英语医学论文投稿信Cover letter示例

英文论文投稿信Cover letter模板qiusuo BY - 2006-1-17 8:59:00Dear Editor;We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons"; which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons; which are degenerated in Parkinson’s disease. In this paper; we report an unexpected; acute effect of GDNF on A-type potassium channels; leading to a potentiation of neuronal excitability; in the dopaminergic neurons in culture as well as in adult brain slices. Further; we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus; this study has revealed; for the first time; an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons; and suggest that the normal function of GDNF is to regulate neuronal excitability; and consequently dopamine release. These results mayalso have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest; we request that Drs. XXX of Harvard Univ.; and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration; I amSincerely yours;case2Dear Editor;We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release"; which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First; we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second; we show that the GDNFeffect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further; GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity; leading to an enhancement of Ca2+ influx. Thus; this study has identified; for the first time; a molecular target that mediates the long-term; synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.0630投稿写作某杂志给出的标准Sample Cover Letterthe example used is the IJEBCase 3Sample Cover Letterthe example used is the IJEBDear Editor of the please type in journal title or acronym:Enclosed is a paper; entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the journal title. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies if no matching subject/theme; enter 'Subject highly related to subject of journal but not listed by please type in journal title or acronym3. Why the material is important in its field and why the material should be published in please type in journal title or acronymThe necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management systemhas become increasingly important today's distributed environment. However; the conventional centralized architecture; which routinely requests the status information of local units by the central server; is not sufficient to manage the growing requests. Recently; a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic; distributes management tasks; and improves operational performance. Given today's bandwidth demand over the Internet; it is important for the journal title/acronym readersto understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the journal title/acronym.4. Names; addresses; and email addresses of four expert referees.Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster; NY 00012-6666; USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: Expertise: published a related paper "TCP/IP and OSI: Four Strategies for Interconnection" in CACM; 383; pp. 188-198. Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123; Harbor Drive Sydney;Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail:Expertise: published a related paper "Creating Mobile Agents" in IEEE TOSE; 188; pp. 88-98.Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888; Putong RoadKeelung; Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail:Expertise: published a related paper "Network Management for E-Commerce" in IJ Electronic Business; 14; pp. 18-28. Relationship: Former professor; dissertation chairman.Mr. Frank YoungPartner; ABC Consulting888; Seashore HighwayWon Kok; KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail:Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices. Relationship: I have worked with Mr. Young in several consulting projects in the past three years.Finally; this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely;Johnny SmithCase 1Dear Editor;We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons"; which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons; which are degenerated in Parkinson’s disease. In this paper; we report an unexpected; acute effect of GDNF on A-type potassium channels; leading to a potentiation of neuronal excitability; in the dopaminergic neurons in culture as well as in adult brain slices. Further; we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus; this study has revealed; for the first time; an acute modulation of ion channelsby GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons; and suggest that the normal function of GDNF is to regulate neuronal excitability; and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest; we request that Drs. XXX of Harvard Univ.; and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration; I amSincerely yours;case2Dear Editor;We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release"; which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First; we report that GDNFhas a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second; we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further; GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity; leading to an enhancement of Ca2+ influx. Thus; this study has identified; for the first time; a molecular target that mediates the long-term; synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.0630投稿写作某杂志给出的标准Sample Cover Letterthe example used is the IJEBCase 3Sample Cover Letterthe example used is the IJEBDear Editor of the please type in journal title or acronym:Enclosed is a paper; entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the journal title. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies if no matching subject/theme; enter 'Subject highly related to subject of journal but not listed by please type in journal title or acronym3. Why the material is important in its field and why the material should be published in please type in journal title or acronymThe necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management systemhas become increasingly important today's distributed environment. However; the conventional centralized architecture; which routinely requests the status information of local units by the central server; is not sufficient to manage the growing requests. Recently; a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic; distributes management tasks; and improves operational performance. Given today's bandwidth demand over the Internet; it is important for the journal title/acronym readersto understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the journal title/acronym.4. Names; addresses; and email addresses of four expert referees. Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster; NY 00012-6666; USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: Expertise: published a related paper "TCP/IP and OSI: Four Strategies for Interconnection" in CACM; 383; pp. 188-198. Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123; Harbor Drive Sydney;Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail:Expertise: published a related paper "Creating Mobile Agents" in IEEE TOSE; 188; pp. 88-98.Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888; Putong RoadKeelung; Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail:Expertise: published a related paper "Network Management for E-Commerce" in IJ Electronic Business; 14; pp. 18-28. Relationship: Former professor; dissertation chairman.Mr. Frank YoungPartner; ABC Consulting888; Seashore HighwayWon Kok; KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail:Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices. Relationship: I have worked with Mr. Young in several consultingprojects in the past three years.Finally; this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely;。

