NUMECA-NLH

NheI产品编号 产品名称 包装 D6489NheI200U产品简介：NheI 内切酶为进口分装，基本信息如下：识别序列 缓冲液兼容性(%)酶切温度 失活条件 甲基化干扰？G ^CTAGC CGATC ^G1X B1X G1X O1X R1X Y2X Y37ºC65ºC 20min有时有干扰100 20-50 0-20 0-20 100 0-20根据识别序列邻近序列的不同，酶切效果受GC methylase 导致的DNA 甲基化的影响。

酶储存液组成为：10mM Tris-HCl (pH8.0 at 25ºC)，50mM KCl ，1mM DTT ，0.1mM EDTA ，0.2mg/ml BSA and 50% glycerol 。

1X Buffer Y 组成为：33mM Tris-acetate (pH7.9 at 37ºC)，10mM magnesium acetate ，66mM potassium acetate ，0.1mg/ml BSA 。

酶切和连接效率：50倍过量的本内切酶消化1小时，>95%被酶切的片段可以被连接并被重新酶切(recut)。

活性单位定义：在37ºC ，50微升反应体系中反应1小时，将1微克的λ DNA 完全分解的酶量定义为1个活性单位，即1U 。

包装清单：产品编号 产品名称 包装 D6489-1 NheI (10U/µl) 200U D6010Y10X Buffer Y 1ml —说明书1份保存条件：-20ºC 保存。

注意事项：内切酶使用时宜存放在冰盒内或冰浴上，使用完毕后宜立即放置于-20ºC 保存。

如果发现预期的酶切位点不能切开，请确认是否存在甲基化干扰问题。

特别注意：甘油含量大于5%，低盐浓度，pH >8.0或酶大大过量(约20倍以上)可能会导致星号活性，即产生非特异性酶切。

目录通用机床数据/系统设定值------------------------------------------------------------------------------------------ 1通用机床数据/修调开关设定--------------------------------------------------------------------------------------- 6通用机床数据/中央驱动器数据------------------------------------------------------------------------------------ 7通用机床数据/系统专用存储器设定------------------------------------------------------------------------------ 7通道专用机床数据/基本通道机床数据------------------------------------------------------------------------- 11通道专用机床数据/数字化功能的机床数据------------------------------------------------------------------- 15通道专用机床数据/通道辅助功能设置------------------------------------------------------------------------- 16通道专用机床数据/通道中转换定义---------------------------------------------------------------------------- 17通道专用机床数据/单冲和步冲---------------------------------------------------------------------------------- 19通道专用机床数据/通道专用存储器设置---------------------------------------------------------------------- 20轴参数/配置 ---------------------------------------------------------------------------------------------------------- 21轴参数/编码器的匹配---------------------------------------------------------------------------------------------- 23轴参数/闭环控制 ---------------------------------------------------------------------------------------------------- 23轴参数/回参考点 ---------------------------------------------------------------------------------------------------- 25轴参数/主轴 ---------------------------------------------------------------------------------------------------------- 26轴参数/监控功能 ---------------------------------------------------------------------------------------------------- 27轴参数/安全集成 ---------------------------------------------------------------------------------------------------- 28轴参数/移动到固定停止------------------------------------------------------------------------------------------- 29轴参数/轴专用存储设置------------------------------------------------------------------------------------------- 31设定数据/通用设定数据------------------------------------------------------------------------------------------- 31设定数据/通道专用设定数据------------------------------------------------------------------------------------- 31设定数据/轴专用设定数据---------------------------------------------------------------------------------------- 33驱动参数 --------------------------------------------------------------------------------------------------------- 34通用机床数据/系统设定值(返回)通用机床数据/修调开关设定(返回)通用机床数据/中央驱动器数据(返回)通用机床数据/系统专用存储器设定(返回)通道专用机床数据/基本通道机床数据(返回)通道专用机床数据/数字化功能的机床数据(返回)通道专用机床数据/通道辅助功能设置(返回)通道专用机床数据/通道中转换定义(返回)通道专用机床数据/单冲和步冲(返回)通道专用机床数据/通道专用存储器设置(返回)轴参数/配置(返回)轴参数/编码器的匹配(返回)轴参数/闭环控制(返回)轴参数/回参考点(返回)轴参数/主轴(返回)轴参数/监控功能(返回)轴参数/安全集成(返回)轴参数/移动到固定停止(返回)轴参数/轴专用存储设置(返回)设定数据/通用设定数据(返回)设定数据/通道专用设定数据(返回)设定数据/轴专用设定数据驱动参数(返回) 4294967295以下列出第二个电机的驱动器机床数据，MSD。

