《中国学术期刊影响因子年报》发布,《中国药理学通报》三项第一

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Relationship between endoplasmic reticulum stress and cerebral ischemia reperfusion injury wu Cai—xia ,f.LIU Rui ,DU Guan.hua (1.National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences, Beijing 100050,China;2.School ofLife Science and Biopharmaceutics,Shenyang Pharmaceutical University, Shenyang 1 10016,China;3.Shandong Medical College,Linyi Shangdong 276002,China) 

Abstract:Endoplasmic reticulum is the main site of protein syn— thesis,modification and transport.Endoplasmic reticulum stress (ERS)is defined as a situation of gathering misfolded and(or) unfolded protein in endoplasmic reticulum and the failure of Ca“ homeostasis.Early ERS will induce unfolded protein response (UPR)which may be protective to cells.On the contrary,long— time strong ERS will induce cell apoptosis,even death.A grow— ing number of studies have suggested that ERS induced neuronal apoptosis was involved in the injury of cerebral ischemia and reperfusion.This review mainly summarizes recently reposed discoveries concerning ERS associated with cerebral ischemia and reperfusion,which may reveal novel insight into the basic and clinical research of stroke and provide new ideas for the drug discovery. Key words:cerebral ischemia reperfusion injury;endoplasmic reticulum stress;signaling;Ca“;reactive oxygen species;in— flammation;apoptosis 

◇消 息◇ 《中国学术期刊影响因子年报》发布,《中国药理学通报》三项第一 2012年12月26日,由中国科学文献计量评价中心与清华大学图书馆研制的《中国学术期刊影响因子年报&国际引证报 告(2012版)》发布会在北京国际会议中心举行。《中国药理学通报》复合影响因子1.541,期刊综合影响因子1.081,基础研究 类影响因子1.064,三项指标在学科排序中均列第一名。其他指标:基金论文比:0.94,他引总引比0.79,WEB下载量19.15万 次(基于中国知网)。 (黄河胜)