模板1Dear Prof. XXXXX,Here within enclosed is our paper for consideration to be published on “(Journal name)”. The further information about the paper is in the following:The Title: XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXThe Authors: XXXXXXXXXX XXXXXXXXXXXX and XXXXXXXXXXThe authors claim that none of the material in the paper has been pub lished or is under consideration for publication elsewhere.I am the corresponding author and my address and other information is as follows,Address: Department of XXXXXXXXX,Tsinghua University,Beijing, 10084,P.R.ChinaE-mail:Tel: 86-10-62785001Fax: 86-10-62785001Thank you very much for consideration!Sincerely Yours,Dr. XXXXXXXXXXX模板2Dear XX (Editor):Here is our paper submitted to "(XX Journal)".The Title: XXXXThe Authors: XXX XXX and XXXIn this paper, we ...The authors claim that none of the material in the paper has been published or is under consideration for publication elsewhere.The corresponding author is Dr. XXX and his address and other information is as following:Address: Department of XXX, XX University, ..., P.R.ChinaE-mail:Tel: +86-xxx-xxxxxxxxFax: +86-xxx-xxxxxxxxThank you very much for consideration!Sincerely Yours,Dr. xxx模板3Dear Mr. **We believe the paper may be of particular interest to the readers of your journal as it ........1. The work described has not been submitted elsewhere for publication, in whole or in part, and all the authors listed have approved the manuscript that is enclosed.2. I have read and have abided by the statement of ethical standards for manuscripts submitted to Neuroscience.kind regards.Your sincerely,通讯作者Dear Prof. Gil:This is a manuscript by**and **entitled “.......”. It is submitted to be considered for publication as a “...” in your journal. This paper is new. Neither the entire paper nor any part of its content has been published or has been accepted elsewhere. It is not being submitted to any other journal.Correspondence should be addressed to **at the following address, phone and fax number, and email address:...Thanks very much for your attention to our paper.Sincerely yours,**投稿信模版四（实例）Case 1Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels andtransmitter release", which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.HighlightsHighlights are a short collection of bullet points that convey the core findings and provide readers with a quick textual overview of the article. These three to five bullet pointsdescribe the essence of the research (e.g. results or conclusions) and highlight what is distinctive about it.Highlights will be displayed in online search result lists, the contents list and in the online article, but will not (yet) appear in the article PDF file or print.Author instructions:Highlights should be submitted as a separate file in EES by selecting "Highlights" from thedrop-down list when uploading files. Please adhere to the specifications below.Specifications:•Include 3 to 5 highlights.•There should be a maximum of 85 characters, including spaces, per highlight.•Only the core results of the paper should be covered.ExamplesJournal of Health Economics, Volume 29, Issue 4, July 2010, 524-535Highlights•We model two hospitals which have regulated prices and compete on quality.•We examine changes in the level of information about hospital quality.•Increasing information will increase quality if hospital costs are similar.•Increasing information will decrease quality if hospital costs are very different.•Welfare effects depend on ex-ante or ex-post assumptions about quality information.Applied Catalysis A, General, Volumes 411-412, 16 January 2012, 7-14 Highlights•Highly c-axis oriented ZnO nanowires were grown on glass using aqueous solutions.•The growth temperature does not exceed 95 °C in any step of the synthesis.•The photocatalytic and wetting properties were studied upon UV irradiation.•ZnO nanowires show superior photocatalytic activity.•We report a reversible photo-induced transition from hydrophobic to super-hydrophilic.Biochimica et Biophysica Acta (BBA), Bioenergetics, Volume 1807, Issue 10, October 2011, 1364-1369Highlights• A conformational two-state mechanism for proton pumping complex I is proposed.•The mechanism relies on stabilization changes of anionic ubiquinone intermediates.•Electron-transfer and protonation should be strictly controlled during turnover.•The mechanism explains the full reversibility of complex I.Learning and Instruction, Volume 21, Issue 6, December 2011, 746-756 Highlights•Fading of a script alone does not foster domain-general strategy knowledge.•Performance of the strategy declines during the fading of a script.•Monitoring by a peer keeps performance of the strategy up during script fading.•Performance of a strategy after fading fosters domain-general strategy knowledge.•Fading and monitoring by a peer combined foster domain-general strategy knowledge.。