15/R 03USOLENOID VALVESno voltage release (tamperproof)manual reset construction1/4213FEATURES• The valves are certified according to IEC 61508 Functional Safety data and have SIL-3 capability (Exida approval)• Compact Tamperproof/Manual Reset function which means that the valve has to be energized as well as manually operated before it stays in the "latched" position. Because of the tamperproof feature there will be no flow from port 3 to port 2 if only the push button is pressed. The No Voltage Release (NVR) function will make sure that the valve trips when de-energized• The solenoid valves are recommended for pilot applications with basic flow, wide pressure ranges and no minimum operating pressure• PTFE rider rings and graphite-filled PTFE seals reduce friction and eliminate sticking• Coils used in metal enclosures have class H insulation materials• Peak voltage suppression diodes are standard in DC solenoids with metal enclosures• The solenoid valves satisfy all relevant EC DirectivesGENERALDifferential pressure 0 - 10 bar [1 bar = 100kPa]Maximum viscosity 65 cSt (mm 2/s)Response times75 - 100 msfluids (✶)temperature range (TS)(1)seal materials (✶)air, inert gas, water, oil-20 to +120°C -50 to + 60°CFPM (fluoroelastomer)(F)VMQ ((sillicone)(1)Can be limited by the operator ambient temperature range for explosion proof solenoidsMATERIALS IN CONTACT WITH FLUID(✶) Ensure that the compatibility of the fluids in contact with the materials is verifiedBrass bodyStainless steel body Body Brass AISI 316Stem Stainless steel Stainless steel Core tube Stainless steel Stainless steel Core and plugnut Stainless steel Stainless steel Springs Stainless steel Stainless steel Sealings and poppets FPM or (F)VMQFPM or (F)VMQ Rider Ring PTFE PTFEBPMPRPLP1,8W 3,6W - 3,7W 5,7W - 5,8W Not Available Low powerReduced powerMedium powerBasic powerPOWER LEVELS - cold electrical holding values (watt)SPECIFICATIONSpipe size orificesizeflowcoefficientKv operating pressuredifferential (bar)powerlevel prefix optional solenoidsbasic catalogue number min.max. (PS)NEMA 7&9ATEX / IECExIP65air/water (✶)Ex d Ex e mb Ex mb (mm)(m 3/h)(l/m)~/=~/=EF NF WSCR EM WSCREM PV SC brass stainless st.U - Universal, FPM sealings and poppets, manual reset1/45,70,559,2010MP -●-●--● 327B221 327B2221/45,70,559,2010RP -●-●--● 327B121327B1221/45,70,559,2010LP --●-●--- 327B322U - Universal, (F)VMQ sealings and poppets, manual reset1/45,70,559,2010MP -●-●--● 327B271 327B2721/45,70,559,2010RP -●-●--● 327B171327B1721/45,70,559,2010LP --●-●--- 327B372U - Universal, FPM sealings and poppets, manual reset tamperproof1/45,70,559,2010MP -●-●--● 327B231 327B2321/45,70,559,2010RP -●-●--● 327B131327B1321/45,70,559,2010LP --●-●--- 327B332U - Universal, (F)VMQ sealings and poppets, manual reset tamperproof1/45,70,559,2010MP -●-●--● 327B281 327B2823/2Series32715/R 03PRODUCT SELECTION GUIDESTEP 1Select basic cataloguenumber,including pipe thread indentification letter. Refer to the specifications table on page 1.Example: 8327B221STEP 2Select prefix (combination). Refer to the specifications table on page 1 and the prefix table on page 2, respect the indicated power level.Example: NFSTEP 3Select suffix (combination) if required. Refer to the suffix table on page 2, respect the indicated power level.Example: COSTEP 4Select voltage. Refer to standard voltages on page 3.Example: 230V / 50/60 Hz STEP 5Final catalogue / ordering number. Example:NF 8327B221 CO 230V / 50/60 HzPREFIX TABLEprefix description power level 1234567LP RP MP BPE M Waterproof IP66/67 - Metal enclosure (EN/IEC 60079-7,-18 and -31)*-●●-E T Threaded conduit/hole (M20 x 1,5)-●●-N F Flameproof - Aluminium (EN/IEC 60079-1, 60079-31)*-●●-S C Solenoid with spade plug connector (EN/IEC 60730)-●●-W P Waterproof IP67 - Metal enclosure -●●-W S Waterproof IP67 - 316 SS enclosure -●●-W S C R Flameproof 316L SS (EN/IEC 60079-0+1+31)*●---W S C R E M Increased Safety / Encapsulated 316L SS (EN/IEC 60079-0+7+18+31)*●---W S E M Waterproof IP66/67 - 316 SS enclosure (EN/IEC 60079-7,-18 and -31)*-●●-WS N F Flameproof - 316L SS (EN/IEC 60079-1, 60079-31)*-●●-T Threaded conduit (1/2" NPT)-●●-X Other special constructions-●●-SUFFIX TABLEsuffix descriptionpower level 12345LP RP MP BPN V FPM (fluoroelastomer) and parts cleaned for oxygen service -●●-C OEpoxy coating on all external surfaces-●●-● Available feature ❍ Available feature in DC only- Not available * A TEX/IECEx valves using these solenoids are approved according to EN 13463-1 (non electrical)(1)Functional Safety certification is not applicable with this featureOPTIONS & ACCESSORIEScatalogue number spare part kit no.(2)mounting bracket ~ / =SC 327B121C132251⏹SC 327B122C132251⏹SC 327B131C132253⏹SC 327B132C132253⏹SC 327B171C117646⏹SC 327B172C117646⏹SC 327B181C117647⏹SC 327B182C117647⏹SC 327B221C132251⏹SC 327B222C132251⏹SC 327B231C132253⏹SC 327B232C132253⏹SC 327B271C117648⏹SC 327B272C117648⏹SC 327B281C117649⏹SC 327B282C117649⏹Select 8 for NPT ANSI 1.20.3 or select G for ISO G(228/1)(2)Standard prefixes/suffixes are also applicable to kits ⏹ Mounting holes in bodyORDERING EXAMPLES VALVES:SC 8327B 12124V /DC WSEMT G 327B 122CO 24V /DC NFET G 327B 221230V /50/60 HzWSEMG 327B 12224V /DC NF 8327B 231CO 24V /DC WS G 327B 121CO 24V /DC EM8327B 221230V /50/60 Hzprefix pipe thread voltagebasic numbersuffixORDERING EXAMPLES KITS:C132251(3)NF C117646WSEM C132251prefixsuffixbasic number(3)Basic kit number applies to SC coil construction15/R 03EXPLANATION OF TEMPERATURE RANGES OF SOLENOID VALVESValve temperature rangeThe valve temperature range (TS) is determined by the selected seal material, the temperature range for proper operation of the valve and sometimes by the fluid (e.g. steam)Operator ambient temperature range The operator ambient temperature range is determined by the selected power level and the safety codeTotal temperature rangeThe temperature range of the complete solenoid valve is determined by the limitations of both temperature ranges