帕瑞昔布钠联合高乌甲素PCIA泵在肩关节镜术后镇痛的效果观察

帕瑞昔布钠联合锁骨下臂丛神经阻滞对手外科患者术后镇痛的效果观察王卓群;张洁;梁伟民【期刊名称】《中国临床医学》【年(卷),期】2011(018)002【摘要】目的:探讨帕瑞昔布钠联合锁骨下臂丛神经阻滞用于手外科患者术后镇痛的有效性及安全性.方法:择期行单侧肘关节以下小手术患者100例,随机分为帕瑞昔布钠组(P组)和对照组(C组),每组50例.锁骨下臂丛神经阻滞实施成功后,P组于手术实施前15 min静脉注射帕瑞昔布钠40 mg(用0.9%氯化钠液2 mL稀释),C组给予等体积0.9%氯化钠液.分别于术后6 h、8 h、12 h、24 h进行视觉模拟(VAS)疼痛评分,记录最早出现疼痛的时间及VAS疼痛评分,术后24 h内要求镇痛的患者数,首次用镇痛药的时间及VAS疼痛评分,并观察术后不良反应的发生情况.结果:患者术后8 h、12 h的VAS疼痛评分、术后24 h内要求镇痛的患者数及首次要求镇痛时的VAS疼痛评分P组均低于C组(P<0.05).而2组患者术后不良反应的发生情况相似,差异无统计学意义(P>0.05).结论:帕瑞昔布钠联合锁骨下臂丛神经阻滞用于手外科患者术后镇痛安全、有效.【总页数】3页(P237-239)【作者】王卓群;张洁;梁伟民【作者单位】复旦大学附属华山医院麻醉科,上海,200040;复旦大学附属华山医院麻醉科,上海,200040;复旦大学附属华山医院麻醉科,上海,200040【正文语种】中文【中图分类】R971+.1【相关文献】1.帕瑞昔布钠联合下肢神经阻滞在膝关节及远端手术后镇痛效果分析 [J], 魏小伍2.帕瑞昔布钠超前镇痛联合臂丛麻醉对断肢（指）术后镇痛的疗效研究 [J], 付作文;张晓曼;黄咏;赵根隆;程朝晖;黄咏冬3.帕瑞昔布钠对于肿瘤外科患者术后镇痛的效果观察 [J], 骆华连4.帕瑞昔布钠联合持续臂丛神经阻滞用于肩关节镜术后镇痛的安全性及有效性 [J], 徐闯;刘明廷;王建明;李健;尚义美5.帕瑞昔布钠联合头皮神经阻滞用于神经外科开颅术后镇痛的研究 [J], 黄福森;吴超然因版权原因，仅展示原文概要，查看原文内容请购买。

氯诺昔康联合帕瑞昔布钠对接受下肢骨科手术的患者进行术后镇痛治疗的效果分析唐　燕1，廖申坤2（1.重庆永荣矿业有限公司总医院药械科，重庆　402460；2.重庆市荣昌区妇幼保健院药剂科　重庆　400013）[摘要]目的：分析用氯诺昔康联合帕瑞昔布钠对接受下肢骨科手术的患者进行术后镇痛治疗的临床效果。

方法：选取2018年3月至2020年12月在某医院接受下肢骨科手术的120例患者为研究对象。

采用随机数表法将其分为观察组和对照组。

术后，采用氯诺昔康对对照组患者进行镇痛治疗，采用氯诺昔康联合帕瑞昔布钠对观察组患者进行镇痛治疗。

对比两组患者用药不良反应的发生情况、按压病人自控镇痛（PCA）泵的总次数及有效的按压次数、术后使用芬太尼的剂量、接受镇痛治疗后不同时间疼痛的程度、对镇痛治疗效果的满意度。

结果：用药期间，与对照组患者相比，观察组患者不良反应的总发生率较低，P＜0.05。

与对照组患者相比，观察组患者按压PCA泵的总次数及有效的按压次数、术后使用芬太尼的剂量均较少，其对镇痛治疗效果的总满意率较高，P＜0.05。

接受镇痛治疗后第6 h、第12 h及第24 h，两组患者视觉模拟评分法的评分相比，P＞0.05。

结论：采用氯诺昔康联合帕瑞昔布钠对接受下肢骨科手术的患者进行镇痛治疗可取得良好的镇痛效果，且治疗期间其不良反应的发生率较低，其使用麻醉药物的剂量较少，其对镇痛治疗效果的满意度较高。