Dear Editor of the 此处写期刊英文名称:Thank you for your letter and thanks for your careful review to our manuscript entitled "论文题目". We would like to submit the revised manuscript entitled "论文题目（修改后的）". In our revised manuscript, the advices of reviewers were accepted and we make some revise. The list of revised items was upload as supporting information (filename: list of revised items). The following is the answer for the reviewer’s comment s. Problems Answered:1. On Page 3 (lines 50-55), the authors said that preliminary studies have shown that 4 hours were sufficient for attaining equilibrium. Which are these preliminary studies?, Y ou should give the references.Answer: We made a mistake. We want to say that according to our previous experiments, four hours were sufficient for attaining equilibrium. Our English is not so good. In fact, the composition of two phases remains the same after two hours. In order to make sure that the equilibrium is attained, four hours are given.The time used here for equilibrium and phase splitting was fixed according to results from our previous experiments.2. On Table 2 is expected that: w1,II + w2,II + w3,II + w4,II be equals to 1. However, using your results for the last series I obtain the following result: 0.327 + 0.658 + 0.016 + 0.002 = 1.003. Why?Answer: According to the original data, it is a mistake that 0.327 should be 0.324.3. In the Abstract and in the page 5 (line 24) the authors stated that “the reliability of the experimental data were taste using the Othmer –Tobias correlation”. Good correlation results with the empirical Othmer –Tobias equation are not criteria accuracy of the fitting data. This is wrong. Good representation of the experimental data with the empirical equation do not means that the data accurate. Even wrong data can be accurately correlates with any empirical equations.Answer: We think you are right and we revised it. But Reference [16], [17] also said so. The abstract of Reference [16] is following:Liquid-liquid equilibrium (LLE) data for four ternary systems comprising cyclohexane + (benzene, toluene, ethylbenzene, or cumene) + sulfolane have been measured at 303.15 K and at atmospheric pressure. The LLE data for a six-component system including (cyclohexane + benzene + toluene + ethylbenzene + cumene + sulfolane) has also been measured at the above conditions. The reliability of the experimental data was testedusing the Othmer-Tobias correlation. The LLE data were then analyzed using a UNIFAC model with group-interaction parameters extracted from the UNIFAC-LLE data bank and a NRTL version with temperature-dependent binary parameters determined from the experimental LLE data (NRTL/2), both as programmed by the Aspen Plus simulator. Based on the analysis of these data, both models represented the experimental data with sufficient accuracy as revealed from the very small values of the root mean square error and the average absolute deviation in composition.4. Please give some comment how extraction of the samples from each phase is effected on the uncertainty of the measurements. Because, when samples extracting from the phase the equilibrium condition can be slightly changed.Answer: We tried our best to get the samples of two phases at the same time and the amounts of samples are much less compared with that of the material of two phases. So the uncertainty that extraction of the samples brought up can be neglected reasonably.We have reviewed the final version of the manuscript and approve it for publication.All authors have read the manuscript and approved to submit it to your journal. Correspondence and phone calls about the paper should be directed to 通信作者名字at the following address, phone, and e-mail address：通信作者Institute: ………………Address: ………………Tel：……E-mail：………………Thank you very much for your attention and consideration.Sincerely yours，通信作者The following is the revised items:page 1, line 28: “The reliability of the experimental data was tested using the Othmer-Tobias correlation” → “The experimental data was correlated using the Othmer-Tobias correlation”Page 3, line 53: “The preliminary studies have shown that this time was sufficient for attaining equilibrium.” → “The time used here for equilibrium and phase splitting wasfixed according to results from our preliminary tests.”Page 5, line 7-17: all of the “11ω” → “1,ωⅠ”; all of the “21ω” → “2,ωⅠ”; all of the “12ω” → “1,ωⅡ”; all of the “22ω” → “2,ωⅡ”Page 5, eq 3: “1121221121221ln ln 1a b ωωωωωω⎛⎫⎛⎫+-=+ ⎪ ⎪--⎝⎭⎝⎭” → “3,2,3,2,11ln ln a b ωωωω⎛⎫⎛⎫--=+ ⎪ ⎪ ⎪ ⎪⎝⎭⎝⎭ⅠⅡⅠⅡ” Page 5, line 24: “The reliability of the experimental data can be ascertained by applying the Othmer-Tobias correlation” → “The experimental data can be correlated by applying the Othmer-Tobias correlation”Page 5, line 33: “Where a and b are the fitting parameters of Othmer-Tobias correlation.” → “Where a and b are the fitting parameters of Othmer-Tobias correlation. 3,ωⅠ is the DMF mass fraction in the extract phase.” Page 6, line 1: “11.4” →”11.36”Page 6, line 11-12: Remove “Certainly, how the solvent acts on the extraction is another interesting question.”Table 1 was change as follow ：extract phaseraffinate phaseSK 1,ωI 2,ωI 3,ωI 4,ωI 1,ωⅡ 2,ωⅡ 3,ωⅡ 4,ωⅡ(4)/(3)10/90ωω=0.054 0.043 0.722 0.181 0.122 0.757 0.109 0.012 7.79 0.44 0.102 0.057 0.672 0.168 0.175 0.703 0.110 0.012 7.19 0.58 0.149 0.071 0.624 0.156 0.219 0.644 0.124 0.014 6.17 0.68 0.207 0.084 0.567 0.142 0.257 0.595 0.133 0.015 5.71 0.81 0.249 0.093 0.526 0.131 0.311 0.460 0.206 0.023 3.96 0.80 0.299 0.126 0.460 0.115 0.349 0.408 0.218 0.0242.770.86(4)/(3)15/85ωω=0.050 0.030 0.737 0.184 0.139 0.802 0.054 0.006 9.62 0.36 0.100 0.048 0.682 0.170 0.199 0.736 0.059 0.0077.710.500.151 0.062 0.629 0.157 0.241 0.691 0.062 0.007 6.98 0.63 0.202 0.077 0.577 0.144 0.275 0.638 0.078 0.009 6.09 0.73 0.246 0.088 0.533 0.133 0.321 0.587 0.083 0.009 5.11 0.77 0.301 0.112 0.470 0.117 0.369 0.516 0.103 0.0113.760.82(4)/(3)16/84ωω=0.053 0.028 0.735 0.184 0.153 0.832 0.013 0.001 10.29 0.35 0.082 0.031 0.710 0.177 0.222 0.747 0.028 0.003 8.90 0.37 0.102 0.033 0.692 0.173 0.265 0.703 0.029 0.003 8.20 0.38 0.130 0.037 0.667 0.167 0.312 0.615 0.066 0.007 6.93 0.42 0.142 0.041 0.654 0.164 0.359 0.538 0.093 0.0105.190.40(4)/(3)17/83ωω=0.054 0.024 0.692 0.231 0.165 0.833 0.001 0.001 11.36 0.33 0.073 0.025 0.677 0.226 0.241 0.743 0.014 0.002 9.00 0.30 0.095 0.028 0.658 0.219 0.279 0.707 0.013 0.001 8.60 0.34 0.112 0.029 0.644 0.215 0.324 0.658 0.016 0.0027.840.35It was re-calculate all parameters reported in Table 2 using the correct form of the Othmer-Tobias correlation.(4)/(3)ωω N a b R 2 SD 10/90 6 -0.1175 0.6906 0.9690 0.08 15/85 6 0.1750 0.8771 0.9976 0.02 16/84 5 -0.5826 0.2745 0.9920 0.02 17/834-0.46250.22520.92510.03The li terature cited was corrected according to the reviewer’s requests.。

