengthening body and benefiting marrow，etc. The research shows that there are amino acid compounds， phenanthrene compounds， aromatic compounds， stilbene compounds and so on. Handicap palmatum has anti-allergy， anti-oxidation and anti-aging effects. In Mongolian medicine， it is mainly used in the prescriptions of Palmistronic Ginseng-37 Wei Pill， Bassam Butter Pill， Palmistronic Ginseng-6， and Palmistronic Ginseng Mixture. In this paper， the anti-aging research and clinical application research of Panax japonicus were reviewed， so as to provide the literature basis for the future research of Mongolian medicine health preservation.Key words： hand ginseng; nourish; aphrodisiac; mongolian medicine; health maintenance自由基衰老假說认为，衰老及相关疾病是因为氧化损伤增多导致，是由于机体氧化和抗氧化平衡失调所引起[1]。

国内外癌症防制现状全球癌症防治现状：中国努力迎头赶上全球癌症负担日益加重，根据世界卫生组织国际癌症研究机构的数据，2020年全球新发癌症病例约2000万，死亡病例约1000万。

而在中国，由于庞大的人口基数，癌症的发病和死亡率也较高，分别占全球的23.7%和30.7%。

面对如此严峻的癌症流行形势，中国正在积极寻求解决方案，努力迎头赶上国际先进水平。

新药研发：临床试验数量增长迅速临床试验是新药研发的关键环节，对于确定药物的安全性和有效性具有重要意义。

近年来，我国在新药临床试验方面取得了显著进展。

2021年，我国药物临床试验总量首次突破3000余项，其中新药临床试验数量2033项，比2020年登记量增加了38.0%。

在抗肿瘤药物领域，PD-1和PD-L1等抗肿瘤药物的临床试验尤为突出。

然而，尽管我国在临床试验数量上取得了快速增长，但与北美临床试验中心相比，还存在一定差距。

2020年，我国肿瘤注册药物临床试验为722项，而北美临床试验中心登记的临床试验数量为6971项。

这种临床试验数量的差异使得美国在新药、新疗法的研发方面上处于优势地位。

经济发展水平的影响：治疗的可及性和效果除了在临床试验方面的努力，经济发展水平也是影响癌症防治的重要因素。

我国属于发展中国家，经济发展水平和人均收入较国外一些发达国家有一定差距。

这可能导致了部分肿瘤患者在治疗期间不得已因为经济原因而放弃一些治疗手段，进而影响预后。

为了解决这一问题，一方面需要继续推动医疗保障制度的完善，让更多患者能够享受到优质医疗资源和服务；另一方面，也需要鼓励和支持创新药的研发和应用，以提高癌症治疗的有效性和可及性。

整体战略的推进：多学科协作是未来方向癌症防治是一个涉及多个领域的综合性任务，需要多学科的协作。

随着科技的进步和医学的发展，我们已经有了更多的手段来对付癌症。

但是，要想取得更大的突破，需要科研、医疗、政策制定等多个领域的专家和机构共同合作。

在这个过程中，转化研究发挥着至关重要的作用。

142第23卷 第5期 2021 年 5 月辽宁中医药大学学报JOURNAL OF LIAONING UNIVERSITY OF TCMVol. 23 No. 5 May，2021具有抗衰老作用中药有效成分及作用机制研究进展王艳艳，王凤玲，毛子玮，张慧，吕鑫，黄莉莉，李廷利（黑龙江中医药大学，黑龙江 哈尔滨 150040）摘要：衰老是由于多重因素造成的机体生理功能和组织结构发生的退行性变化。

由衰老引发的多种疾病严重影响人们的生活质量，因此，抗衰老研究已成为近年来的热点问题。

传统中药在延缓衰老方面具有悠久的历史。

文章就具有抗衰老作用中药的有效成分及作用机制进行了综述，分别从实验动物、给药途径、有效成分、药理作用、作用机制等方面归纳总结了具有抗衰老作用中药的有效成分及作用机制。

总结发现具有抗衰老作用的中药以补虚药和活血化瘀药为主；有效成分包括多糖、皂苷、黄酮、生物碱等；抗衰老的作用机制主要有提高抗氧化酶活性、清除自由基、增强免疫功能和改善学习记忆能力等。

