4. Title and Subtitle
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I:根据JCR分类的期刊的影响因子、全称相关的问题,练习使用JCR和作者查询;5%--5道题II:根据Web of Science搜索作者+单位+领域得到的文章及被引次数的问题;5%--5道题III:一篇Title+Abstract的划分几部分,每部分分别到哪里相关的问题;P20810%--5道题Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. AbstractWithout an approved vaccine or treatments,Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission.These approaches,however,have yet to end the2014outbreak of Ebola after its prolonged presence in West Africa./Here we show that a combination of monoclonal antibodies(ZMapp),optimized from two previous antibody cocktails,is able to rescue 100%of rhesus macaques when treatment is initiated up to5days post-challenge./High fever,viraemia and abnormalities in blood count and blood chemistry were evident in many animals before ZMapp intervention.Advanced disease,as indicated by elevated liver enzymes,mucosal haemorrhages and generalized petechia could be reversed,leading to full recovery.ELISA and neutralizing antibody assays indicate that ZMapp is cross-reactive with the Guinean variant of Ebola./ZMapp exceeds the efficacy of any other therapeutics described so far,and results warrant further development of this cocktail for clinical use.Questions:11.Among the eight types of titles,which type does this title belong to?A:noun phrase and prepositional phrase.12.How many parts can you divide the abstract into Name each part?A:Four parts.1.Background,2.objective,3.Methods and Reults,4.Conclusion.13.What is the objective of the study?A:Here we show that…up to5days post-challenge.14.What are the results?A:Advanced disease…with the Guinean variant of Ebola.15.In the sentence,”Advanced disease,as indicated by elevated liver enzymes,mucosal haemorrhages and generalized petechia could be reversed,leading to full recovery.”Please translate the term“generalized petechia”into Chinese?A:全身瘀斑IV:最后一次课,无PPT一篇Introduction+Reference Title:P21720%--10道题IntroductionEbola virus(EBOV)infections cause severe illness in humans,and after an incubation period of3to21days,patients initially present with general flu-like symptoms beforea rapid progression to advanced disease characterized by hemorrhage,multi-organ failure and a shock-like syndrome1.In the spring of2014,a new EBOV variant emerged in the West African country of Guinea2,an area in which EBOV has not been previously reported.Despite a sustained international response from local and international authorities including the Ministry of Health(MOH),World Health Organization(WHO)and Médecins Sans Frontières(MSF)since March2014,the outbreak has yet to be brought to an end after five months.As of15th August2014, there are2127total cases and1145deaths spanning Guinea,Sierra Leone,Liberia and Nigeria3.So far,this outbreak has set the record for the largest number of cases and fatalities,in addition to geographical spread4.Controlling an EBOV outbreak of this magnitude has proven to be a challenge and the outbreak is predicted to last for at least several more months5.In the absence of licensed vaccines and therapeutics against EBOV,there is little that can be done for infected patients outside of supportive care,which includes fluid replenishment,administration of antivirals,and management of secondary symptoms6,7.With overburdened personnel,and strained local and international resources,experimental treatment options cannot be considered for compassionate use in an orderly fashion at the moment.However,moving promising strategies forward through the regulatory process of clinical development has never been more urgent.Over the past decade,several experimental strategies have shown promise in treating EBOV-challenged nonhuman primates(NHPs)after infection.These include recombinant human activated protein C(rhAPC)8,recombinant nematode anticoagulant protein c2(rNAPc2)9,small interfering RNA(siRNA)10,positively-charged phosphorodiamidate morpholino oligomers(PMO plus)11,the vesicular stomatitis virus vaccine(VSVΔG-EBOVGP)12,as well as the monoclonal antibody(mAb)cocktails MB-003(consisting of human or human-mouse chimeric mAbs c13C6,h13F6and c6D8)13and ZMAb(consisting of murine mAbs m1H3,m2G4and m4G7)14.Of these,only the antibody-based candidates have demonstrated substantial benefits in NHPs when administered greater than24hours past EBOV exposure.Follow-up studies have shown that MB-003is partially efficacious when administered therapeutically after the detection of two disease“triggers”15,and ZMAb combined with an adenovirus-based adjuvant provides full protection in rhesus macaques when given up to72hours after infection16.The current objective is to develop a therapeutic superior to both MB-003and ZMAb, which could be utilized for outbreak patients,primary health-care providers,as well as high-containment laboratory workers in the future.This study aims to first identify an optimized antibody combination derived from MB-003and ZMAb components, before determining the therapeutic limit of this mAb cocktail in a subsequent experiment.In order to extend the antibody half-life in humans and to facilitate clinical acceptance,the individual murine antibodies in ZMAb were first chimerized with human constant regions(cZMAb).The cZMAb components were then producedin Nicotiana benthamiana17,using the large-scale,cGMP-compatible Rapid Antibody Manufacturing Platform(RAMP)and magnICON vectors that currently also manufactures the individual components of cocktail MB-003,before efficacy testing in animals.References1.Bausch DG,Sprecher AG,Jeffs B,Boumandouki P.Treatment of Marburg and Ebola hemorrhagic fevers:a strategy for testing new drugs and vaccines under outbreak conditions.Antiviral Res.2008;78:150–161.doi:10.1016/j.antiviral.2008.01.152.[PubMed][Cross Ref]2.Baize S,et al.Emergence of Zaire Ebola Virus Disease in Guinea-Preliminary Report.N Engl J Med.2014doi:10.1056/NEJMoa1404505.[PubMed][Cross Ref]3.WHO.int.WHO-Ebola virus disease(EVD)2014<http://www.who.int/csr/don/archive/disease/ebola/en/>..Chronology of Ebola Hemorrhagic FeverOutbreaks.2014</vhf/ebola/resources/outbreak-table.html>.5.Reliefweb.int.W.African Ebola epidemic‘likely to last months’:UN.2014<http://reliefweb.int/report/guinea/w-african-ebola-epidemic-likely-last-mo nths-un>.6.Clark DV,Jahrling PB,Lawler JV.Clinical management of filovirus-infected patients.Viruses.2012;4:1668–1686.doi:10.3390/v4091668.[PMC freearticle][PubMed][Cross Ref]7.Guimard Y,et anization of patient care during the Ebola hemorrhagic fever epidemic in Kikwit,Democratic Republic of the Congo,1995.J InfectDis.1999;179(Suppl1):S268–273.doi:10.1086/514315.[PubMed][Cross Ref]8.Hensley LE,et al.Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever.J Infect Dis.2007;196(Suppl2):S390–399.doi: 10.1086/520598.[PubMed][Cross Ref]9.Geisbert TW,et al.Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor:a study in rhesus ncet.2003;362:1953–1958. doi:10.1016/S0140-6736(03)15012-X.[PubMed][Cross Ref]10.Geisbert TW,et al.Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference:a proof-of-conceptncet.2010;375:1896–1905.doi:10.1016/S0140-6736(10)60357-1.[PubMed][Cross Ref]Questions:16.What is the difference between abstract and introduction?A:There are no references in the abstract and no results in introduction.17.How many parts can you divide the introduction into?Name each part?A:Four Parts.Background,Conclusion,Objective,Method18.What problem is posed on this article?A:The current objective is to develop a therapeutic superior to both MB-003and ZMAb,which could be utilized for outbreak patients,primary health-care providers, as well as high-containment laboratory workers in the future.19.In the first paragragh,what does“supportive care”refer to?A:It includes fluid replenishment,administration of antivirals,and management of secondary symptoms20.What style of referencing system does it belong to?A:Citation order system.21.How many authors are listed in item1?A:Four.22.Where is the article published in Item2?A:New England Journal of Medicine.23.What kind of the reference source does item3belong to?24.What type does the title belong to in item10?A:Title and subtitle25.Please translate the Chinese title“肝素疗法的前瞻性随机研究:into English by using the same method as Item10.A:Heparin therapy:Prospective randomized studyVI:Journal Instruction for authors:10%--11道题General InformationJAMA Internal Medicine is an international peer-reviewed journal providing innovative and clinically relevant research for practitioners in general internal medicine and internal medicine subspecialities. The Editor of JAMA Internal Medicine is Rita F.Redberg,MD,MSc,University of California San Francisco School of Medicine,San Francisco,California.The journal is published online every Monday and in print each month.Authorship Criteria and Conditions and Authorship FormEach author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content.One or more of the authors should take responsibility for the integrity of the work as a whole,from inception to published article.1,2According to the guidelines of the International Committee of Medical Journal Editors(ICMJE),as revised in2013,2authorship credit should be based on the following4criteria:(1)substantial contributions to conception or design of the work,or the acquisition,analysis,or interpretation of data for the work;and(2)drafting of the work or revising it critically for important intellectual content;and(3)final approval of the version to be published;and(4)agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Each author should be accountable for the parts of the work he or she has done.In addition,each author should be able to identify which coauthors are responsible for specific other parts of the work and should have confidence in the integrity of the contributions of any coauthors.Changes in AuthorshipAuthors should determine the order of authorship among themselves and should settle any disagreements among themselves before submitting their manuscripts.Changes in authorship(ie,order,addition,and deletion of authors)should be discussed and approved by all authors.Any requests for such changes in authorship after initial manuscript submission and before publication should be explained in writing to the editor in a letter or email from all authors.1(pp134-135)Manuscript SubmissionManuscripts should be submitted online via the online manuscript submission and review system.At the time of submission,complete contact information(affiliation,postal/mail address,e-mail address, telephone and fax numbers)for the corresponding author is required.First and last names,e-mail addresses,and institutional affiliations of all coauthors are also required.Manuscripts submitted through the online system should not also be submitted by mail or e-mail.After the manuscript is submitted,the corresponding author will receive an acknowledgment confirming receipt and a manuscript number.Authors will be able to track the status of their manuscripts via the online system. After manuscript submission,all authors of Letters to the Editor and Invited Commentaries will be sent an Authorship Form to complete and submit(see sample Authorship Form).All authors of all other manuscripts will receive an Authorship Form at the time of request for/receipt of a revision to their manuscript.See Manuscript Checklist,Manuscript Preparation and Submission Requirements,1,2and other details in these instructions for additional requirements.Manuscript StyleManuscripts should be prepared in accordance with the AMA Manual of Style,10th edition,1and/or the ICMJE Recommendations for the