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Cevimeline hydrochloride_107220-28-0_DataSheet_MedChemExpress

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Product Name:Cevimeline hydrochlorideCAS No.: 107220-28-0Cat. No.:HY-70020BMWt:235.77Formula:C10H18ClNOSPurity :>98%Solubility:Mechanisms:Biological Activity:References:

Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com[1]. Witsell DL, et al. Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.Head Neck. 2012 Aug;34(8):1136-42. doi: 10.1002/hed.21894. Epub 2012 Jan 9.[2]. Ono K, et al. Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.Arch Oral Biol. 2012 Apr;57(4):421-8. Epub 2011 Nov 17.[3]. Kondo Y, et al.Cevimeline-induced monophasic salivation from the mouse submandibular gland:decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.J Pharmacol Exp Ther. 2011 Apr;337(1):267-74. Epub 2011 Jan 14. [4]. Voskoboynik B, et al.Cevimeline (Evoxac) overdose.J Med Toxicol. 2011 Mar;7(1):57-9.[5]. Tajiri S, et al. Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tabletformulations.Int J...Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. IC50 value:Target: M3 receptor Pathways:Neuronal Signaling; Target:mAChR Pathways:GPCR/G protein; Target:mAChRProduct Data SheetSoluble to 75 mM in water and to 50mM in DMSO

11 Deer Park Drive, Suite 102D Monmouth Junction, NJ 08852,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com

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Maprotiline_hydrochloride_LCMS_20720_MedChemExpress

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File ..60617 2016-06-17 09-40-36\BIZ2016-617-WJ2.D Tgt Mass (CHM): Injection Date : 17 Jun 16 1:09 pm +0800 Seq. Line : 47 Sample Name : BIZ2016-617-WJ2 Location : P1-C-09 Acq. Operator : Su Xiao Ying(LCMS-02) Inj : 1 Spec. Reported : MS Integration Inj Volume : 3 ul

Acq. Method : D:\Aglient 1260\Data\20160617\20160617 2016-06-17 09-40-36\100-1000MS+3MIN-

Analysis Method : D:\AGLIENT 1260\DATA\20160617\20160617 2016-06-17 09-40-36\100-1000MS+3MIN-

Catalog No : HY-B0444 Batch#20720 A-RP-153

Method Info : HY-365_5HO1RS,M,A-RP-108，210nm,23min

min*0.511.522.53mAU

050010001500*DAD1 B, Sig=214,4 Ref=off

1.5401.856

2.367

min*0.511.522.53mAU

02040*DAD1 C, Sig=254,4 Ref=off

1.4641.855

2.358

min0.511.522.530100000200000300000 MSD1 TIC, MS File ES-API, Pos, Scan, Frag: 50

1.863

min0.511.522.53-0.1-0.0500.05 Ion 1, MSD1 1,Target Mass 0 +H Positive, EIC=0.7:1.7

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Inhibitors, Agonists, Screening

Safety Data SheetRevision Date:May-24-2017Print Date:May-24-2017

1. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Cenerimod

Catalog No. :HY-17606

CAS No. :1262414-04-91.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USA

Tel:609-228-6898

Fax:609-228-5909

E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-6898

2. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.

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Inhibitors, Agonists, Screening

Safety Data SheetRevision Date:Sep.-15-2017Print Date:Sep.-15-2017

1. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Valrocemide

Catalog No. :HY-100379

CAS No. :92262-58-31.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USA

Tel:609-228-6898

Fax:609-228-5909

E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-6898

2. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.

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Inhibitors, Agonists, Screening

Safety Data SheetRevision Date:Aug.-29-2017Print Date:Aug.-29-2017

1. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Tapentadol (hydrochloride)

Catalog No. :HY-70042A

CAS No. :175591-09-01.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USA

Tel:609-228-6898

Fax:609-228-5909

E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-6898

2. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.