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伊立替康相关腹泻及粒细胞缺乏致死亡曹凯;司继刚;孙敏【摘要】A 62-year-old man with colon cancer was given irinotecan at a dose of 80 mg by intravenous administration on day 1 and day 8. After the treatment, diarrhea was followed lasting for 11 days, and it aggravated with fever on day 13. The patient was sent to the emergency for the further therapy. The laboratory examination revealed that WBC was0.34×109·L-1, NEUT was 5.94%, L was 85.34%, RBC was 3.84×1012·L-1, Hb was 114.0 g·L-1, PLT was 33×109·L-1, blood urea nitrogen was 13.71 mmol·L-1 and serum creatinine was 291μmol·L-1. The patient received a serial of therapy, including anti-infection with cefpirome, enhancing leukocytes with recombinant human granulocyte colony stimulating factor injection, immune regulation, controlling diarrhea, protecting the renal functions and lfuid resuscitation, etc. On the second day of admission, the patient appeared septic shock while the anti-shock treatment was adopted. On the third day, the patient was in deep coma and blood pressure was dififcult to maintain. The patient eventually died of circulatory and respiratory failure.%1例62岁结肠癌男性患者，接受伊立替康80 mg静脉滴注d1、d8化疗。