Conduct,Reporting,Editing,and Publication of Scholarly Work in Medical Journals.TitleTitles should be concise,specific,and informative and should contain the key points of the work.1(p8) Please limit the length of titles to150characters for reports of research and other major articles and 100characters for Editorials,Viewpoints,Commentaries,and Letters.For scientific manuscripts, overly general titles are not desirable and questions and declarative sentences should be avoided.For reports of clinical trials,meta-analyses,and systematic reviews,include the type of study as a subtitle (eg,A Randomized Clinical Trial,A Meta-analysis,A Systematic Review).For reports of other types of research,do not include study type or design in the title or subtitleReferencesAuthors are responsible for the accuracy and completeness of the references and for their correct text citation.Cite all references in the text or tables.Number references in the order they appear in the text;do not alphabetize.In text,tables,and legends,identify references with superscript arabic numerals.When listing references,follow AMA style1(pp39-79)and abbreviate names of journals according to the journals list in PubMed.List all authors and/or editors up to6;if more than6,list the first3followed by“et al.”Note:Journal references should include the issue number in parentheses after the volume number.Examples of reference style:1.Garbutt JM,Banister C,Spitznagel E,Piccirillo JF.Amoxicillin for acute rhinosinusitis:a randomized controlled trial.JAMA.2012;307(7):685-692.2.Centers for Medicare&Medicaid Services.CMS proposals to implement certain disclosure provisions of the Affordable Care Act./apps/media/press/factsheet.asp?Counter=4221.Accessed January30,2012.3.McPhee SJ,Winker MA,Rabow MW,Pantilat SZ,Markowitz AJ,eds.Care at the Close of Life: Evidence and Experience.New York,NY:McGraw Hill Medical;2011.Questions:25.What kinds of articles does JAMA provide?A:They provide innovative and clinically relevant research for practitioners in general internal medicine and internal medicine subspecialities.26.How many criteria are the authorship credit based on?A:There are4criteria.27.What is required if there are changes in authorship?A:Any requests for such changes in authorship after initial manuscript submission and before publication should be explained in writing to the editor in a letter or email from all authors28.Can authors submit their articles via mail or e-mail?A:No29.How do authors know the status of their manuscript?A:Authors will be able to track the status of their manuscripts via the online system30.What is the requirement for the title of reports of research and other major articles?A:Please limit the length of titles to150characters for reports of research and other major articles 31.Structured abstract can be further divided into two kinds.What are they?A:The first kind is divided into five parts:Background,Objective,Methods,Results and Conclusion and the other one is divided into four parts:Objective,Methods,Results and Conclusion.32.In test,tables,and legends,how are the references identified?A:In text,tables,and legends,identify references with superscript arabic numerals.33.If the authors are more than six,how to list the authors’name?A:if more than6,list the first3followed by“et al.”34.In reference Item3,what is“Care at the Close of Life:Evidence and Experience”?A:The name of the cited book.35.In reference Item3,NY:McGraw Hill Medical is publisher.。
Scope and Policy of the JournalBiomedical Research on Trace Elements (BRTE) is the official quarterly journal of the Japan Society for Biomedical Research on Trace Elements, publishing articles regarding research on trace elements. Submitted manuscripts must be in English or Japanese with the work described not being submitted for publication elsewhere. Manuscripts will be reviewed by two or more specialists. Manuscripts accepted for publication become the copyright of the Japan Society for Biomedical Research on Trace Elements. When appropriate, fully informed consent should be obtained and noted in the manuscripts.Manuscript CategoriesAuthors are invited to submit articles in the following categories:1. Review Article;2. Original Article (including Rapid Communication);3. Case Report; The maximum length of Review Articles are twelve, Original Articles are eight, Rapid Communications and Case Reports are four printed pages, respectively, including all text, figures and tables. About 4,800 characters (including space) can be printed in one page if it contains no figure and table.ManuscriptsManuscripts should be submitted by e-mail preferably as files less than 5 megabytes in size or sent in triplicate (including figures and tables) by registered mail to: Editor-in-Chief, Biomedical Research on Trace Elements, Hideo Saji, Ph.D, Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.Tel: +81-75-753-4567E-mail:brte@pharm.kyoto-u.ac.jpAuthors should keep one set of text, tables, and illustrations, as the Editor cannot accept responsibility for loss or damage to manuscripts. Manuscripts and Discs will not be returned to authors.Manuscripts should be clearly typed in double-spacing on one side only ofgood-quality A4 paper (30 × 21 cm).Conventional ManuscriptThe manuscript should be arranged as follows, with each section beginning on a separate page.1.Cover letter: Manuscripts should be accompanied by a cover letter, statingthat the manuscript is not being submitted for publication elsewhere.2.Title Page: The title page should include the following, in this order:(1)The category of the manuscript (as listed above) should appear on the titlepage. (2) Title and subtitle. (3)A short running title, no longer than 50 words. (4) Full names of the authors. (5) Departments and institutions in which the work was performed. (6) Name and the full postal address, E-mail address, and the telephone and facsimile number of the corresponding author.(7) Number of text pages, reference pages, tables, figures, and legends tofigures.3.Abstract should be a concise abstract of no more than 300 words.4.Key words: No more than five key words.5.Text: The text of an observational and experimental article is usuallydivided into sections with the following headings: Introduction, Methods, Results, and Discussion. Long articles may need subheadings within somesections.6.Acknowledgements: Acknowledgements should be made only to persons who havemade genuinecontributions and who endorse the data and conclusions.7.References: Cite references in the text by using superior Arabic numeralsin the order in which they appear in the text. Abbreviate titles of thejournals according to the Index Medicus.Examples of correct reference format:Standard journal articles (list all authors when six or less; when seven or more list only the first six and add et al.).[6] Du SL, Leng T, Gu YH, Ushijima H, Kodama H. Long-term treatment with high-dose zinc sulphate in 36 children with Wilson's disease. Biomed Res Trace Elements 2002; 13: 85-88.Books and monographs[8] Kodama H. Molecular genetics and clinical aspects of Menkes disease and occipital horn syndrome. In: Massaro EJ, editor. Handbook of Copper Pharmacology and Toxicology. New Jersey: Humana Press, 2002: 319-332.8.Tables and FiguresIn preparing a manuscript, consider one table or figure (or a set of figures given the same figure number) as equivalent to a single typed page.(1) Tables should be included on a separate page, numbered with Arabicnumerals, and accompanied by short titles at the top. Each table must be referred to in the text. Explanatory matter should be placed in footnotes below the tabular matter and not included in the title. Vertical rules and horizontal rules between entries should be omitted.(2) High-contrast photographic copies of the original line drawings, reducedto final journal dimensions, are required. Photographs must be sharp, glossy black-and-white prints. Quality laser printouts, with a minimum resolution of 300 dpi, are equally acceptable.The whole cost of reproducing color figures will be charged to the author(s).(3) Figure Legends: All figures require legends typed on a separate sheetand double-spaced. All illustrations are classified as figures and should be numbered with Arabic numerals in the order in which they are referred to in the text. When a full facial photograph is to be reproduced, writtenpermission from the patient or the patient's guardian should be attached to the corresponding figure legend.OffprintsThirty offprints will be supplied free to authors, but additional copies may be ordered on the printed form sent with the proofs.Charges to Author(s)1.Color in Print: Authors are responsible for the costs of color reproduction.2.Charge for English Editing: Accepted manuscripts may be copy-edited at theeditor's discretion.Manuscripts on Disk1.Authors are required to provide their manuscript on disk in the case ofsending a manuscript by registered mail when the manuscript was accepted.Authors should use a new disk rather than a reformatted disk, and the disk should contain the relevant file(s) only. Authors should supply theiraccepted paper as formatted text (most word-processing formats can behandled). It is essential that the hardware and the word-processing package are specified on the disk (e.g. IBM, Word 2000), as well as the first author's surname and the manuscript title.2.The entire article - (i) title page, (ii) text, (iii) acknowledgements, (iv)references, (v) figure legends, (vi) tables and legends, (vii) appendices - should be saved in a single file; only electronic figures should be supplied as separate files. The following instructions should be adhered to.It is essential that the final, revised version of the manuscript and the file saved on disk are identical (i.e authors should supply a new disk if the article is revised).Do not use the carriage return (enter) at the end of lines within a paragraph.Do not use l (ell) for 1 (one), O (upper case oh) for 0 (zero) or s (German esszett) for s (beta), and specify any special characters used to represent non-keyboard characters.Use a tab, not spaces, to separate data points in tables.。