aboveELECTRICAL CHARACTERISTICSCoil insulation class HElectrical safety IEC 335Standard voltages DC (=) 24V - 48V; Allowable voltage variation ± 10%AC (~) 24V - 48V - 115V - 230V/50/60Hz; Other voltages are available on requestprefix optionpower ratingsoperator ambienttemperature range safety codeelectrical enclosure protection (EN 60529)replacement coil / kit type (2)inrush holding hot/cold ~~=~=(VA )(VA )(W )(W ) (C°)(1)230V/50/60 Hz 24V/DC Medium Power (MP)SC5,85,85,85,2/5,7-40 to +90EN 60730IP65, moulded 400924-297400923-44201WP/WS 5,85,85,85,2/5,7-40 to +90EN 60730IP67, steel /SS 400921-297400914-44202NF/WSNF 5,85,85,85,2/5,7-60 to +60/75/90II2G Ex d IIC Gb T6/T5/T4, II2D Ex tb IIIC Db IP66/67, alu./SS 400921-297400914-44203EM/WSEM 5,85,85,85,2/5,7-40 to +40/75II2G Ex e mb IIC Gb T5/T4, II2D Ex tb IIIC Db IP66/67, steel /SS 400921-297400914-44202Reduced Power (RP)(3)SC3,73,73,73,2/3,6-40 to +60EN 60730IP65, moulded - (3)400923-04201WP/WS 3,73,73,73,2/3,6-40 to +60EN 60730IP67, steel /SS - (3)400914-24202NF/WSNF 3,73,73,73,2/3,6-60 to +60II2G Ex d IIC Gb T6, II2D Ex tb IIIC Db IP66/67, alu./SS - (3)400914-24203EM/WSEM 3,73,73,73,2/3,6-40 to +40/60II2G Ex e mb IIC Gb T6/T5, II2D Ex tb IIIC Db IP66/67, steel /SS - (3)400914-24202Low Power (LP)(3)WSCR 1,851,851,851,5/1,8-60 to +60II2G Ex d IIC Gb T6, II2D Ex t IIIC Db IP66/67, SS - (3)400961-54204WSCREM1,851,851,851,5/1,8-60 to +60II2G Ex e mb IIC Gb T6, II2D Ex tb IIIC DbIP66/67, SS- (3)400961-54204(1) Temperature range can be limited by sealings (2)Refer to the dimensional drawings on page 4(3)AC (~) limited to 127V/50/60Hz or 125V/DC - Not availableELECTRICAL CONNECTIONSprefix connectionSCSpade plug connector with cable gland EN175301-803A (ISO 4400) for cables with an outer dia-meter from 6 to 10 mmWP , WS, EM, WSEM M20 cable gland for cables with an outer diameter from 7 to 12 mm. With an internal and external facility for an earthing or bonding conductorNF , WSNF , WSCR 1/2" NPT threaded cable entry. Enclosures are supplied without cable glandWSCREM M20 x 1,5 316 SS cable gland for cables with an outer diameter from 7,2 to 11,7 mm.NFET, WSNFET M20 x 1,5 threaded cable entry. Enclosures are supplied without cable glandADDITIONAL OPTIONS●Ex mb/mD (prefix "PV") solenoid can be supplied with various cable lengths ●Compliance with "UL", "CSA" and other local approvals available on request ●Manual Reset constructions suitable for -40°C are available on requestINSTALLATION●Multi language installation/maintenance instructions are included with each valve ●The solenoid valves can be mounted in any position without affecting operation ●The mounting holes are provided in the valve body●Threaded pipe connection identifier is 8 = NPT (ANSI 1.20.3); G = G (ISO 228/1)●Declarations of conformity are available on request●Ex e mb Prefix "EM" execution: solenoid enclosure has a cable gland with integral strain relief for cables with an o.d.from 7 to 12 mm and is provided with an internal and external connection facility for an earthing or bonding conductor ●Ex d Prefix "NF/WSNF" enclosure is provided with a 1/2" NPT threaded entry hole, M20 x 1,5 (prefix "ET") is optional Both are supplied