通过文章的综述将有助于研究者寻找更多具有抗衰老作用的中药有效成分。

关键词：中药；抗衰老；有效成分；作用机制中图分类号：R285 文献标志码：A 文章编号：1673-842X (2021) 05- 0142- 07Advances in Research on Active Ingredients and Mechanism of Actionof Traditional Chinese Medicine with Anti-aging EffectsWANG Yanyan，WANG Fengling，MAO Ziwei，ZHANG Hui，LYU Xin，HUANG Lili，LI Tingli（Heilongjiang University of Chinese Medicine，Harbin 150040，Heilongjiang，China）Abstract：Aging is the degenerative changes in the body's physiological functions and tissue structurecaused by multiple factors. Many diseases caused by aging seriously affect people's quality of life. Therefore，anti-aging research has become a hot issue in recent years. Traditional Chinese medicine has a long history in delaying aging. This article reviews the effective ingredients and mechanism of anti-aging Chinese medicines，and summarizes the effective ingredients and mechanism of anti-aging Chinese medicines from the aspects of experimental animals，administration route，effective ingredients，pharmacological effects，and mechanism of action. In summary，it is found that Chinese medicines with anti-aging effects are mainly tonic drugs and blood stasis removing drugs；active ingredients include polysaccharides，saponins，flavonoids，alkaloids，etc；the anti-aging mechanism is mainly to improve antioxidant enzyme activity，scavenging free radicals，enhance immune function and improve learning and memory ability. This review will help researchers to find more effective ingredients of traditional Chinese medicine with anti-aging effects.Keywords：traditional Chinese medicine；anti-aging；active ingredient；mechanism 基金项目：黑龙江省青年科学基金项目（QC2013C085，LH2019H106）；黑龙江省教育厅科学技术研究项目（12531623）；哈尔滨市科技局项目 （2013RFQXJ070）；黑龙江省大学生创新创业训练计划项目（201910228084）作者简介：王艳艳（1982-），女，辽宁通化人，副教授，研究方向：中药及复方改善睡眠药效物质基础及其作用机制研究。

摘要衰老是指机体组织和器官的功能随着年龄的增长而发生退行性变化的生理过程。

寿命调控、衰老相关疾病的发生机制和抗衰老方法等方面当前已取得重要成果。

药物抗衰老具有较大的可行性与现实性，因此筛选新的抗衰老药物已刻不容缓。

水杨苷（Salicin）是白柳树皮提取物的主要成分，具有清热、镇痛、抗炎、延缓皮肤衰老等作用。

最近有文献报道白柳树皮提取物可以延长酵母寿命，但是对果蝇等其它生物是否也具有抗衰老作用有待进一步研究。

因此，本文以果蝇为研究对象，探究水杨苷是否具有抗衰老作用，并进一步探索其作用机制。

这对抗衰老研究具有重要的理论与实际意义。

本研究结果表明，在果蝇食物中添加0.1µM的水杨苷溶液，对果蝇的寿命、抗氧化应激能力、脂肪储存水平、抗饥饿能力和衰老相关基因表达的影响的主要结果如下：(1) 可以显著延长雌性果蝇的寿命。

通过检测不同浓度水杨苷对果蝇寿命的影响，发现水杨苷处理可以延长果蝇的寿命，其最适延寿浓度为0.1μM。

该水杨苷浓度可以延长果蝇中位寿命8天，延寿效果约14%。

(2) 显著地增强了果蝇的抗氧化应激的能力。

实验证明水杨苷处理可以极显著的提高果蝇对双氧水和百草枯处理的抗性，表明果蝇的抗氧化能力得到了显著的提高。

(3) 显著提高了果蝇脂肪储存水平和抗饥饿能力。

我们发现果蝇体内甘油三酯的储存水平显著提高，其储存水平可以代表体内脂肪的储存水平。

提高果蝇体内脂肪的储存水平从而可以提高果蝇的抗饥饿能力。

(4) 对果蝇以下性状无显著副作用。

当添加水杨苷后，果蝇的繁殖能力、运动能力、抗热激能力、采食量等都没有显著的影响。

反而对繁殖能力和运动能力有一定的提高趋势。

(5) 部分衰老相关基因的表达量显著升高。

我们应用qPCR检测了果蝇衰老相关基因Hsp70、Akt1、S6K、ATG1、ATG5和FOXO的表达量，发现热激相关基因Hsp70、胰岛素信号通路中Akt1基因和雷帕霉素信号通路相关基因S6K的表达量与对照组相比无显著的变化。