PARENTHETICAL CITATION and the WORKS CITED: MLA STYLEDepartment of English and Film Studies, University of Alberta 2010The MLA style (MLA Handbook, 2009) allows documentation of an abbreviated kind to appear in the body of your essay in parentheses, thus eliminating all but explanatory or elucidatory footnotes. The parenthetical citations will refer your reader to a list of “Works Cited” (see below) in which all sources quoted or referred to will be alphabetically arranged.Parenthetical Citation1. Author’s name mentioned. If you introduce a quotation or fact or paraphrase by mentioning the author’s name, you need only give the pagination.An early authority on fairy tales, Henry Bett, claims that the wholestudy was shoddy but “very instructive” (53).Note: When a quotation ends with an exclamation mark or a question mark, leave the punctuation inside the quotation marks and place the period after the parentheses: Bett thought that the whole study was shoddy but “very instructive!” (53).2. Author’s name not mentioned. If you do not mention the author’s name before you quote, you should include the last name in parentheses with no punctuation between the name and the page numberOne early authority on fairy tales referred to the whole study as a shoddy but“very instructive” exercise (Bett 53).3. Author unknown. Some very old documents, and some very new on-line ones, may not have a known author, or may not state an author’s name. You can signal the title of the work, or include a short title in parentheses.The Harvard Report on Baseball Deaths had no firm figures for 1911.One source had no firm figures for 1911 (Harvard).n.b. Book titles are italicized; article titles are placed between quotation marks.4. Page number unknown. Many web sources have no page numbers. You may omit the page number and just use the author’s name or the title of the article.Researchers have noticed a sharp rise in death by boredom at major golf tournaments (Duffer).Duffer says that golfing head injuries are on the rise (“Golf Woes”).If a web source uses paragraph or screen numbers, use “par.” or “pars.” or “Screen” in parentheses: (Duffer pars. 2-3).5. Two or more authors. Include the last names in parentheses as they are listed in the text from which you are citing.(Duffer and Curses 45)For more than three authors use “et al.” (Duffer et al 45).6. A multi-volume work. Give the number of the volume followed by a colon and then the page number.In the second volume of Hegel’s Aesthetics, he discusses the sublime features of the puppet show(2: 350-355).7. Verse plays and poems. Give the act, scene, and line numbers from the play. Separate these with periods.In King Lear Gloucester cries foul when his eyes are taken out (4.2 148-149).Or if the play’s name is not mentioned, include it in the citation.This is similar to the moment when Gloucester loses his eyes (Lear, 4.2 148-149).When quoting poetry, give the line numbers and show the line breaks.In Cowper’s, The Task, the author says that Milton’s poetry “surpassed/ The struggling effortsOf my boyish tongue/ To speak its excellence” (4. 710-12).When quoting three or more lines of poetry, do not use quotation marks (unless they appear in the text itself) and indent the quotation one tab. You do not need to use slashes to show line breaks in this case, but must be sure to reproduce the text precisely.In “Inchoate Road” bp Nichol traces the language of place, reading in the Assiniboine and RedRiversthosealphabets theseriversstrokes ofpens together in the plainwords dried ink dyesstrained thru books (3 14-19)8. Placement of parenthetical reference. When quoting part of a sentence (or line of poetry) or less than three sentences (or lines), put the quotation in quotation marks and integrate it into your own text, changing tense and grammar as needed. In this case, the parenthetical reference follows the closing quotation mark (with one space in between) and punctuation follows the parenthetical reference: i.e. …end of quotation” (Smith 31). When quoting more than three sentences, indent the quotation. You do not need to use quotation marks in this case, since the indent serves the same symbolic purpose as quotation marks for longer quotations. For longer, indented quotation, the quotation is closed with punctuation and the parenthetical reference follows the closing punctuation:i.e. … end of quotation. (Smith 31)Works CitedThe list of works cited appears at the end of your essay, following your last sentence. It is organized alphabetically by the authors’ last names and by the names of sources for which the author is unknown. The works cited should be double spaced, with no extra space left between entries. The first line of each entry, with the author’s last name or the name of the source when the author is unknown, is flush with the left margin. All subsequent lines in each entry are indented. The works cited must include every work from which you quote or to which you refer in the essay, and must not include any you do not actually cite. The works cited must match the parenthetical references in your essay: i.e. if you refer in the essay to Smith, then Smith must be the point of identification for that source in the works cited.There are many possible sources across a range of media. You may be quoting from print and web materials, films, interviews, radio programs, class notes, letters, emails, TV shows, videos, DVDs, advertisements, or other sources. In order to ensure that you are quoting from and citing your sources correctly, check the online citation guides available through the Humanities and Social Sciences Library, “Using MLA Style to Cite and Document Sources” (http://www.library.ualberta.ca/subject/english/mla/index.cfm).The basic principle of MLA style, however, is that there are certain necessary fields for every type of citation. Examples are provided here for print and online books, and for print and online articles. For all other sources, as well as for edited volumes, later editions, reprints, translations, works without authors, works with multiples authors, or multiple works by a single author, please check the online citation guides or the MLA Handbook.A print book. 1 Author (last name first)2 Title and subtitle (underlined or italicized)3 City of publication4 Publisher5 Date of publication6 Medium1 2 3 4 5 6Michaels, Anne. Fugitive Pieces. Toronto: McClelland and Stewart, 1996. Print.An online book. 1 Author (last name first)2 Title and subtitle (underlined or italicized)3 Title of web site (underlined or italicized)4 Sponsor of site5 Update date (“n.d.” if there is no date)6 Medium7 Date of access1 2 3 4 5 6 7Milton, John. Paradise Lost: Book I. . Poetry Foundation, 2008. Web. 14 Dec. 2008.An article in a periodical. 1 Author (last name first)2 Title and subtitle of article (in quotation marks—not underlined or italicized)3 Name of periodical (underlined or italicized)4 Volume and issue number (for scholarly journal)5 Date or year of publication6 Inclusive page numbers7 Medium1 2 3Gerson, Carole. “The Snow Drop and The Maple Leaf: Canada’s First Periodicals for Children.” Canadian Children’s Literature 18-19 (1980): 10-23. Print.4 5 6 7An article accessed online. 1 Author (last name first)2 Title of article (in quotation marks—not underlined or italicized)3 Name of periodical, volume and issue numbers4 Date of publication5 Inclusive page numbers6 Name of database (underlined or italicized)7 Medium of database8 Date of access1 2 3Davis, Rocío G. “A Graphic Self: Comics as Autobiography in Marjane Satrapi’s Persepolis.” Prose Studies: History, Theory, Criticism 27.3 (2005): 264-79. EBSCOhost. Web. Dec. 18, 2009.4 5 6 7 8A work in an anthology. 1 Author (last name first)2 Title of work (in quotation marks)3 Title of anthology (underlined or italicized)4 Editor(s) (names not reversed)5 Place of publication6 Publisher7 Date of publication8 Inclusive page numbers9 Medium1 2 3 4 Erdrich, Louise. “Dear John Wayne.” The Longman Anthology of World Literature. Volume F. The Twentieth Century. Ed.Djelal Kadir and Ursula K. Heise. New York: Pearson Longman, 2004. 737-38. Print.5 6 7 8 9A DVD. Note that the title of the film/DVD appears first.Finding Neverland. Dir. Marc Forster. Perf. Johnny Depp, Kate Winslet, Julie Christie, Radha Mitchell, and Dustin Hoffman. Miramax, 2004. DVD.Please note that your essay must include page numbers and your last name in the top right corner of every page. There should be no separate title page. Your name, the course title, the instructor’s name, and the date of the assignment should appear in the top left corner of the first page only, double spaced. The title of your essay should appear immediately below this information, and the essay should begin immediately below the title. Double space the entire essay, including the works cited. Do not leave extra space between paragraphs. Your essay title should not be underlined. You should use a 12 point font throughout the essay.Your NameENGL course numberInstructor’s NameDateThe Really Interesting Title of Your Essay including the Title and Author of the Work You Are Discussing Your essay should begin with the first paragraph indented. You should leave margins of around an inch on all sides, as we have done on this sample page. The text of your essay will be flush with the left margin, but the right margin should remain unjustified. If you try to align the right margin, it may interfere with spacing in your essay. When you are quoting, it is productive to use signal phrases whenever you can: in this way, you can integrate quoted material and identify the author of the material you are quoting. You might signal a quotation in this way: as Smith has suggested, “quoting is the best way to demonstrate to your reader why s/he should believe the claims you are making about a particular work of literature” (72). If you are not identifying the author in your sentence, you need to be sure to identify him or her in the parenthetical reference following the quotation (Smith 72). It is very important to familiarize yourself with the elements of MLA style that are relevant to your essay. Use the online library resources to find the correct way of citing and documenting all the sources you use in your essay.Begin your next paragraph in the same way, indenting it and not leaving extra space between the two paragraphs.。
论文作文纸题目和副标题格式模板英文回答:Paper Title and Subtitle Formatting Template for Essay Papers。
Title: The Importance of Formatting Titles and Subtitles in Essay Papers。
Subtitle: A Guide for Students。
Title: The Impact of Social Media on Adolescent Development。
Subtitle: An Examination of the Positive and Negative Effects。
Title: The Challenges of Teaching in the 21st Century。
Subtitle: Facing the Evolving Needs of Students in aDigital Age。
Title: The Role of Artificial Intelligence in the Healthcare Industry。
Subtitle: Transforming Diagnosis, Treatment, and Patient Outcomes。
Title: The Ethics of Genetic Engineering。
Subtitle: Balancing Scientific Advancements with Social Responsibilities。
Title: The Impact of Climate Change on Coastal Communities。
Subtitle: Rising Sea Levels and the Threat to Coastal Populations。
Chinese Answer:论文题目与副标题格式模板。
八种基本标题类型
标题在文档、文章或演示文稿中起着重要的组织和引导作用。
以下是八种基本的标题类型:
1.顶级标题(Title):文档或文章的主要标题,通常在开头展示,概括整个内容,具有最高级别的重要性。
2.副标题(Subtitle):位于顶级标题之下,用于进一步说明或概括主标题的内容,提供更多细节或信息。
3.章节标题(Chapter Heading):用于区分文章或文档中的不同章节或主要部分,具有较高的层次结构。
4.子章节标题(Subchapter Heading):在章节标题之下,用于划分章节内的不同子部分或主题,使内容更具可读性。
5.次级标题(Subheading):在章节或子章节标题之下,用于进一步细分内容、引领段落或小节,帮助读者更好地理解主题。
6.标签标题(Tagline):通常用于引言或广告中,简洁地概括或强调主题,吸引读者或观众的注意力。
7.问题标题(Question Heading):将问题或疑问形式呈现为标题,引导读者思考或激发兴趣。
8.功能性标题(Functional Heading):指导或说明特定功能、步骤或过程的标题,用于指导读者执行特定任务或操作。
这些标题类型可以根据文档或内容的特性和目的进行组合和应用,有助于提供清晰的结构和引导,使读者更容易理解和导航文档的内容。
