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生物工程专业专业英语复习重点

生物工程专业专业英语复习重点
生物工程专业专业英语复习重点

Chapter One

Fundamentals of Medicine

Passage 1

Anatomy of Mouse and Human Heart

单词:

Anatomy 解剖学

anatomical 解剖的,解剖学的

atria 心房

atria chamber 心房腔

cardiovascular 心血管系统

genetical 遗传的

conception 受孕

diaphragm 横膈,横膈膜

fetus 胎儿,胎

gestational 妊娠的,妊娠期的

morphological 形态学的

murine 鼠类,鼠性的

neonatal 新生的,新生期的,新生儿的,新生婴儿

pericardial cavity 心包腔

prenatal 产前的,出生前的

pulmonary 肺的

septation 分隔,中隔,隔膜

thoracic cavity 胸腔

句子:A fast-increasing number of genetically modified mouse models with structural and functional abnormalities in the cardiovascular system undoubtedly will contribute to an improved understanding of molecular and morphological mechanisms that regulate human heart development in health and disease.(5分)小鼠基因修饰模型是通过改变小鼠基因因而使其心血管系统结构和功能异常得到改变的一种动物模型。这类模型的大量增加,无疑会促进我们理解人的心脏在健康及病理状态下的分子和形态学机制。

Developmentally, it is interesting to note that the gestational window during which the heart develops is quite different in the mouse and human. In the human it takes about 2 mo (from conception) for the heart to complete septation, followed by another 7 mo to further mature until the baby is born and the pulmonary circulation kicks in. In the mouse, however, it takes only 2 wk from the time of conception for cardiac septation to complete. After that, the mouse fetus has less than 1 wk of prenatal life before birth.

Without going into any detail, it suffices to say that some of the developmental events that in the human are more or less completed at birth are still in progress in the neonatal mouse.

人们有趣地发现小鼠与人的心脏在孕育其中的发育有很大不同。人的心脏约在最初2个月的时间(自受孕起)完成中隔生长,并在随后的7个月中进一步成熟,直至胎儿出生和肺循环产生。而小鼠,其心脏自受孕开始只用2周时间来完成中隔的生长。之后不到一周的时间小鼠便出生了。不需要太多细节,我们有充分的理由说,某些在人类婴儿出生时已基本完成的发育过程,在新生小鼠身上还继续进行着。

Passage 2

A Framework for the Study of Human Physiology

单词:

生理学physiology

circulatory system 循环系统

digestive system 消化系统

endocrine glands 内分泌系统

extracellular fluid 细胞外液

gastrointestinal tract 胃肠道

homeostasis 内环境稳定

intermediary metabolism 中间代谢

respiratory system 呼吸系统

virus 病毒

bacteria 细菌

1.Even small viruses weighing one millionth of a single bacterium have the characteristics of life, for they feed on their surroundings, they grow and reproduce and they excrete by-products. These very minute living structures are the subject of the simplest type of physiology, viral physiology. Physiology becomes progressively more complicated and vast as it extends through the study of higher and higher forms of life such as cells, plants, lower animals, and finally human beings. Therefore, the vast field of physiology can be divided into viral physiology, cellular physiology, human physiology, and many more subdivisions.

甚至细小的病毒,哪怕重量只有一个细菌的百分之一,也具有生命的特征,因为它们靠周围环境生活,会生长繁殖,而且会排泄副产品。这些非常微小的生命结构是最简单的生理学、病毒生理学的研究课题。当生理学研究的生命形式愈来愈高级,例如细胞、植物、低等动物以及最后达到人类时,生理学就变得愈来愈复杂而广泛。因此,生理学的广泛领域可分为病毒生理学、细胞生理学、植物生理学、人体生理学等许多分支。

About 60 percent of the adult human body is fluid. Although most of this fluid is inside the cells and is called intracellular fluid, about one third is in the spaces outside the cells and is called extracellular fluid. This extracellular fluid fills the spaces between the cells. This fluid is called the internal environment of the body—it is this environment that the cells live. The extracellular fluid contains the nutrients and other constitutions necessary for maintenance of cellular life. The functions of most of the organs of the body are geared toward maintaining constant physical conditions and concentrations of dissolved substances in this internal environment. This condition of constancy in the internal environment is called homeostasis.