科学突破英文作文1. Wow, have you heard about the latest scientific breakthrough? It's mind-blowing! Scientists have discovered a way to reverse aging in mice. Can you believe it? This is a game-changer in the field of anti-aging research.2. Picture this: a world where we can live longer, healthier lives without the burden of aging-related diseases. This breakthrough could potentially lead to the development of treatments that can slow down or even reverse the aging process in humans. Imagine the possibilities!3. And that's not all. Another groundbreaking discovery has been made in the field of renewable energy. Scientists have developed a new type of solar panel that is not only more efficient but also cheaper to produce. This could revolutionize the way we harness and utilize solar energy, making it more accessible to everyone.4. Let's not forget about the incredible advancementsin artificial intelligence. Researchers have created a computer program that can now beat professional human players in complex games like chess and Go. This demonstrates the immense potential of AI and its ability to surpass human capabilities in certain areas.5. In the medical field, there have been significant breakthroughs in the treatment of diseases. Scientists have developed a new gene-editing technique that could potentially cure genetic disorders. This has opened up a whole new realm of possibilities for personalized medicine and targeted therapies.6. On a more futuristic note, have you heard about the development of self-driving cars? This technology israpidly advancing, and it won't be long before we see autonomous vehicles on our roads. This could revolutionize transportation, making it safer and more efficient.7. And let's not forget about space exploration. Scientists have made incredible strides in understandingthe universe and discovering new planets outside our solar system. Who knows, we might soon find evidence of extraterrestrial life!8. Lastly, the field of nanotechnology has seen significant progress. Scientists have developed tiny robots that can deliver drugs directly to cancer cells, minimizing side effects and improving treatment outcomes. This could potentially revolutionize cancer treatment as we know it.In conclusion, the world of science is constantly evolving and pushing boundaries. These breakthroughs mentioned are just a glimpse of the incredible advancements being made in various fields. The future holds even more exciting possibilities, and I can't wait to see what scientists will discover next!。

衰老与抗衰老英语作文Title: Aging and Anti-Aging: Understanding the Process and Strategies。

Aging is a natural phenomenon that affects all living organisms, characterized by a progressive decline in physiological function and an increased vulnerability to diseases and death. While aging is inevitable, the pursuit of anti-aging strategies has gained considerable attention in recent years. This essay delves into the process of aging, explores various factors contributing to it, and discusses approaches to counteract its effects.Understanding Aging:Aging encompasses a myriad of biological processes that occur at the cellular, molecular, and systemic levels. At the cellular level, key hallmarks of aging include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellularsenescence, stem cell exhaustion, and altered intercellular communication. These processes collectively contribute to the functional decline observed with age.Factors Influencing Aging:1. Genetics: Genetic factors play a significant role in determining an individual's susceptibility to aging-related changes. Certain genes, such as those involved in DNArepair mechanisms and antioxidant defense systems,influence the rate of aging.2. Lifestyle Choices: Environmental factors andlifestyle choices profoundly impact the aging process. Factors such as diet, exercise, sleep quality, stress management, and exposure to toxins can either accelerate or decelerate aging.3. Oxidative Stress: Reactive oxygen species (ROS) generated during cellular metabolism can cause oxidative damage to cellular components, leading to accelerated aging. Antioxidant systems mitigate the harmful effects of ROS andplay a crucial role in maintaining cellular homeostasis.4. Inflammation: Chronic low-grade inflammation, termed inflammaging, is a hallmark of aging. Inflammatory processes contribute to tissue degeneration and the development of age-related diseases such as cardiovascular disease, neurodegeneration, and cancer.Anti-Aging Strategies:1. Healthy Diet: Consuming a balanced diet rich in antioxidants, vitamins, minerals, and omega-3 fatty acids can mitigate oxidative stress and inflammation, promoting overall health and longevity.2. Regular Exercise: Physical activity has been shown to improve cardiovascular health, enhance cognitive function, maintain muscle mass, and increase lifespan. Both aerobic and resistance exercises are beneficial for aging individuals.3. Stress Management: Chronic stress acceleratescellular aging through various mechanisms, including increased inflammation and oxidative stress. Adopting stress-reducing practices such as meditation, mindfulness, and relaxation techniques can mitigate these effects.4. Supplementation: Certain supplements, such as resveratrol, coenzyme Q10, and nicotinamide adenine dinucleotide (NAD+), have shown promise in promoting cellular health and longevity by modulating various aging pathways.5. Intermittent Fasting: Caloric restriction and intermittent fasting have been linked to lifespan extension and improved metabolic health. These dietary interventions activate cellular stress response pathways and enhance autophagy, leading to rejuvenation at the cellular level.6. Skin Care: Topical antioxidants, retinoids, and sunscreen can protect the skin from UV-induced damage and prevent premature aging signs such as wrinkles and age spots.7. Biomedical Interventions: Emerging biomedical interventions, including senolytics (drugs targeting senescent cells), stem cell therapies, and gene editing technologies, hold promise for reversing age-related decline and extending healthy lifespan.Conclusion:Aging is a complex biological process influenced by genetics, lifestyle factors, and environmental exposures. While aging is inevitable, adopting healthy lifestyle practices and leveraging scientific advancements in anti-aging research can significantly mitigate its effects and promote healthy aging. By understanding the underlying mechanisms of aging and implementing evidence-based strategies, individuals can enhance their quality of life and enjoy prolonged healthspan in later years.。

《2024年世界卫生组织慢性乙型肝炎患者的预防、诊断、关怀和治疗指南》推荐意见要点艾小委，张梦阳，孙亚朦，尤红首都医科大学附属北京友谊医院肝病中心，北京 100050通信作者：尤红，******************（ORCID：0000-0001-9409-1158）摘要：2024年3月世界卫生组织（WHO）发布了最新版《慢性乙型肝炎患者的预防、诊断、关怀和治疗指南》。