2 Robots1. How has robot become the familiar figure in popular culture over the past century?Over the past century, robot has become the familiar figure in popular culture through books such as Isaac Asimov’s I, Robot, movies such as Star Wars and television shows such as Star Trek.2. What is the reason for the gap between real robots and their science-fiction counterparts according to the passage?One reason for this gap is that it has been much harder than expected to enable computers and robots to sense their surrounding environment and to react quickly and accurately.3. What was the goal of Bill Gate s’ visiting several leading universities about computer talks in 2004?His goal was to help students understand how exciting and important computer science can be, and he hoped to encourage a few of them to think about careers in technology.4. What are the two greatest fruits that Craig Mundie’s team has achieved?One is tackling the problem of concurrency, and the other is the development of the technology DSS (decentralized software services) which helps to simplify the writing of distributed robotic applications.5. In what fields will the future robots play their important part?The future robots will play an important role in providing physical assistance; in helping people with disabilities get around and extending the strength and endurance of soldiers, construction workers and medical professionals. Besides, robots will maintain dangerous industrial machines, handle hazardous materials and monitor remote oil pipelines. They will also enable health care workers to diagnose and treat patients who may be thousands of miles away, and they will he a central feature of security systems and search-and-rescue operations.5 Computer Technology1. Why professionals such as photographers, graphic designers, architects and those who often work in teams would welcome multi-touch computing?Because the multi-touch screen interface could improve collaboration without a mouse or keyboard, and it even could allow the commands of multiple hands from multiple people.2. What would Jeff Han’s future customers of this multi-touch technology be like?Jeff Han expects the multi-touch technology to find a home in graphically intense businesses such as energy trading and medical imaging.3. What was the toughest difficulty of multi-touch technology?The multi-touch technology's toughest hurdle is achieving fine-solution fingertip sensing. The solution required both hardware and software innovations.4. Which industries are more likely to apply Microsoft’s “Surface computer” technology?Microsoft is shipping Surface table computers to four partners in the leisure, retail and entertainment industries, which it believes arc most likely to apply the technology.5. According to the author, what is the great advantage of multi-touch technology?The great strength of multi-touch is letting multiple people work together on a complex activity.7 Climate Change1. What do studies of the Earth’s climate history involve?Studies of Earth's climate history involve any material that contains a record of past climate, for example, deep-ocean cores collected from sea-going research vessels, ice cores drilled by fossil-fuel machine power in the Antarctic or Greenland ice sheets or by hand or solar power in mountain glaciers: softsediment cores hand-driven into lake muds; hand-augered drills that extract thin wood cores from trees; coral samples drilled from tropical reefs.2. What are the four great revolutions contributing to the ongoing study of climate history?The four great revolutions are: in the 1700s James Hutton concluded that Earth is an ancient planet with a long history of gradually accumulated changes produced mainly by processes working at very slow rates; in 1859 Charles Darwin published his theory of natural selection; in 1912 Alfred Wegener proposed the concept of continental drift, which eventually led to the theory of plate tectonics; and the major advances in this field began in the late 1900s, continue today, and seem destined to go on for decades.3. According to the author, what is basalt and how can the basalt layers be dated?Basalt is the solid rock that is formed by the skeletal remains found in ancient lake sediments sandwiched between two layers of lava, and the basalt layers can be dated by the radioactive decay of key types of minerals enclosed within.4. Why does the author say that researches on climate and human history share similarity with crime solving? These research fields have much in common with the field of crime solving because both of them concentrate on the past.5. How does a hypothesis become recognized as a theory eventually?1 Monograph专著1. The general definition of a monographScientific treatises of book length but otherwise variable format prepared by acknowledged experts on specialized topics for the benefit of others who have specialized in. or who wish to obtain a specialist's appreciation of, these topics.2. The value of monographs for scientific researchesThe value of monographs lies in the coherence and comprehensiveness of the information and knowledge they contain, which is important to the specialized researchers to whom they are directed and, therefore, to the advancement of science and engineering generally.3. The qualities of the authors of monographsThe authors of monographs should have exceptional breadth and depth of knowledge, and must be able to collect, collate, analyze, integrate, and synthesize all relevant contributions to the archival literature of the scientific and engineering journals and to add original material as required.4. The differences between monographs and books of conference proceedingsMonographs generally are written by specialists for the benefit of other specialists. Textbooks are pedagogical works which, even if written on fairly narrow subjects, are designed to serve broader and more junior readerships than specialized research communities.5. The differences between monographs and books of conference proceedingsConference papers commonly take the form of premature announcements of new scientific discoveries. Conference proceedings generally have a short shelf life.6. The main components of a monographThe author, title and subtitle, date of publication, dust cover or blurb, content pages, bibliography and index, illustrations, preface and introduction.7. An indication of the book’s successThe number of editions is an indication of the boo k’s success.8. The function of the blurbIt gives the reader a rapid overview of the contents and approach. It might also say what the book contains and for whom it is written.2 Academic Journal学术期刊1. The general definition of an academic journalAn academic journal is a peer-reviewed periodical in which scholarship relating to a particular academic discipline is published.2. The significance of peer-review processThe peer-review process is considered critical to establishing a reliable body of research and knowledge.3. The definition of review articlesReview articles, also called “reviews of progress”, are checks on the research published in journals.4. One difference between original research articles and review articlesUnlike original research articles, review articles tend to be solicited submissions, sometimes planned years in advance.5. The places where science journals are authoritatively rankedNatural science journals are categorized and ranked in the Science Citation Index, and social science journals in the Social Science Citation Index.6. The possible quantitative factors to reflect an academic journal’s prestigeThe number of later articles citing articles already published in the journal, the overall number of citations, how quickly articles are cited, and the average “half-life” of articles.7. The financial resources of humanities and social science academic journalsSubsidies by universities or professional organizations and advertising fees by advertisers.8. The role of internet in the production of, and access to, academic journalsThe Internet has revolutionized the production of, and access to, academic journals, with their contents available online via services subscribed to by academic libraries or even in a way of open access.3 Organization of a Scientific Paper科技论文的篇章结构1. In most scientific journals, scientific papers include the following sectionsSummary or Abstract, Introduction, Materials and Methods, Results, Discussion, Acknowledgments.2. The content of Summary or AbstractIt gives a brief background to the topic, describes concisely the major findings of the paper, and relates these findings to the field of study.3. The Introduction section deals with the following two pointsIt describes first the accepted state of knowledge in a specialized field; then it focuses more specifically on a particular aspect, usually describing a finding or set of findings that led directly to the work described in the paper.4. The purpose of Materials and MethodsIts purpose is to describe the materials used in the experiments and the methods by which the experiments were carried out.5. The two ways of organizing ResultsIn some papers, the results are presented without extensive discussion, which is reserved for the following section. In other papers, results are given, and then they are interpreted, perhaps taken together with other findings not in the paper, so as to give the logical basis for later experiments.6. The purposes of the Discussion sectionThe data in the paper are interpreted; the findings of the paper are related to other findings in the field; this serves to show how the findings contribute to knowledge, or correct the errors of previous work; some of the logical arguments are often provided when it is necessary to clarify why later experiments were earned out. 7. The reason for combining the Results and DiscussionBecause the data need extensive discussion to allow the reader to follow the train of logic developed in the course of the research.8. The difference between the abstracts in Science and those in NatureIn Science, the abstract is self-contained; in Nature, the abstract also serves as a brief introduction to the paper.4 Reading a Scientific Paper科技论文的阅读方法1. The order to understand the major points of the work, you should first readThe Abstract.2. Reading the Title and the Abstract serves three purposesFirst, it clarifies whether you in fact know enough background to appreciate the paper. Second, it refreshes your memory about the topic. Third, it helps you integrate the new information into your previous knowledge about the topic.3. When reading in a familiar field, you can skim or even skipThe Introduction.4. The three typical codewordsData not shown, unpublished data, preliminary data.5. The poorly written papers are often related to three types of writersThose who are poor writers; those who do not enjoy writing, and do not take the time or effort to ensure that the prose is dear and logical; those who are so familiar with the material that it is difficult to step back and see it from the point of view of a reader not familiar with the topic.6. The three characteristics of “bad writing”First, the logical connections are often left out. Second, papers are often cluttered with a great deal of jargon. Third, the authors often do not provide a clear roadmap through the paper.7. In better writing, the side issues are dealt with in the following waysThey are relegated to Figure legends or Materials and Methods or clearly identified as side issues, so as not to distract the reader.8. Another problem faced by the readers is that when they seek to understand just the experiment was, they may findThe authors refer back to previous papers; these refer in turn to previous papers m a long chain.。
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ieee会议四级标题格式摘要:一、IEEE 会议标题格式简介1.IEEE 会议的级别及数量2.四级标题的含义和作用二、IEEE 会议四级标题格式详解1.一级标题(Main Title)a.字体和字号b.段落格式c.编号规则2.二级标题(Subtitle)a.字体和字号b.段落格式c.编号规则3.三级标题(Section Title)a.字体和字号b.段落格式c.编号规则4.四级标题(Subsection Title)a.字体和字号b.段落格式c.编号规则三、IEEE 会议四级标题格式应用1.各级标题在文章中的布局2.标题编号和引用规范3.标题与正文:IEEE 会议是电气和电子工程领域的重要学术会议,会议论文的撰写有一定的格式要求。
其中,四级标题格式是论文结构的重要组成部分。
了解和掌握IEEE 会议四级标题格式,对于撰写高质量的会议论文具有重要意义。
一、IEEE 会议标题格式简介IEEE 会议的级别分为四级,分别对应论文的不同部分。
四级标题分别为:一级标题(Main Title)、二级标题(Subtitle)、三级标题(Section Title)和四级标题(Subsection Title)。
这四级标题在论文中起到提纲挈领的作用,帮助读者快速了解论文的结构和内容。
二、IEEE 会议四级标题格式详解1.一级标题(Main Title)a.一级标题通常使用较大的字体和字号,居中显示。
b.段落格式一般为首行缩进,其余行距为固定值。
c.一级标题的编号规则为阿拉伯数字,如:“1.Main Title”。
2.二级标题(Subtitle)a.二级标题的字体和字号通常比一级标题小,左对齐显示。
b.段落格式与一级标题相同,为首行缩进,其余行距为固定值。
c.二级标题的编号规则为字母加数字,如:“1.1 Subtitle”。
3.三级标题(Section Title)a.三级标题的字体和字号比二级标题更小,左对齐显示。
