-
29
Ubiquitin (泛素）对PRR信号的调节
泛素由76个氨基酸残基组成，其中包括7个赖氨酸残基(K), 其C末端可与 底物的赖氨酸残基形成异肽键，从而引起底物泛素化。泛素的K11、K29 、K48和K63均能参与形成泛素与泛素间的异肽键 (Isopeptide bond)。
-
3030
Ubiquitination for RIG-I signaling
Fujita T
-
25
2-2） structure of RIG-I
RIG-I 结合 5’-ppp dsRNA
-
26
MAVS： adapter for RIG-I
Seth, R.B., Sun, L., Ea, C., and Chen, Z.J., "Identification and characterization of MAVS: a mitochondrial antiviral signaling protein that activates NF-κB and IRF3." Cell, 122:669-682, 2005
has been shown to induce the innate immune response in adult Drosophila. Like Drosophila Toll, human Toll is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat (LRR) domain, and a cytoplasmic domain homologous to the cytoplasmic domain of the human interleukin (IL)-1 receptor. Both Drosophila Toll and the IL-1 receptor are known to signal through the NF-kappaB pathway. We show that a constitutively active mutant of human Toll transfected into human cell lines can induce the activation of NF-kappaB and the expression of NF-kappaB-controlled genes for the inflammatory cytokines IL-1, IL-6 and IL-8, as well as the expression of the co-stimulatory molecule B7.1, which is required for the activation of naive T cells.
