[26] Ker WH, Wagner WH. Gynecologic surgery and the management of hemorrhage.

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GynecologicSurgeryandtheManagementofHemorrhage

WilliamH.Parker,MDa,*,WillisH.Wagner,MD

b

Surgicalbloodlossofmorethan1000mLorbloodlossthatrequiresabloodtransfu-sionusuallydefinesintraoperativehemorrhage.1Intraoperativehemorrhagehasbeen

reportedin1%to2%ofhysterectomystudies.Acutelossofmorethan25%ofthepatient’sbloodvolumeoralossthatissufficienttorequireaninterventiontosavethepatient’slifedefinesmassivehemorrhage.2Cardiovascularinstabilitywithsignificanthypotensionoftenresultsfromalossof30%to40%ofthepatient’sbloodvolume.Morethan40%bloodlossislifethreat-ening.Severehemorrhagecanleadtomultiorganfailureanddeathunlessresuscita-tionisaccomplishedwithinanhour.Severepostoperativeanemiacanaffectmortality.Inastudyof300patientswhorefusedbloodtransfusionforreligiousreasons,itwasfoundthatpatientswithhemo-globinlevelsof5.1to7.0g/dLhadmortalityof9%.Mortalitywas30%inpatientswithhemoglobinlevelsbetween3.1and5.0g/dLand64%inthosewithhemoglobinlevelslessthan3.0g/dL.However,hemoglobinlevelsbetween7and8g/dLdidnothaveanyadverseeffectonmortality.3

PREOPERATIVEEVALUATIONPreoperativeevaluationofthepatientcanaidsurgicalplanningtohelppreventintra-operativehemorrhageorprepareforthemanagementofhemorrhage,shoulditoccur.

MedicalHistoryPersonalorfamilyhistoryofprolongedbleeding,postpartumhemorrhage,needfortransfusions,orpersistentanemiashouldbedetermined.vonWillebranddisease(VWD)occursin2%ofwomeninthegeneralpopulation;however,17%ofwomen

aDepartmentofObstetricsandGynecology,SaintJohn’sHealthCenter,UniversityofCalifornia

LosAngelesSchoolofMedicine,1450TenthStreet,SantaMonica,LosAngeles,CA90401,USAbVascularLaboratory,SaintJohn’sHealthCenter,2121SantaMonicaBoulevard,SantaMonica,

CA90404,USA*Correspondingauthor.E-mailaddress:wparker@ucla.edu

KEYWORDS󰀂Gynecologicsurgery󰀂Hemorrhage󰀂Hemostasis

ObstetGynecolClinNAm37(2010)427–436doi:10.1016/j.ogc.2010.05.003obgyn.theclinics.com0889-8545/10/$–seefrontmatterª2010ElsevierInc.Allrightsreserved.

多器官衰竭术前措施评估,减少术中出血及相关处理措施准备withmenorrhagiahaveVWD.Becausemenorrhagiaisacommonindicationforgyne-cologicsurgery,ahistoryofmenorrhagiasincemenarcheshouldtriggerfurthereval-uationbyahematologist.Ifthediagnosisismade,desmopressin(DDAVP)canbeusedtoreduceintraoperativebleedingbyincreasingtheplasmaconcentrationandactivityofvonWillebrandfactor.Womenwithreligiousbeliefsthatprecludetransfu-sionwithallogenicbloodshouldbeidentifiedbeforeelectivesurgery.Increasinghemoglobinconcentrationsbeforesurgeryshouldbestronglyconsidered(seelatersections).

MedicationHistoryBecausecoagulationmaybeinhibitedbymedications,includingprescription,over-the-counter,oralternativeformulations,thesurgeonshouldinquireabouttheuseofthesesubstances.Patientsoftendonotmentiontheseproducts.Aspirin,oftenusedforfever,headache,orpainshouldbediscontinued7to10daysbeforesurgery.Aspirininhibitsplateletcyclooxygenasewithin1hourofingestion.4Thiseffectisirreversible,soplateletaggregationstudiescangiveabnormalresultsforupto10days.Nonsteroidalantiinflammatorydrugs(NSAIDs)causeinhibitionofcyclooxygenase,whichisreversible.Plateletfunctionreturnstonormalwithin24hoursafterthelastdoseofibuprofen,butwithmostotherNSAIDsplateletfunctionisabnormalfor3days.5Clopidogrelbisulfate(Plavix),along-actingoralantiplateletmedication,causesadose-dependentinhibitionofplateletaggregation2hoursafterthefirstdose.Withcontinueduse,ittakesabout5daysaftertreatmentisdiscontinuedforbleedingtimetoreturntonormal.A1.5%increaseinthefrequencyofsurgicalbleedingeventswasreportedinameta-analysisofmenandwomentakinglow-doseaspirinandundergoingnoncardiacsurgeriesandinvasiveprocedures.However,neithertheseverityofbleedingcomplicationsnortheperioperativemortalityincreasedforabdominalsurgery.6PatientswithahistoryofcardiovasculardiseaseorthrombosiswhotakeaspirinorPlavixforprophylaxisshouldbemanagedjointlywithaninternist.Continueduseofthesedrugsdependsonthepotentialriskofthromboticcomplicationsthatariseifaspirinisdiscontinuedversustherisksofperioperativebleedingassociatedwithcontinuedtherapy.7Stoppingaspirintherapyformorethan5daysinpatientswith

underlyingcardiovasculardiseasemayincreasetheriskofanacutecoronarysyndromeorstroke.Managementofwarfarinorheparinshouldalsobecoordinatedbytheprescribingclinician.

AlternativeMedicationsImpairedhemostasishasbeenshowntobemorethan2timesaslikelyforpatientsusingtraditionalChineseherbalmedicinesthanfornonusers.8Garlic,Ginkgobiloba,

andginsengmayalsoaffectcoagulationthroughtheinhibitionofplateletaggregation.9

PreoperativeLaboratoryEvaluation󰀂Abaselinehematocrit(Hct)shouldbeobtainedbeforesurgery,preferablyintime