Tariquidar_methanesulfonate,_hydrate_COA_08460_MedChemExpress

VEREGEN TM 12 3 4 5 6 78 910111213141516171819202122(sinecatechins)Ointment, 15%Rx OnlyFor Topical Dermatologic Use OnlyNot for Ophthalmic, Oral, Intravaginal, or Intra-anal UseDESCRIPTIONVeregen TM is a botanical drug product for topical use. The drug substance in Veregen™ is sinecatechins, which is a partially purified fraction of the water extract of green tea leaves from Camellia sinensis (L.) O Kuntze, and is a mixture of catechins and other green tea components. Catechins constitute 85 to 95% (by weight) of the total drug substance which includes more than 55% of Epigallocatechin gallate (EGCg), other catechin derivatives such as Epicatechin (EC), Epigallocatechin (EGC), Epicatechin gallate (ECg) and some additional minor catechin derivatives i.e. Gallocatechin gallate (GCg), Gallocatechin (GC), Catechin gallate (Cg), and Catechin (C). In addition to the known catechin components, it also contains gallic acid, caffeine, and theobromine which together constitute about 2.5% of the drug substance. The remaining amount of the drug substance contains undefined botanical constituents derived from green tea leaves. The structural formulae of catechins are shown below.General Structure of Catechins23242526272829303132333435363738Each gram of the ointment contains 150 mg of sinecatechins in a water free ointment base consisting of isopropyl myristate, white petrolatum, cera alba (white wax), propylene glycol palmitostearate, and oleyl alcohol.CLINICAL PHARMACOLOGYPharmacodynamicsThe mode of action of Veregen TM Ointment, 15% involved in the clearance of genital and perianal warts is unknown. In vitro, sinecatechins had anti-oxidative activity; the clinical significance of this finding is unknown.PharmacokineticsThe pharmacokinetics of topically applied Veregen™ Ointment has not been sufficiently characterized at this time. However, data suggest that systemic exposure to catechins after repeated topical application of Veregen™ Ointment 15% is likely to be less than observed after a single oral intake of 400ml green tea.CLINICAL STUDIES 3940414243444546474849505152535455 Two Phase 3 randomized, double-blind, vehicle-controlled studies were performed to investigate the safety and efficacy of Veregen TM Ointment in the treatment of immunocompetent patients 18 years of age and older with external genital and perianalwarts. The subjects applied the ointment 3 times daily for up to 16 weeks or until complete clearance of all warts (baseline and new warts occurring during treatment).Over both studies the median baseline wart area was 51 mm2 (range 12 to 585 mm2), andthe median baseline number of warts was 6 (range 2 to 30).The primary efficacy outcome measure was the response rate defined as the proportion of patients with complete clinical (visual) clearance of all external genital and perianal warts (baseline and new) by week 16, presented in Tables 1 and 2 for all randomized subjects dispensed medication.Table 1: Efficacy by Region Table 2. Efficacy by GenderCompleteClearanceCompleteClearanceAll Countries(includes the United States)MalesVeregen TM 15% (N = 397) 213 (53.6%) Veregen TM 15% (N = 205) 97(47.3%)Vehicle (N = 207) 73 (35.3%) Vehicle (N = 118) 34(28.8%) United States FemalesVeregen TM 15% (N = 21) 5 (23.8%) Veregen TM 15% (N = 192) 116(60.4%)Vehicle (N = 9) 0 (0.0%) Vehicle (N = 89) 39(43.8%)565758596061626364656667686970 .Median time to complete wart clearance was 16 weeks and 10 weeks, respectively, in the two phase 3 clinical trials.The incidence rate of recurrence of external genital and perianal warts after treatment in patients with complete clearance is unknown.INDICATION AND USAGEVeregen TM is indicated for the topical treatment of external genital and perianal warts (Condylomata acuminata) in immunocompetent patients 18 years and older.CONTRAINDICATIONSVeregen TM is contraindicated in individuals with a history of sensitivity reactions to any of the components of the ointment. In case of hypersensitivity, treatment should be discontinued.WARNINGS 7172737475767778798081828384858687888990919293949596979899 100 101 102 103 104 105 106 107 108 109 110 111 112 113 Veregen TM has not been evaluated for the treatment of urethral, intra-vaginal, cervical, rectal, or intra-anal human papilloma viral disease and should not be used for the treatment