人体大约有60%是液体。虽然这些液体多数存在于细胞内,成为细胞内液,但还有大约1/3存在于细胞外,称为细胞外液。细胞外液充满细胞间的间隙。该液体称为身体的内环境—细胞正是生活在此环境中。细胞外液包含营养物质和维持细胞生存所需要的其他成分。身体大多数器官的功能是适应于维持此内环境中物理条件和溶解物质浓度的恒定。内环境的这种恒定状态称之为稳态。

The digestive system performs a similar function for other nutrients besides oxygen; it processes nutrients that are then absorbed into the blood and are rapidly transported throughout the body fluids, where they can be used by the cells. The liver, the endocrine glands, and some of other organs participate in what is collectively known as intermediary metabolism, which converts many of the nutrients absorbed from the gastrointestinal tract into substances that energy has been extracted by the cells, and other organs provide for hearing, feeling, tasting, smelling and seeing, all of which aid the animal or the human being in his search for and selection of food and also help him to protect himself from dangers so that he can perpetuate the almost utopian internal environment in which his cells continue their life processes.

消化系统对除氧以外的其他营养物执行着相似的功能,它加工营养物,使其被吸收进入血液并迅速运

送到所有体液,在那里它们可以被细胞利用。肝脏、内分泌腺以及某些其他器官都参与所谓的中间代谢,它将由胃肠道吸收的许多营养物转变成可被细胞直接利用的物质。肾脏将细胞已经提取其能量后的营养物所剩余的东西排除,而其他器官为身体提供听觉、感觉、味觉、嗅觉和视觉等功能,所有这些都帮助动物和人寻找和选择食物,并且还帮助他保护自己免遭危险,以便他能够使几乎是乌托邦式的内环境保持不变,在该环境中他的细胞将继续其生命过程。

Passage 3

Inflammation, Tissue Damage and Repair

单词:

Inflammation炎症

aetiological病因论的;病原学的

albumin白蛋白

arterioles小动脉

asphyxia窒息

capillary bed毛细血管床

connective tissue结缔组织

emigration游出

endothelial内皮的

exudation渗出

leucocyte白细胞,白血球

lymphatics淋巴系统

neutrophils中性粒细胞

phagocytic cell吞噬细胞

phagocytosis吞噬作用

rheumatoid arthritis类风湿关节炎

syphilis梅毒

untoward effect副作用

vascular permeability血管渗透性

vasodilation血管舒张

tuberculosis结核(病);肺结核

Inflammation can be divided into two types: acute and chronic. The division of inflammation is based according to the time course and cellular components involved. These categories are not mutually exclusive, and some overlap exists.

Acute inflammation is the immediate and early response to an injurious agent and affects the vascular and connective tissue adjacent to the injured cells. There are three major components in the process of acute inflammation: increased blood flow (vasodilation), increased vascular permeability (exudation) and egress of white blood cells into the injured tissue (emigration). There three components are coordinated and interrelated by numerous chemical mediators produced or released at the site of injury.

炎症可以分为两种类型:急性炎症和慢性炎症。这种分类是根据时间周期和细胞内容物来划分的。这些分类不是绝对的,可以互相交叉。

急性炎症是机体对有害因子的即时和早期反应,影响着与受损细胞邻接的血管及结缔组织。急性炎症过程

有三大组成部分:血流加快(血管扩张),血管渗透性增高(渗出)及白细胞外出到受损组织内(白细胞游出)。损伤处产生或释放许多化学介质,是这三个部分彼此协调、互相联系。

