chroman_1_HNMR_06673_MedChemExpress

File ..170619 2017-06-19 09-04-59\WW4359-003-1_1.D Tgt Mass (CHM): Injection Date : 19 Jun 17 11:17 am +0800 Seq. Line : 27 Sample Name : WW4359-003-1_1 Location : P2-A-02 Acq. Operator : CLJ_701 Inj : 1 Spec. Reported : MS Integration Inj Volume : 0.5 ul

Acq. Method : D:\chem32\1\DATA\20170619\20170619 2017-06-19 09-04-59\1-POS-3MIN.M

Analysis Method : D:\CHEM32\1\DATA\20170619\20170619 2017-06-19 09-04-59\1-POS-3MIN.M

Catalog No : HY-16973 Batch#25003 A-RP-186

Method Info : Mobile Phase: A: water(0.01%TFA) B:ACN(0.01%TFA)

Gradient: 5% to 95%B within 1.3 min

Flow Rate :1.8ml/min

Column :SunFire C18, 4.6*50mm,3.5um A-RP-186

Oven Temperature : 45C

min0.511.522.5mAU

05001000 DAD1 B, Sig=214,4 Ref=off

1.586

1.7472.084

min0.511.522.5mAU

0200400600 DAD1 C, Sig=254,4 Ref=off

1.455

1.482

1.7412.084

min0.511.522.5050000100000 MSD1 TIC, MS File ES-API, Pos, Scan, Frag: 70

Inhibitors, Agonists, Screening Certificate of Analysis

PHYSICAL AND CHEMICAL PROPERTIES Molecular Formula:C21H20O11Molecular Weight:448.38Storage:Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 monthChemical Structure:

ANALYTICAL DATA Appearance:Light yellow to yellow (Solid)1 H NMR Spectrum:Consistent with structureLCMS:Consistent with structurePurity (LCMS):99.24%Conclusion:The product has been tested and complies with the given specifications.Product Name:IsoorientinCat. No.:HY-N0767CAS No.:4261-42-1Batch No.:25753Chemical Name:4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-6-β-D-glucopyranosyl-5,7-dihydroxy-

Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852,

ProductName:Inhibitors, Agonists, Screening

Nivolumab

Certificate of Analysis

Product Name:Cat. No.: CAS No.:Batch No.:Chemical Name:

Appearance:31687HY-P9903

Colorlesstolightyellow(Solution)Appearance:Purity (SEC-HPLC):10.0 mg/ml<0.5 EU/mgSterility:Storage Buffer:PBS, pH 7.298.56%Colorless to light yellow (Solution)

Concentration:Endotoxin Level:Sterilized via a 0.22 μm filter and packaged aseptically

Codon Optimization:YesExpression System:CHO stable cellPurification:Storage and Handling: after first use to avoid multiple freeze-thawsProtein was obtained from supernatant, followed by AC, CEX and SECStore at -80°C. Aliquots should be stored at the same temperature

Caution: Product has not been fully validated for medical applications. For research use only.lilhdhAddress: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USATel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@

Product Name:Ozanimod

CAS No.: 1306760-87-1

CHY12288Product Data Sheet

Cat. No.:HY-12288

MWt:404.46

Formula:C23H24N4O3

Purity :

>98%

Solubility:

Mechanisms:

Biological Activity: Pathways:Others; Target:Others10 mM in DMSO

Ozanimod is a novel, oral, once daily, selective sphingosine 1-phosphate 1 and 5 receptormodulator in development for autoimmune indications including relapsing multiple sclerosis (RMS) and ulcerative colitis (UC). Target: sphingosine 1-phosphate 1 and 5 receptorOzanimod represents a potential franchise in immunology. Ozanimod is the potential next-to-marketoral agent for the treatment of relapsing multiple sclerosis. In a Phase 2 trial in patients with RMS,Ozanimod achieved the primary endpoint of reduction in MRI brain lesion activity as well assecondary endpoints measuring effects on other MRI parameters. The overall safety profile of