一、投稿信1. Dear Dr. Defendi ML:I am sending a manuscript entitled “” by – which I should like to submit for possible publication in the journal of - .Yours sincerely2. Dear Dr. A:Enclosed is a manuscript entitled “” by sb, which we are submitting for publication in the journal of - . We have chosen this journal because it deals with - . We believe that sth would be of interest to the journal’s readers.3. Dear Dr. A:Please find enclosed for your review an original research article, “” by sb. All authors have read and approve this version of the article, and due care has been taken to ensure the integrity of the work. No part of this paper has published or submitted elsewhere. No conflict of interest exits in the submission of this manuscript, and we have attached to this letter the signed letter granting us permission to use Figure 1 from another source.We appreciate your consideration of our manuscript, and we look forwardto receiving comments from the reviewers.二、询问有无收到稿件Dear Editors,We dispatched our manuscript to your journal on 3 August 2006 but have not, as yet, receive acknowledgement of their safe arrival. We fear that may have been lost and should be grateful if you would let us know whether or not you have received them. If not, we will send our manuscript again. Thank you in advance for your help.三、询问论文审查回音Dear Editors，It is more than 12 weeks since I submitted our manuscript (No: ) for possible publication in your journal. I have not yet received a reply and am wondering whether you have reached a decision. I should appreciated your letting me know what you have decided as soon as possible.四、关于论文的总体审查意见1. This is a carefully done study and the findings are of considerable interest. A few minor revision are list below.2. This is a well-written paper containing interesting results which merit publication. For the benefit of the reader, however, a number of points need clarifying and certain statements require further justification. There are given below.3. Although these observation are interesting, they are rather limited and do not advance our knowledge of the subject sufficiently to warrant publication in PNAS. We suggest that the authors try submitting their findings to specialist journal such as –4. Although this paper is good, it would be ever better if some extra data were added.5. This manuscript is not suitable for publication in the journal of –because the main observation it describe was reported 3 years ago in a reputable journal of - .6. Please ask someone familiar with English language to help you rewrite this paper. As you will see, I have made some correction at the beginning of the paper where some syntax is not satisfactory.7. We feel that this potentially interesting study has been marred by an inability to communicate the finding correctly in English and should like to suggest that the authors seek the advice of someone with a good knowledge of English, preferable native speaker.8. The wording and style of some section, particularly those concerning HPLC, need careful editing. Attention should be paid to the wording ofthose parts of the Discussion of and Summary which have been underlined.9. Preliminary experiments only have been done and with exception of that summarized in Table 2, none has been repeated. This is clearly unsatisfactory, particularly when there is so much variation between assays.10. The condition of incubation are poorly defined. What is the temperature? Were antibody used?五、给编辑的回信1. In reply to the referee’s main criticism of paper, it is possible to say that –One minor point raised by the referee concerns of the extra composition of the reaction mixture in Figure 1. This has now been corrected. Further minor changes had been made on page 3, paragraph 1 (line 3-8) and 2 (line 6-11). These do not affect our interpretation of the result.2. I have read the referee’s comments very carefully and conclude that the paper has been rejected on the sole grounds that it lake toxicity data.I admit that I did not include a toxicity table in my article although perhaps I should have done. This was for the sake of brevity rather than an error or omission.3. Thank you for your letter of –and for the referee’s commentsconcerning our manuscript entitled “”. We have studied their comments carefully and have made correction which we hope meet with their approval.4. I enclosed a revised manuscript which includes a report of additional experiments done at the referee’s suggestion. You will see that our original findings are confirmed.5. We are sending the revised manuscript according to the comments of the reviewers. Revised portion are underlined in red.6. We found the referee’s comments most helpful and have revised the manuscript7. We are pleased to note the favorable comments of reviewers in their opening sentence.8. Thank you for your letter. I am very pleased to learn that our manuscript is acceptable for publication in Cancer Research with minor revision.9. We have therefore completed a further series of experiments, the result of which are summarized in Table 5. From this we conclude that intrinsic factor is not account.10. We deleted the relevant passage since they are not essential to the contents of the paper.11. I feel that the reviewer’s comments concerning Figures 1 and 2 result from a misinterpretation of the data.12. We would have include a non-protein inhibitor in our system, as a control, if one had been available.13. We prefer to retain the use of Table 4 for reasons that it should be clear from the new paragraph inserted at the end of the Results section.14. Although reviewer does not consider it is important to measure the temperature of the cells, we consider it essential.15. The running title has been changed to “”.16. The Materials and Methods section now includes details for measuring uptake of isotope and assaying hexokinase.17. The concentration of HAT media (page12 paragraph 2) was incorrectly stated in the original manuscript. This has been rectified. The authors are grateful to the referees for pointing out their error.18. As suggested by both referees, a discussion of the possibility of laser action on chromosome has been included (page16, paragraph 2).19. We included a new set of photographs with better definition than those originally submitted and to which a scale has been added.20. Following the suggestion of the referees, we have redraw Figure 3 and 4.21. Two further papers, published since our original submission, have been added to the text and Reference section. These are:22. We should like to thank the referees for their helpful comments and hope that we have now produced a more balance and better account ofour work. We trust that the revised manuscript is acceptable for publication.23. I greatly appreciate both your help and that of the referees concerning improvement to this paper. I hope that the revised manuscript is now suitable for publication.24. I should like to express my appreciation to you and the referees for suggesting how to improve our paper.25. I apologize for the delay in revising the manuscript. This was due to our doing an additional experiment, as suggested by referees.Date: ***Dear Editors:We would like to submit the manuscript entitled “***”, which we wish to be considered for publication in ***.We certify that we have participated sufficiently in the work to take public responsibility for the appropriateness of the study design and method, and the collection, analysis, and interpretation of the data.We have reviewed the final version of the manuscript and approve it for publication. To the best of our knowledge and belief, this manuscript has not been published in whole or in part nor is it being considered for publication elsewhere.Best Regards.Yours Sincerely,Authors : ***,***,***(Submitting author: ***, ***University. EMAIL: ***;Corresponding author: ***,*** University. EMAIL: ***)1、什幺是cover letter？指的是投稿信2、cover letter的内容主要包括那些？应该简述所投稿件的核心内容、主要发现和意义，拟投期刊，对稿件处理有无特殊要求等（如“not to review” list）。