without cable gland●All DC solenoids with metal enclosure are provided with switch-off peak voltage suppression diodes15/R 03DIMENSIONS (mm), WEIGHT (kg)TYPE 01:TYPE 02:Epoxy mouldedSC: IEC 335 / ISO 4400Metal, epoxy coated / AISI 316 SS WP / WS: IEC 335EM / WSEM: EN/IEC 60079-7+18+31327B121 / B122 / B131 / B132 / B221 / B222 / B231 / B232327B121 / B122 / B131 / B132 / B221 / B222 / B231 / B232TYPE 03:TYPE 04:Aluminium, epoxy coated / AISI 316L SS NF / WSNF: EN/IEC 60079-1, 60079-31AISI 316L SS WSCR : EN/IEC 60079-0, 60079-1, 60079-31WSCREM : E N/IEC 60079-0, 60079-7, 60079-18,EN/IEC 60079-31B121 / B122 / 327B131 / B132 / B221 / B222 / B231 / B232327B322 / B332 / B372 / B382ABCØ5,512232741DGJKELMDIMENSIONS (mm), WEIGHT (kg)type prefix/option power level A B C D E F G H J K L M N weight 01SCMP/RP 5030249814995915633552786-1,30 kg 02WP , WS, EM, WSEM MP/RP 773024101158-120-81552789-1,30 kg 03NF , WSNFMP/RP 973024125176-102-545527113882,70 kg 04WSCR, WSCREMLP923024127178-116-755527115-3,10 kg15/R 03EXHAUST PROTECTOR ORDER NUMBERS¼ISO 228/1brass/nickelB-MV110014NPT B-PV110014ISO 228/1stainless steelB-VX110014NPTB-PV110014EXHAUST PROTECTOR213SECTIONAL DRAWINGExecution : Reduced Power Tamperproof-G B -- A v a i l a b i l i t y , d e s i g n a n d s p e c i fic a t i o n s a r e s u b j e c t t o c h a n g e w i t h o u t n o t i c e . A l l r i g h t s r e s e r v e d .15/R 03。

中性粒细胞淋巴细胞比值（ＮＬＲ）与晚期非小细胞肺癌一线化疗疗效及预后的关系叶　韬，盛桂凤，董益忠，凌　扬，周　彤，宋红蕾ＲｅｌａｔｉｏｎｓｈｉｐｂｅｔｗｅｅｎＮＬＲａｎｄｅｆｆｉｃａｃｙａｎｄｐｒｏｇｎｏｓｉｓｏｆｆｉｒｓｔｌｉｎｅｃｈｅｍｏｔｈｅｒａｐｙｆｏｒａｄ ｖａｎｃｅｄｎｏｎ－ｓｍａｌｌｃｅｌｌｌｕｎｇｃａｎｃｅｒＹＥＴａｏ，ＳＨＥＮＧＧｕｉｆｅｎｇ，ＤＯＮＧＹｉｚｈｏｎｇ，ＬＩＮＧＹａｎｇ，ＺＨＯＵＴｏｎｇ，ＳＯＮＧＨｏｎｇｌｅｉＤｅｐａｒｔｍｅｎｔｏｆＯｎｃｏｌｏｇｙ，ＣｈａｎｇｚｈｏｕＴｕｍｏｒＨｏｓｐｉｔａｌＡｆｆｉｌｉａｔｅｄｔｏＳｏｏｃｈｏｕＵｎｉｖｅｒｓｉｔｙ，ＪｉａｎｇｓｕＣｈａｎｇｚｈｏｕ２１３０３２，Ｃｈｉｎａ．【Ａｂｓｔｒａｃｔ】　Ｏｂｊｅｃｔｉｖｅ：ＴｏａｎａｌｙｚｅｔｈｅｉｍｐａｃｔｏｆＮＬＲｏｎｏｖｅｒａｌｌｓｕｒｖｉｖａｌ（ＯＳ）ａｎｄｔｏｅｘｐｌｏｒｅｔｈｅｖａｌｕｅｏｆｃｈａｎｇｅｓｉｎｔｈｅＮＬＲｗｉｔｈｔｒｅａｔｍｅｎｔａｓａｒｅｓｐｏｎｓｅｉｎｄｉｃａｔｏｒｉｎｎｏｎ－ｓｍａｌｌｃｅｌｌｌｕｎｇｃａｎｃｅｒ（ＮＳＣＬＣ）．Ｍｅｔｈｏｄｓ：Ａｒｅｔｒｏｓｐｅｃ ｔｉｖｅａｎａｌｙｓｉｓｗａｓｐｅｒｆｏｒｍｅｄｏｎ１０２ｐａｔｉｅｎｔｓｗｉｔｈａｄｖａｎｃｅｄＮＳＣＬＣｆｒｏｍＤｅｃ，２０１１ｔｏＤｅｃ，２０１６ｉｎＣｈａｎｇｚｈｏｕＴｕｍｏｒＨｏｓｐｉｔａｌＡｆｆｉｌｉａｔｅｄｔｏＳｏｏｃｈｏｕＵｎｉｖｅｒｓｉｔｙ．ＴｈｅｐｒｅｔｒｅａｔｍｅｎｔａｎｄｐｏｓｔｔｒｅａｔｍｅｎｔＮＬＲｉｎａｌｌｐａｔｉｅｎｔｓｗｅｒｅｃａｌｃｕｌａｔｅｄｂａｓｅｄｏｎｃｏｍｐｌｅｔｅｂｌｏｏｄｃｏｕｎｔｓ．Ｔｈｅｂｅｓｔｃｕｔ－ｏｆｆｖａｌｕｅｏｆＮＬＲｗａｓｉｄｅｎｔｉｆｉｅｄａｃｃｏｒｄｉｎｇｔｏｔｈｅｒｅｃｅｉｖｅｒｏｐｅｒａｔｉｎｇｃｈａｒａｃｔｅｒｉｓｔｉｃｃｕｒｖｅ（ＲＯＣｃｕｒｖｅ），ａｎｄａｌｌｐａｔｉｅｎｔｓｗｅｒｅｄｉｖｉｄｅｄｉｎｔｏｔｗｏｇｒｏｕｐｓｂａｓｅｄｏｎｔｈｅＮＬＲｖａｌｕｅ．Ｔｈｅｐｒｏｇｎｏｓ ｔｉｃｉｍｐａｃｔｏｆＮＬＲｏｎｓｕｒｖｉｖａｌｉｎｐａｔｉｅｎｔｓｗｉｔｈａｄｖａｎｃｅｄＮＳＣＬＣｗａｓｔｅｓｔｅｄｂｙｕｎｉｖａｒｉａｔｅａｎｄｍｕｌｔｉｖａｒｉａｔｅａｎａｌｙｓｅｓ．Ｒｅｓｕｌｔｓ：Ａｍｏｎｇａｌｌｐａｔｉｅｎｔｓ，ｔｈｅｖａｌｕｅｓｏｆｔｈｅｐｏｓｔｔｒｅａｔｍｅｎｔＮＬＲａｆｔｅｒｔｗｏｃｙｃｌｅｓｏｆｃｈｅｍｏｔｈｅｒａｐｙ（ＮＬＲ２）ａｎｄｔｈｅｐｒｅｔｒｅａｔｍｅｎｔＮＬＲ（ＮＬＲ０）ｗｅｒｅ（２．５３±１．２７）ａｎｄ（３．２５±１．７２）．ＮＬＲ２ｗａｓｓｉｇｎｉｆｉｃａｎｔｌｙｌｏｗｅｒｔｈａｎＮＬＲ０（Ｐ＝０．０００）．ＮＬＲ２ｗａｓｃｏｒｒｅｌａｔｅｄｗｉｔｈｔｈｅｒｅｓｐｏｎｓｅｏｆｆｉｒｓｔｌｉｎｅｔｒｅａｔｍｅｎｔｗｉｔｈｔｗｏａｎｄｆｏｕｒｃｙｃｌｅｓｏｆｃｈｅｍｏｔｈｅｒａｐｙ．ＴｈｅｐｒｏｐｏｒｔｉｏｎｏｆｈｉｇｈＮＬＲ２ｉｎｔｈｅｐａｔｉｅｎｔｓｗｉｔｈｐｒｏｇｒｅｓｓｉｏｎｄｉｓｅａｓｅｗａｓｈｉｇｈｅｒｔｈａｎｔｈｅｐｒｏｐｏｒｔｉｏｎｏｆｈｉｇｈＮＬＲ２ｉｎｔｈｅｐａｔｉｅｎｔｓｗｉｔｈｐａｒｔｉａｌｒｅｓｐｏｎｓｅｏｒｓｔａｂｌｅｄｉｓｅａｓｅ．Ａｃｃｏｒｄｉｎｇｔｏｕｎｉｖａｒｉａｔｅａｎａｌｙｓｉｓ，ｔｈｅＯＳｗａｓａｓｓｏｃｉａｔｅｄｗｉｔｈＮＬＲ０，ＮＬＲ２ａｎｄｔｈｅｒｅｓｐｏｎｓｅｏｆ４ｃｙｃｌｅｓｏｆｆｉｒｓｔｌｉｎｅｃｈｅｍｏｔｈｅｒａｐｙ（Ｐ＜０．０５），ｂｕｔｎｏｔｗｉｔｈｇｅｎｄｅｒ，ａｇｅ，ｐｅｒｆｏｒｍａｎｃｅｓｔａ ｔｕｓ，ｈｉｓｔｏｌｏｇｙ，ｓｔａｇｅ，ｓｔａｔｕｓｏｆＥＧＦＲｇｅｎｅａｎｄｔｈｅｒｅｓｐｏｎｓｅｏｆ２ｃｙｃｌｅｓｏｆｆｉｒｓｔｌｉｎｅｃｈｅｍｏｔｈｅｒａｐｙ（Ｐ＞０．０５）．ＴｈｅｍｕｌｔｉｖａｒｉａｔｅａｎａｌｙｓｉｓｓｈｏｗｅｄｔｈａｔＮＬＲ０（Ｐ＝０．０００）ａｎｄｔｈｅｒｅｓｐｏｎｓｅｗｉｔｈ４ｃｙｃｌｅｓｏｆｆｉｒｓｔｌｉｎｅｃｈｅｍｏｔｈｅｒａｐｙ（Ｐ＝０．０４７）ｗｅｒｅｉｎｄｅｐｅｎｄｅｎｔｐｒｏｇｎｏｓｔｉｃｉｎｄｉｃａｔｏｒｓｉｎａｌｌｐａｔｉｅｎｔｓ．Ｃｏｎｃｌｕｓｉｏｎ：ＴｈｅｓｔｕｄｙｓｈｏｗｅｄｔｈａｔＮＬＲ０ｗａｓｗｅｌｌｃｏｎｎｅｃｔｅｄｗｉｔｈｏｕｔｃｏｍｅｓａｎｄＮＬＲ２ｗａｓｗｅｌｌｃｏｎｎｅｃｔｅｄｗｉｔｈｔｈｅｒｅｓｐｏｎｓｅｏｆｆｉｒｓｔｌｉｎｅｃｈｅｍｏｔｈｅｒａｐｙ．ＮＬＲｍａｙｂｅａｂｉｏｍａｒｋｅｒｆｏｒｐｒｅｄｉｃｔｉｎｇｔｈｅｏｕｔｃｏｍｅｓａｎｄｒｅｓｐｏｎｓｅｏｆｆｉｒｓｔｌｉｎｅｃｈｅｍｏｔｈｅｒａｐｙｉｎｐａｔｉｅｎｔｓｗｉｔｈａｄｖａｎｃｅｄｎｏｎ－ｓｍａｌｌｃｅｌｌｌｕｎｇｃａｎｃｅｒ．【Ｋｅｙｗｏｒｄｓ】ｎｏｎ－ｓｍａｌｌｃｅｌｌｌｕｎｇｃａｎｃｅｒ，ｒｅｓｐｏｎｓｅ，ｎｅｕｔｒｏｐｈｉｌ－ｔｏ－ｌｙｍｐｈｏｃｙｔｅｒａｔｉｏＭｏｄｅｒｎＯｎｃｏｌｏｇｙ２０２１，２９（１２）：２０７６－２０８１【摘要】　目的：观察中性粒细胞淋巴细胞比值（ＮＬＲ）及其动态变化与晚期非小细胞肺癌（ＮＳＣＬＣ）患者一线化疗疗效和预后的关系。