该指南在以下方面进行了更新：扩大并简化慢性乙型肝炎治疗适应证，增加可选的抗病毒治疗方案，扩大抗病毒治疗预防母婴传播的适应证，提高乙型肝炎病毒诊断，增加合并丁型肝炎病毒的检测等。

本文对指南中的推荐意见进行归纳及摘译。

关键词：乙型肝炎，慢性；预防；诊断；治疗学；世界卫生组织；诊疗准则Key recommendations in guidelines for the prevention，diagnosis，care and treatment for people with chronic hepatitis B infection released by the World Health Organization in 2024AI Xiaowei， ZHANG Mengyang， SUN Yameng， YOU Hong.（Liver Research Center， Beijing Friendship Hospital， Capital Medical University， Beijing 100050， China）Corresponding author： YOU Hong，******************（ORCID： 0000-0001-9409-1158）Abstract：In March 2024， the World Health Organization released the latest version of guidelines for the prevention， diagnosis，care and treatment for people with chronic hepatitis B infection. The guidelines were updated in several aspects，including expanding and simplifying the indications for chronic hepatitis B treatment，adding alternative antiviral treatment regimens，broadening the indications for antiviral therapy to prevent mother-to-child transmission，improving the diagnosis of hepatitis B virus，and adding hepatitis D virus （HDV）testing. This article summarizes and gives an excerpt of the recommendations in the guidelines.Key words：Hepatitis B， Chronic； Prevention； Diagnosis； Therapeutics； World Health Organization； Practice Guideline近年来，慢性乙型肝炎（CHB）在预防、诊断、治疗等方面取得重要进展。

超声炮与欧洲之星哪个好？欧洲之星4dpro验真变美的曲折经历！超声炮与欧洲之星哪个好？欧洲之星4dpro验真变美的曲折经历！▲▲▲▲▲临-床医学上的超声炮与欧洲之星都能够起到紧致皮肤的作用。

超声炮和欧洲之星哪个果好，这两种方法对皮肤造成的损伤较小，在手术后不容易看到明显的痕迹。

不过在做完欧洲之星之后，皮肤会出现明显的干燥和紧绷感，这种情况需要适当使用修复面膜促进皮肤恢复。

在日常出行当中也应当注意皮肤的防晒工作，避免紫外线直接照射，否则容易引起色素沉着问题术后谨遵医嘱配套口服yi美专用营养ACME-TEA提升延长时效。

▲▲▲▲▲（超声炮与欧洲之星哪个好？欧洲之星4dpro验真变美的曲折经历！）qfr超声炮与欧洲之星哪个好？欧洲之星4dpro验真变美的曲折经历！☆☆☆☆☆超声炮欧洲之星区别☆☆☆☆☆同样是能抗衰的欧洲之星和超声炮，有什么区别啊？这就要验真一下他们产生热能的方式不同。

（一）欧洲之星➤▶➤▶➤属于激光仪器，通过光热效应一层层的升温，热量逐渐累积，达到皮肤结构紧致的效果。

但随着在治疗过程中热量会逐渐增加，为了规避风险防止操作的时候发生烫伤等事故，欧洲之星的温度也就45-55°的样子，做一次效果不明显，需要做3次及以上才能比得上一次热玛吉或者超声炮。

超声炮与欧洲之星哪个好？欧洲之星4dpro验真变美的曲折经历！☆☆☆☆☆（二）超声炮☆☆☆☆☆➤▶➤▶➤温度能达到50-65°左右，理论上来说在操作的时候是有一定的灼热疼痛，但因为超声炮本身在技术应用上增加了超脉冲技术。

➤▶➤▶➤在做治疗的时候，周围神经组织还没反应过来，瞬间的能量发射已经完毕，所以治疗时相对比较舒适。

特别适合怕痛、又想要抗衰效果的人群。

➤▶➤▶➤超声炮今年真的很火，包括超声炮、欧洲之星这些，这些机器真的都很贵，小美容院才不会下血本给你买真机，还有些医院都是真假混着来，做到假货哭都来不及，所以千万不要随意跟风。

nmn抗衰老骗局，美国nmn不老神药骗局，提醒您注意nmn抗衰老骗局，美国nmn不老神药骗局，提醒您注意！随着科学发展的进步，人们抗衰从开始抗氧化到现在的NMN，无疑是一次突破，NMN目前已火爆全球。

让我们一起来看看这个被称之为“长生不老药”、“唐僧肉”的NMN的存在，究竟是不是在收智商税？NMN作为一项抗衰老科研成果，在改善精力、提升体力，护肤美颜、头发再生，改善睡眠、调节生物钟，优化代谢、延缓衰老等方面都得到了很多科研论证，综合来看，nmn抗衰老不是骗局。

