What is Introduction?
Introduction is the first section of a
scientific paper, including the background
information of the research, the nature and
scope of the problem investigated.
作者在结论的第一句重述主旨, 但不重复用过的词语,以免单 调乏味 。作者在这结论的第二 、三句里也用了另外一种结论 方法:对讨论的问题提出建议 或方法。
(“Problems Caused by MicrowaveOvens”)
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【 宽 背 景 】Delta-aminolevulinic acid (ALA) dehydratase (ALAD)is the second
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lead burdenand causes the toxicity of lead in some soft tissues, such as bone marrow. The larger fraction of lead in blood cells is mainly bound to ALAD protein [Sakai et al., 1982; Bergdahl et al., 1997]. Thus, ALAD might also play an important role in the dynamic interchange of the body lead pool.Human ALAD gene is located in chromosome 9q34 [Potluri et al., 1987]. The gene frequencies of ALAD alleles 1 and 2 were rereportedly about 0.9 and 0.1, respectively, in several Caucasian populations [Battistuzzi et al., 1981; Benkmann et al., 1983; Astrin et al., 1987]. In 1991, a simple method using polymerase chain reaction (PCR) was developed for the analysis of the ALAD genotype [Wetmur et al., 1991a]. In comparison with the ALAD1 sequence, the only difference in the ALAD2 cDNA was a G-to-C transversion of nucleotide 177 in the coding region, which creates an MspI restriction site and causes the replacement of a lysine by a asparagine [Wetmur et al., 1991a]. The difference in the amino acid might result in a distinct charge isozyme, and the ALAD2 protein may bind lead more tightly than a dose of the ALAD1 protein [Wetmur, 1994].