治疗后血压变化:ARB
Clinical Outcomes According to Baseline Blood Pressure in Patients With a Low Ejection Fraction in the CHARM (Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity) Program
结论:对AHF病人,在不同的LVEF时SBP(AHF发作时)对死亡 率预测作用不同,即当LVEF<40%时,SBP与死亡率呈线性负相 关;当LVEF>50%时,SBP与死亡率呈J型相关
提示高血压者AHF时 血2压019控/8/2制5 在140 mmHg 左右可能预后更好
European Journal of Heart Failure 201100
压,降低心血管事件发生 • 指南观点先使用RAAS系统阻断剂,常因血压降低不能耐受, β阻
滞剂?
2019/8/25
19
对这部分心力衰竭患者先使用阻滞剂可能是更好的选择
• 有理论基础
• the activation of cardiac sympathetic neurons has been shown to be one of the earliest features of neurohormonal modulation in CHF, and in late CHF the extent of cardiac sympathetic activation correlates with an adverse outcome
Ather et al, Am Heart J 20811