英文文章coverletter[五篇材料]第一篇：英文文章 cover letter1、什么是cover letter？指的是投稿信2、cover letter的内容主要包括那些？应该简述所投稿件的核心内容、主要发现和意义，拟投期刊，对稿件处理有无特殊要求等（如“not to review” list）。

另外，请附上主要作者的中文姓名、通讯地址、电话、传真和e-mail地址。

此外有的杂志要求推荐几位审稿人及其联系方式。

以及谁已经阅读过该文（当然是牛人）。

我投的那个杂志是要求说明你论文研究的意义，以及与这个杂志的相关性，另外还有的可能要写明你没有一搞多投等。

此外临床实验要求写明符合伦理学要求。

3、如何写cover letter？各个杂志的具体要求是不一样的，在杂志的guide for authors一般会有要求。

如果没有具体的要求，大家可按照通用要求处理。

4、常用模板：（1）Cover letterDear Mr.**1.The work described has not been submitted elsewhere for publication, in whole or in part, and all the authors listed have approved the manuscript that is enclosed.2.I have read and have abided by the statement of ethical standards for manuscripts submitted to Neuroscience.kind regards.Your sincerely,通讯作者（2）Dear Dr.主编name:We submit our manuscript entitled “ 文章title” to 杂志名for publication.接着简单介绍你文章的主要创新点和意义，不易过多，但要突出新意和关键点。

