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化学传递学说的发展
100多年前 化学传递？电传递？
1921: 德国科学家 Loewi 的双蛙心实验
1926年: Dale等证明迷走物质为乙酰胆碱
(Acetylcholine , ACh) 1936年获诺贝尔奖
1946：Von Euler 证明拟交感胺物质为去甲肾
上腺素Norepinephrine （NE）或 Noradrenaline （NA）
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化学传递？电传递？
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The idea for the famous heart experiment came to Otto Loewi in his sleep. In Loewi's own words: "In the night of Easter Saturday, 1921, I awoke, turned on the light, and jotted down a few notes on a tiny slip of paper. Then I fell asleep again. It occurred to me at six o'clock in the morning that during the night I had written down something most important, but I was unable to decipher the scrawl. That Sunday was the most desperate day in my whole scientific life. During the next night, however, I awoke again, at three o'clock, and I remembered what it was. This time I did not take any risk; I got up immediately, went to the laboratory, made the experiment on the frog's heart, described above, and at five o' clock the chemical transmission of nervous impulse was conclusively proved."--- quoted from Loewi, O., From the Worksh o p o f Disco veries , Lawren ce : Un iv ersity o f Kansas Press, 1953 .