The Power of Titles and Subtitles in EnglishEssaysIn the realm of academic writing, the importance oftitles and subtitles cannot be overstated. These elements serve as the first impression for readers, often决定了whether they will engage with the content or move on to something else. The art of crafting engaging titles and subtitles lies in a careful blend of creativity, clarity, and relevance.Titles should be concise yet impactful, capturing the essence of the essay while piquing the reader's interest. They should reflect the main idea or argument of the piece, avoiding vague or generic language. A strong title sets the tone for the entire essay, setting expectations for the reader and framing their understanding of the content.Subtitles, on the other hand, serve to break up the text, guiding the reader through the essay. They introduce new ideas or sections, providing structure and organization. Effective subtitles are specific and descriptive, giving readers a clear sense of what each section will cover. Theyalso help to maintain the flow of the essay, ensuring that the reader remains engaged and informed.When writing an English essay, it is crucial to consider the cultural context and readability. Titles and subtitles should be written in a language that is both accessible and engaging for the target audience. Avoiding complex vocabulary or jargon can help ensure that the message is communicated effectively.In conclusion, titles and subtitles are integral to the success of an English essay. By taking the time to craft engaging and relevant titles and subtitles, writers can significantly improve the readability and impact of their work. Remember, first impressions count, and a strong title and subtitle can be the difference between a reader who stops and a reader who keeps going.**标题与副标题在英语作文中的力量**在学术写作领域,标题与副标题的重要性不容忽视。
英文作文标题和副标题格式Title and Subtitle Formatting for English Essays.When crafting an English essay, it is crucial to follow the appropriate formatting guidelines for the title and subtitle. This ensures that the essay adheres to academic conventions and facilitates effective communication of your ideas. Here are the key points to consider when formatting the title and subtitle of your English essay:Title Formatting:1. Capitalization: The title should be capitalizedusing title case. This means that the first letter of each word (except for articles, conjunctions, and prepositions) should be capitalized. For example: "The Impact of Globalization on Cultural Identity."2. Font and Size: The title should be in a bold or italicized font to distinguish it from the rest of the text.The font size should be larger than the body text, typically 12-14 points for the title and 10-12 points for the body.3. Position: The title should be centered on the page, either at the top or slightly below the center, depending on the formatting requirements of your institution or journal.4. Punctuation: The title should end with a period, unless it is a question or an exclamation, which.。
英语作文专题封面设计Title: English Essay Special Topic Cover Design。
Designing a cover for a special topic English essay requires a blend of creativity, clarity, and relevance. The cover serves as the gateway to the content, enticing readers while also providing a glimpse of what lies inside. Here's a comprehensive guide on how to create an impactful cover design:1. Title and Subtitle: The title should be prominent and easily readable, conveying the essence of the topic. It should be concise yet descriptive. Consider using a larger font size or bold typography to make it stand out. Additionally, include a subtitle if necessary to provide more context or clarify the focus of the essay.2. Visual Elements: Incorporate relevant visual elements that complement the topic of the essay. This could include images, illustrations, or graphics that symbolizekey themes or concepts discussed in the essay. Choosevisuals that are high-quality, engaging, and align with the tone and message of the essay.3. Color Scheme: Select a color scheme that resonates with the theme of the essay and evokes the desired emotions or associations. For instance, warm tones like red, orange, or yellow can convey energy and passion, while cool tones like blue or green can evoke a sense of calm or professionalism. Ensure that the chosen colors are visually appealing and harmonious.4. Typography: Pay attention to typography to enhance readability and visual appeal. Choose fonts that are clear, legible, and appropriate for the subject matter. Consider using a combination of fonts for the title, subtitle, and other text elements to create hierarchy and visual interest. Experiment with different font styles, sizes, and weightsto find the perfect balance.5. Layout and Composition: Arrange all elements on the cover in a balanced and visually pleasing manner. Payattention to spacing, alignment, and proportions to createa cohesive layout. Experiment with different arrangements until you find one that effectively highlights the titleand visual elements while maintaining clarity and coherence.6. Brand Identity: If the essay is part of a series or publication, ensure consistency with the brand identity.Use consistent colors, fonts, and design elements to reinforce brand recognition and establish a cohesive visual identity across all materials.7. Finishing Touches: Add finishing touches to polishthe design and make it more professional. This couldinclude effects like shadows, gradients, or textures to add depth and dimension to the cover. Avoid overcrowding the design with excessive elements and keep it clean and streamlined.8. Feedback and Iteration: Seek feedback from peers, mentors, or design professionals to refine the cover design further. Be open to constructive criticism and iterate onthe design based on the feedback received. Continuouslyrefine and improve the design until it effectively communicates the essence of the essay and captures the attention of the audience.By following these guidelines and incorporating your own creativity and vision, you can create a compelling cover design that sets the stage for an engaging and informative English essay.。
AD_________________ Award Number: DAMD17-02-1-0459TITLE: Wilms’ Tumor 1 (WT1) as Novel Molecular Target in BreastCancerPRINCIPAL INVESTIGATOR: Ana Tari, Ph.D.CONTRACTING ORGANIZATION: The University of TexasM.D. Anderson Cancer CenterHouston, Texas 77030REPORT DATE: March 2006TYPE OF REPORT: FinalPREPARED FOR: U.S. Army Medical Research and Materiel CommandFort Detrick, Maryland 21702-5012DISTRIBUTION STATEMENT: Approved for Public Release;Distribution UnlimitedThe views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.REPORT DOCUMENTATION PAGE Form ApprovedOMB No. 074-0188Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 205032. REPORT DATE3. REPORT TYPE AND DATES COVERED1. AGENCY USE ONLY(Leave blank)March 2006Final (15 Mar 2002 – 15 Feb 2006)4. TITLE AND SUBTITLE5. FUNDING NUMBERSWilms’ Tumor 1 (WT1) as Novel Molecular Target in Breast Cancer6. AUTHOR(S)Ana Tari, Ph.D.DAMD17-02-1-04597. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) The University of Texas M.D. Anderson Cancer Center Houston, Texas 77030E-Mail:********************8. PERFORMING ORGANIZATION REPORT NUMBER9. SPONSORING / MONITORINGAGENCY NAME(S) AND ADDRESS(ES)10. SPONSORING / MONITORING AGENCY REPORT NUMBERU.S. Army Medical Research and Materiel CommandFort Detrick, Maryland 21702-501211. SUPPLEMENTARY NOTES12a. DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited12b. DISTRIBUTION CODE13. ABSTRACT (Maximum 200 Words)High levels of Wilms' Tumor 1 (WT1) mRNA in breast tumors have been linked with poor prognosis for breast cancer patients. However, the function of WT1 protein in breast cancer was not known. We reported the expression of WT1 protein in 9 out of 10 human breast cancer cell lines. The levels of WT1 protein were increased by the HER2/neu oncogene and 17β-estradiol. We demonstrated that WT1 protein is vital to the proliferation of breast cancer cells since down regulation of WT1 protein expression led to breast cancer growth inhibition and apoptosis, which was correlated with decreased cyclin D1 and Bcl-2 levels. WT1 has been shown to undergo two splicing events, which result in four different isoforms. Stable transfection of the different WT1 isoforms was performed in MCF-7 cells. Our data indicate that the WT1 isoforms enhance the in vitro proliferation of MCF-7 breast cancer cells, but do not modulate the sensitivities of MCF-7 cells to doxorubicin, taxol, or tamoxifen. WT1 protein enhances breast tumorigenesis induced by other oncogenes or growth factors, such as HER2/neu and estradiol, but its over expression alone is not sufficient to induce breast tumorigenesis.14. SUBJECT TERMS15. NUMBER OF PAGES9 Proliferation, apoptosis, chemoresistance, signal transduction16. PRICE CODE17. SECURITY CLASSIFICATION OF REPORTUnclassified 18. SECURITY CLASSIFICATIONOF THIS PAGEUnclassified19. SECURITY CLASSIFICATIONOF ABSTRACTUnclassified20. LIMITATION OF ABSTRACTUnlimitedNSN 7540-01-280-5500Standard Form 298 (Rev. 2-89)Table of Contents Cover (1)SF 298 (2)Introduction (4)Body (4)Key Research Accomplishments (7)Reportable Outcomes (7)Conclusions (8)References (8)List of Personnel receiving pay from the research effort (9)INTRODUCTIONThe Wilms’ Tumor 1 (WT1) protein and mRNA is expressed in human breast tumors and breast cancer cell lines. Loeb et al. [1] demonstrated that WT1 mRNA and protein are expressed in nearly 90% of breast cancers, but not in most normal breast tissues. Silberstein et al. [2] suggested that there was an association of WT1 protein expression with a biologically aggressive phenotype of breast cancer. Recently, Miyoshi et al. [3] correlated high levels of WT1 mRNA with poor prognosis in breast cancer patients. But it is not known how WT1 protein contributes to breast tumorigenesis. One aim of this project is to determine if the WT1 protein contributes to breast tumor progression by deregulating cell proliferation and apoptosis. The deregulation of proliferation and survival pathways has been associated with chemoresistance in many tumors. Therefore, it is hypothesized that WT1 regulates chemoresistance in breast cancer cells. This project seeks to determine the mechanisms and the isoforms by which WT1 deregulates breast cancer cell proliferation and apoptosis.BODYSpecific Aim 1: To determine whether WT1 overexpression increases the proliferation and survival of breast cancer cells in cell culture modelsWe observed that the levels of WT1 protein correlated with the proliferation of breast cancer cells [4]. When the proliferation of breast cancer cells was stimulated by 17β-estradiol, WT1 protein expression increased. But when the proliferation of breast cancer cells was inhibited by tamoxifen or all-trans retinoic acid, WT1 protein expression decreased [4]. We also observed that MCF-7 breast cancer cells stably transfected with the HER2/neu oncogene express approximately 3-fold higher levels of WT1 protein than parental MCF-7 cells [5]. Conversely,inhibition of HER2/neu with the anti-HER2/neu trastuzumab (Herceptin™) antibody or inhibition of Akt with an Akt inhibitor decreased WT1 protein levels in HER2/neu-overexpressing BT-474 and SKBr3 breast cancer cells, indicating that HER2/neu engages Akt to increase WT1 protein expression [5]. Since WT1 protein levels were increased by 17β-estradiol and HER2/neu, two factors known to stimulate breast tumor proliferation, we hypothesize that WT1 protein plays a role in regulating breast cancer cell proliferation. Using liposome-incorporated WT1 antisense oligodeoxynucleotides, we found that downregulation of WT1 protein expression led to cell cycle