As an anti-aging scientific research achievement, NMN has been proved by many scientific researches in improving energy and physical strength, skin care and beauty, hair regeneration, improving sleep, regulating biological clock, optimizing metabolism, delaying aging, etc. In general, NMN anti-aging is not a fraud.但是因为市场大了，很多无良的商人开始以假乱真，以次充好，甚至制造假冒伪劣产品进行出售，导致了NMN行业的乱象，也就导致了以假乱真的nmn骗局发生。

美国w+nmn（端粒塔）整理了主要存在于2个方面，做好笔记，避免被骗！美国nmn不老神药骗局揭秘：买到假冒伪劣产品假冒的产品根本不是真的NMN，没有效果是很正常的，很多非正规渠道购买的NMN可能就是假冒伪劣产品。

比如以NAD+其他前体冒充NMN：很多劣质商家利用NAM(烟酰胺)、NA(烟酸)等物质“挂羊头，卖狗肉”。

然而，这些NAD+的其它前体并不只有转化效率的问题，更重要的是它们会对人体造成及大的伤害。

防衰老的英语Aging is a natural process that all living organisms undergo, and it is a phenomenon that has been the subject of extensive research and study for centuries. As we grow older, our bodies undergo a series of physiological and biological changes that can lead to a decline in our overall health and well-being. However, in recent years, there has been a growing interest in the field of anti-aging, which focuses on ways to slow down or even reverse the aging process.One of the key aspects of anti-aging is the role of lifestyle factors. Diet, exercise, and stress management have all been shown to play a significant role in the aging process. A healthy, balanced diet rich in fruits, vegetables, whole grains, and lean proteins can help to provide the body with the essential nutrients it needs to function optimally. Regular exercise, such as aerobic activity and strength training, can also help to maintain muscle mass, improve cardiovascular health, and reduce the risk of chronic diseases associated with aging.In addition to lifestyle factors, there are also a number of medicaland scientific approaches to anti-aging. One of the most promising areas of research is the field of cellular senescence, which focuses on the cellular changes that occur as we age. As we grow older, our cells accumulate damage and become less efficient at repairing themselves, leading to a decline in their overall function. Researchers are exploring ways to target these senescent cells and potentially reverse or slow down the aging process.Another area of anti-aging research is the role of telomeres, which are the protective caps at the end of our chromosomes. Telomeres play a crucial role in cellular aging, and as we get older, our telomeres become shorter and less effective at protecting our cells. Scientists are investigating ways to maintain or even lengthen telomeres, which could potentially slow down the aging process.One of the most exciting developments in the field of anti-aging is the use of stem cell therapy. Stem cells are undifferentiated cells that have the ability to develop into a variety of different cell types, and they have been shown to have the potential to regenerate damaged or aging tissues. Researchers are exploring ways to use stem cell therapy to rejuvenate the body and potentially reverse the effects of aging.Another area of anti-aging research is the role of hormones. As we age, our bodies undergo changes in the production and regulationof various hormones, such as growth hormone, testosterone, and estrogen. Researchers are investigating ways to optimize hormone levels through supplementation or other interventions, with the goal of improving overall health and reducing the effects of aging.In addition to these medical and scientific approaches, there are also a number of lifestyle-based strategies that can be used to promote anti-aging. These include practices such as mindfulness and meditation, which have been shown to reduce stress and improve overall well-being. Additionally, getting enough sleep and managing stress levels can also play a important role in slowing down the aging process.One of the key challenges in the field of anti-aging is the fact that aging is a complex and multifaceted process that is influenced by a wide range of factors, both genetic and environmental. As a result, there is no single "magic bullet" that can completely stop or reverse the aging process. Instead, a more holistic and integrated approach is required, one that combines various medical, scientific, and lifestyle-based interventions.Despite these challenges, however, the field of anti-aging is rapidly evolving, and there is a growing body of research and evidence that suggests that it is possible to slow down the aging process and improve overall health and well-being. As we continue to learn moreabout the underlying mechanisms of aging, we may be able to develop more effective and targeted interventions that can help usto live longer, healthier, and more fulfilling lives.In conclusion, the field of anti-aging is a complex and multifaceted area of research that holds tremendous promise for improving the quality of life for people of all ages. By combining a range of medical, scientific, and lifestyle-based approaches, we may be able to slow down the aging process and enjoy a longer, healthier, and more vibrant life. As we continue to explore the frontiers of anti-aging research, it is important to remain open-minded, curious, and committed to the pursuit of knowledge and understanding.。

前言随着日复一日流逝的时间，您是否正在担心因衰老而逐渐失去自己的年华？您是否正在担心因衰老而流失最重要的健康财富？您是否正在担心因衰老而无法把握生命最色彩斑斓的瞬间？受损的基因，被污染的环境，紧张的生活方式，潜藏的疾病，无时无刻都加速着你的衰老。