Passage 3

Green Chemistry

adipic己二烯dehydrogenation脱氢作用

alkylation烷基化hazardous危险

aqueous-based水性基础的polystyrene聚苯乙烯

benign良性的styrene苯乙烯

carcinogen致癌源

The twenty-fi rst century brings an urgent need for chemists to devel op environmentally friendly “green” methods. We have already discussed several green methods over the course of our study Environmentally benign chemistry is especially important in the chemical industry, where the worl dwide sythesis of a compound may involve billions of pounds of chemicals a year. We can think of many ways to reduce the impact on the environment of a large-scal e process: We can run the reaction in safer aqueous-based systems instead of potentially hazardous organic solvents, we can carry out the reaction at ambient temperature instead of with applied heat, we can recycl e materials, and we can use pathways that do not use or generate toxic substances. All of these may l essen the impact of the process on the environment in terms of pollution or consumption of resources. Consider two new possibilities that replace benzene, a know carcinogen, with a safer alternative. 21世纪,化学家们面临的新的任务是发展环境友好的“绿色化学”。对于化工行业而言,全世界范围内每年产生某一个化合物所需的化学原料或试剂多达十几亿磅,因此,发展环境无害化学非常具有意义。我们可以通过改变合成的路线来减轻大规模生产对环境的影响;可以将反应在相对安全的水相中进行,这样就可以避免有机溶剂的潜在危害;可以将反应在室温下进行,可以节省热量;我们可以将物料循环利用;我们还可以通过比较优先选择不会使用或产生有害物质的反应路线。这些考虑都可以减轻对环境的影响,减少污染及自然资源的消耗。苯是一种致癌性物质,以下我么举两个用其他更安全的原料代替苯的例子来具体说明了绿色化学的实践。

These exampl es illustrate the opportunities that await students of today as they become the well-trained chemists of the future who will tackl e chall enges like these.

今天的学生们,即未来的化学家们,应做好准备,从绿色化学的角度出发,解决这类难题。Chapter Three Medicinal Chemistry

Passage 1 Medicinal Chemistry

bioorganic chemistry 生物有机化学

carcinogenicity 致癌

immuno-stimulatory 免疫促进

medicinal chemistry 药物化学

molecular biology 分子生物学

physical chemistry 物理化学

quantitative drug design 药物定量设计

receptor 受体

structure-activity realationship 构效关系

thalidomide 反应停(一种保胎药)

toxicity 毒性

teratogenicity 致畸

Early advances in medicinal chemistry were concerned principally with the estimation , isolation ,structural determination ,and synthesis of medicinal agents of natural origin .A second major area was the synthesis of simplified fragments of complex drug molecules .

药化的早期发展被认为是源于天然的药剂的预测,分离,结构测定以及合成。第二个主要发展阶段是合成复杂的药物分子的简单片段。

The golden age (1940-1960) in the discovery of medicinals by these empirical strategies came to an end concomitant with the thalidomide tragedy .An arid middle age marked by pessimism in drug synthesis in drug synthesis in both industrial and academic quarters ensued because of the com- bined difficulties of toxicity ,carcinogenicity ,and teratogenicity ,and the relatively low return from random synthesis .这些经验式策略的药物发现黄金时段(1940~1960)随着反应停悲剧的出现而结束。随扈跟来的是一个以工业界与学术界队药物合成的悲观为标志的枯燥中期,因为有致毒、致癌、致畸和因为随意合成而相对低回报的双重苦难。Passage 2 Selective Optimization of Side Activities :Another Way for Drug Discovery

"The most basis for the discovery of a new drug is to start with an old drug."

Sir James Black,

Winner of the 1988 Noble Prize in Physiology and Medicine

antagonist 拮抗剂

agonist 激动剂neuropeptide 神经肽

dysfunction 功能障碍high-throughput screening 高通量筛选

A retrospective analysis of the ways leading to discovery of new drugs suggests that there are four types of successful strategies leading to new lead compounds.

The first strategy consists of systematic screening of sets of compounds arbitrarily chosen for their

diversity ,by selected biological assays . 对发现新药的各种方法进行总结,一共可以归纳为四条途径,这四条途径可有效的发现新药。

第一条途径是对各种有代表性结构特征的化合物运用特定的生物分析方法进行系统筛选。

The second strategy is based on the modification and improvement of existing active molecules . The objective is to start with known active principles and , by various chemical transformations , prepare new molecules (sometimes referred to as "me-too compounds ")for which an increase in potency , a better specific activity profile , improved safety , and a formulation that is easier to handle by physicians and nurses or more acceptable to the patient are claimed.

