蛙的神经肌肉接 点处
引自《分子神经生物 学》，陈宜张主编
（Nature Rev Mol Cell Biol,2001,2:98106）
（Annu. Rev. Cell Dev. Biol. 2000. 16:19–49）
Figure 1 Synaptic vesicle life cycle. The synaptic vesicle life cycle begins with the synthesis of vesicleassociated proteins in the cell body (step 1), followed by targeting to synaptic terminals (step 2). At the terminal, the vesicle undergoes a maturation process involving membrane fusion and endocytosis before neurotransmitter is actively transported across the membrane (step 3). A reserve pool of vesicles is tethered to the cytoskeleton (step 4).Mobilization (step 5) from the cytoskeleton is followed by vesicle docking (step 6), which consists of the approach of the vesicle toward the active zone plasma membrane and the formation of protein complexes linking the two membranes. Exocytosis requires an ATP-dependent priming reaction (step 7) as a prerequisite for Ca2+triggered membrane fusion (step 8). Following release of the neurotransmitter, vesicle membrane and protein constituents are recycled via endocytosis, mediated at least in part by clathrin coats (step 9).Recycled vesicles shed their coats, then can directly reuptake neurotransmitter (10a) or first pass