arrest at the G1 phase and increased apoptosis, which is correlated with decreased cyclin D1 and Bcl-2 levels, in breast cancer cells [4, 5]. These results indicate that WT1 protein plays a vital role in mediating the proliferative and anti-apoptotic signals in breast cancer cells. Our data support earlier observations that WT1 may play a vital role in the aggressive phenotypes of breast cancer cells [1, 3].WT1 has been shown to undergo two splicing events, which result in four different isoforms. These isoforms are able to bind to different DNA promoter elements and different protein partners. Plasmids encoding the four isoforms “A”, “B”, “C”, and “D” of the wild type WT1 gene were transfected into human MCF-7 breast cancer cells to prove that overexpression of the WT1 gene will increase breast cancer cell proliferation and survival. Stable transfectant clones were selected. The transfection remained stable for up to at least 6 months. Western blot confirmed that WT1 protein was expressed about 2-3 levels higher in the transfectants than in the parental cells. The CellTiter 96 Aqueous nonradioactive proliferation (MTS) assay was used to determine the proliferative rates of these transfectants. Compared to parental and vector-transfected cells, all four isoforms increase MCF-7 cell proliferation by about 130-150%. Butflow cytometric analysis does not show any difference in the distribution of cells in the different phases of the cell cycle between the WT1 transfectants and the control cells.Specific Aim 2: To determine whether WT1 overexpression increases breast tumor growth in animal modelsMCF-7 wild type cells and MCF-7 transfectants (vector control, WT1 isoform “A”, WT1 isoform “D”) were implanted into the mammary fat pad of nude mice that had 0.72 mg of 17β-estradiol pellets. We chose WT1 isoforms “A” and “D” for the in vivo studies because these isoforms were believed to regulate different genes since they were found to bind to different DNA elements [6]. Four weeks later, tumors were found from mice implanted with the control wild type and vector cells. Six out of nine mice implanted with MCF-7wild type cells form tumors, and eight out of eight mice implanted with MCF-7/vector cells form tumors. However, no tumor was found in mice implanted with the MCF-7 cells stably transfected with the WT1 “A” isoform or the WT1 “D” isoform. Our data support those of Zhang et al. [7] who found that WT1 protein inhibited tumor growth of MDA-MB-231 breast cancer cells in nude mice.Specific Aim 3: To determine whether WT1 regulates chemoresistance in breast cancer cells MTS assay was used to compare the chemosensitivity of WT1 transfectants with control cells. No difference is observed between the doxorubicin and the taxol sensitivity of any of the isoforms and the control cells. Similarly, no difference is observed between the tamoxifen sensitivity of any of the isoforms and the control cells.KEY ACCOMPLISHMENTS• Published our data that WT1 protein increases the expression of cyclin D1 protein, and increases the proliferation of breast cancer cells.Zapata-Benavides, P., Tuna, M., Lopez-Berestein, G., and Tari, A. M.Downregulation of Wilms' Tumor 1 Protein Inhibits Breast Cancer Proliferation.Biochem. Biophys. Res. Commun., 295:784-790, 2002.• Published our data that the HER2/neu oncogene engages the Akt pathway to increase the expression of WT1 protein. WT1 protein stimulates the transcription of cyclin D1 and Bcl-2 genes. WT1 protein plays a vital role in mediating proliferative and anti-apoptotic functions in HER2/neu-overexpressing breast cancer breast cancer cells.Tuna, M., Chavez-Reyes, A., and Tari, A. M. HER2/neu increases the expression of Wilms’ Tumor 1 (WT1) protein to induce S-phase proliferation and inhibitapoptosis in breast cancer cells. Oncogene, 24:1648-1652, 2005.REPORTABLE OUTCOMESAbstract1. Tuna, M. and Tari, A. M. HER2/neu uses Akt to increase WT1 expression in breastcancer cells. Proc. Amer. Assoc. Cancer Res., 44 (1st ed): 1939, 2003.The abstract was selected for oral presentation. Dr. Tuna received an AACR research award for the abstract.Manuscripts1. Zapata-Benavides, P., Tuna, M., Lopez-Berestein, G., and Tari, A. M. Downregulation ofWilms' Tumor 1 Protein Inhibits Breast Cancer Proliferation. Biochem. Biophys. Res.Commun., 295:784-790, 2002. (See attached)2. Tuna, M., Chavez-Reyes, A., and Tari, A. M. HER2/neu increases the expression ofWilms’ Tumor 1 (WT1) protein to induce S-phase proliferation and inhibit apoptosis in breast cancer cells. Oncogene, 24:1648-1652, 2005. (See attached)CONCLUSIONSWe are very surprised that the four WT1 isoforms, which have been shown to bind to different partnering proteins and different DNA sequences, appear to behave quite similarly in vitro in the MCF-7 breast cancer cell background. Furthermore, it was very disappointing that the WT1 transfectants did not form tumors in nude mice. Thus, we believe that WT1 protein enhances breast tumorigenesis induced by oncogenes and growth factors, such as HER2/neu and estradiol. But its overexpression alone is not sufficient to induce breast tumorigenesisREFERENCES1. Silberstein, G., Van Horn, K., Strickland, P., Roberts, C., and Daniel, C. Alteredexpression of the WT1 wilms tumor suppressor gene in human breast cancer,Proc. Natl.Acad. Sci. U S A 94: 8132-8137, 1997.2. Loeb, D., Evron, E., Patel, C., Sharma, P., Niranjan, B., Buluwela, L., Weitzman, S.,Korz, D., and Sukumar, S. Wilms' tumor suppresor gene (WT1) is expressed in primarybreast tumors despite tumor-specific promoter methylation,Cancer Res. 61: 921-925, 2001.3. Miyoshi, Y., Ando, A., Egawa, C., Taguchi, T., Tamaki, Y., Tamaki, H., Sugiyama, H.,and Noguchi, S. High expression of wilms' tumor suppressor gene predicts poor prognosis in breast cancer patients,Clin. Cancer Res. 8: 1167-1171, 2002.4. Zapata-Benavides, P., Tuna, M., Lopez-Berestein, G., and Tari, A. M. Downregulation ofWilms' Tumor 1 Protein Inhibits Breast Cancer Proliferation. Biochem. Biophys. Res.Commun., 295: 784-790, 2002.5. Tuna, M., Chavez-Reyes, A., and Tari, A. M. HER2/neu increases the expression ofWilms’ Tumor 1 (WT1) protein to induce S-phase proliferation and inhibit apoptosis in breast cancer cells. Oncogene, 24: 1648-1652, 2005.6. Bickmore, W., Oghene, K., Little, M., Seawright, A., van Heyningen, V., and Hastie, N.Modulation of DNA binding specificity by alternative splicing of the Wilms Tumor wt1 gene transcript,Science 257: 235-237, 1992.7. Zhang, T., Yu, S., Guan, L., and Wang, Z. Inhibition of breast cancer cell growth by theWilms' tumor suppressor WT1 is associated with a destabilization of beta-catenin.Anticancer Res. 23: 3575-3584, 2003.LIST OF PERSONNEL RECEIVING PAY FROM THE RESEARCH EFFORTPrincipal Investigator: Ana M. TariPostdoctoral fellows: Musaffe Tuna, Yolanda Gutierrez-PuenteResearch Assistant: Galina Kiriakova。
英语演讲稿副标题格式英文中的副标题(subtitle)在学术著作、论文、刊物中极为常见。
在结构与内容上它们具有一定特点,是读者经常读到的一种副标题格式。
英语正副标题在结构上凝练精当,这是他们的一大特色,也是读者欣赏他们的一个重要原因。
这一特色主要表现在其衔接方法上。
英文剧标题与正标题的衔接方法主要有三种基本方式。
1、破折号衔接式(正标题—刚标题)这种类型的标题是一种常见的种类。
然而,值得引起注意的是,所使用的破折号不需要缩进另起行,可直接衔接副标题。
这与中文传统的正副标题有很大不同。
例如:Challenger-A Lesson for the FutureBell College-A Language SchoolReuters-The Oldest News Service in the WorldAlfred Nobel-A Man of Contrasts2、冒号衔接式(正标题:副标题)“Writing Academie English”一书中指出:“Useacolon between the main title and the subtitle of a book,arti cleor play.”(P.236)(王英格,1996)。
以上可以充分表明,使用冒号来衔接英语正副标题是比较规范的选择方法。
在语言实际运用中,这类形式也是作者最愿选用的。
例如:Hand and Mind:What Gestures Reveal about Thought The Leamer as manager Managing Learing or Managing to Leam Second Language Reading Instruction Its Effects on Comprehension and word Inference Ability Strategy Instruction in the Language Classroom:An Empirical Investigation3、语义衔接式(正标题,副标题)这样的英文正副标题可以是词组或是两个句子,前者是正标题,后者是副标题。
t et e c hni c aln ot et e ch nDocument is available to the public through the National Technical Information Service, Springfield, Virginia 22161U.S. Department of Transportation Federal Aviation Administration William J. Hughes Technical Center Atlantic City International Airport, NJ 08405June 1998DOT/FAA/CT-TN98/2Human Factors Technical Writer’s Guide Earl S. Stein, Ph.D, ACT-530Michael D. Snyder David J. Bryant, Ph.D.Jean DunnNOTICEThis document is disseminated under the sponsorshipof the U.S. Department of Transportation in the interest of information exchange. The United States Government assumes no liability for the contents or use thereof.The United States Government does not endorse products or manufacturers. Trade or manufacturers’names appear herein solely because they are considered essential to the objective of this report.Technical Report Documentation Page 1. Report No.DOT/FAA/CT-TN98/22. Government Accession No.3. Recipient’s Catalog No.4. Title and SubtitleHuman Factors Technical Writer’s Guide 5. Report DateJune 19986. Performing Organization Code ACT-5307. Author(s) Michael D. Snyder, David J. Bryant, Ph.D., and Jean Dunn, FDC Science and Engineering Group and Earl S. Stein, Ph.D., ACT-5308. Performing Organization Report No. DOT/FAA/CT-TN98/29. Performing Organization Name and Address Federal Aviation AdministrationWilliam J. Hughes Technical Center Atlantic City International Airport, NJ 0840510. Work Unit No. (TRAIS)11. Contract or Grant No. DTFA03-94-C001212. Sponsoring Agency Name and Address Federal Aviation Administration Human Factors Division800 Independence Ave., S.W. Washington, DC 2059113. Type of Report and Period Covered Technical Note14. Sponsoring Agency CodeAAR-10015. Supplementary Notes16. AbstractThe Program Directorate for Aviation Simulation and Human Factors (ACT-500) of the Federal Aviation Administration William J. Hughes Technical Center determined that there should be a standardized method to create technical documents. The Human Factors Branch (ACT-530) was tasked to develop this document. They decided that standardizing technical documents should not only dwell on developing the document but teaching basic writing techniques to make all ACT-500 documents consistent. A small team was selected from ACT-530 support personnel to develop a handbook and teach the basics of technical writing. The handbook includes four distinct sections: Organization, General Writing Concerns, Sentence Construction, and Special Topics. The team also developed a slide presentation that tracks the handbook very closely. This document is the published version of the handbook.17. Key Wordstechnical writing, human factors, organization, general writing concerns, sentence construction, special topics 18. Distribution StatementThis document is available to the public through the National Technical Information Service, Springfield, Virginia, 2216119. Security Classif. (of this report) Unclassified 20. Security Classif. (of this page)Unclassified21. No. of Pages7122. PriceForm DOT F 1700.7 (8-72)Reproduction of completed page authorizedPrefaceGood writing is a lifetime endeavor. No matter how well you write, you can always improve. It is important to improve your writing; the world is full of miscommunication, and each of us can do our part to reduce the problem. In this course, we review the basic rules of good writing. You probably know most of these rules but do not take the time to follow all of them, at least not all the time. We want to help you use these rules consistently and effectively.What is CoveredIn this handbook, we review the rules of style, grammar, and punctuation. We tell you what they are and, more importantly, why they are helpful in your writing. It is important to think about the rules from time to time. This