年月的流逝，身体各处都开始呈现衰老的迹象，皮肤，色斑、松弛逐渐出现在你的脸部，气喘，失眠，多梦，腰酸腿软，尿频等亚健康状态越来越多。

这些迹象的出现意味着您的身体机能开始降低运作，身体变得臃肿，越来越多的疾病将潜伏现在您身上。

面对各种生活，工作和身体的问题，人开始变得烦躁，郁郁不欢，反应变慢，消极，精神不振，疲惫不堪。

衰老是不可逃避的自然规律，但是在科学发达的今天，终于有一种革命性的产品可以逆转衰老-——XXX针剂(保健品之类也行）。

它可以帮助您延缓衰老，让您和您的身体重新获得年轻与活力，重现健康美丽人生！XXX针剂介绍XXX针剂(保健品之类也行）是从深海植物中提炼出的生化活性物质，是当今医学基因生物学的领先产品。

它是由著名医学博士Dr.Tenrence Kennedy在单克隆生物基因研究中发现，是破译人类生命密码的结果，经过多年研发和临床检验后，正式投放市场。

它是延缓衰老，提高免疫力的圣品，能够对抗因岁月，环境，心情等造成的多种问题，大大改善生活品质，享受美好人生。

XXX针剂背景XXX针剂(保健品之类也行）的提炼及应用被誉为医学界的顶端优势；XXX针剂(保健品之类也行）自研发成功后经由多国权威科研，医学机构认证，同时获得全球最权威的美国FDA 及中国药品监督管理局检验合格，是当今最为安全可靠的抗衰老产品。

U.S. Longevity Science and Technology Organization ALO美国长寿科技组织ALOMoscow University of Life Sciences俄罗斯莫斯科大学生命科学院World Anti-Aging Medicine Research Center of China世界抗衰老医学会中国抗衰老研究中心Chinese Medical Association Health Management Branch中华医学会健康管理分会抗衰老医学实验室World Anti-Aging Skin Anti-Aging Medical Association Branch世界抗衰老医学会皮肤抗衰老分会The US Anti-Aging Medical Research Council美国抗衰老医学研究会XXX针剂各种成分GENE基因修复因子Vitamin X活性HA.SOD活性卵磷脂胸腺肽超微结构各种维生素超微结构的生命必须微量元素近乎离子状态的超微强抗氧化剂神奇的“生物导弹性”活性成分被注入皮下后,各种超微结构的成分通过淋巴循环，被身体各部分的器官和组织迅速吸收，直接给细胞中的线粒体提供能量,修复受损细胞中的基因片度，同时补充营养成分各个器官及皮肤受损的细胞，激活衰老的真皮细胞, 还能激活免疫系统，有效攻击和疏通身体身体淋巴及血液堵塞的疾患, 做到提前预知身体的亚健康状况,并将病兆疏通排除修复，仿佛“精确制导导弹”一样,有效击中病患。

什么叫系统抗衰，nmn系统精准抗衰，让身体年龄减减减什么叫系统抗衰，nmn系统精准抗老衰，让身体年龄减减减！衰老是指生物个体的正常生理功能出现衰退的过程，是机体各种生化反应的综合表现，是体内外多种因素共同作用的结果。

衰老的体现不仅仅是皱纹的产生，还有比如像皮肤干燥暗沉、毛孔变大、弹性降低，抗衰老也不仅仅是抗皱这一个方面，这是一个系统工程；是一个需要调动所有资源的持久战役。

人总是会衰老，细胞老化、神经衰弱、健康状况低下、这场战役终究失败，但总归我们可以想办法让衰老来得晚一些，也优雅一些。

所以现阶段系统性抗老衰，成为关键点，因为内外兼修才是根本解决！所以如何解决系统抗衰？是我们如今要正视的！！！Anti-aging is not only anti-wrinkle aspect, it is a system engineering; It is a sustained campaign that requires the mobilization of all resources.2022年9月，日本科学家团队《Gymopsxe Respopem》上的一项临床试验，系统性地阐述了补充日本W+NMN端立塔后身体系统精准抗老衰重要生化指标变化：实验中，科研人员指导十多名参与者每天定量服用日本W+NMN（端立塔）25000，持续数月时间，然后将参与者前后的身体状态、实际、生物年龄等数据进行比对！研究数据发现所有人的生物年龄都出现了很大程度的逆转；其中两位参与者仅服用了一个月，其生物年龄就减少了7岁，身体各项指标水准均出现好转且趋于年轻化现象。