To,The Publisher,In****************dation,Subject: Submission of [Following are the categories of manuscripts. Delete whatever is not applicable]“Review Article, Original Article, Short Report,Rapid Communication, Case Series, Case In Images, Case Reports, Clinical Images, Letter to Editors” titled, “[Type or copy/paste here the title of the manuscript]”.Dear Sir/Ma’amWe are submitting a [Following are the categories of manuscripts. Delete whatever is not applicable]“Review Arti cle, Original Article, Short Report, Rapid Communication, Case Series, Case In Images, Case Reports, Clinical Images, Letter to Editors” titled, “[Type or copy/paste here the title of the manuscript]s” for consideration for publication in your Journal “ Advance Research Journal of Multidisciplinary Discoveries”I, ___________________________________________ (Corresponding author) certify that: ∙The manuscript is being submitted by me (Corresponding author) on behalf of all the authors.∙Written, informed consent was taken from the patient/parents/legal guardians/next of kin for reporting this case (strike out whatever is not applicable).∙The manuscript is original work of all authors.∙All authors made a significant contribution to this study.∙This manuscript has not been submitted for publication; it has not been accepted for publication and has not been published in any other journal.∙All authors have read and approved the final version of the manuscript.Thank youSincerely,Sign here[Insert name of the corresponding author]( You can write the cover letter in your own word, otherwise replace your own information related to your paper in the red colored area and send back to our mail with attach your paper . Please submit the cover letter and papers at arm。

Cover Letter对于论文投稿至关重要。

以下是小编总结的SCI论文投稿全过程中要用到的cover letter等投稿信模板，供大家分享借鉴。

一、最初投稿Cover letterDear Editors:We would like to submit the enclosed manuscript entitled “Paper Title”, which we wish to be considered for publication in “Journal Name”. No confli ct of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.In this work, we evaluated …… (简要介绍一下论文的创新性). I hope this paper is suitable for “Journal Name”.The following is a list of possible reviewers for your consideration:1) Name A E-mail: ××××@××××2) Name B E-mail: ××××@××××We deeply appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any q ueries, please don’t hesitate to contact me at the address below.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××二、催稿信Dear Prof. ×××:Sorry for disturbing you. I am not sure if it is the right time to contact you to inquire about the status of my submitted manuscript titled “Paper Title”. (ID: 文章稿号), although the status of “With Editor” has been lasting for more than two months, since submitted to journal three months ago. I am just wondering that my manuscript has been sent to reviewers or notI would be greatly appreciated if you could spend some of your time check the status for us. I am very pleased to hear from you on the reviewer’s comments.Thank you very much for your consideration.Best regards!Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××三、修改稿Cover letterDear Dr/ Prof..（写上负责你文章编辑的姓名，显得尊重，因为第一次的投稿不知道具体负责的编辑，只能用通用的Editors）:On behalf of my co- authors, we thank you very much for giving us an opportunity to revise our manuscript, we appreciate editor and reviewers very much for their positive and constructive comments and suggestions on our manuscript entitled “Paper Title”. (ID: 文章稿号).We have studied reviewer’s comments carefully and have made revision which marked in red in the paper. We have tried our best to revise our manuscript according to the comments. Attached please find the revised version, which we would like to submit for your kind consideration.We would like to express our great appreciation to you and reviewers for comments on our paper. Looking forward to hearing from you.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××四、修改稿回答审稿人的意见（最重要的部分）List of ResponsesDear Editors and Reviewers:Thank you for your letter and for the reviewers’ comments concerning our manuscript entitled “Paper Title” (ID: 文章稿号). Those comments are all valuable and very helpful for revising and improving our paper, as well as the important guiding significance to our researches. We have studied comments carefully and have made correction which we hope meet with approval. Revised portion are marked in red in the paper. The main corrections in the paper and the responds to the reviewer’s comments are as flowi ng:Responds to the reviewer’s comments:Reviewer #1:1. Response to comment: (……简要列出意见……)Response: ××××××2. Response to comment: (……简要列出意见……)Response: ××××××。