of these conditions.PRECAUTIONSGeneralUse of Veregen TM on open wounds should be avoided.The safety and efficacy of Veregen TM in immunosuppressed patients have not been established.Safety and efficacy have not been established for Veregen TM in the treatment of external genital and perianal warts beyond 16-weeks or for multiple treatment courses.Patients should be advised to avoid exposure of the genital and perianal area to sun/UV-light as Veregen TM has not been tested under these circumstances.Information for PatientsGeneral InformationPatients using Veregen TM should receive the following information and instructions:1. This medication is only to be used as directed by a physician. It is for external useonly. Eye contact should be avoided as well as application into the vagina or anus.2. It is not necessary to wash off Veregen TM prior to the next application. When thetreatment area is washed or a bath is taken, the ointment should be applied afterwards.3. It is common for patients to experience local skin reactions such as erythema,erosion, edema, itching, and burning at the site of application. Severe skin reactions can occur and should be promptly reported to the healthcare provider.Should severe local skin reaction occur, the ointment should be removed by washing the treatment area with mild soap and water and further doses held.4. Sexual (genital, anal or oral) contact should be avoided while the ointment is onthe skin, or the ointment should be washed off prior to these activities. Veregen TM may weaken condoms and vaginal diaphragms. Therefore the use in combination with Veregen TM is not recommended.5. Female patients using tampons should insert the tampon before applying theointment. If the tampon is changed while the ointment is on the skin, accidental application of the ointment into the vagina must be avoided.6. Veregen TM may stain clothing and bedding.7. Veregen TM is not a cure and new warts might develop during or after a course oftherapy. If new warts develop during the 16 –week treatment period, these should also be treated with Veregen TM.8. The effect of Veregen TM on the transmission of genital/perianal warts is unknown.9. Patients should be advised to avoid exposure of the genital and perianal area tosun/UV light as Veregen TM has not been tested under these circumstances.114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 15710. The treatment area should not be bandaged or otherwise covered or wrapped as tobe occlusive.11. Uncircumcised males treating warts under the foreskin should retract the foreskinand clean the area daily.Carcinogenesis, Mutagenesis, Impairment of FertilityThe Maximum Recommended Human Dose (MRHD) of Veregen TM Ointment, 15%was set at three times daily topical administration of 250 mg, 750 mg total, containing 112.5 mg sinecatechins for the animal multiple of human exposure calculations presented in this labeling. Dose multiples were calculated based on the human equivalent dose (HED).In an oral (gavage) carcinogenicity study, sinecatechins was administered daily for 26 weeks to p53 transgenic mice at doses up to 500 mg/kg/day (22-fold MRHD). Treatment with sinecatechins was not associated with an increased incidence of either neoplastic or non-neoplastic lesions in the organs and tissues examined. Veregen TM Ointment, 15% has not been evaluated in a dermal carcinogenicity study.Sinecatechins was negative in the Ames test, in vivo rat micronucleus assay, UDS test, and transgenic mouse mutation assay, but positive in the mouse lymphoma mutation assay.Daily vaginal administration of Veregen TM Ointment, 15% to rats from Day 4 before mating and throughout mating until Day 17 of gestation did not cause adverse effects on mating performance and fertility at doses up to 0.15 mL/rat/day. This dose corresponds to approximately 150 mg/rat/day (8-fold MRHD).Pregnancy Category: CEmbryo-fetal development studies were conducted in rats and rabbits using intravaginal and systemic routes of administration, respectively. Oral administration of sinecatechins during the period of organogenesis (gestational Days 6 to 15 in rats or 6 to 18 in rabbits) did not cause treatment related effects on embryo-fetal development or teratogenicity at doses of up to 1,000 mg/kg/day (86-fold MRHD in rats; 173-fold MRHD in rabbits).In the presence of maternal toxicity (characterized by marked