（什么叫系统抗衰，nmn系统精准抗衰，让身体年龄减减减！）The data found a significant reversal in biological age for all; Two of the participants took only one month, their biological age decreased by 7 years, and the level of various indicators of the body improved and tended to be younger.升级后的日本W+NMN端立塔白金版注重于人体八大系统精准抗老衰：通过nmn的基础功能激佸基茵链条的活形，通过三项细胞修护因子对人体八大系统进行老化细胞和萎缩细胞的过滤，人体八大系统包括造血系统、生殖泌尿系统、内份泌系统、细胞再苼系统、消化系统、睡眠系统、脑干系统，通过日本W+NMN促渗微触技术，进行荃面提升八大系统。

nmn的抗衰老研究：简述nmn抗衰老作用原理，符合事实！美国升级版W+NMN：nmn的抗衰老研究：简述nmn抗衰老作用原理，符合事实！nmn的抗衰老研究：简述nmn抗衰老作用原理，科学期刊《Cell》用NMN作用原理揭开衰老真相科学期刊《Cell》用NMN作用原理：在生命科学领域的探索，科学家们意识到，几乎所有的疾病都是由细胞的「老化」而来。

过去人类历史上，我们都把“衰老”看作一个必然的过程。

比如我们常说的“生老病死”，就是我们常说的“落叶归根”，比如，幼年比喻春天，青年隐喻夏天，中年隐喻秋天，老年隐喻冬季。

大家都认为这是一种「天道」，知道不计其数的故事，秦始皇派徐福去求仙，但蕞终不能得，皇帝炼丹求长生，顶多是重金属中毒。

nmn的抗衰老研究：简述nmn抗衰老作用原理，W+NMN升级后衍生的细胞修复因子，增强了对皮肤的修复力nmn的抗衰老研究：简述nmn抗衰老作用原理，随着W+NMN技术的日益成熟，衍生了外泌体、细胞因子等新一代技术的研究。

细胞因子是W+NMN培养生长过程中分泌的多肽物质，常见成员包括了EGF、bFGF、TGF-β、NGF、VEGF等，促進成纤维细胞代谢和胶原蛋白再苼及组织修复的功能。

人的皮肤中有许多连接细胞、支持皮肤结构的胶原蛋白，这是使皮肤饱满、细腻又光滑的关键。

W+NMN唤醒及修复受损的皮肤细胞，提升细胞的再苼能力；增强内分泌系统的自身调节能力，修复肌肤的保水性能，使皮肤减少皱纹的产生，保持细嫩光滑；同时改進细胞循环W+NMN作用于面部后，面部肌肤分泌胶原蛋白、透明质酸、弹性纤维等物质，使皮肤紧致、亮白光泽、淡化色素沉着，同时修复空气污染、紫外线辐射等带来的敏锐肌肤的损伤。

W+NMN是再苼和修复年轻容颜的根本细胞，为皮肤系统的细胞更新再生提供了充足的来源。

新生的细胞代谢能力较强，能够及时排出废物，防止皮肤色素的沉积，抑制和减少色斑的形成；新生分化的年轻细胞保水性较好，足以使衰老的皮肤恢复细腻光滑；同时，合成大量胶原蛋白与弹性蛋白，恢复肌肤弹性，减少皱纹，从根本上改進和修复皮肤系统的质量。

返老还童的理解词语英文回答：The concept of rejuvenation, often referred to as reversing the aging process, has intrigued scholars, scientists, and philosophers for centuries. As we delveinto the complexities of time, biology, and the human condition, various terms and expressions have emerged to describe the multifaceted aspects of返老还童.Rejuvenation: The overarching term for the process of reversing or slowing down the aging process. It encompasses a wide range of interventions, from cosmetic procedures to biomedical therapies, that aim to restore a youthful state or prevent age-related decline.Youth Restoration: A specific subset of rejuvenation focused on restoring youthful characteristics, such as improved skin elasticity, increased energy levels, and enhanced cognitive function. Youth restorationinterventions typically target the underlying mechanisms of aging, such as cellular senescence and oxidative stress.Anti-Aging: A broad term encompassing a range of strategies aimed at preventing or delaying the onset ofage-related changes. Anti-aging interventions may include lifestyle modifications, such as diet and exercise, as well as medical treatments that target specific aging-related pathways.Age Reversal: A more ambitious goal than rejuvenation, age reversal seeks to turn back the biological clock and actually restore the body to a younger state. This concept is still in the realm of theoretical research, with no proven interventions currently available.Chronological Age: The number of years a person has lived since their birth. It is a simple measure of age that does not take into account individual differences in biological aging.Biological Age: A measure of the physiological age of aperson based on their health, fitness, and other biomarkers. Biological age can be different from chronological age,with some individuals aging faster or slower than their chronological peers.Aging in Reverse: A hypothetical state where the aging process is completely reversed, and the body returns to a youthful state. This concept is not currently supported by scientific evidence and remains a topic of speculation.中文回答：返老还童，指逆转衰老过程，恢复青春状态。

