压片机设计说明书

目录

第1章 绪论 ···································································································· 1

背景 ··············································································· 错误！未定义书签。

第2章 压片样机概述······················································································· 4

2.1 主要用途及使用范围 ·············································································· 4

2.2 压片机的主要型式 ················································································· 5

2.3 精密样品压片机简介 ·············································································· 5

2.4 精密样品压片机的结构 ··········································································· 6

第3章 压片样机总体方案设计 ·········································································· 8

3.1 压片样机的功能要求 ·············································································· 8

3.2 工艺分析 ····························································································· 8

3.3 确定压片机主要构件 ·············································································· 9

3.3.1 液压泵的选择 ··············································································· 9

3.3.2 液压缸的选择 ·············································································· 12

3.3.3 压样模具的设计 ··········································································· 13

3.4 压片机的传动原理设计 ·········································································· 14

3.5 液压系统的油路控制设计 ······································································· 16

第4章 主要机构设计和参数计算 ······································································ 18

4.1 液压缸的设计计算 ················································································ 18

4.2 液压泵的参数计算 ················································································ 22

4.3 电动机的选择 ······················································································ 24

4.4 联轴器的选择 ······················································································ 25

4.5 油箱的设计及液压介质的选用 ································································· 26

4.5.1 油箱容量的确定 ··········································································· 26

4.5.2液压介质的选用 ············································································ 26

第5章 主要零件的强度校核 ············································································ 28

5.1 上横梁的强度校核 ················································································ 28

5.2 左立柱的强度校核 ················································································ 29

5.3 液压缸套筒和下横梁联接的可靠性检测 ····················································· 30

5.4 键的选择及强度校核 ············································································· 31

5.4.1选择键联接的类型和尺寸 ································································ 31

5.4.2 键联接强度计算 ··········································································· 32

结 论 ··········································································································· 34

致谢 ·············································································································· 35

参考文献 ········································································································ 36

1 第1章 绪论

引言

压片机与压片技术是医药制剂工业中最普遍的亦是最重要的，尽管压片机从19世纪初已经出现，但是至今，新的压片机及压片技术仍在不断的涌现。近十年来，随着GMP改造在我国的推进，压片机及压片技术亦获得了快速的发展，中国的压片机制造商已有近三十多家，能够生产高速压片机的亦有5-6家之多，然而长期以来，由于基础研究的薄弱，人才的贫乏以及缺乏完善的创新机制，因此与国外的先进的压片机及压 片技术还存在很大的差距。近年来，密闭性、模块化、自动化、规划化及先进的检测技术将是压片机与压片技术最主要的发展方向，压片机将朝着完善生产不断的进步。

1）向高速高产发展是压片机首要的发展方向

高速高产量是压片机生产商多年以来始终追求的目标，目前世界上主要的压片机厂商都拥有每小时产量达到100万片的压片机。

目前国内行业标准中规定高速压片机的转台节圆线速度应超过60 m/min。按这个标准，目前国外生产的压片机大多数均超过这个速度，有些压片机的转台节圆线速度已达200m/min。

如：Manestry公司生产的Xpress 700型压片机最高产量达100万片/h；

Korsch 公司生产的XL800型压片机最高产量达102万片/h；

Courtoy 公司生产的 ModulD 型压片机最高产量达107万片/h；

Fette 公司生产的4090 i 型压片机最高产量达150万片/h；

为了提高产量，国外不少压片机的转台越做越大，冲位数亦越来越多，当然机器的尺寸亦会越来越大。

例如：Fette公司的4090i 型压片机转台节径达1060mm，最大冲位数为122 冲，外形尺寸为1810×1810×2240 mm。主电机功率为

18.5kW。

2 Korsch 公司的XL 800 型压片机转台节径达840 mm，最大冲位数为95 冲，TRP 700/900型压片机的转台节径为 780/1000mm。

Courtoy生产的ModulD 型压片机最大冲位数达89冲。

2）全封闭的一体化的片剂成型系统是压片机的一个主要发展方向。

当今的片剂设备面临着两个主要矛盾：一是在安全有效地生产出更多药品的同时，不断降低生产成本；二是在大批量规模化生产的同时亦要考虑最大的灵活性。目前国外的压片机十分注重输入、输出环节的密闭性，尽可能的减少交叉污染及粉尘飞扬，而国内的压片机大多数这个过程是敞开的。全封闭的、一体化的片剂成型系统包括：上料、压片、除尘、筛片、检测等多台设备，以及这些设备的联接。

3）集成化、模块化使得压片机的发展取得巨大的成功。

Fette 公司新近也研发了一款新的压片机，其核心在于用冲盘组件来代替传统的冲模台板，而后者 需要逐一把每一只冲模装入冲模台板中，再用螺钉逐一紧固。如此在更换产品或清洗上下场时非常耗

时，新一款的压片机只需要3～5个冲盘组件，每个组件只需2个卡箍和2个螺钉紧固即可。这些独立的冲盘组件均有硬度，上面可以按所需压片的模腔 尺寸直接做在冲模台板上，而不再有分列的中模。

用这种技术带来的优势是：①大大节约了拆卸装配 所需的时间，据统计可节约 88 ％的时间。②清洁效果更佳。③产品损失少。④生产能力更高。⑤设备 磨损小，维护简单。这项技术由 Fette 公司独创，技 术上处于领先地位