第二途径主要为对现有的活性化合物的进行结构修士。目的就是利用已知的活性规则,通过一系列的化学转化,之辈得到具有更强的药效,更高的作用转移性,安全性更高的新的化合物分子(又是也称为“me-too 化合物”),并且使其具有更适于临床用药,更为患者所接受的新的剂型。

The third approach resides in the retroactive exploitation of various pieces of biological information that sometimes results from new discoveries made in biology and medicine and sometimes are just the fruits of more or less serendipitous observations.

第三条途径就是利用各种生物学信息,常常是借助在生物学及药学领域有较大的突破或某一偶然的发现,进行反向活性的药物设计和筛选。

Finally, the fourth route to new active compounds is a rational design based on the knowledge of the molecular cause of the pathological dysfunction. 最后,第四条新的活性化合物的发现途径是基于疾病发生的病理学分子机制,进行化合物的合理设计。

The Tricarboxylic acid cycle : a carborn and energy wheel :

单词:Tricarboxylic acid cycle

Pyruvic acid 丙酮酸

Aerobic Respiration 有氧呼吸

Coenzyme 辅酶

Dehydrogenation 脱氢

Decarboxylation 脱羧

Ribosome 核糖体

Electron transport 电子传递

Pathway途径

Glucolytic pathway 糖酵解途径

Intermediate compounds

Metabolic 代谢的

Phosphorylation 磷酸化

In the first step of tricarboxylic acid cycle, pyruvic acid is converted to a compound that can be fed into the TCA cycle proper.

在三羧酸循环的第一步,丙酮酸被转化成能适当地进入三羧酸循环的化合物形式。

This step involves the first oxidation-reduction reaction of this phase of respiration , and it also removes a carbon as carbon dioxide.

这一步发生呼吸过程的第一个氧化还原反应,除去一个碳形成CO2.

During this very complex reaction , a cluster of enzymes and coenzyme A participates in the dehydrogenation(oxidation) of pyruvic acid, the reduction of NAD to NADH, and the decarboxylation of pyruvic acid to a 2-carbon acetyl group.

在这个非常复杂的反应中一系列的酶和辅酶A参与其中,将丙酮酸脱氢(氧化)。使NAD还原为NADH,丙酮酸则脱羧形成2碳的乙酰基。

The NADH formed during this reaction will be shuttled into election transport and used to generate ATP; its formation is one of five dehydrogenations associated with the TCA cycle and is what accounts for the relatively greater output of ATP in aerobic respiration.

这个反应中所形成的NADH将在电子传递链中穿梭,来生成ATP,它的形成是与TCA循环相关联的5个脱氢反应之一,这也说明了在有氧呼吸中相对较高的ATP产出原因。

TEXT B Induction and feedback repression

汉译英:

有些酶属于组成型的,也就是说,在细胞生长时它们总是大量的合成。

Some enzyme are produced constitutive, that is , they are always made in substantial amounts when cell are growing .

其它酶是诱导型的,也就是说,只有在培养基中关键底物出现时,它们才能形成。

Other enzymes are inducible ,that is ,they are formed only in the presence of key substrates in the medium.

当这些关键底物不存在时,诱导酶的结构基因通常是不活跃的,或在很低的水平活动。

The structural gens of inducible enzymes are normally inactive or operate at a very low “basal”rate in the absence of the key substrates.

当这些关键底物存在时,结构基因才被启动,于是进行转录和翻译。

When the key substrate is present,the structure gene is switched on and transcription and translation occur.

单词:

反馈:feedback

阻遏子: repressor

操纵基因: operator gens

分解代谢的 catabolic

合成代谢的:anabolic

脱辅基阻遏子:apo-repressor

辅阻遏物:co-repressor

Regulation of Branched Metabolic Pathway

单词:

同工酶: isoenzyme

偶联反馈抑制调节:concerted feedback regulation

积累反馈抑制调节:cumulative feedback regulation

汉译英:

生物合成途径通常具有共同的酶反应序列,然后分支合成不止一种终产物。

Biosynthetic metabolic pathways often have a common enzyme sequence and then branch leading to more than one end-product.