local irritation at the administration sites and decreased body weight and food consumption) in pregnant female rabbits, subcutaneous doses of 12 and 36 mg/kg/day of sinecatechins during the period of organogenesis (gestational Days 6 to 19) resulted in corresponding influences on fetal development including reduced fetal body weights and delays in skeletal ossification. No treatment related effects on embryo-fetal development were noted at 4 mg/kg/day (0.7-fold MRHD). There was no evidence of teratogenic effects at any of the doses evaluated in this study.A combined fertility / embryo-fetal development study using daily vaginal administration of Veregen TM Ointment, 15% to rats from Day 4 before mating and throughout mating158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 until Day 17 of gestation did not show treatment-related effects on embryo-fetal development or teratogenicity at doses up to 0.15 mL/rat/day (8-fold MRHD).A pre- and post-natal development study was conducted in rats using vaginal administration of Veregen TM Ointment, 15% at doses of 0.05, 0.10 and 0.15 mL/rat/day from Day 6 of gestation through parturition and lactation. The high and intermediate dose levels of 0.15 (8-fold MRHD) and 0.10 mL/rat/day resulted in an increased mortality of the F0 dams, associated with indications of parturition complications. The high dose level of 0.15 mL/rat/day also resulted in an increased incidence of stillbirths. There were no other treatment-related effects on pre- and post-natal development, growth, reproduction and fertility at any dose tested.There are no adequate and well-controlled studies in pregnant women. Veregen TM Ointment, 15% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Nursing MothersIt is not known whether topically applied Veregen TM is excreted in breast milk.Pediatric UseSafety and efficacy in pediatric patients have not been established.Geriatric useSeven patients (1.4%), older than 65 years of age were treated with Veregen TM in clinical studies. This, however, is an insufficient number of subjects to determine whether they respond differently from younger subjects.ADVERSE REACTIONSAdverse Events / Local Skin ReactionsIn Phase 3 clinical trials, a total of 397 subjects received Veregen™Ointment, 15% three times per day topical application for the treatment of external genital and perianal warts for up to 16 weeks.Serious local adverse events of pain and inflammation were reported in two subjects (0.5%), both women.In clinical trials, the incidence of local adverse events leading to discontinuation or dose interruption (reduction) was 5% (19/397). These included the following events: application site reactions (local pain, erythema, vesicles, skin erosion/ulceration), phimosis, inguinal lymphadenitis, urethral meatal stenosis, dysuria, genital herpes simples, vulvitis, hypersensitivity, pruritus, pyodermitis, skin ulcer, erosions in the urethral meatus, and superinfection of warts and ulcers.199 200 201 202 203 204 205 206 207 Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect rates observed in practice.Local and regional reactions (includes adenophathy) occurring at >1% in the treated group are presented in Table 3.Table 3: Local and Regional Adverse Reactions DuringTreatment (% Subjects)Veregen™(N=397)Vehicle(N=207)Erythema7032Pruritus6945Burning6731Pain/discomfort56 14Erosion/Ulceration49 10Edema4511 Induration3511Rash vesicular 20 6Regional Lymphadenitis 3 1Desquamation5<1Discharge3<1Bleeding2<1 Reaction2Scar10 Irritation1Rash1208209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 A total of 266/397 (67%) of subjects in the Veregen™, 15% group had either a moderate or a severe reaction that was considered probably related and of these 120 (30%) subjects had a severe reaction. Severe reactions occurred in 37% (71/192) of women and in 24% (49/205) of men. The percentage of subjects with at least one severe, related adverse event was 26% (86/328) for subjects with genital warts only, 42% (19/45) in subjects with both genital and perianal warts and 48% (11/23) of subjects with perianal warts only.Phimosis occurred in 3% of uncircumcised male subjects (5/174) treated with Veregen™ and in 1% (1/99) in vehicle.The maximum mean severity of erythema, erosion, edema and induration was observed by week 2 of treatment.Less common local adverse events included