AUSTRALIA - HK - CHINA - SINGAPORE Formula Pro Settings#Photo Powder Brand Name/Type STAGE SETTING 1A2 Platinum infant (1)152A2/澳洲A2 Platinum premium follow-on formula (2)273A2 Platinum toddler (3)384Abbott Eleva (1) 菁智155Abbott Eleva (2) 菁智276Abbott Eleva (3) 菁智377雅培Abbott Eleva Organic Infant Formula(1)138Akara 爱瑞嘉 (1)179愛他美Aptamil AllerPro Gold+ (1)1810愛他美Aptamil AllerPro Gold+ (2)2711愛他美Aptamil Comfort N/A612愛他美Aptamil First Milk Breastmilk Substitue (1)1613愛他美Aptamil Follow On Formula (2)27614愛他美Aptamil Growing Up Milk (3)3815愛他美Aptamil Growing Up Milk (4)4316愛他美Aptamil Gold+ Pronutra (1)14 17愛他美Aptamil Gold+ Pronutra (2) 25 18愛他美Aptamil HA Gold+ (1)13 19愛他美Aptamil Hungry Milk Breastmilk Substitue N/A6 20愛他美Aptamil Pro expert Prematil (Pre)N/A N/C 21Arla 爱氏晨曦 baby & me Organic (1)16 22Arla baby & me Organic (3)35 23澳優Ausnutria Puredo 1938 美纳多 Infant formula (1)11 24Babybio伴宝乐 Babybio Optima Lait Nourrisson(1)16 25Babynat Organic Infant Milk from birth to 6 month N/A6 26Babynat Organic Optima Follow-on Milk From 6 Mos N/A5 27Bein Mate (1) 贝因美14 28Bein Mate (2) 贝因美26 29Bein Mate (3) 贝因美36 30貝拉米Bellamy's Organic infant formula (1)16 31貝拉米Bellamy's Organic follow on formula (2)26 32貝拉米Bellamy's Organic toddler milk drink (3)3833Biostime合生元 Supreme care Infant formula (1)14 34Biostime合生元 Supreme care older Infant formula (2)26 35Biostime合生元 Supreme care young children formula (3)38 36澳佳寶Blackmores Newborn Birth-6mos14 37澳佳寶Blackmores Follow-On formula 6-12 mos23 38Bubs Goat Milk Advanced Plus13 39COLES Gold newborn formula 14 40COLES Gold Follow on formula 26 41牛欄牌Cow & Gate Follow On (2)23 42牛欄牌Cow & Gate Growing up (4)47 43牛欄牌Cow & Gate Infant (1)14 44Dumex (1) 多美滋14 45Dumex (3) 多美滋310 46Dumex (4) 多美滋47 47美贊臣Enfagrow A+ (3)34 48美贊臣Enfagrow A+ (4)44 49美贊臣Enfakid A+ (4)4450美贊臣Enfamil A+ (1)13 51美贊臣Enfamil A+ for premature infant (1) 早产儿（出院后）15 52美贊臣Enfamil A+ Gentle Care (1)13 53美贊臣Enfamil A+ Lactofree N/A6 54美贊臣Enfapro A+ 6-12 Months N/A5 55美贊臣EnfaSchool A+ (6)63 56Enfinitas Infant Formula (1)11 57Enfinitas 蓝臻 Infant Formula (2)21 58飞鹤（FeiHe）星飞帆（1）, from 0-6months17 59美素佳兒Friso Gold First Steps (2)25 60美素佳兒Friso Gold Young Explorer (3)310 61美素佳兒Friso Gold Bright Star (4)4N/C 62美素佳兒Frisolac Gold New Beginnings Infant Formula (1)14 63美素佳兒Frisolac Prestige皇家美素力 0-6mos (1)12 64亨氏Heinz Nurture GOLD + (1)16 65亨氏Heinz Nurture Original (1)15 66喜寶Hipp Combiotic® 1st infant milk(1)1667喜寶Hipp Combiotic® follow on milk (3)39 68喜寶Hipp Combiotic® growing up milk (3)38 69喜寶Hipp Combiotic® hungry infant milk (2)28 70凱莉Holle Organic Growing-up Milk (3)3N/C 71凱莉Holle Organic Infant Follow-on milk (2)210 72凱莉Holle Organic Infant Formula(1)19 73凱莉Holle Organic Infant Goat Milk Follow-on Formula (2)29 74 Hyprocal1897 Infant