英文论文投稿信Cover-letter-模板英文论文投稿信Cover letter模板qiusuo BY - 2006-1-17 8:59:00Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we repo rt an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involvesactivation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this studyhas identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the example used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym])3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]?The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management systemhas become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operationalperformance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readersto understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].4. Names, addresses, and email addresses of four expert referees.Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster, NY 00012-6666, USAphone: +1-888-888-8888 - fax: +1-888-888-8886e-mail: wgates@Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198.Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally. Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123, Harbor Drive Sydney,Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886 e-mail: jadams@.auExpertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98. Relationship: None. I have never met Dr. Adams. Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888, Putong RoadKeelung, Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail: chchen@.twExpertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28.Relationship: Former professor, dissertation chairman.Mr. Frank YoungPartner, ABC Consulting888, Seashore HighwayWon Kok, KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail: fyoung@Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices. Relationship: I have worked with Mr. Young in several consulting projects in the past three years.Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely,Johnny SmithCase 1Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the example used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please type in journal title oracronym])3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]?The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management systemhas become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local units by the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readersto understand this technology and its benefits. This study gives a real-life example of how to use mobile agents for distributed network management. It is the first in the literature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].4. Names, addresses, and email addresses of four expert referees.Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster, NY 00012-6666, USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: wgates@ Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198.Relationship: I met Dr. Gate only once at a conference in 1999. I didn't know him personally.Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123, Harbor Drive Sydney,Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail: jadams@.auExpertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98.Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888, Putong RoadKeelung, Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail: chchen@.twExpertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28.Relationship: Former professor, dissertation chairman.Mr. Frank YoungPartner, ABC Consulting888, Seashore HighwayWon Kok, KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail: fyoung@Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices.Relationship: I have worked with Mr. Young in several consulting projects in the past three years.Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely,。

Cover Letter对于论文投稿至关重要。

以下是小编总结的SCI论文投稿全过程中要用到的c o v e r l e t t e r等投稿信模板，供大家分享借鉴。

一、最初投稿Cover letterDear Editors:We would like to submit the enclosed manuscript entitled “Paper Title”, which we wish to be considered for publication in “Journal Name”. No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed.In this work, we evaluated …… (简要介绍一下论文的创新性). I hope this paper is suitable for “Journal Name”.The following is a list of possible reviewers for your consideration:1) Name A E-mail: ××××@××××2) Name B E-mail: ××××@××××We deeply appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any queries, please don’t hesitate to contact me at the address below.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××二、催稿信Dear Prof. ×××:Sorry for disturbing you. I am not sure if it is the right time to contact you to inquire about the status of my submitted manuscript titled “Paper Title”. (ID: 文章稿号), although the status of “With Editor” has been lasting for more than two months, since submitted to journal three months ago. I am just wondering that my manuscript has been sent to reviewers or not?I would be greatly appreciated if you could spend some of your time check the status for us. I am very pleased to hear from you on the reviewer’s comments.Thank you very much for your consideration.Best regards!Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××三、修改稿Cover letterDear Dr/ Prof..（写上负责你文章编辑的姓名，显得尊重，因为第一次的投稿不知道具体负责的编辑，只能用通用的Editors）:On behalf of my co- authors, we thank you very much for giving us an opportunity to revise our manuscript, we appreciate editor and reviewers very much for their positive and constructive comments and suggestions on our manuscript entitled “Paper Title”. (ID: 文章稿号).We have studied reviewer’s comments carefully and have m ade revision which marked in red in the paper. We have tried our best to revise our manuscript according to the comments. Attached please find the revised version, which we would like to submit for your kind consideration.We would like to express our great appreciation to you and reviewers for comments on our paper. Looking forward to hearing from you.Thank you and best regards.Yours sincerely,××××××Corresponding author:Name: ×××E-mail: ××××@××××四、修改稿回答审稿人的意见（最重要的部分）List of ResponsesDear Editors and Reviewers:Thank you for your letter and for the reviewers’ comments concerning our manuscript entitled “Paper Title” (ID: 文章稿号). Those comments are all valuable and very helpful for revising and improving our paper, as well as the important guiding significance to our researches. We have studied comments carefully and have made correction which we hope meet with approval. Revised portion are marked in red in the paper. The main corrections in the paper and the responds to the reviewer’s comme nts are as flowing:Responds to the reviewer’s comments:Reviewer #1:1. Response to comment: (……简要列出意见……)Response: ××××××2. Response to comment: (……简要列出意见……)Response: ××××××。