urethritis, perianal infection, pigmentation changes, dryness, eczema, hyperesthesia, necrosis, papules, and discoloration. Other less225226227228229230231 232 233234 235 236237238239240241242243244245246247248249250251 252 253254 255 256257 258259 260261 262 263264265 266 common adverse events included cervical dysplasia, pelvic pain, cutaneous facial rash and staphylococcemia.In a dermal sensitization study of Veregen™ Ointment in healthy volunteers, hypersensitivity (type IV) was observed in 5 out of 209 subjects (2.4%) under occlusive conditions.OVERDOSAGEOverdosage with Veregen TM has not been reported.DOSAGE AND ADMINISTRATIONVeregen TM Ointment, 15% is to be applied three times per day to all external genital and perianal warts.It is recommended to wash the hands before and after application of Veregen TM. About a 0.5 cm strand of the Veregen TM Ointment, 15% should be applied to each wart using the finger(s), dabbing it on to ensure complete coverage and leaving a thin layer of the ointment on the warts.It is not necessary to wash off the ointment from the treated area prior to the next application.Treatment with Veregen TM should be continued until complete clearance of all warts, however no longer than 16 weeks.Local skin reactions (e.g. erythema) at the treatment site are frequent. Nevertheless, treatment should be continued when the severity of the local skin reaction is acceptable. HOW SUPPLIEDVeregen TM Ointment, 15% is a brown ointment and is supplied in aluminium tubes containing 15 gram ointment per tube.Storage ConditionsPrior to dispensing to the patient, store refrigerated 2°C to 8°C (36°F to 46°F). After dispensing, store refrigerated or up to 25°C (77°F). Do not freeze.Keep out of reach of childrenNDC # 10337-450-15The VEREGEN trademark is used by Bradley Pharmaceuticals, Inc. under license from MediGene AG.Manufactured by:267 268 269 270 271 272 C.P.M. Contract Pharma GmbH & Co. KG Frühlingstrasse 7D-83620 Feldkirchen-Westerham GermanyManufactured for:273274 275 276 277 278 279 280 281 383 Route 46 WestFairfield, NJ 07004 2402 USACo-marketed with Kenwood Therapeutics, a division of Bradley Pharmaceuticals, Inc. December 2006PATIENT INFORMATION 123 4 5 6 7 8 9101112131415161718192021222324252627282930313233343536373839404142Veregen™(sinecatechins)Ointment, 15%Rx OnlyRead this leaflet carefully before you start using Veregen™ Ointment, 15% and each time you refill your prescription. There may be new information. This information does not take the place of your doctor’s advice. If you have any questions about Veregen™ Ointment, 15% or your condition ask your doctor or pharmacist. Only your doctor can prescribe Veregen™ and determine if it is right for you.What is Veregen™ Ointment, 15%?Veregen™ Ointment, 15% is a medicine for skin use only (topical) for the treatment of warts on the outside of the genitals and around the outside of the anus. It is not a treatment for warts in the vagina, cervix, or inside the anus. Your doctor may recommend examination and screening tests (such as a Pap smear) to evaluate these areas.Who should not use Veregen™ Ointment, 15%?Do not use Veregen™ Ointment, 15% if you are allergic to an ingredient in Veregen™ Ointment, 15%. The list of ingredients is at the end of this leaflet.What should I tell my doctor before taking Veregen™ Ointment, 15%?Tell your doctor about all your health conditions and all the medicines you take including prescription, over-the-counter medicine, vitamins, supplements, and herbals. Be sure to tell your doctor if you are:•pregnant or planning to become pregnant, as it is not known if Veregen™ Ointment, 15% can harm your unborn baby. Your doctor will determine whether the benefit outweighs the risk.•breastfeeding, as it is not known if Veregen™ Ointment, 15% can pass into your milk and if it can harm your baby.•using any other type of skin product or have open wounds on the area to be treated. Veregen™ Ointment, 15% should not be used until your skin has healed from other treatments applied to the same area.•immunocompromised. This means that your immune system cannot fight infections as well as it should.4445464748495051525354555657585960616263646566676869707172737475767778798081828384 How should I use Veregen™ Ointment, 15%?•Use Veregen™ Ointment, 15% only on the area affected exactly as prescribed by your doctor.