四环素族药物
Teracyclines
抑制蛋白质合成 抑制细菌 二甲胺四环素 多西环素
二甲胺, 100mg 2/日,1周 多西 ,首次100mg/日, 2次, 以后50mg,2/日
广谱 对Aa 效果好
龈沟液的浓度高(2-10倍), 抑制胶原酶, 根面处理的应用, 7岁前禁用
大环内酯类抗菌素
Macrolides
Issue
Drug distribution Drug concentration
Systemic administration
Wide distribution Variable levels in different body compartments site,
Local administration
非甾体类抗炎药物
Non-steroid-anti-inflammatory Drugs
PGE是牙槽骨吸收最有力的刺激因子:诱发炎症,血管扩
张,诱导骨吸收,抑制骨胶原形成
NSAIDs的抗炎机制 降低PGE的产生 抑制炎症细胞释放PGE 减弱IL-1, TNF-α等细胞因子对PGE合成的诱导 作用
NSAIDs药物种类
Therapeutic potential May reach widely distributed microorganisms better
Problems
Systemic side effects
Clinical limitations
Requires good patient compliance
a. False. Chlorhexidine is a bisbiguanide antimicrobial. b. True. Retention in the oral cavity is one of the most important properties of this agent. c. False. Chlorhexidine is a broad-spectrum antimicrobial. d. False. The concentrations are 0.12% and 0.2%. e. False. Chlorhexidine stains teeth independently of whether the patient smokes.