reinforces the rules in your memory and helps you apply them in your writing. We provide examples of good and bad writing to show you how the rules improve writing. Examples make it easier to see how to put the rules into practice. Following each section, we provide exercises to hone your newly acquired skills.This document contains four major sections: Organization, General Writing Concerns, Sentence Construction, and Special Topics. Organization covers the crucial planning and outlining that you should do before writing a single word of a paper. We discuss how to set a goal, determine what your audience wants to know and how you can convey it to them, devise logical arguments, and use an outline to organize your paper.General Writing Concerns covers the actual writing of a paper. These are issues of style and grammar that apply to every part of a paper. We discuss the use of paragraphs, how to write in the active voice, being concise, and how to be coherent in your writing.Sentence Construction covers grammatical rules and punctuation. These rules really determine whether your individual sentences have meaning and are understandable. This is the most basic level of writing. It is vital that you make each sentence clear and concise for the larger meaning to get across to the reader. We discuss grammatical rules, subject-verb agreement, using pronouns, and how to use punctuation effectively.Special Topics covers issues related to technical and scientific writing. You write specialized reports, and there are unique rules governing how you should write them. We cover how to write an abstract, how to cite references, reporting statistics, proofreading, and technical language.Our ApproachWe sum up the philosophy behind our course as: do everything possible to help your reader understand. Your desire to show personal style, display your intelligence, or entertain your readers is all secondary.What Makes Good Writinga.Follow the rules of grammar, style, and organization. These rules are a set of heuristicsfor effective writing. They are useful techniques for achieving the goal of concise,understandable communication. You should always follow the rules, but you can express them in many ways.- Rules for Writing Real Good -“Don’t use no double negatives.Make each pronoun agree with their antecedents.Join clauses good, like a conjunction should.About them sentence fragments.When dangling, watch your participles.Verbs has got to agree with their subjects.Don’t write run-on sentences they are hard to read and often have thereader confused unless they have had extensive familiarity with the subjectmatter.Don’t use commas, that aren’t necessary.Try to not ever split infinitives.Its important to use your apostrophes correctly.Proofread your writing to see if you any words out.Correct speling is essential.Eschew ostentatious erudition.Avoid clichés like the plague,” (“Rules for Writing,” 1997).Do you recognize any common mistakes that you make?b.Plan what you are going to say. Organize your thoughts before writing anything!Planning is the most important part of writing. It prevents you from going off-topic;running on; presenting weak or illogical arguments; and slipping into awkward, vague, or incoherent writing. A plan will make writing easier by listing all the points you want tomake.c.Remember, writing is for the reader. Always ask yourself, “Does this section, paragraph,or sentence tell the reader something he or she wants to know?” Test yourself by asking,“Will this sentence be understandable to the reader?” Look at your writing from theperspective of a reader to ensure that you1.present relevant, logical content;2.are concise; and3.are coherent.d.Practice writing. Write often and put the rules of grammar, style, and organization intopractice. Edit your writing carefully. Always try to improve what you have written.Table of ContentsPage Preface (iii)1. Organization (1)1.1 Writing for the Reader (1)1.1.1 Relevance (1)1.1.2 Reader Expectations (1)1.1.3 Reader Understanding (2)1.1.4 Help Your Reader Understand (3)1.2 Planning (3)1.2.1 Setting a Goal (4)1.2.2 Presenting Your Thesis (4)1.3 Outlining (5)1.3.1 Types of Outlines (5)1.3.2 Choosing an Outline (7)1.3.3 Organizing an Outline (7)1.3.4 Principles for Writing an Outline (8)1.3.5 Order (10)1.3.6 The Hourglass Structure (12)1.3.7 Motivating Writers to Outline (12)1.4 Sections of a Paper (13)1.4.1 Introduction (13)1.4.2 Method (14)1.4.3 Results (15)1.4.4 Discussion (15)1.4.5 References (16)1.4.6 Appendix (16)2. General Writing Concerns (16)2.1 Paragraphs (16)2.2 Active Voice (17)2.3 Conciseness (18)2.4 Coherence (21)2.5 Clarity (22)2.6 Tense Consistency (23)2.7 Parallel Construction (23)2.8 Using Lists, Tables, and Figures (23)3. Sentence Construction (24)3.1 Grammar (24)3.1.1 Subject-Verb Agreement (24)3.1.2 Pronouns (25)Table of Contents (Cont.)Page 3.2 Punctuation (26)3.2.1 Commas (26)3.2.2 Semi-Colons, Colons, Parentheses, and Hyphens (28)3.2.3 Quotation Marks (31)3.2.4 Italics (31)3.3 Miscellaneous (32)3.3.1 Troublesome Words (32)3.3.2 Dangling Modifiers (33)3.3.3 Expressing Numbers as Figures (34)3.3.4 Expressing Numbers as Words (35)3.3.5 Use of the Abbreviation Etc (35)3.3.6 Non-Sexist Language (36)4. Special Topics (36)4.1 Abstracts and Executive Summaries (36)4.1.1 Qualities of a Good Abstract (36)4.1.2 Writing an Effective Abstract or Executive Summary (37)4.2 References (37)4.2.1 How to Reference Citations in Text (37)4.2.2 How to Reference Citations in a Reference List (41)4.3 Reporting Statistics (43)4.4 Proofreading (44)4.4.1 Proofreading for Higher Order Concerns (45)4.4.2 Proofreading for Lower Order Concerns (46)4.4.3 Proofreading for Commas (46)References (49)AppendixesA - Annotated BibliographyB - Exercises for Various SectionsC - Exercises and SolutionsList of IllustrationsTables Page1. Expendable Phrases (19)2. Qualifying Words and Their Replacement (20)3. Redundant Pairs and Their Replacement (21)4. Forming Meaningless Phrases (22)5. Singular and Plural Pronouns (25)1. Organization1.1 Writing for the Reader“Misconception: The important thing is what you say, not how you say it,” (Sternberg, 1977, p. 2).You need the reader; he or she does not need you. The reader is a “customer” who wants to obtain information from you. If the reader cannot get the information from you, you have not achieved your goal.An idea is made better by being well written. You cannot separate communication from content because the quality of ideas depends on their impact on the audience. A reader either will not understand a poorly written idea or not read the paper at all.1.1.1 RelevanceReaders have a goal to learn certain things. They will try to learn these things in the quickest, most efficient way possible. Thus, you do not help the reader by including unwanted material, expressing your ideas in a cumbersome fashion, or disguising your meaning with vague or fancy writing.Anticipate who will read your paper and why they will read it. Tailor your ideas to include only those that will be important to readers. Anticipate readers’ questions and plan to answer these in your paper. Also organize your ideas and arguments in a way that will make it easy for the reader to understand. Evaluate the strength of your arguments from the perspective of the reader.1.1.2 Reader ExpectationsReaders have expectations about your topic and about how papers are structured in general (Sternberg, 1992). As they read your document, readers form impressions of your goal and what arguments and evidence they expect you to make. Readers expect logical arguments, completeness, and balance in the presentation of arguments. It is harder to understand unexpected than expected ideas and arguments. Plan your paper to give readers information in a way they expect.a.Tell your readers why your topic will interest them (Sternberg, 1992). Do not expectreaders to know why you find a topic interesting or why they should want to read about it.Show them! The more you can relate your topic to concerns of your reader, the moreinterest you will generate. Draw relations between your ideas and relevant theoreticalissues.b.Highlight arguments or findings that will violate expectations (Sternberg, 1992). Whenreading, people “fill in the blanks,” relying on experience and context to get the mainpoint. The risk with this is readers coming away with the wrong idea. To prevent this,highlight, either through words (“An unexpected finding…” or “Jones’ theory runscounter to prevailing views.”) or text (bold), ideas that are unexpected or go against what you have been saying.c.Tie up loose ends (Sternberg, 1992). Make sure that you resolve every issue raised atsome point in your paper (preferably, immediately after you raise the issue). Points thatyou raise but do not resolve serve no purpose. At best, they waste the reader’s time. At worst, they confuse the reader and become mixed up with other, more important ideas.Writing an outline ensures that you know exactly what arguments you will make andexactly when you will introduce, support, and resolve them.d.Make sure the paper does what it says it will do (Sternberg, 1992). “In this article, I willcharacterize the meaning of life, solve the problem of world hunger, and reveal RichardNixon’s secret plan to end the Vietnam War.” Many writers produce papers that do notdeliver what they promise. These papers are disappointments to readers, and peoplequickly stop reading them. When framing the issues of the paper, make sure that theyfollow logically from theoretical perspectives and empirical results. Then, make sure that you support all the claims you make regarding the issues.1.1.3 Reader UnderstandingA major problem is that writers tend to assume, incorrectly, that readers know what the writer knows (Sternberg, 1992). This, of course, is impossible. Further, the assumption violates the purpose of communicating new information to the reader. This faulty assumption leads to a number of flaws in writing. Writers will depend on incomplete or vague explanations, relying on the reader to “read between the lines.” Writers will use jargon, assuming that the reader knows what it means. It is crucial to compose arguments and write the paper so the reader will be able to understand.a.Do not refer to undefined ideas or arguments (Sternberg, 1992). When you introduce anidea or argument, explain it completely. Do not simply refer to an idea without telling the reader what it means. The reader may or may not understand the idea before reading your paper, but it is your job to make sure the reader understands after reading your paper.Make your paper a self-contained unit.b.Do not assume readers will “know what you mean” or be familiar with abbreviations orjargon (Sternberg, 1992). Readers seldom understand anything you have written as well as you do. If you use abbreviations, acronyms, or jargon, you are asking the reader tounderstand your code. This forces the reader to do extra work. Another problem withjargon is that it allows you to write sentences that even you may not fully understand.Always be on the watch for impressive sounding sentences that are confusing or havelittle, true meaning. To ensure that you really understand something, write it in plainEnglish. It is much harder to fake understanding when you write plainly.c.Always explain what empirical results mean (Sternberg, 1992). “Finally, we obtained a 7-way interaction among the independent variables, clearly showing that the variables need to be considered in terms of their interactive as well as their additive