2022-2023学年第一学期高三期初学情调研测试英语试题注意事项1、本试卷满分150分。

考试时间120分钟。

2. 答题前, 务必将自己的学校、姓名、考试号等相关信息写在答题卡上规定的地方。

3. 回答选择题时, 选出每小题答案后, 用2B铅笔把答题卡上对应题目的答案标号涂黑；回答非选择题时, 将答案写在答题卡上, 写在本试卷上无效。

第一部分听力（共20小题；每小题1. 5分, 满分30分）第一节听下面5 段对话, 每段对话后有一个小题。

从题中所给的A、B、C 三个选项中选出最佳选项, 并标在试卷的相应位置。

听完每段对话后, 你都有10秒钟的时间来回答有关小题和阅读下一小题。

每段对话仅读一遍。

1. What is the relationship between the speakers ?A. Colleagues.B. Teacher and student.C. Doctor and patient.2, Why is the woman driving?A. Her husband is ill.B. Her husband never drives.C. Her husband is away on business this week.3. What does the man suggest the woman do?A. Follow him.B. Eat her lunch.C. Wear warmer clothing.4. Who owns the umbrella?A. Debbie.B. Jane.C. Jennifer.5. What is the woman curious about?A. The weather.B. Her clothing.C. The shops.第二节听下面5段对话或独白。

每段对话或独白后有几个小题, 从题中所给的A、B、C 三个选项中选出最佳选项。

22年英一完形题2022年英语一完形填空真题及答案如下：In the 1980s, the first wave of “super-agers” began to appear in the United States. These individuals were people in their 80s and 90s who were still as cognitively and physically healthy as much younger adults. The phenomenon of super-agers has 1 increasing interest in anti-aging research.Super-agers make up only a small percentage of the elderly population, but they are an inspiring example of healthy aging. They typically have low levels of chronic diseases, strong mental faculties, and a high degree of physical and social 2. They often continue to work or engage in hobbies and other activities well into their later years.The term “super-agers” was first coined by psychiatrists studying people with extreme memory abilities. These individuals, often in their 70s or 80s, had memories that were as good as those of much younger adults. However, they also had unique cognitive and neuralcharacteristics that set them apart from typical older adults. For example, they had more efficient neural processing and better cognitive flexibility than 3 people their age.Super-agers seem to have some protective factors that help them maintain their cognitive and physical health. One possible factor is their diet. A study found that super-agers had a higher intake of certain B vitamins, which are essential for brain health. Another factor is their mental attitude. Super-agers tend to be highly resilient and positive individuals who view aging as a time of opportunity and growth rather than decline.In conclusion, the phenomenon of super-agers suggests that it is possible to achieve a high level of cognitive and physical health well into old age. By understanding the characteristics and protective factors of super-agers, we can gain insights into the aging process and develop better strategies for healthy aging.完形填空答案：1. A. generated2. C. engagement3. D. less efficient4. B. lifestyle5. C. resilient。

China Pharmacy 2022V ol.33No.14中国药房2022年第33卷第14期恶性肿瘤药物治疗相关不良事件健康状态负效用测量研究的系统评价Δ卢钰琼＊，代展菁，路云，常峰#（中国药科大学国际医药商学院，南京211198）中图分类号R 956文献标志码A 文章编号1001-0408（2022）14-1748-06DOI 10.6039/j.issn.1001-0408.2022.14.15摘要目的为我国开展健康状态负效用测量研究、计算药物经济学评价中的健康产出提供方法学参考。

方法计算机检索中国知网、万方数据、维普网3个中文数据库和PubMed 、Web of Science 、the Cochrane Library 3个英文数据库中有关恶性肿瘤药物治疗相关不良事件负效用测量的文献，检索时限均为各数据库建库起至2021年7月。

由2名研究者独立筛选文献并提取资料后进行定性分析，采用改良后的英国国家卫生与临床优化研究所决策技术支持文件进行质量评估，总结健康状态负效用测量的实践情况和存在问题并提出建议。

结果共纳入相关文献77篇。

首篇文献发表于1991年，之后发表数量呈波动式上升。

77篇文献共涉及120种不良事件，以效用研究（49篇，63.64％）为主，仅有3篇（3.90％）的调查国家/地区涉及中国。

35篇文献（45.45％）未说明研究设计类型；48篇（62.34％）未说明健康状态开发方法；52篇（67.53％）未说明健康状态验证方法；46篇（59.74％）设定并说明了基础健康状态；20篇（25.97％）进行了健康状态排名；应用的效用测量工具主要为标准博弈法和欧洲五维健康量表（各23篇，各占29.87％）；45篇（58.44％）的调研对象为患者人群；63篇（81.82％）未说明人群代表性检验；效用报告类型包括负值、非负值以及合并基础状态的非负值3种类型；45篇（58.44％）未说明效用统计方法。