AOPP患者血清MCP-1的表达及意义

青岛大学硕士学位论文
得到标准品的直线回归方程：Ｙ＝Ｏ．００４１Ｘ＋０．０８５８（ｒ２＝Ｏ．９８９２），根据回归方程计算各组上清液中ＭＣＰ一１的含量。

３．１．２胃癌组织中ＭＣＰ一１含量与临床分期的关系
各期胃癌组织中ＭＣＰ－１含量均比正常胃组织高，差异具有极显著统计学意义（Ｐ＜Ｏ．０１）；随分期增高，胃癌组织中ＭＣＰ—ｌ的含量逐渐增加，Ｉ期、ＩＩ期、ＩＩＩ期、Ⅳ期差别具有统计学意义（Ｆ＝４９６．２３５，ＰＫＯ．０５）；１５例Ｉ期和１０例ｌＩ期胃癌组织中ＭＣＰ一１的含量差别无统计学意义（Ｐ＞０．０５）。

表３．１．２各临床分期胃癌组织ＭＣＰ—ｌ含量（ｘ±８，ｎｇ／Ｌ）
３．１．３胃癌组织中ＭＣＰ－１含量与Ｔ分期的关系
各Ｔ分期胃癌组织中ＭＣＰ一１的含量均明显高于正常胃组织，差异具有极显著统计学意义（Ｐ＜０．０１）；Ｔ１、Ｔ２、Ｔ３、Ｔ４分期胃癌组织中ＭＣＰ一１的含量逐渐升高，差别具有统计学意义（Ｆ＝３２５．４７５，Ｐ＜Ｏ．０５）；１５例Ｔ１期和１０例Ｔ２期胃癌组织中ＭＣＰ一１的含量差别无统计学意义（Ｐ＞Ｏ．０５）。

表３．１．３各Ｔ分期胃癌组织ＭＣＰ一１含量（工±ｓ，ｎｇ／Ｌ）。

血清MCP-1蛋白水平对肺癌及肺结核患者诊断的临床意义作者：李德来来源：《医学信息》2019年第19期摘要：目的 ;探討MCP-1蛋白表达在肺癌及肺结核患者中的临床意义。

方法 ;选取2017年1月～2018年12月我院呼吸科收治的40例肺癌及40例肺结核患者为研究对象，同时选取同期在我院体检健康人群40例为对照组，对比三组血清及PBMC上清液中MCP-1浓度及不同期、不同病理类型肺癌患者血清及PBMC上清液中MCP-1浓度和初治和复治肺结核血清及PBMC上清液中MCP-1浓度。

结果 ;肺结核组及肺癌组血清及PBMC上清液中MCP-1浓度高于对照组，且肺结核组高于肺癌组，差异有统计学意义（P0.05）;肺结核复治患者血清及PBMC上清液中MCP-1浓度分别为（173.65±13.22）pg/ml、（520.11±67.28）pg/ml，高于肺结核初治患者的（156.21±9.13）pg/ml、（498.34±50.03）pg/ml，差异有统计学意义（P关键词：单核细胞趋化蛋白-1; 肺癌; 肺结核中图分类号：R734.2 ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;文献标识码：A ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;DOI：10.3969/j.issn.1006-1959.2019.19.057文章编号：1006-1959（2019）19-0171-03Clinical Significance of Serum MCP-1 Protein Level in the Diagnosisof Lung Cancer and Pulmonary TuberculosisLI De-lai（Department of Clinical Laboratory，Beichen Hospital of Traditional Chinese Medicine，Tianjin University ofTraditional Chinese Medicine，Tianjin 300000，China）Abstract：Objective ;To investigate the clinical significance of MCP-1 protein expression in patients with lung cancer and pulmonary tuberculosis. Methods ;40 patients with lung cancer and 40 patients with pulmonary tuberculosis admitted to our hospital from January 2017 to December 2018 were enrolled in the study. At the same time， 40 healthy subjects in our hospital were selected as the control group，and the concentration of MCP-1 in serum and PBMC supernatant in the three groups were compared.The concentration of MCP-1 in serum and PBMC supernatant of lung cancer patients with different pathological types and the concentration of MCP-1 in serum and PBMC supernatant of newly diagnosed and retreated pulmonary tuberculosis.Results ;The concentration of MCP-1 in serum and PBMC supernatant of pulmonary tuberculosis group and lung cancer group was higher than that of control group， and the tuberculosis group was higher than that in lung cancer group， the difference was statistically significant （P<0.05）; the concentration of MCP-1 in serum and PBMC supernatant of late stage lung cancer patients was （152.71±12.56）pg/ml、（419.52±33.93）pg/ml， which was higher than that in early stage lung cancer patients （73.21±7.90）pg/ml、（312.60±28.62）pg/ml，the difference was statistically significant （P<0.05）; there was no significant difference in the concentration of MCP-1 in serum and PBMC supernatant of three different pathological types （P>0.05）; the concentration of MCP-1 in serum and PBMC supernatant of retreated pulmonary tuberculosis patients was （173.65±13.22）pg/ml、（520.11±67.28）pg/ml， which was higher than that in untreated pulmonary tuberculosis patients （156.21±9.13）pg/ml、（498.34±50.03）pg/ml， the difference was statistically significant（P<0.05）.Conclusion ;Serum MCP-1 protein level is closely related to the occurrence and development of lung cancer and tuberculosis， and it will increase with the progress of the disease. It can be used as an important indicator for diagnosis and treatment.Key words：Monocyte chemoattractant protein-1;Lung cancer;Tuberculosis单核细胞趋化蛋白-1（monocyte chemoattractant protein-1，MCP-1）是趋化性细胞因子β亚家族的代表，其主要作用为激活并趋化单核细胞至炎症部位。