英文论文投稿信C o v e r l e t t e r集团文件发布号：（9816-UATWW-MWUB-WUNN-INNUL-DQQTY-英文论文投稿信Cover?letter模板qiusuo BY - 2006-1-17 8:59:00Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability,in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that thenormal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implicatio ns in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitterrelease at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also have general implications in the cell biology of neurotransmitter release.[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the example used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed network management system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym])3. Why the material is important in its field and why the material should be published in [please type in journal titleor acronym]The necessity of having an effective computer network israpidly growing alongside the implementation of information technology. Finding an appropriate network management systemhas become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local unitsby the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readersto understand this technology and its benefits. This studygives a real-life example of how to use mobile agents for distributed network management. It is the first in theliterature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].4. Names, addresses, and email addresses of four expert referees.Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster, NY 00012-6666, USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198. Relationship: I met Dr. Gate only once at a conference in 1999.I didn't know him personally.Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123, Harbor Drive Sydney,Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail:Expertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98.Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888, Putong RoadKeelung, Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail:Expertise: published a related paper ("Network Management for E-Commerce") in IJ Electronic Business, 1(4), pp. 18-28. Relationship: Former professor, dissertation chairman.Mr. Frank YoungPartner, ABC Consulting888, Seashore HighwayWon Kok, KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail:Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices. Relationship: I have worked with Mr. Young in several consulting projects in the past three years.Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely,Johnny SmithCase 1Dear Editor,We would like to submit the enclosed manuscript entitled "GDNF Acutely Modulates Neuronal Excitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons", which we wish to be considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbrain dopaminergic neurons, which are degenerated in Parkinson’s disease. In this paper, we report an unexpected, acute effect of GDNF on A-type potassium channels, leading to a potentiation of neuronal excitability, in the dopaminergic neurons in culture as well as in adult brain slices. Further, we show that GDNF regulates the K+ channels through a mechanism that involves activation of MAP kinase. Thus, this study has revealed, for the first time, an acute modulation of ion channels by GDNF. Our findings challenge the classic view of GDNF as a long-term survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine release. These results may also have implications in the treatment of Parkinson’s disease.Due to a direct competition and conflict of interest, we request that Drs. XXX of Harvard Univ., and YY of Yale Univ. not be considered as reviewers. With thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled "Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release", which we wish to be considered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron. First, we report that GDNF has a long-term regulatory effect on neurotransmitter release at the neuromuscular synapses. This provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic transmission. Second, we show that the GDNF effect is mediated by enhancing the expression of the Ca2+-binding protein frequenin. Further, GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ influx. Thus, this study has identified, for the first time, a molecular target that mediates the long-term, synaptic action of a neurotrophic factor. Our findings may also havegeneral implications in the cell biology of neurotransmitter release.[0630][投稿写作]某杂志给出的标准Sample Cover Letter[the example used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled "Mobile Agents for Network Management." Please accept it as a candidate for publication in the [journal title]. Below are our responses to your submission requirements.1. Title and the central theme of the article.Paper title: "Mobile Agents for Network Management." This study reviews the concepts of mobile agents and distributed networkmanagement system. It proposes a mobile agent-based implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agent-based network over the conventional client-server architecture in a large network environment.2. Which subject/theme of the Journal the material fitsNew enabling technologies (if no matching subject/theme, enter 'Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym])3. Why the material is important in its field and why the material should be published in [please type in journal title or acronym]The necessity of having an effective computer network is rapidly growing alongside the implementation of information technology. Finding an appropriate network management systemhas become increasingly important today's distributed environment. However, the conventional centralized architecture, which routinely requests the status information of local unitsby the central server, is not sufficient to manage the growing requests. Recently, a new framework that uses mobileagent technology to assist the distributed management has emerged. The mobile agent reduces network traffic, distributes management tasks, and improves operational performance. Given today's bandwidth demand over the Internet, it is important for the [journal title/acronym] readersto understand this technology and its benefits. This studygives a real-life example of how to use mobile agents for distributed network management. It is the first in theliterature that reports the analysis of network performance based on an operational prototype of mobile agent-based distributednetwork. We strongly believe the contribution of this study warrants its publication in the [journal title/acronym].4. Names, addresses, and email addresses of four expert referees.Prof. Dr. William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster, NY 00012-6666, USAphone: +1-888-888-8888 - fax: +1-888-888-8886 e-mail: Expertise: published a related paper ("TCP/IP and OSI: Four Strategies for Interconnection") in CACM, 38(3), pp. 188-198. Relationship: I met Dr. Gate only once at a conference in 1999.I didn't know him personally.Assoc Prof. Dr. John AdamsDirector of Network Research CenterCollege of Business Australian University123, Harbor Drive Sydney,Australia 56789phone: +61-8-8888-8888 - fax: +61-8-8888-8886e-mail:Expertise: published a related paper ("Creating Mobile Agents") in IEEE TOSE, 18(8), pp. 88-98.Relationship: None. I have never met Dr. Adams.Assoc Prof. Dr. Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888, Putong RoadKeelung, Taiwan 100phone: +886-2-8888-8888 - fax: +886-2-8888-8886e-mail:Expertise: published a related paper ("Network Management forE-Commerce") in IJ Electronic Business, 1(4), pp. 18-28. Relationship: Former professor, dissertation chairman.Mr. Frank YoungPartner, ABC Consulting888, Seashore HighwayWon Kok, KowloonHong Kongphone: +852-8888-8888 - fax: +852-8888-8886e-mail:Expertise: Mr. Young provides consulting services extensively to his clients regarding network management practices. Relationship: I have worked with Mr. Young in several consulting projects in the past three years.Finally, this paper is our original unpublished work and it has not been submitted to any other journal for reviews.Sincerely,。