百令胶囊对高通量血液透析患者残余肾功能保护的作用机制研究刘锦洲 胡 敏广东省江门市新会区人民医院肾内风湿科，广东江门 529100[摘要] 目的 研究百令胶囊对高通量血液透析患者残余肾功能（RRF）保护作用的机制。
方法 将江门市新会区人民医院2022年1月至2023年5月60例进行高通量血液透析治疗的患者按随机数表法分为对照组（n=30，常规治疗）和研究组（n=30，常规治疗+百令胶囊治疗），分析并比较两组患者RRF相关指标、炎性因子水平、营养相关状况。
结果 治疗后，两组血肌酐（Scr）、尿素氮（BUN）及24 h尿蛋白定量水平均较治疗前降低，肌酐清除率（Ccr）水平较治疗前升高，且研究组的Scr、BUN及24 h尿蛋白定量水平均低于对照组，而Ccr水平高于对照组，差异有统计学意义（P < 0.05）。
治疗后，两组血红蛋白（Hb）、白蛋白（ALB）、转铁蛋白（TRF）、前白蛋白（PA）水平均较治疗前升高，主观整体营养状况评估量表（SGA）总评分均较治疗前降低，且研究组的Hb、ALB、TRF、PA水平均高于对照组，SGA总评分低于对照组，差异有统计学意义（P < 0.05）。
治疗后，两组超敏Ｃ-反应蛋白（hs-CRP）、降钙素原（PCT）水平均较治疗前降低，且研究组的hs-CRP、PCT水平低于对照组，差异有统计学意义（P < 0.05）。
结论 在对高通量血液透析患者进行治疗时，使用百令胶囊辅助常规治疗可明显改善RRF相关指标和营养相关状况，并有助于调节炎性因子水平。
[关键词]百令胶囊；高通量血液透析；残余肾功能；炎性因子水平；营养相关状况[中图分类号] R277.5 [文献标识码] A [文章编号] 2095-0616（2024）07-0082-04DOI:10.20116/j.issn2095-0616.2024.07.19Study on the mechanism of action of Bailing Capsules in protecting residual renal function in patients undergoing high-flux hemodialysis LIU Jinzhou HU MinDepartment of Renal Rheumatology, Jiangmen Xinhui People’s Hospital, Guangdong, Jiangmen 529100, China [Abstract] Objective To investigate the mechanism of action of Bailing Capsules in protecting residual renal function (RRF) in patients undergoing high-flux hemodialysis. Methods A total of 60 patients who underwent high-flux hemodialysis treatment at Jiangmen Xinhui People’s Hospital from January 2022 to May 2023 were divided into a control group (receiving conventional treatment) and a study group (receiving conventional treatment + Bailing Capsules treatment) by a random number table, with 30 cases in each group. RRF related indicators, inflammatory factor levels, and nutrition-related status of the two groups of patients were analyzed and compared. Results After treatment, the quantitative levels of serum creatinine (Scr), blood urea nitrogen (BUN), and 24-hour urine protein in both groups decreased compared to those before treatment, while the level of endogenous creatinine clearance rate (Ccr) increased compared to that before treatment. The quantitative levels of Scr, BUN, and 24-hour urine protein in the study group were lower than those in the control group, while the Ccr levels were higher than those in the control group, with statistically significant differences (P < 0.05). After treatment, the levels of hemoglobin (Hb), albumin (ALB), transferrin (TRF), and prealbumin (PA) in both groups increased compared to those before treatment, and the total subjective global assessment (SGA) score decreased compared to that before treatment. Moreover, the levels of Hb, ALB, TRF, and PA in the study group were higher than those in the control group. The total score of the SGA was lower in the study group than in the control group, with statistically significant differences (P < 0.05). After treatment, the levels of hypersensitive C-reactive protein (hs-CRP) and procalcitonin (PCT) in both groups decreased compared to those before treatment, and the levels of hs-CRP and PCT in the study group were lower than those in the control group, with statistically significant differences (P < 0.05). Conclusion When treating patients undergoing high-flux hemodialysis, the use of Bailing Capsules as an adjunct to routine treatment can significantly improve RRF related indicators and nutrition-related status, and help regulate inflammatory factor levels.[Key words] Bailing Capsules; High-flux hemodialysis; Residual renal function; Inflammatory factor levels; Nutrition-related status高通量血液透析是一种重要的肾脏替代治疗方式，临床常应用于治疗慢性肾衰竭患者中，该方式虽有效清除体内代谢产物和溶质，维持生命稳定，但长期的血液透析可导致残余肾功能（residual renal function，RRF）下降和炎性反应的发生，严重影响患者的生存质量和临床预后效果[1]。