effects.” Statisticsare abstract and require work to interpret. The reader wants to know what you found, not the statistical tests used to assess the reliability of trends and differences. Interpret yourresults for the reader. You should always begin a results section by stating the differences, trends, and correlations found in the data.d.Have someone else read your paper (Sternberg, 1992). The best way to find out whetheryour paper is clear is to have someone else read it. Find someone who is representative of your audience. That person can tell you whether you have addressed the relevantquestions and whether you have answered them in a clear, concise fashion.1.1.4 Help Your Reader UnderstandDo not assume knowledge in your reader and actively seek to explain things (Sternberg, 1992). Lead the reader through arguments. Here’s how:a.Start strong (Sternberg, 1992). “Smith and Jones (1986) found that 83% of readers nevergot beyond the first paragraph of the majority of articles they began to read.” Thisopening is an example of how to be boring, as are these: “Past research shows…” or “It is interesting to note that…” (says who?). A strong start asks a question or states a problem pertinent to the theme of your paper. Dullness blunts the impact of many potentiallyinteresting articles. Tell readers what the article is about in a provocative but direct way.Stating the issue up front helps inform and interest the reader.b.End strongly and state a clear concluding message (Sternberg, 1992). “In sum, there is aneed for further research to clarify the issues.” This ending is boring and uninformative.There is always room for further research; you do not have to tell that to readers. Readers want a punch line. They want a paper with a clear conclusion. Write a conclusion thatyour reader will remember: a conclusion that is direct, short, and answers the questionsraised in the paper.c.Explain what you are going to say, say it, and then restate what you have said (Sternberg,1992). This technique provides an advance organizer for readers to help them understand and commit to memory what you will say. After introducing the main idea, give the fullexplanation, which you can relate to the major themes of your paper. Then, emphasize the main points to reinforce that material and help readers remember it.d.Give concrete examples (Sternberg, 1992). Some writers think that the more abstract andhigh-sounding their writing is, the more they will impress readers. On the contrary, most readers need concrete examples or analogies to understand other people’s ideas. Themore abstract the points, the more readers need examples.1.2 Planning“Misconception: Writing a technical paper is the most routine, least creative aspect of the scientific process,” (Sternberg, 1977, p. 1).Often, researchers are interested in planning research and making discoveries but neglect communicating discoveries to others. There is, however, no real separation of the discovery process and the communication process. Writing forces you to analyze, evaluate, and organize your ideas. Writing your ideas clearly and concisely helps you create logical arguments andgenerate new ideas. This is an incentive to tie up loose ends and confront conceptual weaknesses. Thus, writing is an integral part of the creative process.1.2.1 Setting a Goal“Before beginning a paper, it is crucial to have a highly detailed plan ofa.what you are going to say,b.how you are going to say it, andc.how many words (or pages) you are going to devote to saying it,” (“Developing YourThesis,” 1997).Write down your purpose for writing the paper (“When You Start,” 1997). What do you need to explain, support, or question in your paper? Decide whether you want to argue a point of view or evaluate several approaches. Determine whether you need to give a detailed account or just present the most important aspects of the topic. In this stage, clearly determine the content of the paper, the approach you will take, and the length of the paper.From the ideas you generated, identify the one, or possibly two, major ideas. Make it your goal toa.explain this idea,b.support assertions,c.present evidence for and against your idea, andd.present a conclusion (what has been learned).1.2.2 Presenting Your ThesisA thesis is a single idea or closely related set of ideas that you want to explore or defend (“Developing a Central,” 1997). It will be the focus of your entire paper. You must relate every part of the paper to the thesis. If something does not bear on the thesis, it is irrelevant to the paper and you should remove it. Your thesis comes from your goal. When you know what you want to communicate, state your goal as the thesis.In most cases, it is best to state your main idea or thesis in the first paragraph. The reader will know right away what you will argue and what to expect. If the reader has a good idea of what the thesis is about, he or she will be better able to understand your paper.Try to state the thesis in one sentence (“Developing a Central,” 1997). A short, concise thesis is easy to understand and easy to remember. If you cannot write the thesis simply, you probably have a poor idea of what you are writing. A complex or comprehensive thesis may require several sentences, but such topics are rare. Use the remainder of your paper to develop and defend the thesis and explain why it is valid.TIP: Think about how you would explain your topic to an audience in 5 minutes. You will probably come up with the most important points you want to make.When specifying your thesis, it is important to ask questions. Mulling over a topical checklist helps to prevent writer’s block and provides the ideas that you will organize into an outline. This checklist can help you discover possibilities for developing a thesis (“Developing Your Thesis,”1997).a.Exactly what is my subject? Be as specific as possible.b.Do I need or want to emphasize the positive or the negative aspects of my subject?Clearly state what you are asserting and whether you want to persuade your readers of a particular point of view.c.Can I divide my subject into parts? Determine how you can organize the material. Is oneaspect more important than others? What ideas do you need to stress to develop ordefend the thesis?d.Of what does my subject remind me? Find relevant papers that are similar to your paper.These sources can provide context for understanding the thesis.e.What effects have my topic had or is likely to have? Identify the consequences of thethesis and make these an important part of your paper. Especially in the conclusion, tellthe reader what important effects have resulted from the thesis.1.3 OutliningAn outline isa. a logical, general description;b. a schematic summary;c.an organizational scheme; andd. a visual and conceptual design for your writing (“Developing an Outline,” 1997).An outline lays out the topics of your paper. It establishes how you will group and order ideas in the paper. By summarizing topics on one or two pages, you can see how you structure your arguments, thus, allowing you to easily make changes.An outline is more than a list of topics. By making an outline, you determine what ideas you need to present to create a complete and logical argument. Determine where and what transitions you need, then you can structure and defend your entire thesis.1.3.1 Types of OutlinesThere are at least three ways you can complete an outline. We will discuss outlines in which we compare three differences between en route and terminal facilities.1.3.1.1 Keyword OutlineIn this kind of outline, you restrict yourself to keywords at each level of description (Sternberg, 1977). You should merely indicate the topic of each section of your paper. Link your notes totopics so that, when writing, you can elaborate on each topic with research material. An example of a keyword outline follows.I.IntroductionII.EquipmentA.En route: HostB.Terminal: ARTSIII.AltitudesA.En route: > 10,000 feetB.Terminal: < 10,000 feetIV.DistanceA.En route: > 10 milesB.Terminal: < 10 milesV.Conclusion1.3.1.2 Topic OutlineFor the topic outline, use phrases and clauses at each level of description (Sternberg, 1977). This kind of outline provides more information when organizing and evaluating arguments. It provides the starting point for writing because it is easy to transform phrases into paragraphs at each level. An example of a topic outline follows.parison between en route and terminal facilitiesII.Type of air traffic data processingA.En route: data currently processed by Host equipmentB.Terminal: data currently processed by ARTS equipmentIII.Differences in controlled altitudesA.En route: generally controls altitudes greater than 10,000 feetB.Terminal: generally controls altitudes less than 10,000 feetIV.Distance controlled around airportA.En route: generally controls aircraft further than 10 miles from the airportB.Terminal: generally controls aircraft less than 10 miles from the airportV.Summary of data processing equipment, altitudes, and distance1.3.1.3 Sentence OutlineIn this kind of outline, you use sentences at each level of description (Sternberg, 1977). This kind of outline provides greater detail and suggests how you will write the paper. It is especially usefulbecause you can do the majority of writing while outlining and then fill in transitions, details, examples, and so forth. An example of a sentence outline is shown below.I.This outline compares en route and terminal facilities, altitudes, and distances.II.The facilities differ in type of air traffic data processing used.A.The en route consoles display air traffic data currently processed by Hostequipment.B.The terminal consoles display air traffic data currently processed by ARTSequipment.III.The facilities also differ in the altitudes they control.A.En route controllers generally maintain separation of aircraft at altitudesgreater than 10,000 feet.B.Terminal controllers generally maintain separation of aircraft at altitudes lessthan 10,000 feet.IV.Finally, air traffic control facilities control aircraft within a certain distance from the airport.A.En route controllers generally control aircraft further than 10 miles from theairport.B.Terminal controllers generally control aircraft less than 10 miles from theairport.V.In conclusion, this section summarizes the differences of data processing equipment, altitudes, and distance controlled by en route and terminal facilities.1.3.2 Choosing an OutlineThere is no single correct outline; you should use the type of outline that facilitates your writing (Sternberg, 1977). Some authors like the keyword outline because it organizes one’s thoughts but leaves maximum flexibility in the writing. Other authors like the sentence outline because it essentially writes the paper. The sentence outline, however, can be time consuming. Some people like the topic outline as a compromise. It allows the writer to organize one’s thoughts as well as the sentence outline but leaves more flexibility and is not as time consuming.1.3.3 Organizing an OutlineMisconception: Writers often believe that the logical development of ideas in a paper reflects the historical development of ideas in the writer’s head.You do not have to present ideas in the order you thought of them. More often than not, that order is not the best way to structure your paper. The goal is to create a neat, logical package, so you will want to take your notes and research and create the organization that best communicates the ideas. The focus is on the thesis and your argument. Therefore, it is important to organize。