微生物已经进化出了反馈调节机制,依靠这种机制,合成一种终产物会引起对产生这种产物的代谢分支中第一个酶的反馈抑制。

Microorganism have evolved feedback mechanisms, whereby a build-up of one end-product cause a feedback effect on the first enzyme of the branched leading to that product.

这些调控作用可分为两类:酶活性的抑制和抑制酶的合成。

These regulatory effect can be of two types: inhibition of enzyme activity and repression of enzyme synthesis.

自然界中存在成千上万的微生物,但目前只有相当少的得到了开发利用。

Of the many thousands microbial species ,relatively few are currently exploited.

单词:

有机化能营养菌:chemo-organotrophs

革兰氏阳性菌的: gram-positive

革兰氏阴性的:gram-negative

感染:infect

基因组: genome

脂蛋白:lipoprotein

噬菌体:bacteriopha

管理学专用词汇

目标mission/ objective 内部环境internal environment 外部环境external environment 集体目标group objective 计划planning 组织organizing 人事staffing 领导leading 控制controlling 步骤process 原理principle 方法technique 经理manager 总经理general manager 行政人员administrator 主管人员supervisor 企业enterprise 商业business 产业industry 公司company 效果effectiveness 效率efficiency 企业家entrepreneur 权利power 职权authority 职责responsibility 科学管理scientific management 现代经营管理modern operational management 行为科学behavior science 生产率productivity 激励motivate 动机motive 法律law 法规regulation 经济体系economic system 管理职能managerial function 产品product 服务service 利润profit 满意satisfaction 归属affiliation 尊敬esteem 自我实现self-actualization 人力投入human input 盈余surplus 收入income 成本cost 资本货物capital goods 机器machinery 设备equipment 建筑building 存货inventory 经验法the empirical approach 人际行为法the interpersonal behavior approach 集体行为法the group behavior approach 协作社会系统法the cooperative social systems approach 社会技术系统法the social-technical systems approach 决策理论法the decision theory approach 数学法the mathematical approach 系统法the systems approach 随机制宜法the contingency approach 管理任务法the managerial roles approach 经营法the operational approach 人际关系human relation 心理学psychology 态度attitude 压力pressure 冲突conflict 招聘recruit 鉴定appraisal 选拔select 培训train 报酬compensation 授权delegation of authority 协调coordinate 业绩performance 考绩制度merit system 表现behavior 下级subordinate 偏差deviation 检验记录inspection record 误工记录record of labor-hours lost 销售量sales volume 产品质量quality of products 先进技术advanced technology 顾客服务customer service 策略strategy 结构structure 领先性primacy 普遍性pervasiveness 忧虑fear 忿恨resentment 士气morale 解雇layoff 批发wholesale 零售retail 程序procedure 规则rule 规划program 预算budget 共同作用synergy 大型联合企业conglomerate 资源resource 购买acquisition 增长目标growth goal 专利产品proprietary product 竞争对手rival 晋升promotion 管理决策managerial decision 商业道德business ethics 有竞争力的价格competitive price 供货商supplier 小贩vendor 利益冲突conflict of interests 派生政策derivative policy 开支帐户expense account 批准程序approval procedure 病假sick leave 休假vacation 工时labor-hour 机时machine-hour 资本支出capital outlay 现金流量cash flow 工资率wage rate 税收率tax rate 股息dividend 现金状况cash position 资金短缺capital shortage 总预算overall budget 资产负债表balance sheet 可行性feasibility 投入原则the commitment principle 投资回报return on investment 生产能力capacity to produce 实际工作者practitioner 最终结果end result 业绩performance 个人利益personal interest 福利welfare 市场占有率market share 创新innovation 生产率productivity 利润率profitability 社会责任public responsibility 董事会board of director 组织规模size of the organization 组织

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