•Wash your hands before and after application of Veregen™ Ointment, 15%.A small amount of the ointment should be applied to all wart using your finger(s),dabbing it on to ensure complete coverage and leaving a thin layer of the ointment on the warts as directed by your doctor.•Apply Veregen™ Ointment, 15%three times per day ---in the morning, at noontime and in the evening.•Do not wash off the ointment from the treated area before the next application.When you wash the treatment area or bathe, apply the ointment afterwards.•Treatment with Veregen™ Ointment, 15% should be continued until complete clearance of all warts, however no longer than 16 weeks. If your warts do not go away, or if they come back after treatment call your doctor.•Veregen™ Ointment, 15% is not a cure for warts on your genitals or around your anus with certainty. New warts may develop during or after treatment, and may need treatment.What should I avoid while using Veregen™ Ointment, 15%?•Do not apply Veregen™ Ointment, 15% on open wounds or into the vagina or into the anus.•Genital warts are a sexually transmitted disease, and you may infect your partner.•Avoid sexual contact (genital, anal or oral) when Veregen™ Ointment, 15% is on your genital or perianal skin. If you do choose to have sexual contact, you must wash off the ointment carefully before having protected sexual contact as the ointment may weaken condoms and vaginal diaphragms. Talk to your doctor about safe sex practices.•Avoid contact with your eyes, nostrils and mouth while ointment is on your finger(s).•Women using tampons: insert the tampon before applying the ointment. If you need to change your tampon while the ointment is on your skin, avoid getting the ointment into the vagina.8687888990919293949596979899 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127•Uncircumcised men treating warts under the foreskin should retract the foreskin and clean the area daily.•Do not expose the genital area treated with Veregen™ Ointment, 15% to sunlight, sunlamps or tanning beds.•Do not cover the treated area. Loose-fitting undergarments can be worn after applying Veregen™ Ointment, 15%.•Veregen™ Ointment, 15% may stain your light colored clothes and bedding. It is recommended to wear darker colored undergarments while using Veregen™ Ointment, 15%.What are the possible side effects of Veregen™ Ointment, 15%?The most common side effects with Veregen™ Ointment, 15%are local skin and application site reactions including:•redness•swelling•sores or blisters•burning•itching•painMany patients experience itching, reddening or swelling on or around the application site during the course of treatment. Some of these side effects could be a sign of an allergic reaction. If you experience open sores or other severe reactions at the locations you applied Veregen™, stop treatment and call your doctor right away.You may experience other side effects of Veregen™ Ointment, 15%, which are not mentioned here. Ask your doctor or pharmacist for more information.Patients should be aware that new warts may develop during treatment as Veregen™ Ointment, 15% is not a cure.How should I store Veregen™ Ointment, 15%?•Store Veregen™ Ointment, 15% refrigerated or up to 77ºF (25 ºC).•Do not freeze.•Make sure the cap on the tube is tightly closed.•Safely throw away Veregen™ Ointment, 15% tubes that are out of date or are empty.Keep Veregen™Ointment, 15% and all medicines out of the reach of children.129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 General advice about prescription medicinesMedicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use Veregen™ Ointment, 15% for a condition for which it was not prescribed. Do not give Veregen™ Ointment, 15% to other people, even if they have the same symptoms you have. It may harm them. Do not use Veregen™ Ointment, 15% after the expiration date on the tube.This leaflet summarizes the most important information about Veregen™ Ointment, 15%. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about Veregen™ Ointment, 15% that is written for the doctor.What are the ingredients in Veregen™ Ointment, 15%?Active ingredient:A defined green tea extract named sinecatechins.Inactive ingredients:Isopropyl myristate, white petrolatum, cera alba (white wax), propylene glycol palmitostearate, and oleyl alcohol.Veregen™ is a trademark of MediGene AG, D-82152 Planegg/Martinsried, Germany. Manufactured by: C.P.M. Contract Pharma GmbH & Co. KG, Frühlingstrasse 7, D-83620 Feldkirchen-Westerham, Germany.Manufactured for:156 157 158 159 160 383 Route 46 West Fairfield, NJ 07004 2402 USACo-marketed with:161162163164 December 2006Text for the Outer Carton Label 1NDC # 10337-450-xx 2Rx OnlyVEREGEN TM(sinecatechins) Ointment15%For Topical Dermatologic Use Only.Not for Opthalmic, Oral, Intravaginal, or Intra-anal Use.Keep out of reach of children.Description: Veregen TM is a botanical drug product. The drug substance in Veregen TM is sinecatechins, which is a partially purified fraction of the water extract of green tea leaves of Camellia sinensis (L.) O Kuntze, and is a mixture of catechins, their derivatives and other green tea components.Active ingredient: sinecatechins (150 mg/g).Excipients: isopropyl myristate, white petrolatum, cera alba (white wax), propylene glycol palmitostearate, and oleyl alcohol.Usual Adult dose: See accompanying package insert for full Prescribing Information. Manufactured by: C.P.M. Contract Pharma GmbH & Co. KG, Frühlingstrasse 7, D-83620 Feldkirchen-Westerham, Germany.Manufactured for:383 Route 46 West, Fairfield, NJ 07004-2402 USACo-marketed with Kenwood Therapeutics, a division of Bradley Pharmaceuticals, Inc. Lot:Exp:UPC/Bar CodeYY 3gStore in a refrigerator at 2-8°C (36-46°F) until dispensed to the patient.Patient can store refrigerated or up to 25°C (77°F). Do not freeze.U.S. Patent Nos. 5795911 and 5968973________________________________________________________________________1 Text presented on the outer carton may not appear in the order outlined in this document.2 xx = 15 for the 15g ointment size, xx = 03 for the 30g ointment size3Text for the Immediate Container (Tube) Label 4NDC # 10337-450-xx 5Rx OnlyVeregen TM(sinecatechins) Ointment15%YY 6 gFor Topical Dermatologic Use Only.Not for Opthalmic, Oral, Intravaginal, or Intra-anal Use.Keep out of reach of children. Keep tightly closed.Description: Veregen TM is a botanical drug product. The drug substance in Veregen TM is sinecatechins, which is a partially purified fraction of the water extract of green tea leaves of Camellia sinensis (L.) O Kuntze, and is a mixture of catechins, their derivatives and other green tea components.Active ingredient: sinecatechins (150 mg/g).Excipients: isopropyl myristate, white petrolatum, cera alba (white wax), propylene glycol palmitostearate, and oleyl alcohol.Usual Adult dose: See accompanying package insert for full Prescribing Information.Store in a refrigerator at 2-8°C (36-46°F) until dispensed to the patient.Patient can store refrigerated or up to 25°C (77°F). Do not freeze.For control number and expiration date, see crimp of tube.Manufactured by: C.P.M. Contract Pharma GmbH & Co. KG, Frühlingstrasse 7, D-83620 Feldkirchen-Westerham, Germany.Manufactured for:383 Route 46 West, Fairfield, NJ 07004-2402 USACo-marketed with Kenwood Therapeutics, a division of Bradley Pharmaceuticals, Inc. SAMPLE. NOT FOR SALE. 7U.S. Patent Nos. 5795911 and 5968973________________________________________________________________________4 Text presented on the outer carton may not appear in the order outlined in this document.5 xx = 15 for the 15 g ointment size, xx = 03 for the 30 g ointment size, xx = 99 for the 4 g ointment (physician sample) size.6 YY = 15 for the 15 g ointment size, YY = 30 for the 30 g ointment size, YY = 4 for the 4 g ointment (physician sample) size.7 This statement only applicable for the 4 g ointment (physician sample) size.。

AAcyclovir 带状泡疹、水痘药物治疗成份，需医生处方Adapalene 维他命A酸衍生物治疗痤疮有效成份，需医生处方Adenosine Triphosphate(ATP) 腺三磷酸使皮肤代谢正常Albumin 白蛋白水溶性蛋白质，为中性缓冲液，是一种酵素Alcohol 酒精溶剂Alfalfa Extract 紫花苜蓿萃取含多种氨基酸及红萝卜素，可抗老化Algae Extract 海藻萃取液抗氧化Algisium C 是一种生物保湿剂，可以修护肌肤并使更新暗沉的肤质，延缓老化的速度；其保湿性可维持8-12小时Alkyl Benzoate 烃基安息香酸盐油脂剂，作为基质Allantoin 尿囊素抗炎症、促进细胞修护Almond 杏仁油天然油脂，用作基质Aloe Extract 芦荟萃取镇静、保湿、滋润、抗敏、镇静、去红肿Aloe Vera 芦荟镇静、保湿、滋润、抗敏、镇静、去红肿Alpha Hydroxy(AHA) 果酸最常用的为甘醇酸(Glycolic Acid)及乳酸(Lactic Acid)，主要功效在促进皮肤新陈代谢，具有角质微剥的功效Alpha Lipoic Acid 脂肪酸，硫辛酸抗氧化Alpha Tocopheryl 维他命E 抗氧化Aluminum Chlorohydrate 氢氯酸铝可抑制身体出汗，常来用作止汗剂成份Amino Acid 天然胺基酸防止水份过度的流失，并使肌肤温和不紧绷，护肤、供给肌肤营养Aminocaproic Acid 胺基己酸预防肌肤敏感现象Ammonium Glycyrrhizate 甘草酸胺保湿、预防过敏Amniotic Fluid 羊膜液含丰富肌肤所需的胺基酸Angelica Sinensis Diels Extract 当归萃取具有行气活血功效，可促进肌肤毛细微管血液循环Angelica 白芷当归属，含天然维他命C及预防敏感作用Angiosperm Extract 被子植物酸具有防止发炎及抗过敏效果Anhydroalkannin 去水紫草烯紫草萃取精华，可抗炎、抗菌、活血、去瘀Anthranilates 