[关键词]下肢骨科手术；术后镇痛；氯诺昔康；帕瑞昔布钠；不良反应[中图分类号]R681.8 [文献标识码]A [文章编号]2095-7629-（2022）02-0120-04Effects of lornoxicam combined with Parecoxib sodium on postoperative analgesia in patients undergoing lowerextremity orthopedic surgeryTANG Yan 1, LIAO Shenkun 2(1. Department of Pharmacy, General Hospital of Chongqing Yongrong Mining Co., LTD., Chongqing 402460; 2. Pharmacy Department,Chongqing Rongchang Maternal and Child Health Hospital, Chongqing 400013)[Abstract] Objective: To analyze the clinical effect of lornoxicam combined with Parecoxib sodium on postoperative analgesia in patients undergoing lower extremity orthopedic surgery. Methods: A total of 120 patients who received lower limb orthopedic surgery in a hospital from March 2018 to December 2020 were selected as the study subjects. They were divided into observation group and control group by random number table method. After surgery, lornoxicam was used for analgesic treatment in control group, and lornoxicam combined with parecoxib sodium was used for analgesic treatment in observation group. The incidence of adverse drug reactions, the total number of times of pressing the patient-controlled analgesia (PCA) pump and the number of effective pressing, the dosage of fentanyl after operation, the degree of pain at different times after analgesia treatment, and the satisfaction of analgesia treatment effect were compared between the two groups. Results: During medication, compared with the control group, the total incidence of adverse reactions in the observation group was lower, P < 0.05. Compared with the control group, the total number of compressions of PCA pump, effective compressions and postoperative fentanyl dosage in the observation group were lower, and the total satisfaction rate of analgesic treatment effect was higher, P < 0.05. At 6h, 12 h and 24 h after analgesia treatment, the comparison of visual analog scoring method between the two groups showed P > 0.05. Conclusion: Lornoxicam combined with parecoxib sodium can achieve good analgesic effect in patients undergoing lower extremity orthopedic surgery, and the incidence of adverse reactions during the treatment is low, the dosage of anesthesia is small, and the satisfaction of analgesic effect is high.[Key words] Lower limb orthopedic surgery; Postoperative analgesia; Lornoxicam; Parecoxib sodium; Adverse reactions进行内固定手术是目前临床上对下肢骨折患者进行治疗的主要方法，但术后患者可出现不同程度的疼痛，可影响其术后进行早期功能锻炼，并可影响其康复的效果。

帕瑞昔布钠超前镇痛联合PCIA应用于腹腔镜直肠癌根治术老年患者镇痛效果研究【摘要】目的：分析帕瑞昔布钠超前镇痛与PCIA（静脉自控镇痛）相结合在老年腹腔镜直肠癌治疗中的镇痛作用和效果。

方法：选取54例在2020年2月-2021年2月期间在我院接受直肠癌治疗的老年病患，根据随机数字表法将其分为实验组和对照组，予以对照组病患术前预先使用帕瑞昔布钠进行镇痛，给予实验组病人在对照组基础上术后采取芬太尼静脉自控镇痛，比较两组病患术后对镇痛的满意度以及不良反应等情况。

结果：接受术帕瑞昔布钠超前镇痛的对照组患者对镇痛的满意度显著低于实验组的满意程度，实验组术后出现不良反应的概率明显低于对照组的不良反应的发生几率，两组之间的数据进行对比存有差异，具备临床统计学意义(P<0.05)。

结论：在老年腹腔镜直肠癌根治术中预先使用帕瑞昔布钠镇痛和芬太尼静脉自控镇痛均可行，并且安全可靠，将两者联合使用其病患的镇痛满意度较高，并且不良反应较小，镇痛效果较好。

【关键词】PCIA；帕瑞昔布钠超前镇痛；满意度；不良反应直肠癌作为我国比较常见的一种恶性肿瘤，近年来具有较高的发病率，其根治治疗后有50％以上能存活过5年，临床一般采用开腹手术和腹腔镜根治术给予治疗。

腹腔镜手术具有创伤性小、术后恢复较快的特点被广泛使用于外科临床手术中，同时术后仍存在创口疼痛，其是术后早期，因此只有解决术后疼痛问题，方能更好的体现其优越性[1]。

为此我院为减少病患术后的痛苦，特选取54例此类病患应用不同的镇痛方式进行实验，现报告如下。

1 资料与方法1.1基础资料依据随机数字表法将择取的于2020年2月至2021年2月之间本院接受的54例老年直肠癌患者平均分为对照组27例和实验组27例，此次实验所有参与患者及其家属均知晓且同意，并且经过院方批准实施。

对照组中男性病患17例，女性患者10例，年龄为55-70岁，平均年龄为（62.50±1.54）岁，实验组中女性病患11例，男性患者16例，年龄为56-70岁，平均年龄为（63.00±1.69）岁，两组病患数据的年龄、性别等在基础资料中均无显著的对比差异（P>0.05），代表不存在统计学意义。

帕瑞昔布钠对甲状腺次全切除术患者术后镇痛的效果观察孙秀荣;姜妍;马晓霞【摘要】Objective To discuss the analgestic effect of parecoxib sodium on patients who have undergone subtotal thyroidectomy. Methods We collected the clinical data of 105 cases who had undergone subtotal thyroidecto-my in our hospital from November 2014 to November 2015. The patients were given intravenous injection of parecoxib sodium (40 mg)15 minutes before the end of operation( group A). The patients were given intravenous injection of parecoxib sodium(40 mg)immediately after patients returned to the wards(B group). The patients were given intrave-nous injection of NS(2 mL)solution 15 minutes before the end of operation(group C). Each group included 35 cases. After returning to the ward,visual simulation pain score( VAS score)was made 0,2,4,6,12,24 h later,postoperative analgesia satisfaction rate 1 d after operation and the incidence of side effects of the three groups were observed and compared. Results The VAS scores of A and B groups at each time point were significantly lower than that of C group,the difference was statistically significant(P﹤0. 05);the VAS scores of A group(0,2 hour )were lower than those of B group,the difference was statistically significant(P﹤0. 05). The postoperative occurrence rate of side reac-tions of the three groups had no statistical significance(P﹥0. 05). Conclusion Application of parecoxib during or af-ter thyroid subtotal surgery can reduce postoperative pain and increase satisfaction of analgesic effect. Moreover,appli-cation ofparecoxib is safe and reliable. Giving intravenous injection of parecoxib sodium 15 minutes before the end of surgery is a better choice.%目的：观察用帕瑞昔布钠对甲状腺次全切除术患者进行术后镇痛的临床效果。