Formula (1)12 75I Am Mother 我是妈妈 Infant Formula from 6 mos (3)35 76Ildong Goat milk 0-6mos (1) - Korea/NZ14 77Ildong Goat milk 6-12 mos (2) - Korea26 78Icreo (2) 9-36 mos25 79惠氏illuma (3)3N/C 80惠氏illuma (4)4N/C 81惠氏illuma Follow-On (2)2N/C 82惠氏illuma infant (1)1N/C 83Karicare Aptamil AR 0-12 Months (1/2)1684Karicare Aptamil Gold De-Lact Lactose Free 0-12 Months (1)14 85Karicare Aptamil Gold Plus 0-6 Months (1)13 86Karicare Aptamil Gold Plus 6-12 Months (2)24 87Karicare Aptamil Gold Plus Junior from 2 Years (4)46 88Karicare Aptamil Gold Plus Toddler from 1 year (3)36 89Karicare Aptamil Gold Plus Goat Milk Toddler from 1 year (3)37 90Karihome A3 Goat Infant Formula with Iron Suitable from birth to 12 months (1)13 91Karihome Goat Milk (2)24 92Mamia Gold - Follow On (2)26 93Mamia Gold - Newborn (1)14 94Mamia Gold - Toddler (3)38 95明治Meiji 0-1 year old Infant Formula12 96Milupa美乐宝 Aptamil Pronutra von Geburt an（1）14 97Moohko 麦蔻 Gold Infant Formula（1）14 98Munchkin Grass Fed (1)14 99Murray Goulburn Natra Start Golden Infant Formula（1）16 100Nam Yang Premium Organic (1)15101雀巢Nan AR (1)16102雀巢Nan Pro (2) Probiotics26 103雀巢Nestle Lactogen (1)15 104雀巢Nestle Nan (1) 能恩13 105雀巢Nestlé NAN Comfort (1)15 106雀巢Nestlé NAN Comfort (2)25 107雀巢Nestlé Nan Gro (3)35 108雀巢Nestlé Nan H.A. 能恩24 109雀巢Nestlé Nan H.A. 能恩34 110雀巢Nestlé Nan HA Gold with Probiotics from 6 Months (2)24 111雀巢Nestlé Nan HA Gold with Probiotics from Birth (1)13 112雀巢Nestlé Nan HA Toddler with Probiotics from 1 Year (3)34 113雀巢Nestlé Nan Optipro HA Gold (1)13114雀巢Nestlé Nan PRE (1)110115雀巢Nestlé Nan PRE (2)26 116雀巢Nestlé Nan Pro (1)14 117雀巢Nestlé Nan Pro (2)24118雀巢Nestlé Nan Pro (3)34119雀巢Nestlé Nan Pro Gold (1)14 120雀巢Nestlé Nan Pro Gold with Probiotics from Birth (1)13 121雀巢Nestlé Nan Pro Kid (4)45 122寶怡樂Novalac Colic birth-12mos16 123寶怡樂Novalac Constipation 0-12 months14 124寶怡樂Novalac Gold 6-12 Months (2)24 125寶怡樂Novalac Reflux birth-12mos (1)17 126寶怡樂Novalac Sweet Dreams19 127Nuby (1)14 128Nuby (2)24 129Nuby (3)35 130Nutricia Aptamil AR Gold Plus N/A8 131Nutricia Aptamil de-lact gold plus N/A7 132Nutricia Aptamil Pepti Junior gold plus16 133Nutricia Aptamil Profutura (1)14 134Nutricia Aptamil Profutura premium follow-on formula（2）24135Nutricia Aptamil Profutura（3）36 136Nutricia Aptamil Profutura（4）45 137Nutricia Aptamil with Pronutra Follow On Milk (2) 6-12 mos26 138Nutricia Aptamil Toddler Gold Plus Pronutra（3）37 139Nutricia 纽迪希亚纽荃星 Infatrini, from 0-12months N/A N/C 140纽迪希亚Nutricia Karicare Gold Plus 1 from Birth14 141纽迪希亚Nutricia Karicare Plus from 6 Months (2)24 142Nutricia 纽迪希亚可瑞康 Karicare Plus GOAT MILK from birth (1)14 143纽迪希亚Nutricia Karicare Plus GOAT MILK from 6 Months (2)24 144纽迪希亚Nutricia Karicare Plus GOAT MILK Toddler (3)36 145纽迪希亚Nutricia Karicare Plus Nourish from birth (1)15 146纽迪希亚Nutricia Karicare Plus Toddler from 1 Year (3)36 147纽迪希亚Nutricia Karicare Plus Toddler from 2 Years (4)44 148纽迪希亚Nutricia Karicare Soy All Ages from Birth N/A5 149纽迪希亚Nutricia Nutrilon met Protutra Standaard (2)27 150纽迪希亚Nutricia Nutrilon Pronutra Follow-on Infant Formula(2)27 151OLI Dairy Goat Infant Formula Birth-6mos (1)12152Oli Dairy Goat 6-12 Mos (2)25 153澳仕卡牛Ozcare Infant Formula (1)13 154惠氏Pfizer S-26 Gold Comfort Easy to Digest from Birth N/A6 155惠氏Pfizer S-26 Gold Newborn from Birth (1)13 156惠氏Pfizer S-26 Gold Progress from 6 Months (2)25 157惠氏Pfizer S-26 Original Newborn (1)13 158惠氏Pfizer SMA From Birth N/A3 159惠氏S-26 Gold N/A6 160惠氏S-26 Gold AR19 161惠氏S-26 Gold Lactose Free From Birth (1)17 162惠氏S-26 HA Gold N/A5 163惠氏S-26 Nursoy Gold N/A8 164惠氏S-26 SMA Ultima (1)15 165惠氏S-26 SMA Gold (1)15 166Similac (1) 雅培15 167Similac (2) 雅培25 168Similac (3) 雅培310169Similac (4) 雅培48 170雅培Similac Baby Eye Q Plus Intelli-Pro (1)13 171雅培Similac Gain Eye Q (4)46 172Similac 雅培喜康宝 Similac HighQ+Shield Infant Formula (1)15 173雅培Similac Kid Eye Q Plus Intelli-Pro (4)43 174雪印Snow Brand Smart Baby Follow Up Formula (2)26 175雪印Snow Brand Smart Baby Infant Formula (1)13 176雪印Snow Brand Smart Kid Growing Up Formula (3)38 177雪印Snow Brand Smart Kid Growing Up Formula (4)4N/C 178Topfer 特福芬 Lactana Organic Infant Milk（1）17 179Wondersun Anlicong Gold Infant Formula（1）完達山安力聰13 180惠氏Wyeth S-26 GOLD (1) for babies age 0-1211 181惠氏Wyeth S-26 Progress GOLD (3) for children 1-3 years3N/C 182惠氏Wyeth S-26 Promise GOLD (4) for children 3 years onward4N/C 183惠氏Wyeth S-26 Promil Gold (2) 6-12 mos27 184惠氏Wyeth S-26 Promil Ultima (2) 6-12 mos26 185Yili Pro-Kido (1) 伊利16Canada Fomrula Pro Settings#Powder Brand Name/Type SETTING For Canada settings, refer to babybrezza.ca#Powder Brand Name/Type STAGE Setting 1EnfaBebe Premium Stage 2282美贊臣Enfamil Sin Lactosa Premium De 0 a 12 Meses N/A53Frisolac Gold Intensive HA 0-12 MesesN/A44雀巢Nestle Nido Kinder 1+ con Prebio1+65雀巢Nestlé® Good Start Supreme Confort Plus®N/A56Frisolac Gold Comfort N/A 3Central America Formula Pro Settings#Photo Powder Brand Name/Type STAGE Measuring 1AH Albert Heijn Follow-up milk (2)232AH Albert Heijn Follow-up milk (3)353AH Albert Heijn Follow-up milk hydrolyzed whey protein274AH Albert Heijn HA Infants milk hydrolyzed whey protein 145AH Albert Heijn Infant milk (1)136AH Puur & Eerlijk Infant Milk (1)127AH Puur & Eerlijk Follow-up (2)238AH Puur & Eerlijk Follow-up (3)349Arla Baby & Me Organic (1)1410Arla Baby & Me Organic (2)2611Arla Baby & Me Organic (3)3512伴寶樂Babybio Growth (3)3613伴寶樂Babybio Lunea Thickened Milk2814伴寶樂Babybio Optima Lait De Suite (2)27EU Formula Pro Settings390雀巢Nestlé Wholegrain More Fiber N/A9 391新諾兒Novalac (3)36 392新諾兒Novalac AC Infant Milk N/A6 393新諾兒Novalac AD N/A9 394新諾兒Novalac AE (1)14 395新諾兒Novalac Allernova AR N/A7 396新諾兒Novalac AR (2)26 397新諾兒Novalac AR Digest (1)16 398新諾兒Novalac Calinova (2)25 399新諾兒Novalac CC do 6 meseca (2)25 400新諾兒Novalac HA (2)27 401新諾兒Novalac HA Infant Milk N/A7 402新諾兒Novalac Infant Milk (1)15 403新諾兒Novalac IT Infant Milk N/A3 404新諾兒Novalac NovaRice (1)17510菲思力Physiolac Appetite (2)28 511菲思力Physiolac AR Anti-Régurgitations (1)18 512菲思力Physiolac Bio (1)16 513菲思力Physiolac Bio (2)26 514菲思力Physiolac Bio AR (2)26 515菲思力Physiolac Bio Growth (3) 36 516菲思力Physiolac Growth (3)36 517菲思力Physiolac HA Hypoallergenic N/A6 518菲思力Physiolac Lactose Intolerance N/A9 519菲思力Physiolac precision (1)16 520菲思力Physiolac Relay for Smooth Weaning (1)17 521Picot (2)26 522Picot Action Colic (1)14 523Picot bébé gourmand (1)14 524Picot bébé gourmand (2)26。