化学性防晒成分Apple Extract 苹果萃取含有Vit-C等美容成份，另具有爽肤、镇静消毒作用Apricot Bead 杏桃颗粒通常加在磨砂膏中，用来去除皮肤老废角质Apricot Kernel Oil 杏核油富含矿物质和维他命，是天然的保湿剂，特别适合敏感性肤质Aqua 水，溶液基质Arbutin 熊果素淡化已形成的黑色素，能安定自由基、避免肌肤老化，卫生署公布有效美白成份之一Arnica Extract 山金车萃取活血散瘀Arnica Oil 山金车油可促使伤口愈合、消毒、消肿、防止瘀斑出现Ascorbic Acid 维他命C 抗氧化Ascorbyl Glucoside(AAG) 维他命C甘醣维他命C衍生物，为卫生署公布有效美白成份之一Ascorbyl Pamitate 维他命C棕榈酸盐一种脂溶性维他命C，是安定的维他命CAscorbyl Stearate 酯化C 安定的维他命CAscorbyl Tetraisopalmitate 脂溶性维他命C 安定的维他命C Astragalus Membranaceus(Fisch) Bunge Extract 膜荚黄耆萃取提高肌肤活力，效用比人蔘更佳Avobenzone 化学性防晒成分，属Parsol 1789类，罕见过敏反应Avocado Oil 骆梨油保湿剂、含大量维他命A、C、D、EAzelaic Acid 壬二酸，杜鹃花酸抑制黑色素，抗菌消炎，用来治疗痤疮的温和成份BBaSO4 硫酸钡物理性防晒成份Babassuamidopropylamine 泡沫增强剂Bay Extract 月桂萃取收敛毛孔、抑制油份分泌Bearberry Extract 熊果萃取含食子单宁、葡萄糖甘等成份，具收敛、杀菌消毒、美白等功效Bees Wax 蜜蜡基质，可增强产品浓度Bentonite 膨润土，皂土有很好的清洁和吸附效果，亦具有抑制脸部油脂分泌的功效，用来调置面膜清洁皮肤，或是用作产品基质Benzalkonium Chloride 氯化苯二甲烃铵抗菌、防腐Benzoic Acid 安息香酸，苯甲酸防腐剂Benzophenones(Benzophenone-3) 二苯甲酮衍生物化学性防晒成分，可防御UV A，属苯甲酮类Benzoyl Alcohol 产品赋型剂，作为基质Benzoyl Peroxide 过氧化苯盐是一种氧化剂，有抑菌的效果，特别是对引起青春痘的痤疮杆菌这种厌氧菌特别有效Bergamot Mint Extract 佛手柑萃取收敛毛孔、平衡油脂分泌Betula Alba Extract 桦木芽萃取抗菌Betula Extract 桦木萃取抗菌、收敛、净化作用Bilberry Extract 覆盆子萃取消毒、收敛、消脂、排水Bio-Collagen 生化胶原蛋白保湿Bio-Enzyme 酵素，脢促进细胞新陈代谢Biocatalyst 酵素促进细胞新陈代谢Biopeptide 生化蛋白质刺激胶原蛋白合成，预防老化，有助组织重建Biopeptides 双性缩胺酸促进胶原蛋白、弹力蛋白的产生，改善松弛Biota Orientalis(L.) Endle Extract 侧柏叶萃取镇定肌肤Birch Tree Extract 桦树萃取消毒、收敛，增加皮肤愈合力Bisabolo Extract 没药萃取收敛、消毒杀菌加快伤口愈合Bisabolol 甜没药醇防刺激剂，提取自洋甘菊Bletilla Striata Reichenbach Extract 白芨萃取含天然维他命C，可减少黑色素沉淀Borage Oil 琉璃苣油天然油脂，含丰富的维他命E、F，修补凹洞Bromclain 菠萝酵素代谢老旧细胞角质Burdock Root Extract 牛蒡根萃取调节皮脂分泌、收敛作用Burdock 牛蒡消毒、预防粉刺、促进细胞生长、抗发炎Butyl Methoxydibenzoylmethane 化学性防晒成分，属Parsol 1789类，罕见过敏反应Butyl Paraben 丁酯防腐剂Butyl Stearate 硬脂酸赋型剂、基质Butylene Glycol 丁二醇保湿Butylhydroxyanisol 羟基茴香二丁酯酸化防止剂CC12-15 Alkyl Benzoate 赋型剂、基质CO-Q10 辅脢抗氧化，可以消灭自由基，维持细胞膜的完整和稳定Calcium Pantetheine Sulfonate 维他命B5衍生物，为紫外线吸收剂(化学性防晒成份)Calcium Pantothenate 泛酸钙，维他命B5 抗氧化，促进代谢Calendula Extract 金盏花萃取具舒缓、安抚敏感肌肤等功效Camellia Sinensis Extract 山茶萃取，茶多酚抗氧化Camphor 樟树抗痒、防过敏Candelilla Wax 墈地里拉蜡浓度增强剂Caprylic/Capric Triglyceride 三甘油酯皮肤润滑剂Carbomer 高份子胶浓度增强剂Carbopol 羧乙烯聚合物赋型剂Carboxymethyl Chitin 几丁质衍生物来自虾蟹外壳，为一高分子量之粘多醣体，具有保湿作用Carnauba Wax 棕榈蜡增加光泽感Carrageenan 鹿角菜胶保湿Carrot Oil 胡萝卜油可促使伤口愈合、镇痛、滋养、消毒、抗老化Carthamus Tinctorius L. Extract 红花萃取活化肌肤Castor Oil 蓖麻油含蓖麻油酸(Ricinoleic acid)，可润滑、保湿Centella Asiatica 老公根紧实肌肤、增加弹性Ceramide 3 分子钉保湿剂Ceramide 神经醯胺、细胞质脂保湿剂Ceresin 矿蜡乳化剂Ceteareth-12 乳化剂Ceteareth-20 乳化剂Cetearyl Alcohol 十六硬脂酸酯乳化剂Cetyl Acetate 鲸蜡醋酸盐油脂剂Cetyl Alcohol 鲸腊硬酯醇、十六醇乳化剂Cetyl Dimethicone 鲸蜡硅氧烷油脂剂Cetyl Palmitate 棕榈酸鲸腊酯乳化剂Chamomil Oil 洋甘菊油抗自由基、舒缓Chamomile Extract 洋甘菊萃取含丰富的甘菊蓝，具有防止皮肤发炎的功效，亦具有清洁、安定肌肤的效果Chlorella Extract 绿藻萃取滋润、保湿Cholecalciferol 维他命D3，胆骨化醇内用为增加钙质吸收，外用可治疗牛皮癣Cholesterol 胆固醇乳化剂Cinnamate 桂皮酸盐类化学性防晒成分，也是目前较安全的成份Cinnamon Essential Oil 肉桂精油防腐、杀菌Cinoxate 化学性防晒成分，属桂皮酸盐类Citric Acid 柠檬酸防腐剂及平衡酸碱度Citric Alcohol 柠檬醇乳化剂Citric Oil 柠檬油润肤Citron 法国香柠檬具提神醒肤、消除肌肉疲劳以及对毛孔粗大有收敛效果等作用Citronella Essential Oil 香茅精油清洁、杀菌Citrus Extract 柑橘萃取含有维他命C，具有防菌效果，可以控制油脂分泌作用及防止雀斑、黑斑的形成Coal Tar 煤焦油常用来做为唇膏的染料Cocamidopropyl Betaine 烷基醯胺类界面活性剂，起泡剂，清洁用Cocamidopropyl Hydroxy Sultane 烷基醯胺类界面活性剂，起泡剂，清洁用Cocoamide DEA 非离子界面活性剂清洁用品主要成份。

17349 Lauryl sulfate Broth (Lauryl Tryptose Broth)Selective medium acc. to Mallmann and Darby (1941) for the presumptive testing for coliform and their selective enrichment in the examination of water, dairy products and foodstuffs. The difference to Cat. No. 61749 is that Tryptose is used instead of CaseinComposition:Ingredients Grams/LitreTryptose 20.0Lactose 5.0Dipotassium hydrogen phosphate 2.75Potassium dihydrogen phosphate 2.75Sodium lauryl sulfate 0.1Sodium chloride 5.0Final pH 6.8 +/- 0.2 at 25°CPrepared Broth becomes cloudy if stored at 2-8°C, but it should get cleared at room temperature. Store dehydrated powder, in a dry place, in tightly-sealed containers at 2-25°C.Directions:Dissolve 35.6 g in 1 litre distilled water. Distribute to convenient flasks or disspense 10 ml into each test-tubes containing inverted Durham tubes. Sterilize by autoclaving at 121°C for 15 minutes. Cool down slowly to prevent bubbles in Durham-tubes.Gas production from lactose fermentation is indicated by using inverted Durham tubes. Inoculate the tubes containing 10 ml of Lauryl sulfate Broth and the Durham tubes. Incubate at the wished temperature for 18-24 hours. In case of gas formation the Durham tubes rise or/and show bubbles. Turbidity of the medium accompanied by formation of gas within 48 hours is a positive presumtive test for the presence of E. coli and/or other coliform organisms.Principle and Interpretation:Tryptose provides the nitrogen, carbon compounds, vitamins and amino acids. Lactose is the fermentable sugar. Sodium lauryl sulphate inhibits organisms other than coliforms. Bile salts inhibit gram-positive bacteria especially bacilli and faecal Streptococci. Sodium chloride maintains the osmotic balance of the medium. Potassium phosphates control the pH during fermentation of lactose. Lactose-positive bacteria metabolize lactose with gas formation, within 24 hour or less is a presumptive evidence of the presence of coliform bacteria.After inoculation, incubate the tubes at 37°C for 24-48 hours. For every tube showing fermentation (primary fermentation), inoculate two tubes of Lauryl Tryptose Broth from the tube showing primary fermentation and incubate these tubes at 37°C and 44°C respectively. If there is fermentation in the tube incubated at 44°C after 8 to 24 hours, perform indole test by adding Kovac‘s reagent (Cat. No. 60983). A positive indole test in a broth tube showing gas production at 44°C indicates the presence of Escherichia coli. If no fermentation occurs in the tube incubated at 37°C after 24 hours, the primary fermentation is assumed to be due to organisms other than coliforms.Cultural characteristics after 18-24 hours at 35°C.Organisms (ATCC) Growth Gasformation Indole test (44°C)Enterobacter aerogenes (13048) +++ + - Escherichia coli (25922 and 11775) +++ + + Salmonella typhimurium (14028) +++ - - Staphylococcus aureus (25923) - - - Enterococcus faecalis (29212) - - -References:1. A.E. Greenberg, R.R.Trussell, L.S. Clesceri (Eds.), Standard Methods for the Examination of Waterand Wastewater, 16th ed., APHA Washington, D.C. (1985)2.M. Speck (Ed.), Compendium of Methods for the Microbiological Examination of Foods, 2nd ed.,APHA, Washington, D.C. (1984)3.J. Cowls, Am. Water Werks Association, 30, 979. (1938)4.International Organization for Standardization (ISO) , Draft ISO/DIS 4831 (1991)5.W.L. Mallmann, C.W. Darby, Am. J. Pbl. Health 31, 127 (1941)Precautions and DisclaimerThis product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices.The vibrant M, Millipore, and Sigma-Aldrich are trademarks of Merck KGaA, Darmstadt, Germany orits affiliates. Detailed information on trademarks is available via publicly accessible resources.。

小学上册英语第5单元真题(有答案)英语试题一、综合题(本题有100小题，每小题1分，共100分.每小题不选、错误，均不给分)1. A rabbit has long ______ for jumping.2.She has a ___ (colorful) umbrella.3.I _____ (am/are) going to the park.4. Depression started in the United States in ______ (1929年). The Grea5.What do you call the place where you learn?A. HomeB. SchoolC. StoreD. Hospital答案: B6.What do we call a person who studies the relationship between biology and culture?A. Biocultural AnthropologistB. SociologistC. AnthropologistD. Historian答案: A7.The capital of Russia is _____.8.The _____ (猎豹) is the fastest land animal. 猎豹是最快的陆地动物。

9.n Massacre was a confrontation between British soldiers and ________ (殖民者). The Bost10.How many legs does a spider have?A. SixB. EightC. TenD. Four答案: B11.My uncle is a talented ____ (painter).12.What is the name of the famous ancient city in Iraq?A. BabylonB. UrC. NinevehD. Assur答案:A.Babylon13. (Age) of Exploration led to the discovery of new lands. The ____14.The ancient Egyptians worshiped _______. (太阳神)15.I like to _______ (尝试新餐厅) with my family.16.We play with a ________ outside.17.The _____ (植物生态作用) highlights the interconnectedness of life.18.The process of converting a solid directly into a gas is called _______.19.I keep my toys in a ________ (箱子).20.The main use of chlorine in water treatment is to kill ______.21.The capital of Sint Maarten is __________.22. A tarantula can be found in the ________________ (森林).23.The ________ (ball) is round and bouncy.24.I have a toy ________ (玩具名称) that can light up.25.The chemical formula for ammonia is __________.26.What is the term for a young goat?A. KidB. FawnC. CalfD. Pup答案:a27.The chemical formula for aspirin is ________.28.The ________ was a prominent figure in the movement for justice.29.There are many __________ (动物) in the zoo.30.Many people enjoy _______ to plants in their gardens.31.I can ______ (jump) really far.32.My dad teaches me . (我爸爸教我。